ISSUE FOCUS 38 FEED & ADDITIVE MAGAZINE March 2024 5. As our understanding of molecular effects of mycotoxins is clearer with the use of new analytical techniques, there must be a continued effort to develop cutting edge technologies that can reduce the negative effects of mycotoxins on other organs and organ systems. By looking at the above technologies beyond binding, a search for a suitable replacement name for mycotoxin binder should be on. There are instances of scientists using the name “Mycotoxin Detoxification Agent” (MDA). The definition of detoxification is “the physiological or medicinal removal of toxic substances from a living organism, which is mainly carried out by the liver”. This action mainly refers to the liver and does not include other organs. On top of this, MDA does not include binders such as bentonites and silicates. Another name used is “Mycotoxin Degradation Product” (MDP) which again mainly refers to degrading the mycotoxin into metabolites using enzymes and microbes. This name does not include binders such as bentonites and silicates and other gut health and immunity concepts. Last but not the least, the name Selko uses is “Mycotoxin Mitigation Product” (MDP). Mitigation means “making something less serious, painful, unpleasant etc”. This might include all MOA as they all try to make mycotoxin toxicity less serious. Of course, this is open for discussion. CONCLUDING REMARKS Mycotoxin Binder is a misnomer. This term only covers mycotoxin sequestering MOA without any reference to other technologies in use today. Global scientific and animal industry communities should look for a unified new name. Mycotoxin Mitigation Product may fit the bill and can be discussed further. About Dr. Swamy Haladi Dr. Haladi is the commercial and technical manager for the Mycotoxin Risk Management Programme of Selko Feed Additives. He obtained his Bachelor and Master degrees in veterinary science in India, and then moved to Canada to obtain his PhD in animal and poultry science. During his studies and career, he continued to gain more interest and knowledge in the area of mycotoxins, especially the global challenges around this topic. He published various articles in both peer-reviewed journals as well as industry magazines and he truly understands the global challenge of mycotoxins. He also developed practical limits for mycotoxins in various species. Figure 2. in vivo proof for multiple mode of action supporting breeders against multiple mycotoxins (p < 0.10). Key observations: - Mycotoxins (PC) significantly impaired egg-laying rate and FCR (vs. NC) - 1.0 kg/t TOXO-XL increased egg-laying rate by +4.80% and reduced FCR by -0.17 (vs. PC) - 2.0 kg/t TOXO-XL increased egg-laying rate by +6.89% and reduced FCR by -0.25 (vs. PC)
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