ARTICLE FEED & ADDITIVE MAGAZINE June 2025 79 A CLEAR AND PROVEN MODE OF ACTION AGAINST INFLAMMATION The key mechanism of action of Nuqo RED is its ability to modulate the TRPV1 receptors, which are involved in the body’s response to heat stress. TRPV1 receptors play a critical role in detecting harmful heat levels and initiating inflammatory responses. By desensitizing these receptors, capsaicin reduces the inflammatory response and supports the body's natural ability to cope with heat stress. When TRPV1 receptors are desensitized, the inflammatory response is dampened, leading to improved gut morphology and better nutrient absorption. Moreover, desensitization helps the animals better acclimate to heat stress, rather than hindering their thermoregulation ability. This unique action helps maintain performance even during extreme temperatures, allowing poultry to continue to grow and produce efficiently. Additionally, Nuqo RED's micro-encapsulation technology ensures that the capsaicinoids are delivered in a controlled and efficient manner, enhancing the product’s bioavailability and stability. This makes Nuqo RED a reliable solution for heat stress management in poultry farming. EXTENSIVE SCIENTIFIC SUPPORT: PROVEN THROUGH MULTIPLE TRIALS Anti-Inflammatory Effects in vitro An in-vitro study conducted at the University of Wels, Austria, assessed the anti-inflammatory effects of Nuqo RED. The trial involved challenging macrophages with lipopolysaccharides (LPS) to induce an inflammatory response. The results demonstrated that Nuqo RED effectively reduced the production of pro-inflammatory cytokines, including Interleukin 6 (IL-6) and Tumor Necrosis Factor alpha (TNF-α), compared to the LPS control group. The highest anti-inflammatory efficacy was observed at 50 ppm, confirming Nuqo RED’s ability to modulate inflammation and support better gut health during stress conditions. Performance and Stress Level Improvement in Broilers A comprehensive trial conducted at Ridgeway Research under the supervision of Dr. Maggie Fisher Photo: Courtesy of Cargill 5000 4000 3000 2000 1000 0 Concentration in pg/µL 5000 4000 3000 2000 1000 0 Concentration in pg/µL NC LPS TNF-α IL-6 * * * Impact on Gut Inflammation LPS + RED 50ppm LPS + RED 150ppm NC P < 0,05 LPS LPS + RED 50ppm LPS + RED 150ppm
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