ISSUE FOCUS FEED & ADDITIVE MAGAZINE May 2025 43 the turnover of epithelial cells, while induced apoptosis and weakening of tight junctions compromise the intestinal barrier, increasing permeability (leaky gut). This condition facilitates the entry of bacteria, toxins, and endotoxins into the bloodstream, triggering systemic inflammation. In response to epithelial damage, goblet cells secrete excess mucin as a protective mechanism; however, over time, this leads to their destruction, leaving the intestine even more vulnerable to external aggressions. Together, these processes result in a considerable impact on intestinal homeostasis and overall organism health. Due to variability in mycotoxin levels between grain batches or different grain suppliers, as well as delays in analytical results, traditional powdered products incorporated into feed limit the effectiveness of these strategies as a quick response. By the time contamination is detected, physiological damage may already be well established, negatively impacting animal performance. This highlights the need for more flexible solutions that can intervene rapidly when contamination occurs. An innovative alternative to traditional methods is MiaBond Drink® from MIAVIT GmbH, a water-soluble product that uses an enzymatic inactivation approach to neutralize fumonisins in real-time, allowing precise dosing and a rapid response without the need to reformulate diets. MiaBond Drink® also strengthens immune function, supports intestinal integrity, and improves the animals' energy and water efficiency, promoting faster recovery and more stable productive performance. The introduction of solutions like MiaBond Drink® offers effective control of fumonisins, setting a new standard in mycotoxin risk management in modern animal production. Its ability to quickly neutralize fumonisins, while providing additional physiological benefits, makes it a key tool for improving food safety and maximizing profitability in livestock farming. References available upon request. Immunosuppression Pulmonary oedema Kidney necrosis Nervous system disruption Palmitoyl CoA + Serine Spinganine Ceramide Ceramide Ceramide Ceramide Sphingosine Sphingosine Sphingomyelin Sphingosin-1-phosphate Sphingomyelin Ceramide Synthase Glucosylceramide Ceramide Synthase FUMONISIN FUMONISIN Liver damage Weakened gastrointestinal tract Reduce zootechnical parameters Figure 1. Impact of fumonisins on animal physiology About Mariano Gomory Mariano Gomory is an Agricultural Engineer graduated from the University of Buenos Aires (UBA), where he also served as a teaching assistant in the Beef Cattle Production department. Specializing in animal nutrition, he has gained experience in various technical and commercial roles, particularly in advising on additives and functional ingredients for all animal species. He is currently working as a Junior Product Manager Toxinbinder at MIAVIT GmbH, where he continues to apply his expertise in animal nutrition while seeking innovative solutions for the industry.
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