ISSUE FOCUS FEED & ADDITIVE MAGAZINE October 2024 41 ers who start with just some maternal immunity. On the other hand, butyrate reduces inflammation, which is a universal response to all stress factors broilers must deal with. Moreover, broilers must deal with a continuous high feed intake, and thus absorptive capacity is crucial to achieve their genetic potential. Simultaneously, opportunistic pathogens, for example Salmonella, are waiting in the gut microbiome to generate dysbiosis and disease. Butyrate limits the virulence of this bacterium by modifying its genetic expression and strengthening the host’s defense responses. Butyrate is naturally present in the hindgut of broilers by bacterial fermentation, but for intestinal development and gut integrity it should be administered via feed to target the small intestinal part from duodenum up until ileum. Usually, butyric acid is supplemented as fat coated salts of butyric acid at a dosage of roughly 500 – 1500 g/T in poultry diets depending on age, species and farm conditions. An experimental trial with 720 Ross® 308 broilers showed that supplementing 15001000-500 g/T BUTIFOUR® CCB in broiler diets increased villus length and eventually final body weight significantly. Weaning is a crucial step in the life of pigs. As described above this is coupled with intestinal dysbiosis and post-weaning diarrhea in the first weeks after weaning. The best management strategy is to stimulate feed intake, thus overcoming the weaning dip, and creating a healthy gut with a developed immune system and gut microbiome. Butyrate fits in both categories. All above mentioned effects, i.e. promotion of the intestinal barrier, modulation of Body weight (BW) at day 39 Control BUTIFOUR® CCB b a 2760 2800 2840 2880 2920 BW day 39 (g) Villus length jejunum day 14 Control BUTIFOUR® CCB b a 0.7 0.72 0.74 0.76 0.78 Villus length (mm) Figure 1. Butifour® CCB improves villi development and zootechnical performance in broiler chickens.
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