ARTICLE FEED & ADDITIVE MAGAZINE November 2023 83 Normal liver Criteria Fatty liver Image Histological inference Lipid Accumulation Liver inflammation Hepatocytic damage Oxidative stress due to lipid peroxidation Insulin elevation Triglyceride accumulation Regulation of PPARα (Peroxisome Proliferator-Activated Receptors- alpha) Regulation of P53 Indices of hepatic health: level of AST & ALT Biochemical markers of liver function 1. Total Glyceride (TG) 2. Cholesterol (CHOL) 3. Alkaline phosphatase (ALP) 4. Globulin (GLOB) 5. Albumin (ALB) 6. Total Bile Acid (TBA) Antioxidant enzyme activity 1. Catalase (CAT) 2. Superoxide-dismutase (SOD) 3. Plasma Glutathione peroxidase (GSH-PX) 4. Total Anti-Oxidant Capacity (T-AOC) Malonaldehyde production due to lipid peroxidation causes hepatic toxicity by damaging the protein & DNA in the hepatocyte. Yes Yes Yes Yes Yes Increased High 1. 65% cavitation of cytoplasm 2. Nuclei displaced Figure 2. Difference between Normal & fatty liver No No No No No Decreased Not elevated Elevated Low Low High High Optimal 1. Clear cell boundaries 2. The regular arrangement of hepatic cords Lack of cavitation or pathological changes
RkJQdWJsaXNoZXIy MTUxNjkxNQ==