ISSUE FOCUS FEED & ADDITIVE MAGAZINE January 2026 37 • Quillaja Extracts: Powder and liquid forms standardized in triterpenic saponins. Their defined composition provides predictable immune modulation and health support while helping control pathogen-related challenges, making them valuable during periods of increased biological pressure or vaccination programs. • Quillaja Pulverized: Powders containing saponins and polyphenols. They help maintain gut condition and improve environmental quality in barns and ponds through better litter characteristics and significantly reduced emissions. Both ingredient types share the same origin, sustainability model, and technical control, allowing nutritionists to adapt their use according to health priorities, production phase, and cost sensitivity without changing the underlying scientific foundation. BIOLOGICAL MECHANISMS AND FIELD OUTCOMES The biological activity of Quillaja saponins has been described extensively in the literature and further investigated through research programs led by Plantae Labs in collaboration with independent centers. Their primary mechanism is immune modulation. By activating macrophages and T lymphocytes, these compounds help maintain an alert but balanced immune system, capable of responding efficiently to natural challenges without excessive inflammation. Pathogen Control Immune Mechanisms and Functional Effects of Quillaja Saponin Extracts Quillaja saponins interact with sterol-rich membranes of pathogens, disrupting their structure and reducing colonization. This selective action helps control enteric challenges without affecting attenuated oocyst vaccines or beneficial microbiota, complementing preventive and health-supporting programs. Inflammation control IL-10, TGF-β IFNY, TNFa IFNY, TNFa Defense-activating T cell Th1 Antibody-supporting T cell Th2 IL-12 Cytokines Mediators Epithelium Gut Microbiota Quillaja Saponins Quillaja Saponins Quillaja Saponins Pathogens Antibodies lg Macrophage Dendritic cell Dendritic cell Dendritic cell Regulatory T cell Mucosal T cell Mucus layer Immune Activation and Defense Quillaja saponins stimulate innate and adaptive immunity by activating dendritic cells and macrophages, inducing IL-12 release and promoting a balanced Th1/Th3 response that enhances IFN-γ secretion and antibody synthesis for effective pathogen defense. Immune Regulation and Balance Quillaja saponins modulate immune responses by promoting IL-10 and TGF-β release, activating regulatory T cells that limit inflammation, maintain immune homeostasis, and support efficient energy balance. Barrier Integrity and Protection Quillaja saponins enhance epithelial protection by supporting mucosal immune activity and antibody production, helping preserve tight-junction integrity and promoting tissue repair for optimal barrier function.
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