ARTICLE FEED & ADDITIVE MAGAZINE November 2023 81 The article highlights the significant occurrence of fatty liver disease in aquaculture. It is caused in fish consuming a high-fat diet, resulting in increased oxidative stress, lowered AST and ALT indices, and ultimately leading to mortality. Therefore, to mitigate this, administrating a combination of sorbitol and tri-choline may offer an alternate potential remedy. FATTY LIVER DISEASE IN FISH: IS SORBITOL AND TRICHOLINE COMBINATION A CURE? Amit Ranjan TNJFU-Institute of Fisheries Post Graduate Studies, Chennai Kavitha Malarvizhi TNJFU-Institute of Fisheries Post Graduate Studies, Chennai AN INTRODUCTION TO FATTY LIVER DISEASE IN FISH Fatty liver disease in fish, also known as hepatic steatosis, is a condition where excessive fat accumulates in the liver cells of the fish. The ubiquity of the fatty liver (non-alcoholic, called shortly as NAFLD) is amplifying globally in coordination with metabolic syndrome. Due to this issue, non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, is anticipated to emerge as the escalating problem in causing en-stage cancer liver disease in the Imminent future. In recent times, Aquaculture reports fatty liver has increased. Fatty liver injury in cultured fish is mainly caused by a high-fat diet, as reported by Du Zhenyu (2014). Studies by Luo et al. (2010) and Kim et al. (2006) have shown that this injury results in metabolic dysfunctions, reduced disease resistance, and mortality in cultured fish. As a result, researchers are now focusing on investigating and resolving this issue further. Incorporating higher levels of lipids may lead to "fatty liver," while excessive carbohydrates may cause "carbohydrate-induced hepatic lipidosis," both negatively affecting the liver. To attenuate this, beneficial food like oily fish contains enhanced PUFA content; caffeine and diterpenes in coffee; nuts consisting of MUFA, PUFA, and phenolic acid; flavonol glycosides and catechins in tea. However, in the following section, the use of a nutraceutical to attenuate fatty liver disease is discussed. SOURCES OR INGREDIENTS THAT LEAD TO FATTY LIVER DISEASE Fatty liver is caused due to various factors. The sequestration of the fat in the liver is caused main-
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