SUSTAINABILITY FEED & ADDITIVE MAGAZINE December 2024 73 VERIFICATION OF EFFICACY IN PIGLETS AND POULTRY To verify the effect of GutLukTM on piglet performance and intestinal health (diarrhea and mucosa-associated microbiota as indices), an academic research was conducted. The result confirmed that pigs fed a diet containing GutLukTM significantly improved average daily gain (ADG) compared to the piglets fed a negative control (NC) diet without AGP or ZnO supplementation. GutLukTM fed piglets also showed a comparable growth performance to the pigs fed diets supplemented with AGP (PC1) and ZnO (PC2). Additionally, GutLukTM significantly reduced the incidence of diarrhea and improved gut integrity (V/C ratio) to a comparable level of the AGP- or ZnO-supplemented groups. To assess the effect on gut microbiota, AGP, ZnO, NC, and GutLukTM 0.1% groups were selected for analysis. With the supplementation of GutLukTM, the composition of mucosa-associated microbiota in the jejunum was positively altered compared to the AGP- and ZnO-supplemented groups, as GutLukTM increased Firmicutes:Bacteroidetes (F:B) ratio and reduced population of Proteobacteria in the phylum level. It is well known that the increased F:B ratio positively affects pigs' Epicatechins 3 4 2 1 Vitamin K SYNERGY for BSHI Tributyrin Gut Recovery BSHI BSHI Selection of epicatechins with highest BSHI activity Figure 3. The Combination of GutLukTM
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