ISSUE FOCUS 48 FEED & ADDITIVE MAGAZINE November 2025 “Shifts in the gut microbiota also can disrupt the microbial balance in piglets’ digestive tracts, leading to an overgrowth of harmful bacteria. To address this imbalance, industry practices have traditionally relied on antibiotic growth promoters (AGPs) and high-dose zinc oxide (ZnO). Regulatory pressures related to public health and environmental concerns are causing the industry to move away from the use of AGPs and ZnO. Today’s swine producers are seeking effective, science-backed alternatives that support intestinal stability and maintain animal performance.” Weaning is an incredibly stressful time for any animal, and piglets are no exception. Post-weaning stress can lead to alterations in the gut microbiota - resulting in diarrhoea, reduced nutrient absorption, and slower weight gain. Shifts in the gut microbiota also can disrupt the microbial balance in piglets’ digestive tracts, leading to an overgrowth of harmful bacteria. To address this imbalance, industry practices have traditionally relied on antibiotic growth promoters (AGPs) and high-dose zinc oxide (ZnO). Regulatory pressures related to public health and environmental concerns are causing the industry to move away from the use of AGPs and ZnO. Today’s swine producers are seeking effective, science-backed alternatives that support intestinal stability and maintain animal performance. Responding to the industry’s challenges, scientists at Trouw Nutrition developed Presan®-FX, a synergistic blend of phenolic compounds, slow release C12, target release butyrates, MCFAs and organic acids, which supports gut microbial balance and gut wall integrity. Validated in research studies and onfarm trials, Presan®-FX offers a targeted approach to support microbiota stability and gut integrity. Recent studies have explored how the ingredients in Presan-FX maintain a healthy status of pigs even in poor hygienic conditions. Other research investigated the effects of Presan-FX on levels of volatile fatty acids (VFAs) in digesta in the lower part of weaned piglets’ intestinal tracts. As producers are moving away from supplying high levels of ZnO, researchers also have studied how this feed additive may help reduce or remove the need for high-ZnO to support piglets’ health and performance. EFFECTIVE INGREDIENTS HELP TO IMPROVE INTESTINAL HEALTH Researchers ran a series of trials to better understand which ingredients in Presan-FX optimally has a positive effect on gut health of weaned piglets. ENHANCING PERFORMANCE WITHOUT AGPs OR ZnO: A Smarter Gut Strategy Giseli Heim Product Manager Gut Health Trouw Nutrition
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