Pow.Bio and Bühler have teamed up to bring an integrated continuous precision fermentation platform to market. From established ingredients such as enzymes and organic acids to categories like functional proteins, specialty lipids, and bioactive compounds, the Pow.Bio-Bühler solution is expected to offer a continuous, more efficient production pathway.
Pow.Bio, a pioneer in AI-enabled continuous fermentation technology, and Bühler Group, a global solution provider for food, feed, and advanced materials, are teaming up to bring an integrated continuous precision fermentation platform to market. The collaboration aims to advance industrial biomanufacturing by accelerating process development, reducing unit production costs thanks to a continuous process, and improving operational performance. Bühler and Pow.Bio highlighted that they are now ready to begin onboarding customers.
Unlike traditional fermentation approaches that rely on batch or fed-batch processes – stop-and-start methods that require the tank to be emptied and cleaned between runs – the companies now offer an ultra-efficient and streamlined solution. The offering brings together Pow.Bio’s proprietary continuous fermentation technology with Bühler’s 165 years of engineering, delivery, installation, and commissioning services – all supported by advanced model-driven control software, according to the partners. The result is a platform that allows customers to establish precision fermentation capacity faster, with predictable performance, lower unit costs, and a direct path to scale.
The platform is designed for companies commercializing fermentation-derived products that are currently produced in fed-batch systems but constrained by cost, scalability, or inconsistent output. From established ingredients such as enzymes and organic acids to categories like functional proteins, specialty lipids, and bioactive compounds, the Pow.Bio-Bühler solution is expected to offer a continuous, more efficient production pathway. By replacing traditional fed-batch processes with a continuous, model-driven system, customers could achieve significantly higher productivity, improved process consistency, and more cost-effective manufacturing through an established, low-risk pathway from lab to pilot and full industrial scale.
Photo: Bühler
“Our collaboration with Bühler sets a new benchmark for biomanufacturing: not just faster, but smarter and more robust,” said Shannon Hall, CEO and co-founder of Pow.Bio. “Clients can now capitalize on proven technology and global deployment expertise to unlock commercial-scale production with lower risk and unprecedented efficiency. This partnership solidifies Pow.Bio’s position at the forefront of industrial biotechnology, enabling us to deliver enduring value for our clients and the sector as a whole.”
Photo: Bühler
Bühler points out that the partnership fully aligns with its innovation culture and focus on applied scalable technologies. “Precision fermentation has the potential to impact the food, feed, and specialty ingredients industries. Companies are already using it to produce dairy, meat, and egg substitutes, alternative oils and fats, and even novel pet food – and we are only at the beginning of what this technology can unlock,” said Thierry Duvanel, Bühler’s North American Director of Innovation. “By joining forces with Pow.Bio, we take a clear step toward reducing unit production costs in biomanufacturing, combining complementary expertise to accelerate innovation and deliver a fully integrated system backed by experience, service, and reliability.”
ACCELERATING COMMERCIALIZATION WITH CONFIDENCE
Following Pow.Bio’s successful 3,000 L scale-up with ATV Technologies, achieved with Bühler’s support, this partnership is now positioned to accelerate adoption across the industry. By giving companies a clearer route from development to commercial production, the joint solution is aimed at addressing hurdles that have long slowed scale-up in the sector. “With the technology validated and the full system in place, we are prepared to onboard customers and support them through deployment and scale-up,” noted Adham Rizk, Sales and Commercial Manager at Bühler Group.
