ARTICLE FEED & ADDITIVE MAGAZINE August 2024 77 Tim Goossens Global Scientific & Technical Manager Adisseo Olga Lemâle Global Scientific & Technical Manager Adisseo Amine Mellouk Science Manager, Immunology Adisseo Jessika Consuegra Scientific Team Leader Adisseo WHY INVESTIGATING GLYCERIDES OF LAURIC ACID? The poultry industry continually seeks innovative strategies to enhance the health and productivity of birds. Dietary supplements that can strengthen the natural defense systems of birds are receiving increased attention, especially in today's poultry production landscape, where minimizing disease pressure is of pivotal importance to increase animal performance and profitability. Lauric acid is a medium-chain fatty acid that has been described to have unique antimicrobial and antiviral activities in vitro. Esterifying lauric acid into glycerides of lauric acid (GLA) magnifies its biological activity. Moreover, a GLA product (FRA® C12) was already demonstrated to stimulate the secondary humoral immune response to a booster infectious bronchitis virus (IBV) vaccine, as indicated by increased anti-IBV titer values in the serum of 42-day-old broilers (De Gussem et al., 2021). Following these results, we wanted to explore in more depth the immune reactions prior to this secondary response. More specifically, we investigated the effect of the GLA product on the primary humoral response, as well as the adaptive cellular immunity in more details, and described the results in a recently published scientific article (Mellouk et al., 2024). ENHANCEMENT OF THE PRIMARY HUMORAL RESPONSE... A total of 200 one-day-old male Ross 308 broilers were divided over 3 experimental groups, with 8 replicates per group: a control group receiving no A trial was conducted with broilers that were vaccinated or not with an attenuated infectious bronchitis virus (IBV). Chickens that received dietary glycerides of lauric acid (GLA) on top of vaccination displayed stronger natural defense mechanisms. Their primary immune response was more pronounced, as shown by a higher antiIBV titer. In addition, their cellular immune response was more effective. LAURIC ACID GLYCERIDES BOOST IMMUNE RESPONSE TO IB VIRUS
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