ARTICLE FEED & ADDITIVE MAGAZINE June 2024 69 Despite the bloody diarrhoea symptoms, the treatment of the disease is effective and does not incur a considerable expense compared to other consequences. With that in mind, what makes coccidiosis the most critical disease in poultry? The impaired performance does, with losses reaching up to 80% of the expected income. FCR or the feed conversion ratio can measure this. If scoring and OPG examinations are not scheduled regularly, the lack of performance may not be identified promptly. Afterwards, there is not enough time to catch up with the standards. Several methods of coccidiosis control might be applied through feed or water administration of anticoccidial products, coccidia vaccination, or a combination of both. Coccidiostats, to be effective, need to be shifted and managed carefully. The growing phenomenon of AMR (antimicrobial resistance) has changed the distribution patterns and availability of antibiotics used for animal treatment all over the EU. As some of the coccidiostats show an antimicrobial mode of action, legislation was implemented by the European Union in 2006 to withdraw coccidiostats along with antibiotic growth promoters. However, this legislation has been postponed year after year since 2012 for coccidiostats. Nevertheless, the time will come eventually, and not many can afford to spend it waiting for it to happen. On the other hand, the vaccine can be a good solution, but it is still expensive, and a drop in the dynamic of weight gain can be seen after day 21. Some parts of the world, like the USA, use a combination of both, referred to as a bioshuttle. The vaccine is a non-attenuated one administered at day 0, and chemical coccidiostat is provided via feed from day 21. That allows the vaccine strains to multiply and provides no room for field strain due to competitive exclusion (CE) while natural immunity develops. The chemical coccidiostat eliminates everything. Still, the solution cannot be used constantly and needs to be shuttled to keep it effective. All the programmes mentioned need the support of gut health, inflammation control, performance enhancement, and natural immunity boosters. The versatile solution fits every programme, and its results should be comparable with those of conventional tools. Moreover, it should help preserve the effectiveness of chemotherapeutics for the future when they will be needed for treatment instead of prevention. The question of the impact on the environment is also an issue here. adiCox® AP is a concentrated powder phytobiotic composition of natural ingredients. Micronized herbs enriched with iron provide a metal-organic complex of phytoncides and metal ions. Due to active herbal components like hot pepper, calamus, white mustard, soapwort, and turmeric, antimicrobial, immunomodulating, antioxidative, and growth-promoting properties can be obtained. Extensive research has been conducted at independent universities and institutes to prove the product's effectiveness. Myriad indicators were measured to describe the properties of adiCox® AP. At the University of Environmental Life Sciences in Wroclaw (Poland), the thickness of the endothelial tissue was measured on day 28, post-Eimeria challenge, and on day 21. The challenge was designed to cause the lesions in the Ross 308 broilers’ intestines as 6x105 sporulated oocysts were used in a combination of E. acervulina 3.5x105, E. maxima 1x105 and E. tenella 1.5x105. Despite the decreased lesions and less villi damage, the average thickness
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