ARTICLE FEED & ADDITIVE MAGAZINE June 2025 73 demonstrated that dietary oregano oil can improve nutrient absorption by optimizing gut morphology, strengthening the intestinal barrier, and reduce the incidence of digestive upsets (Zou et al. 2016). TARGETING THE ENTIRE DIGESTIVE TRACT WITH DOSTO® BI-ACTIVE Research has also indicated that oregano essential oil possesses rumen-modifying properties, positively impacting feed efficiency, milk yield, and quality, and even potentially reducing methane production (Dewi Ayu Ratih Daning et al. 2020). However, a significant portion of orally administered oregano oil can be metabolized by rumen microorganisms, limiting its availability in the lower gastrointestinal tract. To overcome this limitation, DOSTOFARM has developed DOSTO® bi-active, an innovative product combining rumen-protected (via a hardened plant fat matrix encapsulation) and rumen-available oregano oil. The added value of DOSTO® bi-active lies in its ability to release oregano oil along the entire digestive tract of ruminants. Easily soluble carriers ensure an effect in the rumen, while rumen-stable aroma pellets deliver the benefits further down the gastrointestinal tract, similar to its action in monogastric animals. CONVINCING RESULTS IN PRACTICE Initial findings from practical trials and a master's thesis reveal that the inclusion of DOSTO® bi-active in dairy cow concentrate or mineral feed led to increased milk yield and improved milk components (fat and protein content). Notably, a positive side effect observed was a reduction in somatic cell counts and the occurrence of ketosis (Figure 1-3). The combination of encapsulated and 0 50 100 150 200 250 300 Milk Fat Content [%] Control Trial Group Trial day Milk Fat [%] 4,2 4,1 4 3,9 3,8 3,7 3,6 3,5 Figure 2. Milk fat content (%) of both groups over the entire trial period 0 50 100 150 200 250 300 350 50 45 40 35 30 25 Milk Yield [kg] Control Trial Group Lactation day Figure 1. Lactation course of the multi-lactating cows in the trial and control group Control Trial Group Trial day Milk Protein Content [%] 3,65 3,6 3,55 3,5 3,45 3,4 3,35 3,3 3,25 0 50 100 150 200 250 300 Milk Protein [%] Figure 3. Milk protein content (%) of both groups over the entire trial period
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