ISSUE FOCUS 58 FEED & ADDITIVE MAGAZINE December 2024 “By addressing the root causes of joint degeneration—such as oxidative stress, inflammation, and bone resorption—natural polyphenol-based solutions provide a more comprehensive approach than conventional symptom-focused treatments. Whether for dogs, cats, or horses, incorporating botanical ingredients like pomegranate, mango leaf, and epimedium into their diets can help enhance mobility and support overall well-being as they age.” With 52% of dogs and 41% of cats experiencing joint pain, and 36% of dog owners and 28% of cat owners purchasing joint health supplements, often based on veterinarian advice, the market for pet joint health supplements is rapidly expanding. The compounds contained in TruGro® CARE Joint Health from Layn Natural Ingredients have been shown to help maintain oxidative balance, a key factor in supporting joint health. Many products designed to promote joint integrity are formulated to provide symptomatic relief by improving the range of motion or reducing discomfort. While these products work to improve the well-being of pet companions, they contribute little to resolving many of the underlying causes that lead to joint dysfunction. Causes such as inflammation, bone resorption, and cartilage loss are all contributory factors that manifest into a loss of strength, motion, and quality of life. Harnessing the power of polyphenols to improve joint integrity has been demonstrated in numerous studies to slow the progress of bone loss and inhibit the destructive nature of oxidative stress and its effects on cartilage and strength. Pomegranate, mango leaf, and Epimedium are three botanicals that offer a rich treasure trove of polyphenols, and when combined, they synergistically work to address the underlying causes of joint impairment by inhibiting inflammation and protecting bone, cartilage, and muscle. The protection that polyphenols provide to plants as a basic part of their physiology can also be applied to pet companions so that, as they age, the typical signs of aging that result in a loss of motion can be mitigated. • Epimedium is the source of a flavonoid named icariin. Icariin has been studied extensively to reduce bone resorption and promote osteoclast production to protect against bone loss. Icariin exerts anabolic effects in bone through the activation of estrogen receptors, as researched in both animal and human studies. • Punicalagin, a phenolic compound in pomegranate, inhibits the production of pro-inflammatory cytokines. These reactive molecules have a damaging effect on healthy cells, tissues, and organs. HOLISTIC SUPPORT FOR JOINT HEALTH IN PETS: ENHANCING MOBILITY AND QUALITY OF LIFE James Roza Chief Scientific Officer Layn Natural Ingredients - USA
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