ARTICLE FEED & ADDITIVE MAGAZINE December 2025 83 Batch-to-Batch Consistency of Optiwall Mean E.coli Binding (%) 1 2 3 4 5 6 7 8 9 101112131415 Binding (%) Across 3 E.coli Strains 90 80 70 60 50 40 30 20 10 0 Optiwall’s distinctive strength lies in its thick, cohesive cell wall and long-chain MOS, which offer effective binding sites for bacterial fimbriae, the tiny “hooks” pathogens use to anchor themselves in the gut. This unique structure, preserved through a controlled and gentle production process, turns Optiwall into a reliable tool to help maintain gut health naturally by preventing the adhesion of undesirable bacteria that would normally occur on the gut epithelium (Figure 2). FROM SPECIFICATION TO FUNCTIONALITY With this breakthrough method, Lallemand brings new insight to yeast cell wall science. It shifts the focus from specifications to functionality, emphasizing measurable biological outcomes. Optiwall stands for a new generation of yeast solutions, scientifically substantiated, structurally optimized, and designed to deliver consistent efficacy support gut health, animal welfare, and performance. Lallemand, internal data, 2025 Figure 1. Across 15 production batches, Optiwall demonstrated an average pathogen-binding rate of 80.4 ± 2.65 % (mean ± SD, n = 15), confirming strong consistency and process reliability Figure 2a and 2b. Scanning electron microscopy (SEM) images showing Optiwall yeast cell walls with bound Escherichia coli (E. coli) Optiwall with E. Coli SP15 strain (left), BW strain (middle) and E22 strain (right)
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