ISSUE FOCUS 32 FEED & ADDITIVE MAGAZINE November 2023 palatability of the feed, depriving the animal of one of the most potentially positive effects at an early age. But undoubtedly, the main factor that conditions the absence of effects on consumption is the low dosage of product recommended for merely commercial reasons. The increased consumption with Butirex C4 in the first weeks of chicken life is dose dependant. In this regard, the product also shows a correlation between the increased final weight of the animals and consumption at early ages. Therefore, from an economic point of view, the use of the highest recommended doses of Butirex C4 during the first two weeks of life is fully justified. Consequently, the initial intake greatly conditions the intestinal integrity of the chicken. Underlying this scenario of optimal absorption and digestibility are all the additional positive effects widely demonstrated with Butirex C4: • Regeneration of the epithelium. • Reinforcement of tight junctions and strengthening of the intestinal barrier for control of intestinal homeostasis and permeability. • Control of inflammatory mediators at the level of the epithelial cell line and the immune system and, of course, the highly beneficial modulation of the microbiota associated with pathogen control. About Javier Sánchez Javier Sánchez, a graduate and Ph.D. in veterinary medicine with a mention as a European Ph.D. from the Faculty of Veterinary Medicine of Cáceres, Spain, complements his solid training with an MBA from the Polytechnic University of Madrid. His professional career has focused on the field of animal nutrition, with a particular focus on intestinal health and integrity, an area in which he has excelled over the last decade. His dedication and experience in this field make him an outstanding expert, currently Technical and Commercial Coordinator of Novation. About Beatriz Saldaña Beatriz Saldaña, a graduate and Ph.D. in Agricultural Engineering from the Polytechnic University of Madrid with international mention and a prestigious Extraordinary Thesis Award, making her a leading figure in the field of animal nutrition. In recent years, she has focused her professional career on research, acquiring a MSc in Animal Health and Nutrition from the Complutense and Polytechnic Universities, as well as participating in several European animal nutrition projects. Her commitment to excellence and her experience on animal nutrition research have made her an invaluable resource as head of R&D at Novation. Figure 3. Increased dose-response consumption with Butirex at early ages. Meta-analysis of 20 trials
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