Zoetis receives European Commission marketing authorization for Solensia® (frunevetmab), a new therapy for feline osteoarthritis pain. Solensia is the first injectable monoclonal antibody (mAb) licensed for alleviation of pain associated with osteoarthritis (OA) in cats.
Zoetis Inc. announced that the European Commission has granted the marketing authorization for Solensia® (frunevetmab), a new feline osteoarthritis treatment to alleviate pain. Osteoarthritis in cats is a very prevalent condition, existing in 40% of cats, and may generate pain and limit a cat’s comfort and quality of life if not treated.
Solensiaworks differently from current treatment options by targeting Nerve Growth Factor (NGF), a key player in osteoarthritis (OA) pain. It functions like naturally occurring antibodies, with minimal involvement of the liver or kidneys in their metabolism and elimination process, and minimal gastrointestinal impact. It is delivered by the veterinarian as a monthly injection (under the skin).
“At Zoetis, our monoclonal antibody research continues to advance the care of animals, and our platform allows us to explore new therapeutic areas for the management of diseases with high prevalence and high unmet needs,” said Catherine Knupp, DVM, MS, Executive Vice President and President, Research and Development at Zoetis. “OA pain in cats remains vastly undertreated, and Solensia is a prime example of our commitment to meaningful innovation in feline medicines. This monthly treatment is an effective new treatment option for veterinarians and cat owners, and we are very pleased to be granted the first approval of a monoclonal antibody therapy for alleviation of pain in cats.”
IMPROVED QUALITY OF LIFE FOR CATS AND THEIR OWNERS
By alleviating pain, Solensia helps generally improve physical activity level, sociability and quality of life of cats with OA. This new product’s benefits are effective pain relief, combined with a positive safety profile in a monthly injectable treatment for OA pain in cats. In a clinical study over three months, pet owners observed signs of pain, including physical activity level, sociability and quality of life. A total of 76% of cat owners reported sustained improvement in signs of pain when their cats were treated with Solensia.
Margaret E. Gruen, DVM, MVPH, PhD, DACVB, Assistant Professor of Behavioral Medicine at North Carolina State University, said: “My clinical research, and personal experience, has shown that OA pain can affect cats in a variety of ways. It impairs their ability to perform their activities of daily living and negatively impacts their quality of life. OA pain can also affect sleep, cognitive function, affect (emotion) and social relationships.”
“NGF is one of the key factors mediating pain, inducing the release of both pro-inflammatory mediators and more NGF contributing to a cycle of pain and inflammation. Anti-NGF therapy could be the most exciting therapeutic advancement in more than 20 years in veterinary medicine to control OA pain, and I welcome this innovative tool for clinicians working to alleviate OA pain. The monthly administration makes it especially useful for cats, with the potential to bring pain relief to millions of cats who suffer from OA,” she said.
Veterinarians believe that Solensia would help more cats with OA pain be treated and for longer. Mike McFarland, DVM, Executive Vice President and Chief Medical Officer at Zoetis said: “In my experience, I have learned that cats can hide their pain well. Cat owners used to come in when their cats were showing signs of discomfort like sleeping more, irritability or lack of activity, but they thought these were just ‘normal’ aging behaviours. Thanks to Solensia, veterinarians will now have a breakthrough solution available for the management of pain associated with osteoarthritis in cats and will ultimately offer new alternatives to cat owners to improve the quality of life of their pets.”
Rob Kelly, Executive Vice President and President, International Operations at Zoetis concludes, “Our focus on feline medicines is not new. It includes a large portfolio of solutions to predict, prevent, detect and treat diseases with rapid-test diagnostics, vaccines and other preventative solutions like Stronghold Plus® against several parasites, Cerenia® for alleviation of vomiting and Synulox® for the treatment of a wide range of bacterial infections in cats. We are very excited to now add Solensia to our portfolio of feline products, as a unique new solution for cat owners and veterinarians in the management of pain associated with osteoarthritis.”
The active substance of Solensia is frunevetmab, a monoclonal antibody (mAb) distinct to that used in Librela (bedinvetmab), its canine counterpart. Each was designed specifically for its target species.
