ARTICLE FEED & ADDITIVE MAGAZINE March 2026 57 PRPP 2. Salvage pathway 1. De novo synthesis IMP OMP UMP UDP AMP AMP kinase UMP kinase GMP kinase ADP ATP GMP GDP GTP UTP CTP Nucleoside diphosphate kinase Orotate PRPP Simple metabolites Simple metabolites Salvage pathway Purine ring synthesized into a sugar Pyrimidine ring synthesized into a sugar Pyrimidine ring synthesized Free bases + ribose-1-phosphate High level of Nucleotide Purines β-alanine β-aminoisobutyrate Uric Acid Glyoxylic acid (excretion) Urine Glycine NH3 + CO2 + Acetyl CoA (recycle) Allantoin Nucleotides Essential pathway (Deficiency: Lesch-Nyhan syndrome) Pyrimidines Dietary Nucleic acids + Nucleotide degradation “Salvaged” nucleic acids 11 Steps 4 Steps (Phosphoribosyl pyrophosphate) PO4 donor nucleotide additive containing 53% total nucleotides (of which 51% was 5'-IMP) and reported linear improvements in both average daily gain (ADG) and average daily feed intake (ADFI) (See Table 1). During the first week (Phase 1), ADG in the 1.0 g/ kg group more than tripled, surging by 225.7% (83.7 g/d vs 25.7 g/d) compared to the control group. For producers, this early stage boost is critical; accelerating the growth curve during Phase 1 reduces total days to market and optimizes nursery throughput. Figure 1. Overview of de novo synthesis and salvage pathways of nucleotides Performance Parameters ADG ADFI G:F Phase 1 (Day 0-7) Phase 2 (Day 7-28) Overall (Day 0-28) Linear increase (P = 0.007) 25.7 vs 83.7 (g/d)† Linear increase (P = 0.005) 150.9 vs 197.1 (g/d)† Linear increase (P = 0.015) 0.014 vs 0.401 (g/g)† Significant Increase* 363.9 vs 386 (g/d)† Linear increase (P < 0.001) 512.1 vs 588 (g/d)† No Effect Linear increase (P = 0.031) 270.9 vs 301.8 (g/d)† Linear increase (P < 0.001) 412.5 vs 480.2 (g/d)† No Effect Table 1. Effect of nucleotide supplementation on growth performance in nursery pigs * Obeserved significant increases specifically from d 14-21 (P = 0.043) and d 21-28 (P = 0.053). † Values presented as 'vs' indicate the measurements for the 0 g/kg and 1.0 g/kg groups, respectively
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