Feed & Additive Magazine Issue 42 July 2024

ARTICLE 70 FEED & ADDITIVE MAGAZINE July 2024 “Understanding the modes of action of various feed ingredients, identifying the gaps, and developing synergistic ingredient combinations provides an innovative approach to improve magnitude and consistency in animal performance benefits. A unique combination of postbiotic Saccharomyces cerevisiae fermentation product and a proprietary blend of seven different essential oil compounds has complementary benefits based on the different individual modes of action.” Gut microbiome is a key component for animal health and performance. In addition to the digestion and absorption of nutrients, gut microbiome is related to the proper functioning of various vital organs in the body through the gut-organ axis. In broiler chickens, various research has shown that the gut microbiome progresses to a more resilient microbiome as the birds get older. The rate of maturation of the gut microbiome is critical for the health and performance of the animal. A healthy microbiome shows an abundance of lactic acid producing bacteria (eg: Lactobacillus) at a younger age while it matures to a more short-chain fatty acid producing population (eg: Lachnospiraceae) as the bird gets older. Use of appropriate feed ingredients can influence the gut microbiome and shift it to a healthier population. There are several feed ingredients used in the poultry industry, such as prebiotics, probiotics, essential oils, organic acids, postbiotics, etc. However, the main challenge the industry is facing is the variability in response from use of these feed ingredients. A better understanding of the modes of action of these feed ingredients, based on several published articles, reveal that they have specific effects. For example, essential oils could have a primary effect on digestive functions, probiotics on gut microbiota, and postbiotics on immunity and gut microbiome. Perhaps, one type of feed ingredient might not be effective under all conditions, considering the many challenging conditions out there in the field. Hence, it’s important to identify the gaps in the modes of action of the feed ingredients and evaluate combinations of feed ingredients which could deliver better consistency and magnitude of beneficial effects. COMBINATION OF POSTBIOTICS AND ESSENTIAL OIL COMPOUNDS Postbiotics are preparations coming out of a controlled fermentation process containing inanimate microorganisms and/or their components which confers a health advantage to the host. The main modes of action of postbiotics are by modulating the immune responses in animals and by shifting the gut microbiome in the distal part of the GI tract to a favorable population. On the other hand, studies have INNOVATIVE APPROACH TO DEVELOP EFFECTIVE FEED INGREDIENTS Vivek Kuttappan Technology Lead Postbiotics-Poultry Cargill Animal Nutrition & Health

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