INTERVIEW 70 FEED & ADDITIVE MAGAZINE April 2025 ius (Figure 4) and other commensal species that support intestinal health. This disruption to the microbial balance correlated directly with the observed performance deficits, establishing a clear link between mycotoxin exposure, microbiota dysbiosis, and compromised poultry health and productivity. These findings underscore the importance of monitoring and managing mycotoxin risk as well as assessing the microbiome as part of a comprehensive approach to optimizing gut health in poultry production systems. What have your trials revealed about the effectiveness of anti-mycotoxin agents in mitigating the effects of mycotoxins on the microbiota? Our trial also demonstrated that not all anti-mycotoxin agents (AMAs) are equally effective against mycotoxins, particularly DON. We evaluated multiple AMAs and found significant variations in their ability to protect the intestinal microbiota from mycotoxin-induced disruption. Encouragingly, we discovered that some AMAs, like Notox™ AMA, showed significant benefits and improved microbiota maturation, restoring favorable microbial profiles in birds fed DON-contaminated diets, and bringing the gut ecosystem closer to that observed in healthy animals. Importantly, we identified a positive correlation between an AMA's effect on microbiota composition and its impact on bird performance, suggesting that microbiota protection represents a key mechanism through which AMAs mitigate mycotoxicosis. Of the AMAs tested, the most beneficial, Notox™ AMA, successfully reduced the prevalence of harmful bacterial groups that proliferate under mycotoxin challenge while supporting the recovery of beneficial bacterial populations that typically decline with mycotoxin exposure. These findings highlight the importance of selecting scientifically validated AMAs that have demonstrated specific efficacy against the mycotoxins present in a given production system. Mycotoxin risk clearly must be managed. Do you have any general recommendations to help poultry farmers effectively mitigate the effects of mycotoxins on their flock’s health and performance? Implementing a rigorous control plan for raw materials is key to effective mycotoxin management. 3.2 3.1 3 2.9 2.8 2.7 2.6 2.5 2.4 2.70 2.65 2.60 2.55 2.50 2.45 2.40 Standardized Relative Fluorescence Standardized Relative Fluorescence Lactobacillus salivarius_2 Campylobacter jejuni a ab b b a a ab b b b NC 28d PC 28d AMA1 28d AMA2 28d Notox AMA 28d Treatment_Age (days) NC 28d PC 28d AMA1 28d AMA2 28d Notox AMA 28d Treatment_Age (days) Figure 4. Effect of DON and AMA on the amount of Campylobacter Jejuni and Lactobacillus salivarius at 28 days of age (bars with different letters are statistically significant with p<0.05)
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