New Study: Indole-rich postbiotic reduces itching in dogs

A new study shows that Kingdom Supercultures’ indole-rich postbiotic, Superculture® Pet Immune, significantly reduces itching and improves skin and coat health in dogs by supporting the gut-skin axis.

New Study: Indole-rich postbiotic reduces itching in dogsA new peer-reviewed study has found that Superculture® Pet Immune, Kingdom Supercultures’ indole-rich postbiotic, significantly reduces itching and improves skin and coat quality in dogs with subclinical but elevated itching behavior. The study presents a promising nutritional approach to support gut-skin health in dogs.

In the randomized, double-blinded, placebo-controlled trial, 30 healthy dogs were assigned to receive either a placebo or the Superculture® Pet Immune postbiotic over a 28-day period. The ingredient contains heat-inactivated Pediococcus acidilactici fermentation product on a tapioca maltodextrin carrier.

The postbiotic group saw a 20% reduction in scratching frequency relative to baseline, measured via accelerometer devices, and a 27% decrease in human-perceived itching using the Pruritus Visual Analog Scale (PVAS) compared to placebo at Day 28. Improvements in coat quality were observed as early as Day 14, with statistical significance over placebo. The postbiotic alwso had measurable effects on the gut microbiome.

Unlike other postbiotic interventions in dogs that have failed to show significant changes in itching or microbiome diversity, Superculture® Pet Immune demonstrated consistent benefits across multiple indicators.

“These findings validate this postbiotic’s ability to reduce itching in dogs with subclinical, but elevated itching behavior, provide evidence of promoting a healthy gut-skin axis and suggest potential as an early intervention in the context of pruritic conditions as well as for broader immune-related benefits,” the authors of the study noted.