Layn Natural Ingredients has launched its natural additive ingredient TruGro CARE Joint Health for the pet wellness. According to the company, the botanicals in the product support a healthy inflammatory response as well as bone, cartilage and muscle health in pets.
A company with a focus on innovation and manufacturing of natural botanical extract ingredients and solutions, Layn Natural Ingredients has announced the launch of TruGro CARE Joint Health, a natural polyphenol-rich botanical extract solution designed for use in pet food, treats, and supplements. This innovative product aims to address the growing demand for natural solutions to support pet joint health.
“Many products designed to promote joint integrity for our pet companions provide symptomatic relief by improving the range of motion or reducing discomfort,” said Jim Roza, Chief Scientific Officer at Layn Natural Ingredients. “However, these products contribute little to resolving the underlying causes of joint dysfunction. Causes such as inflammation, bone resorption, and cartilage loss are all contributory factors that can manifest into a loss of strength, motion, and quality of life. Our TruGro CARE Joint Health ingredient harnesses the power of polyphenols, demonstrated in numerous studies to inhibit oxidative stress, and thereby helping to address the root causes of joint discomfort and impairment.”
The company states that TruGro CARE Joint Health contains a synergistic solution of three polyphenol-rich extracts from epimedium, pomegranate and mango leaf. These botanicals work together to support a healthy inflammatory response and to support bone, cartilage and muscle health.
In its statement, Layn Natural Ingredients shares the following details about epimedium, pomegranate and mango leaf:
– Epimedium is the source of a flavonoid called icariin. Icariin has been studied extensively to reduce bone resorption and promote osteoclast production to protect against bone loss1,2. Icariin exerts anabolic effects in bone through the activation of estrogen receptors as researched in both animal and human studies3
– Punicalagin a phenolic compound in pomegranate inhibits the production of pro-inflammatory cytokines. These reactive molecules have a damaging effect on healthy cells, tissues, and organs. Punicalagins have been shown to help both acute and chronic inflammation through signaling pathways associated with autophagy a process by which the body regulates inflammatory responses4.
– Mangiferin extract from mango leaf is another potent antioxidant shown to reduce oxidative stress by protecting the mitochondria and inhibiting metabolic processes that lead to inflammation. Mangiferin also increases levels of innate cellular antioxidants such as super oxide dismutase (SOD), catalase and glutathione5.
“With 52% of dogs and 41% of cats experiencing joint pain, and 36% of dog owners and 28% of cat owners purchasing joint health supplements often based on veterinarian advice, the market for pet joint health supplements is rapidly expanding,” explains Doris Ip, marketing manager at Layn Natural Ingredients.
“Pet owners are increasingly seeking natural ingredients for their pets, treating them as family members and prioritizing their well-being similarly to human health,” Doris Ip concludes.
The compounds contained in TruGro CARE Joint Health have been shown to help maintain oxidative balance, a key factor in supporting joint health.
References
1. Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells Mol Med Rep. 2017 Jan;15(1):125-130.
2. Icariin accelerates cartilage defect repair by promoting chondrogenic differentiation of BMSCs under conditions of oxygenglucose deprivation J Cell Mol Med 2022 Jan;26(1):202-215
3. Phytoestrogens Annu Rev Plan Biol 2004;55 225-261
4. Punicalagin Prevents Inflammation in LPS-Induced RAW264.7 Macrophages by Inhibiting FoxO3a/Autophagy Signaling Pathway Nutrient. 2019 Nov 15;11(11):2794.
5. Mangiferin exerts protective effects on joints of adjuvant-induced arthritis rats by regulating the MAPKs/NF-κB pathway of fibroblast-like synoviocytes Int Immunopharmacol. 2021 Dec;101(Pt B):108352
