ISSUE FOCUS 44 FEED & ADDITIVE MAGAZINE August 2025 Today, feed additives are a vital component of modern aquaculture nutrition, aimed at enhancing growth performance, improving feed efficiency, and bolstering disease resistance. As global seafood demand continues to rise, sustainable practices have become essential. Phytochemicals derived from plant extracts, in particular, have emerged as powerful natural additives. Rich in bioactive compounds, these phytogenics exhibit antioxidant, anti-inflammatory, and antimicrobial properties, helping to reduce oxidative stress and strengthen fish immune systems as a natural alternative to synthetic growth promoters and antibiotics. The primary challenge has been the slow, complex, and costly process of discovering and validating these compounds. With tens of thousands of natural compounds to screen against hundreds of pathogens and cellular mechanisms, the traditional research approach is economically unfeasible. A full research process for a single additive can cost upwards of $500,000, with a success rate of less than 10%. Fortunately, technological innovation is dramatically changing this landscape, accelerating the path from discovery to application. OVERCOMING THE RESEARCH BOTTLENECK The main obstacle in harnessing the full potential of phytogenics has been the sheer scale of the natural world. Identifying the most potent compounds AI-driven phytogenic additives are transforming aquaculture by accelerating discovery and enhancing understanding of natural compounds. Advanced technologies now enable rapid screening and detailed biological analysis, while AI predicts bioactivity and designs synergistic blends. This shift promises to overcome traditional research bottlenecks, but what future innovations will further reshape the industry remains to be seen. AI-Driven Phytogenic Additives: REVOLUTIONIZING AQUACULTURE NUTRITION Francisco Arancibia Chief Executive Officer ISR-BIO Roberto Ibanez Chief Technology Officer ISR-BIO
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