ISSUE FOCUS 50 FEED & ADDITIVE MAGAZINE April 2025 IMPACT ON YOUNG POULTRY Young birds, particularly chicks, have underdeveloped digestive systems that naturally produce low levels of trypsin and other proteolytic enzymes. Research indicates that trypsin production in chicks remains minimal until approximately day 14, only reaching peak levels around day 21.3 This window of vulnerability coincides with the period when dietary trypsin inhibitors can have the most detrimental impact on protein utilization and growth performance. ENZYME SOLUTIONS TO BREAK THE CHAIN Enzymes are added to bird feed to help address the challenges posed by trypsin inhibitors and ensure birds can meet their growth potential. Protease enzymes contained in CIBENZA® DP100 Enzyme Feed Additive work by breaking down complex proteins and neutralizing the effects of trypsin inhibitors, thus optimizing protein digestion and improving overall feed efficiency. ENZYMES AND BIRD PERFORMANCE • Enhanced Protein Digestion: The protease activity of CIBENZA® DP100 breaks down protein molecules that would otherwise be hindered by trypsin inhibitors, allowing for more efficient amino acid absorption.4 • Improved Gut Health: By reducing undigested protein in the gut, the enzyme decreases substrate availability for pathogenic bacteria such as Clostridium perfringens, E. coli, Salmonella, and Campylobacter.5 This reduction lowers the risk of gut health issues and enhances overall flock performance. • Increased Nutrient Absorption: Proteases contained in CIBENZA® DP100 increase protein breakdown and utilization, resulting in higher growth rates and improved feed conversion ratios (FCR), by reducing the impact of anti-nutritional factors such as trypsin Inhibitors, glycinin and beta-conglycinin.5 • Young Bird Performance: Studies show improvements in body weight, feed conversion ratio, and jejunal viscosity (supporting improved nutrient digestibility) when CIBENZA® DP100 is added to starter diets.6 PERFORMANCE DATA In controlled field trials, birds fed diets supplemented with CIBENZA® DP100 showed significant improvements in feed efficiency and body weight gain. Key results include: • 8% increase in body weight at day 42, compared to non-supplemented controls.7 • 2.4% reduction in FCR, leading to more efficient feed utilization. • 90% reduction in Clostridium perfringens population in the ileum.8 Dietary TI level, mg/g AA ilead digestibility, % 90 85 80 75 70 65 60 55 All AA R2=0.63 Lys R2=0.54 Thr R2=0.54 Met R2=0.56 0.91 1.48 2.04 2.61 3.17 3.74 Figure 2. Trypsin inhibitor impact on amino acid digestibility4
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