ISSUE FOCUS 34 FEED & ADDITIVE MAGAZINE March 2024 About Arno Duchateau Arno Duchateau is a master in bioscience engineering who graduated in 2019 at the University of Leuven (Belgium). Since 2020, he worked as Global Product Manager in the specialty feed additives division at Impextraco focusing on gut health and mycotoxin solutions. Here, he provides technical support to business partners, customers and colleagues as well as managing different product brands from development to marketing and sales. with a bacterial challenge trigger an inflammatory response instead of immunosuppression. This finding was also confirmed by elevated levels of pro-inflammatory cytokines, for example Interleukin-6 (figure 3). In conclusion, it is noted that a combination of LPS and mycotoxins triggers an inflammation response and consequently shows there is a synergy between both endotoxins and mycotoxins. In practice, animals are continuously exposed to various challenges and all of them should be eliminated to avoid gut inflammation and performance losses. Our trial data demonstrated that a single mycotoxin challenge leads to an immune suppression, which makes the animal vulnerable to secondary challenges, but not yet impacts performance. Once an additional challenge, for example endotoxins of bacterial origin is added, an inflammatory reaction arises leading to subsequent performance losses. Since efficient binding is limited to a few classes of mycotoxins, it is evident that effective mycotoxin solutions should focus on safeguarding animal health, i.e. by immunomodulation. Additionally, they contribute to tackling different challenges, like gram-negative bacteria with their inflammatory endotoxins. Figure 3. From left to right: Number of mucosal helper lymphocytes, cytotoxic lymphocytes and interleukin-6 level was increased by aflatoxin and T2toxin contamination and restored by supplementing an anti-mycotoxin solution (p<0.05). Data presented as measured by flow cytometry on broiler blood samples.
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