ISSUE FOCUS FEED & ADDITIVE MAGAZINE July 2025 33 ural homeostatic processes, producers can minimize the negative impacts of stress factors and maintain optimal performance. Santovito et al. have studied the effectiveness of Safmannan® in adsorbing Clostridium perfringens. The researchers used an equilibrium isotherm approach to measure the capability of Safmannan® to adsorb C. perfringens. The study found that Safmannan® can effectively absorb C. perfringens in a dose- and time-dependent manner, with high affinity and capacity. The researchers also observed that the adsorption of C. perfringens by Safmannan® resulted in a reduction in the viability of the pathogen. This suggests that the antimicrobial activity of Safmannan® against C. perfringens can be attributed to an adsorption mechanism, where the yeast postbiotic components bind to the bacterial cells and interfere with their metabolic functions. Furthermore, Alqhatani et al. demonstrated that adding Safmannan® to broilers’ diet can significantly decrease Clostridium perfringens load in the gut of broilers reared under natural heat stress conditions, compared to the challenged, non-supplemented birds (Figure 3). Improving Poultry Performance In addition to its positive effects on gut barrier preservation and Clostridium perfringens reduction, Safmannan® has also been shown to help mitigate the detrimental effects of heat stress on broiler productivity. Multiple trials conducted in different regions around the world have demonstrated Safmannan® capacity to improve feed conversion ratios (FCR) and survival rates in broilers under severe heat stress conditions (Figure 4). These improvements align with the fundamental principle that maintaining homeostasis leads to improved feed efficiency and better growth rates. When birds can allocate energy to productive functions rather than combating stress and pathogens, the economic benefits become evident through enhanced performance metrics. By preserving gut integrity and reducing the risk of enteritis in broilers, Safmannan® enables broilers to better withstand the challenges of heat stress and maintain optimal performance. This makes Safmannan® a valuable tool in the battle against the negative impacts of heat stress in broiler production. Implementation of management practices that support homeostatic balance is increasingly recognized as essential in modern poultry production. Nutritional strategies, including the use of specialized dietary solutions like Safmannan®, represent an effecSafmannan® with heat stress Heat stress p < 0.05 Negative control 0.00b 6.22a 1.80b Log10 CFU 7 6 5 4 3 2 1 0 Figure 3. Clostridium perfringens load at D35 Mexico p<0.01 Heat stress Safmannan® with heat stress 1.74 1.68* 1.71* 1.57 1.51* 1.75 % of control group 100 98 96 94 92 90 China p<0.001 Brazil p<0.05 Figure 4. FCR under severe heat stress (D0- D42, THI 32 – 33)
RkJQdWJsaXNoZXIy MTUxNjkxNQ==