ISSUE FOCUS FEED & ADDITIVE MAGAZINE January 2024 27 In a study shared at the ArMoR event, researchers sought to learn more about what physiological changes might be occurring and which metabolic pathways might be involved in using blended feed additives to manage piglets’ gut health. Tracking when and where feed additives prompt change within the animal supports future generational development and contributes to the efforts of producers using an antibiotic-free production system. Additionally, having a more complete picture of the mode of action can allow for improved precision of use. STUDYING MODE OF ACTION The study explored the mode of action for a blended feed ingredient comprised of organic acids, medium-chain fatty acids, slow release C12, butyrates and phenolic compounds (Presan®-FX). A total of 118 weaned piglets were given one of two diets for a period of 14 days. The diets included one with a blended feed additive and a control. Piglets were tracked for body weight gain and feed intake. Additionally, blood and intestinal samples were collected pre-weaning and throughout the trial. Samples were examined to determine microbiota present and metabolomics. RESULTS AND PRODUCER IMPLICATIONS Overall, piglets receiving the supplemented feed had a similar feed intake to piglets on the control diet. However, piglets receiving the feed additive had an improved average daily gain. The difference in weight gain is thought to stem from a change in fatty acid use and digestion meaning that piglets receiving the feed additive were better able to access the nutrition provided. Internally, researchers observed a shift in response of a range of metabolites such as cholic acid, choline and taurine levels in the feed additive-supplemented feed piglets. Cholic acid levels increased in samples collected from both plasma and the small intestine during the trial. However, levels of both choline and taurine in plasma declined on days 7 and 14. These changes indicated a shift in bile metabolism and potential increase in bile production and secretion, which supports the development of a microbiome that is more bile tolerant. Higher levels of cholic acid may improve nutrient digestion and support the growth of beneficial bacteria as it has an Figure 1. Supporting gut health helps internal processes protect themselves from unwanted bacteria.
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