ARTICLE 60 FEED & ADDITIVE MAGAZINE September 2025 te & Sabatini, 2009), which could drive immune cell activation and function compared to CON. Indeed, there was evidence of this in leukocytes, where they also reported that SM cows tended to have greater expression of the mTOR target L-selectin, a mediator of leukocyte migration to sites of inflammation. Together these results suggest that Met improved immune responsiveness via mTOR, helping cows to better manage the immunometabolic stress of the SMC. Altogether, across multiple stressors, Met supplementation modulates immunometabolism of dairy cows. The responses to Met are driven in part by enhanced mTOR activation in immune cells. This activation, combined with the other immunometabolic benefits of Met, sets dairy cows up to perform better during a health challenge. Such improvements point towards the essentiality of Met in preparing cows to handle the negative effects of a stressor such as subclinical mastitis. TURNING HEALTH INTO MEASURABLE VALUE These benefits of AA balancing on health can now be quantified using Milk$mart, Adisseo’s AA benefit calculator. With this program, farmers and nutritionists can estimate the financial return of Met supplementation on production, reproduction, health and income over feed cost. HEALTHIER COWS, SMALLER CARBON FOOTPRINT There’s also an environmental dimension to health. By improving health and performance through AA balancing, Adisseo solutions contribute to more efficient farming. According to a French ISO-certified farm study (Blonk), this can lead to up to a 15% reduction in the carbon footprint of dairy operations. Indeed, healthier cows stay in the herd longer, produce more milk per day, and waste fewer resources. This means fewer emissions per liter of milk produced and a more sustainable dairy supply chain. CONCLUSION Investing in cow health starts with nutrition. Supplying rumen-protected methionine via Smartamine® M or MetaSmart® does more than just maximize milk production, it activates biological systems that help cows withstand stress, recover faster, and perform longer. This leads to healthier cows that are more productive throughout their lives, meaning more profitable and sustainable milk production on farms. References available upon request. About Dr. Danielle Sherlock A Global Ruminant Technical & Scientific Support Manager at Adisseo, Dr. Danielle Sherlock received her B.S. and M.Sc. degrees in Animal Science form The Ohio State University, and her PhD in Animal Science from the University of Illinois at Urbana-Champaign prior to joining Adisseo. Her doctoral research investigated the impact of methyl donors on immunometabolism during periods of stress in dairy cattle. Sherlock joined Adisseo in 2021 and is based in Madison, Wisconsin, USA, where she develops and manages research projects in Ruminant Nutrition and Health. About Dr. Anne-Sophie Conjat Graduating as a Doctor of Veterinary Medicine in France in 2001, Dr. Anne-Sophie Conjat later completed a Master's degree in Business. She began her career in the veterinary pharmaceutical industry before joining Adisseo in 2015 as Global Category Manager for Selisseo, a role she held for six years. In 2021, she transitioned to the ruminant business segment and is now fully dedicated to marketing. Photo: Freepik
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