Feed & Additive Magazine Issue 41 June 2024

June 2024 Year: 4 Issue: 41 Feed Additive INTERNATIONAL MAGAZINE FOR ANIMAL FEED & ADDITIVES INDUSTRY Lonneke Jansen, Selko Managing heat stress in dairy cows to maintain production Dr. Yves Mercier, Adisseo Revising electrolyte balance in broiler Marie-Valentine Glica, Lallemand Leveraging nutritional expertise for small ruminants www.feedandadditive.com Heat Stress in Animals Global Feed Minerals Market

Due to global warming, temperatures around the world are fluctuating to extremes (extreme heat, extreme cold). This can be quite challenging and threatening to animals as well as humans. High temperatures can negatively affect animals' metabolism and increase their energy consumption, affect the immune system and make them more susceptible to infections and diseases, increase oxidative stress and cause cell damage, and all of which can impair their overall health and reduce their productivity. Farmers are already producing in challenging environments due to food security and sustainability concerns, but now they have to combat the effects of high temperatures in the summer. But there are ways to protect the health, welfare and performance of animals during periods of heat stress. For example, providing appropriate shade, using cooling systems and increasing water consumption, etc. However, according to experts, good heat stress management also requires proper regulation of the animals' diets and ration content. Adapting nutrient density according to need, balancing protein intake, regulating feeding times and so on. The use of feed additives is also an important nutritional element that can help animals cope with heat stress. For example, some vitamin and mineral supplements are known to help animals regulate body temperature and optimize metabolic processes. Thus, additives such as probiotics and prebiotics can reduce the negative effects of heat stress by improving animals' gut health and strengthening the immune system. In conclusion, heat stress poses a serious threat to the health and productivity of farm animals. However, with the right management practices and the use of feed additives, this risk can be minimized. Keep reading our June issue to learn more and discover ways to combat heat stress! Experts in the animal nutrition industry have discussed this month's main focus, 'heat stress', and offered some solutions on how to deal with heat stress in animal farming. Enjoy your reading! Hope to see you in the next issue… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol Zeynep Demirkaya [email protected] Communication & Marketing Lisa Atakul [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR Heat Stress: The Silent Threat to Farm Animals Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadditive

Climate change means taking preventative strategies to mitigate heat stress are essential. With Selko’s Heat Stress Programme we offer feed additive strategies that can support animal health and production during heat stress conditions and increase productivity, reduce infectious diseases and mortality rates. THE BENEFITS HEAT STRESS Reduce oxidative stress Increase osmoregulation interventions Optimize gut health and function Increase animal wellbeing and performance Don’t let heat stress burn through your profits Learn more, visit www.selko.com

4 FEED & ADDITIVE MAGAZINE June 2024 The Association of Kenya Feed Manufacturers (AKEFEMA), is a business membership organization registered in Kenya as the official representative body for the livestock feeds industry. Its mandate is to promote a conducive environment for feed businesses and promote profitable livestock farming in Kenya through producing quality animal feed. We promote a vibrant business environment that draws member benefits through cooperation and coordination of all policy stakeholders and value chain actors for the delivery of quality feedstuffs and related services AKEFEMA’s operations are structured into specialized experts’ committees that deliver specific mandates relevant to the work and sustainability of the association. These committees drive and facilitate various platforms to enhance, protect, and ensure the present and future interests of the industry. KENYA MILLING ENVIRONMENT The Kenyan feed industry is dealing with daunting three major challenges: availability of raw materials, cost, and quality of feed. Most of our feed ingredients are imports, over 80%. This heavy dependence on imports exposes the industry to all international financial and political factors that have a significant effect on the price and quality of raw materials. Fluctuation of the dollar and wars in Eastern Europe, the Mediterranean and the Red Sea have significantly affected our international commodity routes, hence contributing to increased cost of feeds. Regional policies on and the slow embrace of biotechnology in agriculture, continue to affect crop productivity enhancing the dependence on imports and narrowing suitable source markets for raw materials. There is a need to increase domestic production of key ingredients like maize and soya, which are major feed ingredients and comprise up to 75%, depending on the feed type. This strategy would not only lessen reliance on volatile imports but also stabilize costs and create a more sustainable supply chain for a healthy feed industry ADDRESSING CHALLENGES To address the challenges of raw materials, the association is taking an active role in pushing for favourable policies to increase the adoption of biotech in crop farming to increase local production. We are offering a ready market for sunflower, cotton and maize farmers, to promote interest in producing these crops. We are working to promote access to diverse ingredients by promoting use of alternative sources of energy and protein, like Distilled Dried Grains Soluble (DDGS) and Black Soldier Fly (BSF) that are cheaper than conventional imports. The association has upscaled training for its members on the code of conduct for quality milling. Working with quality regulatory institutions to train our members on quality standards and procedures. The Kenya Bureau of Standards has been supportive to members as regulator on sensitizing our members on quality. We are working with higher institutions of learning to link academia with the industry. The industry is supporting the institutions of learning to KENYA'S FEED INDUSTRY AND INCREASING COST PRESSURES Paul Kamau Chief Executive Officer AKEFEMA LEAD ARTICLE

FEED & ADDITIVE MAGAZINE June 2024 5 produce animal nutrition graduates who understand issues in the industry and can be quickly absorbed by the industry. We feel this will produce a competent workforce to produce quality feeds. We have expanded our membership to bring onboard farmers, tech companies and equipment suppliers to bring together key players in the feed value chain and provide inhouse solutions to production challenges. The government has been supporting the industry to bring the cost of feed down, for 13 months, the government forfeited income from feed ingredients allowing all ingredients to be imported duty-free from February 2023 to February 2024. However, due to the war in Ukraine, and the Middle East and the fluctuation of the Dollar (Currency for international trade), there were no significant drops in the price of feed. However, major millers were able to maintain a steady price that cautioned farmers from these international factors that had affected prices of many agricultural commodities. The country is also just bouncing back from the effects of COVID-19 on business, especially as it relates to the availability of poultry stocks. Most breeders lost parent poultry stocks during the COVID-19 period. The long drought between 2021 and 2023 saw farmers lose over 2.5 million cattle in two years. This meant reduced customers for our feed and increased demand for animal protein due to reduced supply. BUSINESS OPPORTUNITY The Eastern Africa region, comprising Kenya, Uganda, Tanzania, Rwanda, Burundi, South Sudan, DR Congo, Somalia and most recently Ethiopia has been experiencing an increase in population growth. The population is estimated at 450 million in 2023 and it is projected to double by 2050. With an annual population growth rate of 3%, the demand for animal protein: egg, milk and meat, is increasing annually. The region has a livestock population of over 650 million (66% ruminant and 34% non-ruminant). However, each of these countries in the region experiences a feed deficit. The case of Kenya has a 60% feed deficit according to Kenya's Ministry of Agriculture and Livestock reports. This provides good business opportunities in the feed industry. To meet the demand for both animal protein for humans and feed, the region needs to employ new strategies in the sector. Innovative science and technology, though not the only solution, can be used to contribute to finding sustainable agricultural solutions. For right technology and efficient production strategies, the country and the region are ready for feed industry growth. With a large skilled labour population, a feed deficit, a large population to feed and a supportive government, Kenya is a leading player in the regional feed industry, and is leading the region in setting up a conducive environment for the feed industry investments along the entire value chain. AKEFEMA FEED EXHIBITION AND CONFERENCE (AFEC) - NAIROBI, 2024 Key industry players are working to open up the market for a profitable feed industry that is capable of meeting the demand in the East Africa Region. AKEFEMA is organizing the first Regional Conference in the East Africa on Feeds: AKEFEMA Feed Exhibition and Conference (AFEC) - Nairobi, 2024 to facilitate livestock industry knowledge sharing. Industry experts and practitioners will be sharing their knowledge and experiences to support the livestock industry in the region to be innovative and develop resilience to survive in the ever-changing feed industry landscape. The theme of the conference is “Resilience and innovation in an ever-changing feed industry landscape” for enhanced food security in the region. AFEC - Nairobi, 2024 will be held at the Safari Park Hotel Nairobi, from 16th to 18th July, 2024. It will feature presentations and training on trends, emerging technologies in feed formulations and production, animal production, genetics, nutrition, health, business, and many more. Suppliers of raw materials, science & technologies, finance, equipment, and facilities used in animal feed production will exhibit their products and services to the feed millers and livestock farmers who will be attending as delegates. This is a regional transforming forum and we invite all to visit www.afec.co.ke or write directly to Paul at [email protected] for details and registration.


CON T E N T S 58 REVISING ELECTROLYTE BALANCE IN BROILER IN A SUSTAINABLE FEED MANUFACTURING STRATEGY Dr. Yves Mercier, Adisseo 62 TRANSFORMING LIVESTOCK NUTRITION FOR PERFORMANCE AND SUSTAINABILITY Tien Le, Alltech 76 LIFE CYCLE ANALYSIS: A JOURNEY TOWARDS SUSTAINABILITY Ewenn Helary, NUQO Feed Additives 64 LEVERAGING NUTRITIONAL EXPERTISE FOR SMALL RUMINANTS Marie-Valentine Glica, Lallemand Animal Nutrition 68 A VERSATILE TOOL FOR COCCIDIOSIS CONTROL Paulina Abramowicz-Pindor, AdiFeed LTD 74 THE PERFECT START FOR YOUR FLOCK OF LAYING HENS: GUIDANCE TO OPTIMIZE GUT HEALTH Estella Leentfaar, Hendrix Genetics Layers ARTICLES HTBA and Abolis partner for polyphenol production 20 Kemin secures first feed additive LCA from GFLI 91 EU feed production is estimated to decline to 147 million tons in 2024 11 New study: Shrimp fed with fungi protein grow faster and healthier 18 Dr. Eckel promises more effect with same dosage via AntaPhyt NXT 14 Nuqo expands to India with its new affiliate 88 Neogen launches new molecular method for Salmonella detection 99 NEWS SUSTAINABILITY MARKET REPORT FEED MINERALS AND GLOBAL MARKET STATUS Sponsored by: 80

NEWS 8 FEED & ADDITIVE MAGAZINE June 2024 Selko, the feed additives brand of Nutreco, shared its research findings on dietary strategies to support pig health, performance, and efficient production during the joint congress of the 27th International Pig Veterinary Society (IPVS) and 15th European Symposium of Porcine Health Management (ESPHM) in Leipzig, Germany, 4-7 June. Selko research findings show that science-based nutrition can help producers navigate pig production challenges including restrictions on the use of high levels of zinc oxide (ZnO) and antibiotic growth promoters and common enteric health issues like post-weaning piglet diarrhoea. Highlights from three Selko research posters displayed at IPVS/ ESPHM are summarized below: • Effect of organic acid blends in feed and water and copper source on feed efficiency and diarrhoea incidence In June 2022, the European Union banned the practice of feeding high levels of ZnO in livestock production and more regions are expected to implement similar bans. A study involving 150 weaned piglets and comparing five dietary treatments looked at the performance effects of a blend comprised of an organic acid, medium chain fatty acid and a phenolic compound (MCOAP) and/or Selko pH in water and IntelliBond Cu in different combinations as a replacement for ZnO. Researchers studied the effects of the blended feed additive, water-based organic acid use and hydroxychloride copper additive on weaned piglets’ growth performance and health status. Study findings revealed that combining a multi-component feed additive with water-based organic acids tended to improve the feed conversion ratio (FCR) compared to ZnO, while the combination of all additives reduced the diarrhoea incidence compared to pigs in the negative control group. Read more>> Selko to focus on dietary strategies for piglets at conference in Germany Skretting introduces its new feed formulation concept Aquaculture has an essential role in meeting the demands of a growing population, while reducing the pressure on the planet’s resources. Skretting has a long history of pioneering solutions to support this ambition. The company emphasizes that in the last decade, it has successfully reduced the dependency on marine raw materials in its feed formulations, while exploring new ways to achieve higher nutritional efficiency and improve the animal’s resource utilisation. As a result of these explorations, the company has announced the launch of its latest innovation, Aminova, a new feed formulation concept that brings an even greater level of precision to fish nutrition. Proteins are essential for fish nutrition. Individual proteins are made of a unique balance of amino acids, each providing a specific function in fish nutrition. Traditionally, aquaculture feeds have been formulated based on crude protein and, subsequently, on digestible protein. With AmiNova, the company is introducing a new way of formulating, based on an ideal digestible amino acid profile. By evaluating the total amino acid level that is effectively ingested by the fish and removing the unnecessary excess, the nutritional needs of fish are met with increased precision and efficiency, according to a press release from Skretting. Read more>>

NEWS FEED & ADDITIVE MAGAZINE June 2024 9 General Mills expands pet food portfolio General Mills announced that it completed the acquisition of Edgard & Cooper, one of Europe’s leading independent premium pet food brands. With this transaction, the company points out that it further advances its acceleration strategy, including the prioritization of its core markets, global platforms and local gem brands to drive sustainable, profitable growth and top-tier shareholder returns over the long term. “Edgard & Cooper is at the intersection of our accelerate strategy's core markets and global platforms," said Jon Nudi, Group President, Pet, International and North America Foodservice, General Mills. "We’re thrilled to welcome the Edgard & Cooper team to the General Mills family, and we look forward to partnering together to advance their mission to revolutionize premium, natural pet food.” Established in 2016, Edgard & Cooper is one of the fastest-growing and most-recognized independent pet food companies in Europe, with estimated 2023 retail sales of more than €100 million across 13 markets. With omnichannel distribution capabilities and a commitment to sustainability, the brand is delivering high-quality pet food to dogs and cats across Europe while reducing its impact on the planet. Headquartered in Kortrijk, Belgium, Edgard & Cooper will be a separate operating unit led by its three founders, Koen Bostoen, Louis Chalabi and Jürgen Degrande, with its financial results consolidated into General Mills’ international segment. Read more>> Portuguese companies introduce new petfood with insect protein The official launch of the new adult dog food product, happyOne Premium Insect Protein, developed in collaboration with pet food manufacturer petMaxi and the insect producer EntoGreen, was held at an event in Lisbon. EntoGreen's Founder and CEO, Daniel Murta, opened the session reflecting on the importance of developing innovative products for the national and international markets and announcing the characteristics of insect proteins that make it a unique and high-quality product to include in petfood. Dr Rui Fortunato, petMaxi's Technical Director, presented the advantages of this new petfood, namely the fact that it is hypoallergenic, with a single protein source, insects, being a high-quality product that is part of petMaxi's Premium range. The companies emphasizes that this product incorporates 25% insect protein and is characterised by being suitable for animals with sensitivities (itching, hair loss, among others) and allergic symptoms. This launch session was also special as it presents one of the first products resulting from the work carried out by the InsectERA Mobilising Agenda, funded under the Portuguese Recovery and Resilience Plan (PRR), a project that is expected to launch more than 100 new products, processes, and services by 2026. Although having a launch session in May, this product reached the Portuguese market in February, and can currently be found in more than 50 physical and online points of sale, including veterinary clinics and pet shops. Read more>>

NEWS 10 FEED & ADDITIVE MAGAZINE June 2024 Germany-based pet food brand Dr. Clauder’s joined forces with protein pioneer Calysta to launch the world’s first dog treats made with FeedKind® Pet protein, a revolutionary new pet food ingredient. The air-dried treats from Dr. Clauder's were presented at the world’s leading pet trade fair, Interzoo. The product contains Calysta’s nutritionally rich protein produced by natural fermentation. According to the companies, its production by natural fermentation makes this protein an excellent nonGMO ingredient that meets market demands for nutritional quality, taste and health for pets. After its debut at Interzoo, the Dr. Clauder Trainee snack cultivated protein treat featuring FeedKind Pet, will be made available for sale in Europe. Calysta explains that FeedKind Pet protein is a fermented ingredient that is nutrient dense, has a complete amino acid profile for dogs, and has postbiotic properties that help maintain a healthy gut in animals. Additionally, FeedKind Pet is a vegan protein source. “Dog owners have high expectations for their pet’s food and are increasingly conscious about the source, quality, and safety of the ingredients used,” said Herman Sloot, vice president commercial development at Calysta. “For the first time, Europe’s pet food sector has the option to choose a high-quality source of protein that is nutritious and kind to the environment. Calysta is now producing at significant scale, and FeedKind Pet is approved for use in pet foods in the EU. We are excited Dr. Clauder’s is introducing a snack featuring FeedKind Pet protein as we set a new standard for dog treats – one that prioritises both taste and health, while looking after our planet,” Sloot added. Read more>> Veramaris announced that it marked a milestone by reaching record production volumes of 50% in 2023, contributing to the supply of alternative sources of Omega-3 EPA & DHA for aquafeed. The company added that it has been at the forefront of addressing the market's growing need for sustainable Omega-3 EPA & DHA, which has risen in parallel with the global trend towards greater demand for aquaculture and healthy seafood. "2023 marks a pivotal year for Veramaris, as we not only achieved a record increase in production volumes but also solidified our market position. We are now poised to scale up sustainably, streamlining our production processes and forging new partnerships," said Gertjan de Koning, CEO of Veramaris. As set out in the company’s new sustainable development report, this significant growth in output was achieved with only a marginal increase in greenhouse gas emissions. Veramaris reported only a 3% rise in total greenhouse gas emissions, demonstrating its progress in decarbonizing its operations. This commitment to sustainability is further evidenced by the recent registration of a 27% lower product carbon footprint, reflecting the company's ongoing efforts across multiple initiatives to simultaneously decarbonize and improve the efficiency of its operations, according to Veramaris. Read more>> Dr. Clauder’s and Calysta unveil fermented protein dog treat Veramaris increases Omega-3 EPA & DHA production

NEWS FEED & ADDITIVE MAGAZINE June 2024 11 European Feed Manufacturers' Federation (FEFAC) explained that the outlook for EU compound feed production in 2024 presents a mixed picture, reflecting varying trends across livestock sectors and influenced by economic, regulatory, and environmental factors. According to the FEFAC, the main market drivers for 2024 include economic uncertainty, regulatory changes, and ongoing environmental and animal welfare policies. These factors will continue to shape production dynamics across the EU, with varied impacts on different animal feed sectors. Based on data collected by FEFAC, industrial compound feed production within the EU27 is expected to decrease in 2024 by 0.3 % compared to 2023, to 147 million tons. Poultry feed production is the only sector showing growth prospects in 2024, with an anticipated increase of 1.6%. This rebound follows a challenging 2023 driven by recovering poultry production in several key member states. Countries like France, Spain and Portugal, as well as Italy, already experienced some recovery from AI impacts in 2023, and are expected to continue leading this growth. However, concerns about imported poultry meat and shifts from organic production towards standard conventional production may affect overall market dynamics. The pig feed sector will face continued challenges, with a projected decline of app. 1-2% in 2024. Factors such as a decrease in the number of pigs and economic and disease pressures on farmers, including African swine fever (ASF), will continue to adversely impact production. However, Ireland and Poland expect a modest recovery (+3% & 2.7%) in pig numbers, contributing to a slowdown of the decrease of the sector’s output. Other countries like Germany, Belgium and The Netherlands refer to continued political pressure to reduce farm emissions or the scale of animal husbandry, resulting in a high level of uncertainty for the sector’s outlook. Read more>> EU feed production is estimated to decline to 147 million tons in 2024 Discover our full range of products designed to keep your livestock healthy and productive even under challenging heat conditions. Visit www.orffa.com for more information and to connect with our specialists. Struggling with reduced milk production and poor animal health due to heat stress? When high temperatures and humidity strike, ruminants face a challenge in maintaining stable body temperature, leading to decreased feed intake and performance. Engineering your feed solutions www.orffa.com - Follow us on COMBAT HEAT STRESS IN RUMINANTS WITH ORFFA’S NUTRITIONAL SOLUTIONS EXCENTIAL SMART Ensures optimal support, high bioavailability and good palatability of trace minerals EXCENTIAL BETAKEY Alleviates cellular stress, supports rumen fermentation, and boosts milk yield ORFFA OFFERS SPECIALIZED SOLUTIONS EXCENTIAL SELENIUM 4000 Enhances antioxidative defense and immunity

NEWS 12 FEED & ADDITIVE MAGAZINE June 2024 Balchem, which develops innovative solutions for health and nutrition markets, launched a storefront on Knowde, the leading digital customer experience platform for ingredients, polymers, and chemicals. Balchem serves companies in the pharmaceutical, nutritional supplement, food and nutrition, and animal nutrition industries with a portfolio of customized food and beverage ingredient systems, science-backed nutrients, specialty-packaged solutions, and chelated minerals. The company’s key brands include OptiMSM® methylsulfonylmethane, Albion® Minerals, K2VITAL® all-trans vitamin K2 MK-7, and VitaCholine® Choline. “We are driven by a commitment to make the world a healthier place by delivering trusted, innovative, and science-backed ingredients. Our Knowde storefront will support customers in the markets we serve to help them find our products and connect with our experts to get answers to their technical and formulation questions,” said Dominik Mattern, Vice President of Science and Marketing for Balchem. Knowde’s industry-leading search capabilities give R&D and procurement professionals the ability to filter by chemistry, application, function, technical properties, and more – including a focus on sustainable ingredients – to find the right ingredients quickly, Balchem explains. Read more>> The Eastern Africa region, comprising of Kenya, Uganda, Tanzania, Rwanda, Burundi, South Sudan and most recently DR Congo has been experiencing an increase in population growth. The population is estimated at 300 million in 2023 and it is projected to double by 2050. With an annual population growth rate of 3%, the demand for animal protein: egg, milk and meat, is increasing annually. The region has a livestock population of over 550 million (66% Ruminant and 34% Non-Ruminant), but each country experiences feed deficit. The case for Kenya having a 60% feed deficit according to the Kenya ministry of Livestock reports. Remote Livestock husbandry practices, issues of animal breed quality and the triple animal feed concerns (availability, quality and cost) continues to affect the performance of the livestock sector in the eastern Africa region. To meet the demand for both animal protein for human food and animal feed, the region needs to employ new strategies in the sector. According to the Association of Kenya Feed Manufacturers (AKEFEMA), innovative science and technology, though not the only solutions, can be used to contribute to finding sustainable agricultural solutions. Good practices from other regions of the world can be shared to contribute to address the food and feed concern frequently experienced in the region, states the association. Read more>> Kenyan feed industry meets for solutions to address feed deficit Balchem opens storefront on digital platform Knowde

NEWS FEED & ADDITIVE MAGAZINE June 2024 13 The number of cat owners continues to rise, as a staggering 59 percent of all “pet parents” now own a cat, with more than one-third owning more than one. This growth can be attributed to cats fitting seamlessly into modern pet parents’ busy and urban lifestyles. Cats, and their devoted owners, were the focus of a recent survey by Cargill, which found that nearly 75% of cat parents look for their cat’s food to help address specific health challenges. While these consumers believe cat food plays an important role in supporting their pet’s health, only 40% reported being satisfied with the current offerings on the market - fueling growth opportunities for pet product makers. “The pet food market has traditionally revolved around dogs, but with the number of cat-loving households rapidly on the rise, it’s clear that cats are having a moment – and brands are taking notice,” says Chad Wethal, Senior Global Marketing Manager, Pet & Lifestyle for Cargill’s Animal Nutrition business. “A noticeable gap exists between what is currently on the market and what cat parents are looking for, opening the space for new solutions like postbiotics that can deliver the science-backed health benefits they are seeking.” Read more>> Pet parents expect their cat's food to help address health challenges Superior & Sustainable Animal Feed Solutions We build equipment that just runs. CPM is the world’s leading provider of innovative and automated solutions for new equipment and aftermarket.

NEWS 14 FEED & ADDITIVE MAGAZINE June 2024 The conference "Smolt Production of the Future", which is being arranged by Nofima and Sunndal Næringsselskap (Suns), is an arena for knowledge exchange between fish farmers and researchers. The two days in October are packed with facts from the researchers and experiences from industry players. Trine Ytrestøyl, Senior Scientist at Nofima, led the work with the program for the conference “Smolt Production of the Future”, which will take place on 16-17th of October 2024 at Sunndalsøra at the west coast of Norway. The conference has attracted 200300 participants from the industry every other year since it started in 2008. "Since the last conference, we have gained more knowledge about smolt production, and experience with solutions in the industry is increasing. Political leadership in the Norwegian Ministry of Trade, Industry and Fisheries is also in place, and we hope that the conference will be a fruitful meeting point," says Ytrestøyl. "There is a rapid development towards increased production of large smolt, at the same time as there are challenges with welfare and mortality in the sea. Good smolt quality is part of the solution to these challenges." The conference is for everyone who is interested in the production of smolt and post-smolt, whether it takes place in closed facilities on land or at sea. The main topics for this year's conference will be experiences with the production of large smolt, smolt quality, fish health and welfare, water quality and feed and feeding in RAS. New this year is a panel debate. Read more>> Research and industry to meet at smolt conference German feed additives manufacturer Dr. Eckel Animal Nutrition has released the newly improved formular of its flagship product Anta®Phyt. The next generation offers a higher quantity of active ingredients, promising more effect with the same dosage. Modern animal production faces multiple challenges: animal health, sustainable production methods and economic profitability must go hand in hand. At the same time, it is important to minimise the use of medication without compromising health, growth, performance and product quality. Dr. Eckel notes that Anta®Phyt is the antibiotic-free plant-based solution against gram-positive bacteria such as clostridia and Strep. suis with uniquely effective hops as the main substance. According to the company, thanks to its phytogenic components, Anta®Phyt naturally supports intestinal health, strengthens the immune system and promotes animal performance. Explaining that the new Anta®- Phyt contains a higher quantity of active ingredients and has a broader spectrum of action, Dr. Eckel states that this means that Anta®Phyt now offers even more benefits for animal health and performance at the same dosage: - Effective against gram-positive bacteria - Supports intestinal health and immune system - Promotes growth and performance - Improves feed conversion - Reduces medication costs - For sustainable, healthy production Read more>> Dr. Eckel promises more effect with same dosage via AntaPhyt NXT

NEWS FEED & ADDITIVE MAGAZINE June 2024 15 Bovaer® How can cows help us fight climate change? Bovaer® helps dairy cows to reduce their methane emissions with on average 30% and lower the carbon footprint of the dairy products we know and love. Bovaer® is the first and only EU-approved feed additive with environmental benefit, recognized for its positive impact on our planet and a key tool to help the more than 150 countries of the Global Methane Pledge achieve its reduction commitments. How it works In a cow’s rumen, microbes help break down food. This releases hydrogen and carbon dioxide. An enzyme combines these gases to form methane. Bovaer® is a feed additive that suppresses the enzyme, so less methane gets generated. Learn more at dsm-firmenich.com/bovaer teaspoon daily in a cow’s feed takes effect in as little as 30 min. less methane produced, on average in dairy cows *proven safe and good for the planet *According to the EFSA assessment (2022) the product is confirmed safe in use and effective in reducing methane emissions, a source of global warming

NEWS 16 FEED & ADDITIVE MAGAZINE June 2024 Producing resilient animals requires optimal conditions at early life stages, wherein strategic nutrition solutions support future growth processes and performance outcomes. ADM published its Optimizing Animal Development with Early Nutrition Report which delves into the intricacies and importance of early-stage nutrition in helping animals reach full genetic potential. The report explores five key considerations for long-term health are prevalent across agriculturally important species—swine, poultry, ruminants and aquaculture—and around the world. A developing fetus is influenced, both positively and negatively, by conditions of the maternal environment. After birth, the main source of nutrition for young mammals is the mother's milk. Maintaining maternal health and nutritional status is critical to affect health and development of the offspring. One of the main roles of the gastrointestinal (GI) tract is to digest feed and absorb the resulting nutrients, supporting healthy development and biological functions. Stress factors can cause digestive disturbances, which are particularly challenging for young animals whose guts are not fully mature. Certain feed solutions can aid GI development and support long-term benefits. Central to an animal's defense is the immune system, which continues to develop over time. This means young animals with relatively immature immune systems are more vulnerable to pathogenic challenges. Many nutritional solutions are designed to support the immune function of young animals, applied either indirectly to the mother, or directly to the young. Read more>> Nutrex nv, one of the leading producers of specialty feed products, announced that the European Commission (EC) granted authorization for placing Nutrase® P, a highly efficient 6-phytase enzyme, on the European market. This approval allows its use as an animal feed additive for all poultry species kept for fattening, all poultry species reared for laying, and ornamental birds. This registration, granted by the European Commission following the positive evaluations by the European Food Safety Authority (EFSA), marks an important milestone in their commitment to innovation and support for the poultry industry, according to Nutrex. "The European registration of Nutrase® P represents a significant milestone and reflects our unwavering commitment to innovation and delivering top-quality nutritional solutions. We firmly believe that Nutrase® P will play a pivotal role in enhancing the poultry industry across Europe by improving nutritional efficiency and promoting sustainable production practices," say Nutrex representatives. "We extend our heartfelt gratitude to our partners, researchers, and everyone involved for their dedication and perseverance. Together, we are taking a crucial step toward creating a healthier and more sustainable poultry industry." Nutrex nv emphasizes that it remains dedicated to research and development, striving to provide cutting-edge solutions that address the demands of modern livestock farming. The European registration of Nutrase® P affirms the Nutrex’s expertise in animal nutrition and solidifies its role as a trusted partner for the poultry industry, according to the company. Read more>> ADM publishes Early-Stage Animal Nutrition Report EC approves Nutrex's 6-phytase enzyme for use in poultry feed

NEWS FEED & ADDITIVE MAGAZINE June 2024 17 For the past four years, the feed industry, alongside numerous other sectors, has been impacted by broader economic factors, such as the COVID-19 pandemic, inflation and escalating energy costs. In light of these challenges, Lallemand Animal Nutrition unveiled significant investments to its production infrastructure in Felixstowe (UK), one of the company’s main production sites for selenium-enriched yeast (ALKOSEL). Lallemand explains that these enhancements are strategically designed to strengthen its resilience and adaptability in response to external pressures and dynamic market conditions and to address sustainability goals while remaining a reliable partner for customers. By investing in these improvements, Lallemand aims to confirm its dedication to delivering high-quality products, meeting the market demand for competitive offerings, while proactively managing risks, optimizing operational efficiency and reducing its environmental footprint by optimizing energy consumption. Producing high-quality, concentrated, selenized yeast is the fruit of proper yeast strain selection, specific process development and strict quality control. Specifically selected yeast strains can convert significant amounts of inorganic selenium to around 100 different organic selenium compounds (such as selenomethionine and selenocysteine). Due to their individual genetic make-up, each yeast strain will bring its own profile in terms of exact composition in organic selenium compounds. Lallemand emphasizes that regarding the production of Lallemand’s selenized yeast (Saccharomyces cerevisiae NCYC R397, ALKOSEL), a specific production process has been developed and is constantly optimized to ensure optimal and consistent quality of the product. Lallemand also shares the information that ALKOSEL is produced by fed-batch culture: nutrients, including selenium, are supplied incrementally to the growing cells. “The crucial part is to add the right amount of selenium at the right time. Adding too little results in a low concentration of organic selenium in the final product, whereas adding too much will inhibit the growth of the yeast,” says Elsa Parmentier, R&D Project Manager at Lallemand Animal Nutrition. Read more>> Lallemand makes investments in its selenized yeast plant Copyright © 2024 Volac International Ltd. All rights reserved. The NEXT GENERATION in MYCOTOXIN and ENDOTOXIN MANAGEMENT For more information visit volac.com or contact [email protected] Now including: • Live yeast for biotransformation • Endotoxin binding capabilities

NEWS 18 FEED & ADDITIVE MAGAZINE June 2024 Global shrimp farmers face challenges with soaring costs and rampaging diseases that diminish their profits. Finnish biotech startup Enifer published a new study conducted by independent study partner AquaBioTech Group, at its aquaculture R&D facility, Innovia, about the health benefits of using Enifer’s PEKILO®Aqua mycoprotein in shrimp feed. The company unveiled that the results were excellent, with shrimp living longer and healthier when fed with PEKILO®Aqua. Currently, shrimp get roughly 10% of their protein from a fishmeal diet. Fishmeal, derived from marine fish, has been a staple in shrimp diets due to its rich protein content. Additionally, fishmeal contributes to the overall palatability of the diet. However, almost 90 percent of global marine fish stocks are now fully exploited or overfished, and the shrimp feed industry is the largest single user of fishmeal. According to the statement of Enifer, the study found that the overall mortality rate was notably reduced in shrimp fed the PEKILO®Aqua diet. The survival rate increased from 74% to 85% among shrimp consuming the 30% PEKILO®Aqua diet. Additionally, following carcass analysis, it was observed that the crude protein content was significantly higher (2.5%) in the PEKILO®Aqua-fed group compared to those fed diets containing higher levels of fishmeal. Shrimp have an innate immune system but no adaptive immune system, meaning they cannot be vaccinated. To make shrimp more resistant to diseases, their immune systems must be stimulated periodically or constantly with separately added compounds. Enifer points out that PEKILO®Aqua already includes immune-enhancing compounds like beta-glucan and nucleotides, which makes it a great feed for disease-prone shrimp as they can build immune cells faster without damaging the shrimp’s energy reserves. The results also showed that PEKILO®Aqua contributes to improved shrimp growth without an increase in feed intake. Additionally, in addition to nucleotides, PEKILO®Aqua contains another shrimp growth-enhancing compound, spermine. Read more>> New study: Shrimp fed with fungi protein grow faster and healthier Kemin Industries, one of the global ingredient manufacturers that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services, submitted a request to the European Commission to allow the use of liquid rosemary extract as an antioxidant feed additive for cats and dogs and received authorization through Commission Implementing Regulation (EU) 2024/1068. The submission leading to this authorization was initiated by Kemin Nutrisurance, the pet food and rendering technologies business unit of Kemin Industries, and the resulting regulation was published in the Official Journal of the European Union on April 15. The Commission Implementing Regulation (EU) 2024/1068 categorizes and approves of the additive as a "technological additive" within the "antioxidants" functional group, effective May 5. Before this approval, the European Union's pet food market primarily consisted of tocopherols for antioxidants, with limited options for antioxidant molecules of natural origin. This new addition of rosemary extracts not only expands the range of available antioxidants but also addresses critical supply chain challenges. Read more>> EU Commission approves Kemin’s rosemary extract

NEWS FEED & ADDITIVE MAGAZINE June 2024 19 ANDRITZ FEED & BIOFUEL andritz.com/feed-and-biofuel-en FEED & BIOFUEL COMPLETE PLANT SOLUTIONS FROM START TO FINISH, WE ENSURE YOUR PROJECTS DEVELOP SEAMLESSLY UNDERSTANDING YOU. STANDING BY YOU. NEVER STANDING STILL. We provide complete plant solutions for the animal feed industry to your exact specifications and with industry-leading cost efficiency by leveraging our extensive processing expertise and experience. By harnessing the power of automation and digitalization, we ensure continuous innovation to keep you at the forefront. AND with the industry’s most trusted services, we are always there for you. For more information, visit our website.

NEWS 20 FEED & ADDITIVE MAGAZINE June 2024 HealthTech Bioactives (HTBA), one of the leading innovators in polyphenol and vitamin B12 solutions for human and animal health and nutrition, announced a new partnership with Abolis Biotechnologies for the production of sustainable, valuable polyphenols. This latest collaboration between the two companies encompasses the development of new microbial strains and aims to address challenges relating to the supply of high-quality polyphenols, driving innovation in this fast-growing segment. At a time of increasing interest in the potential of polyphenols for both human and animal health, this latest venture between HTBA and Abolis marks an important step in the development of solvent-free, fermentation-based production methods for these in-demand ingredients. In its initial phase, the partnership will focus on developing two high-value molecules which currently experience limited sourcing availability. Upon the successful completion of this stage, the established protocols will be applied to up to eight additional molecules with the aim of similarly optimizing their development pipeline. The project’s overall goals are to increase and secure polyphenol manufacturing capacities and enable reduced costs compared to traditional extraction methods, according to the statement of the companies. “Our companies have been working successfully together since 2021 and we are still amazed by the Abolis team, whose values align with our own,” comments Alexandre Valls-Coma, CEO of HTBA. “We are delighted to announce this new phase of our partnership and truly believe that it will take polyphenols to the next level and create to more value for our customers.” Read more>> Easy Automation, Inc., one of the international suppliers of automation technology and equipment to the feed manufacturing industry, launched a new Bin Level Order Projection feature in its NexGen® Platform. The new feature allows feed mills to integrate their whole feed manufacturing processes by creating real-time visibility of feed bin levels and the ability to order based on projected empty data. “In our over 35+ years of experience in the feed industry, we continue to see feed mills challenged by out-of-feed events or the pinch of beginning and end-of-week feed order requests. To help feed mills optimize their facility efficiency, our new Bin Level Order Projection feature helps create visibility of upcoming feed needs based on bin levels and allows operators to create orders based on these readings as they are most efficient for the facility,” said Brady Gaalswyk co-president at Easy Automation, Inc. The Bin Level Order Projection allows feed mills to achieve maximum feed mill optimization by forecasting feed usage needs, preventing out-of-feed events, and filtering by location to schedule feed deliveries more efficiently. Built with customer ease of use in mind, the Bin Level Order Projection feature allows for a seamless two-click order creation directly on the bin level screen. Pulling data from multiple sensor and scale vendors, the platform is meant to seamlessly transfer data in and out of the NexGen Office program. Read more>> HTBA and Abolis partner for polyphenol production Easy Automation launches Bin Level Order Projection for feed industry

NEWS FEED & ADDITIVE MAGAZINE June 2024 21 Granite Creek unveiled that it grew its footprint in the animal health market through its recent funding of Veterinary Pharmaceutical Solutions’ (VPS) acquisition of Diamond Animal Health. Granite Creek supported VPS’ acquisition of Diamond through a follow-on investment from its FlexCap II fund, executing on the firm’s continued pursuit of animal health investment opportunities. Granite Creek purchased VPS, a licensed animal compounding pharmacy focused on supporting the veterinary community in 2020, and has actively supported the company in driving growth through strategic investments in human capital, new product development, and facility expansion. According to the firm, the Diamond acquisition represents the first of many planned platform additions as the company looks to expand its capabilities and market reach. Granite Creek worked closely with VPS leadership through the acquisition of Diamond, a contract manufacturer and researcher of animal vaccines and pharmaceuticals that are utilized by veterinarians of production and companion animals. The combined business provides a full suite of solutions to meet veterinarians’ needs while remaining a valuable partner to other pharmaceutical and biological companies working with Diamond to manufacture their products. Granite Creek added that VPS and Diamond’s combined pharmacy, chemistry, quality, and regulatory capabilities uniquely position the company for rapid innovation. Read more>> Granite Creek expands its animal health portfolio Access the Clean Feed Guide for layer producers Producing more eggs more efficiently.

NEWS 22 FEED & ADDITIVE MAGAZINE June 2024 The CEO of MicroBioGen, an Australian industrial biotechnology company and provider of ‘Yeast Innovation as a Service’, presented on opportunities for producing sustainable, alternative aquafeed using yeast technology, at international aquaculture conference, Aqua Farm 2024. MicroBioGen CEO Geoff Bell discussed how the company’s innovative yeast platform technology, based on improving the industrial capabilities of the yeast Saccharomyces cerevisiae, can be leveraged to transform industrial waste and side streams into valuable single cell protein (SCP), optimised as a fishmeal replacement. Bell presented on day one of the event in the Innovative Alternative Proteins session and joined the subsequent panel discussion. As the global demand for protein continues to rise, so does the demand for fish. With wild fish stocks declining, aquaculture is expanding to fill the gap. Current aquafeeds rely heavily on fishmeal as the main protein component. However, fishmeal as an ingredient for aquafeed is unsustainable, and there is a need for more environmentally friendly protein substitutes that have comparable nutritional value, MicroBioGen states. MicroBioGen’s innovative non-GM yeast technology offers a groundbreaking solution in transforming large-scale industrial waste and side streams into sustainable, high-quality protein. The company continues by explaining that this technology harnesses waste products such as glycerol, organic acids, and residual sugars from ethanol and biodiesel production, as well as lactose from dairy processing, to produce bioavailable protein for fish and animal feeds, thereby promoting environmental sustainability and economic efficiency in aquaculture. In developing a protein rich SCP alternative to fishmeal that can be produced from abundant waste products, the company states that its breakthrough provides a cost-effective, scalable solution to fortify aquafeeds with sustainably sourced, high-quality protein. Additional benefits include a balanced amino acid profile and higher levels of natural, beneficial enzymes that aid in the absorption of nutrients. “For nearly two decades, MicroBioGen has developed yeast technology for industrial purposes aimed at improving our partners and their customers’ process efficiency, economics and sustainability. Here, we enable the transformation of what was once low- and negative-value waste into a high-quality protein that can serve as a fishmeal replacement. In short, we help global industries make more with less, in a more efficient and sustainable way,” says Geoff Bell, CEO and co-founder at MicroBioGen Read more>> MicroBioGen highlights yeast SCP The U.S. Food and Drug Administration (FDA) has confirmed that Bovaer meets safety and efficacy requirements for use in lactating dairy cattle. Elanco Animal Health Incorporated, which has made an agreement with dsm-firmenich to expand distribution of the product across North America to include the Canadian and Mexican markets, expects the product launch in Q3 2024. “This monumental announcement has the ability to accelerate the opportunity for climate-neutral dairy farming while creating a new revenue stream for dairy farmers across the country,” said Jeff Simmons, President and CEO, Elanco Animal Health. “We appreciate FDA’s commitment to maintaining Elanco agrees with dsm-firmenich for Bovaer's North American distribution