ISSUE FOCUS FEED & ADDITIVE MAGAZINE March 2025 65 Selisseo® (SO-0.3 in Figure 5) has activated IL-10 (an anti-inflammatory cytokine) for a longer period (2 and 48 hours) compared to NC and PC. SCFAs regulate immune function by modulating inflammatory cytokine expression and macrophage activity in piglets' intestines. The trial presented in Figure 6 involved supplementing pigs with C4-product after weaning. Myeloperoxidase (MPO) has been analyzed, as it is an enzyme found in inflammatory cells. Results showed reduced MPO production, indicative for reduced intestinal inflammation during the 5 weeks with C4-product, Adimix® Precision, after weaning (vs. control). CONCLUSION The weaning period presents significant challenges for pigs due to the dramatic physiological and social changes they undergo. Despite advancements in management and nutrition, post-weaning diarrhoea remains a prevalent and costly issue in piglets, leading to mortality, reduced growth rates, and increased treatment expenses in pig production. To mitigate these negative impacts, strategies should prioritise rapid feed intake, good digestive feed capacity, healthy gastrointestinal development, and a robust immune system. Adisseo has utilized its expertise to create an innovative program designed to optimize the weaning phase, enabling pigs to reach their full genetic potential. This strategy integrates solutions that enhance performance and health without compromise, resulting in significant improvements in key economic indicators for pigs. It's time to revolutionise the weaning phase - let’s start today! About Maïwenn Bourdoulous Maïwenn Bourdoulous is Customer Solution Manager for Swine at Adisseo, where she develops solutions based on the company's products, services and expertise, and aligns campaigns with market trends and sales needs. She holds agronomy and international business degrees, and her experience includes technical support in Mexico in Premix, Swine nutrition in France, and business development in nutritional additives. milli-units MPO/ml feacal homogenate Countering Postprandial Intestinal Inflammation Weeks after weaning Highest values just after weaning, then decreasing In the Adimix® Precision group: Less MPO, sign. At 5 weeks 300 250 200 150 100 w1 w3 w5 p = 0.03 * Control Adimix® Figure 6. The effect of Adisseo’s protected butyrate on intestinal inflammation responses
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