ISSUE FOCUS 50 FEED & ADDITIVE MAGAZINE April 2024 Clostridium perfringens Positive Control Formycine 1kg/t 24h 48h 72h 15d 7 6 5 4 3 2 1 0 5.795.74 5.34 5.12 3.96 3.36 3.02 0 0 0 0 0 0 0 0 0 Formycine 2kg/t Formycine 4kg/t E. coli Positive Control Formycine 1kg/t 1.57 24h 48h 72h 15d 4 3.5 3 2.5 2 1.5 1 0.5 0 0 0 0 0 0 0 0 0 0 0 0 3.383.383.38 3.38 Formycine 2kg/t Formycine 4kg/t Figures 1 b-c. Reduction of bacterial count due to the addition of Formycine An in-vitro trial was conducted to evaluate the effect of such a combination (Formycine Gold Px) against common poultry pathogens. Poultry feed was spiked with three different bacteria, achieving very high initial contamination of 1,000,000 CFU/g per pathogen. One batch of the contaminated feed served as a control (no additive). To the other contaminated batches, 1, 2, or 4 kg of Formycine per ton of feed were added. The results (means of triplicates) are shown in figures 1 a-c. Formycine Gold Px significantly reduced the bacterial counts in all three cases. A clear dose-response-effect can be seen and by using 2 kg of Formycine / t of feed, pathogens could not be detected anymore in the feed. A further trial showed the positive effects of feeding Formycine Gold Px treated feed to the animals. Also here, the feed for both groups was contaminated with 1,000,000 CFU of Clostridium/g. The feed of the control group was not treated and to the treatment group, 2 kg of Formycine per t was added. The trial showed that Formycine Gold Px reduced the ingestion of the pathogen, and thus could prevent the lesions caused by necrotic enteritis (Fig. 2). The consequence of this improved gut health is a better feed conversion and higher average daily gain (Fig.3a and 3b). Products containing formaldehyde may represent a risk for humans, however, the adequate protection
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