ISSUE FOCUS 64 FEED & ADDITIVE MAGAZINE March 2025 No challenge Challenge Control Unprotected Adisseo’s protected butyrate 328 311 429 191 266 373 6,9 7,2 7,5 Average Daily Gain, in g/day/pig Ratio Villi Height: Crypt depth low in amino acids with low or high net energy, compared to the same diets without Rovabio ® Advance. Adisseo’s FRA® LeciMax Dry is a concentrated lysolecithins based emulsifier that enhances fat digestion across three stages: emulsification, hydrolysis and absorption. Several trials showed an improvement in key performance indicators up to 42 days of age. Adisseo’s protected butyrate (a SFCA) (Adimix®) helps to support weaning piglets overcome digestive issues and challenges. An experimental trial (Figure 4) showed the effect of this solution on ADG and important intestinal health parameters (villi height/crypt depth ratio) in situation of challenge (E. coli K888). Managing oxidative stress and inflammation Adisseo proposes the application of Selisseo® to support the antioxidant system and indirectly reinforce the immune system and the use of protected butyrate (Adimix®) to control the inflammatory response. In the trial presented on Figure 5, piglets were inoculated with E. coli LPS (lipopolysaccharide) to induce inflammation and immune stimulation. The results showed that Selisseo® helps controlling inflammatory response. In the second graphic, IL-10 is analyzed, as it reduces inflammation mediated by macrophages. Figure 4. The effect of Adisseo’s protected butyrate (orange bar) on ADG and VH:CP ratio during an ETEC challenge (E. coli K88), compared to control (left grey bar) and unprotected butyrate (middle grey bar) Temperature Changes After LPS challenge Piglet IL-10 Concentration After LPS Challenge (pg/ml) 41.5 41.0 40.5 40.0 39.5 39.0 Rectal temperature (°C) 0 h 1 h 2 h 3 h 4 h 5 h 6 h NC SS-0.3 SO-0.3 NC SS-0.3 SO-0.3 -24h +2h +48h ab b a a b b pg/ml 500 400 300 200 100 0 Figure 5. The effect of Selisseo® (SO-0.3) on rectal temperature and on IL-10 after LPS challenge
RkJQdWJsaXNoZXIy MTUxNjkxNQ==