ISSUE FOCUS FEED & ADDITIVE MAGAZINE July 2025 39 Improve Immunity Tan (2014) studied the effects of dietary L-arginine supplementation on growth performance, immunosuppression, inflammation, and intestinal barrier dysfunction in broiler chickens. The results demonstrated that additional dietary arginine supplementation is required to get the optimal growth performance and immune function for immunosuppressive broilers, and arginine supplementation attenuated IBDV (Infectious Bursal Disease Vaccine) inoculation induced immunosuppression via modulating circulating T cell subpopulations. Dietary arginine supplementation attenuated intestinal mucosal disruption of coccidiosis-challenged chickens probably through suppressing TLR4 and activating mTOR complex 1 pathway, and attenuated the overexpression of pro-inflammatory cytokines probably through the suppression of the TLR4 pathway and CD14+ cells percentage. CONCLUSION As an amino acid, arginine in poultry is essential. It plays a nutritional and functional role in broilers. The requirement of arginine is increased in antibiotic-free diets and during heat stress in order to ensure the growth performance of broilers. About Xiaoli Dong Getting her Ph.D in animal nutrition from the Chinese Academy of Agricultural Sciences, Xiaoli Dong joined CJ BIO China in 2015 working in the amino acid technology department. Now, she works as a technical director and is responsible for the application and promotion of small variety amino acid in Chinese markets.
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