Feed & Additive Magazine Issue 47 December 2024

SUSTAINABILITY 74 FEED & ADDITIVE MAGAZINE December 2024 weight gain. In addition, Proteobacteria is the phylum the major pathogens, such as Escherichia, Salmonella, are included. This research confirmed the hypothesis that maintaining the concentration of conjugated bile salts can control the overgrowth of pathogens while supporting the growth of beneficial microbiota (Figure 4). A product verified in academic research often fails to show the same efficacy in the commercial production system due to the multiple challenges animals are experiencing. Therefore, it is more important to validate the impact of GutLukTM on the health of piglets in a commercial production system. Efficacies in boosting growth performance and reducing mortality were confirmed in a commercial farm trial with 13,200 piglets in South Korea. The farm has confirmed the presence of ETEC (F4) in feces, wet feeds, and pens. Even though the farm had used ZnO at 2,000 ppm, piglets suffered from a chronic ETEC-associated clinical disease. However, once GutLukTM is supplemented instead of ZnO in the piglet diet, the ADG and FCR were improved, and the mortality rate was reduced (Figure 5). ADG (g) (%) 520 480 440 400 1.81 1.77 1.73 3.0 2.5 2.0 1.5 1.0 0.5 0.0 432 ZnO ZnO ZnO 0.1% GutLuk 0.1% GutLuk 0.1% GutLuk 493 1.8 1.75 2.6 1.4 FCR Mortality Figure 5. Improvement of piglet performance and mortality by supplementing GutLukTM (Commercial farm in South Korea; 2023, Internal study) ADG Gut Microbiota (mucosa) (g) (%) PC1 (AGP) PC1 (AGP) PC1 (AGP) PC2 (ZnO) PC2 (ZnO) NC B a a a a a a b b B B A NC 0.1% GutLuk 0.1% GutLuk Firmicutes: Bacteroidetes (F:B) Firmicutes Bacteroidetes Proteobacteria PC2 (ZnO) NC PC1 (AGP) PC2 (ZnO) NC 0.05% GutLuk 0.1% GutLuk 0.2% GutLuk 0.05% GutLuk 0.1% GutLuk 0.2% GutLuk a a a a a b Diarrhea No Diarrhea Wk1 bbb bbb bbb bbb bbb a a a Wk2 Wk3 440 400 360 320 280 9 8 7 6 5 4 3 2 1 0 90 60 30 0 60 50 40 30 20 10 Figure 4. Improvement of piglet performance, diarrhea, and mucosaassociated microbiota in the small intestine by supplementing GutLukTM (manuscript in preparation)

RkJQdWJsaXNoZXIy MTUxNjkxNQ==