ARTICLE FEED & ADDITIVE MAGAZINE November 2025 69 3. A NEXT-GENERATION NATURAL SOLUTION CJ BIO launched a program to create a natural anticoccidial that balances efficacy with safety. Using its Application Platform, the team screened more than 600 plant-derived compounds through a stepwise process: initial in vitro evaluation, cellbased models, and animal trials. Two compounds emerged as promising candidates. These were then optimized through Response Surface Methodology (RSM), a statistical tool that identifies ideal ratios and concentrations to ensure synergy and stability. The outcome was Coxield™, a feed additive that blends natural ingredients with scientific rigor—bridging the gap between traditional phytogenics and modern, validated solutions. Management Pros Preventive Relatively inexpensive Excellent effect Low price No resistance/residual issues No withdrawal period Slow onset of tolerance High immunogenicity Safe Corrosion of facilities when applying drugs A lot of labor required Rapid onset of tolerance Weak antibiotics Efficacy appears late Differences in efficacy by product Unclear mechanism of action High cost Early pathogenicity No cross-protection Toxicity Long drug withdrawal period Immunosuppression Cons Anticoccidial Drugs Vaccination Natural Compounds Chemical Ionophore 27th - 29th Jan Atlanta, Georgia USA Georgia World Congress Center Figure 3. Main coccidiosis control strategies
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