Feed & Additive Magazine Issue 34 November 2023

November 2023 Year: 3 Issue: 34 Feed Additive INTERNATIONAL MAGAZINE FOR ANIMAL FEED & ADDITIVES INDUSTRY Gonçalo Martins, Delacon™, Cargill Phytogenics: A tool to improve efficiency in lamb feedlots Lea Poppe, EW Nutrition Cryptosporidia in calves – chickens can help Xander de Boer, Alltech Coppens Prebiotics: A pathway to achieving optimal fish health www.feedandadditive.com Weaning and Proper Nutrition in Young Animals Zootechnical Additives: Digestibility Enhancers, Gut Flora Stabilizers, Substances Favourably Affecting Environment

Weaning, in ruminants and pigs, is a critical period in the life of young animals as it involves the transition from a milk-based diet to a solid feed diet. Similarly, in poultry, feeding in the first weeks is the key for hatched chicks to reach advanced life stages in a healthy way. According to experts, this transition process affects not only nutritional intake, but also digestive physiology, intestinal microbiota, immune system and future performance of the animals. For this reason, it can be considered that proper nutrition and a well-managed weaning process in the early stages, even from the womb, will be one of the most important steps taken for an efficient business. Of course, there is no single recipe for this critical process. Experts state that the nutritional needs of young animals may vary depending on many factors such as the animal's species, age, physical and environmental condition. For example, young ruminants need to improve their rumen function and microbial populations during weaning. This requires adequate intake of fermentable fibre, protein and minerals, as well as access to clean water. It is known that colostrum intake immediately after birth is very important to provide passive immunity and prevent infections. Young piglets, on the other hand, face many challenges during weaning, such as separation from the sow, confusion with unfamiliar litters, exposure to pathogens, and nutritional changes. These challenges compromise intestinal integrity, immune function, and feed intake, which can lead to post-weaning diarrhea, growth failure, and death. Therefore, it is recommended to feed piglets a highly digestible ration rich in protein, energy and minerals during the weaning period. Knowing the risks that young animals face, determining their needs by taking these risks into consideration, and providing feeding resources appropriate to these needs can be the summary of how to manage this process properly. Hoping that more information and expert opinion will contribute to this process, in this November issue we include some of the latest research and practical advice on proper nutrition and weaning of young animals. We hope that you will find this issue informative and useful, and that it will help you to improve the weaning process of your young animals on your farms and businesses. Although we do not have the opportunity to express it very often, we welcome your feedback and suggestions and look forward to hearing from you. We wish you a pleasant reading... See you in the next issue! Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR For a healthy and productive future generation... Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadditive

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CON T E N T S SPECIAL STORY CBS Bio Platforms warns farmers and feed mills about mycotoxin 6 Tyson Foods and Protix join forces for sustainable protein production 8 Next generation scientists gather at Selko Young Scientist’s Forum 94 Hill's Pet Nutrition increases production capacity with its new smart facility 10 Evonik and Shandong Vland Biotech join forces to gut health solutions 14 Bioflytech constructions its second plant for BSF larvae production in Spain 90 NEWS REPORTS SOUTH AMERICA ANIMAL FEED MARKET 86 Zootechnical Additives: Digestibility Enhancers, Gut Flora Stabilizers, Substances Favourably Affecting Environment 60 ZOOTECHNICAL FEED ADDITIVES: TOPPLING REGULATORY HURDLES By Pen & Tec Consulting, part of the Argenta Group 66 THE IMPACT OF FORAGE ON CARBON EMISSIONS IN RUMINANTS Virginie Blanvillain, AB Vista 74 INCREASED MILK YIELD AND REDUCED ENTERIC METHANE CONCENTRATION WITH DIETARY INCLUSION OF SUGARCANE EXTRACT By Awais Ahmed, Matthew Flavel, Shane Mitchell, Gregor Macnab, Manisha Dunuarachchi Dunuarachchige, Aniruddha Desai and Markandeya Jois 81 FATTY LIVER DISEASE IN FISH: IS SORBITOL AND TRICHOLINE COMBINATION A CURE? Kavitha Malarvizhi & Amit Ranjan, TNJFU ARTICLES 57 DISABLING DYSBIOSIS IN ITS ATTACK ON CHICKEN PERFORMANCE AND PROFITS Dr. Alain Riggi & Dr. Ruth Raspoet, Phileo by Lesaffre 70 PREBIOTICS: A PATHWAY TO ACHIEVING OPTIMAL FISH HEALTH Xander de Boer, Alltech Coppens

NEWS 6 FEED & ADDITIVE MAGAZINE November 2023 Taking steps to protect feed from contaminants is advised for livestock farmers and feed mills post this year’s harvest, said feed quality experts. This is especially important in higher-risk production regions of Canada and the U.S. – such as Southern Ontario and key pockets of the midwest – that received high rainfall over the growing season. In addition, mitigation is an important consideration everywhere given the higher costs invested in raising livestock. “The flags are up that protecting feed quality will be important this year post-harvest,” says Paul Garvey with CBS Bio Platforms. “We’re advising farmers and feed mills to plan and have mitigation options ready. Grain management technology can help you safeguard your feed to protect feed supply, animal health, and productivity.” "Harvest in some areas is delayed with late summer and fall rains. As a result, sampling and testing for mycotoxin levels is also behind. But all indications point to taking action," he says. “Here in Southern Ontario, for example, we had much higher than normal rainfall levels in late summer, including some flooding, in major corn growing regions. The corn crop has been stressed and harvest will be later. The good news is we’re expecting strong yields. But anytime in the past we’ve stressed the crop and had a later harvest, it’s been more prone to mycotoxin concerns. Taking steps to protect feed is a good insurance policy to protect the investment in each animal.” Garvey states that the stakes are higher today than in past years because that investment is much higher due to significantly priced commodities and other factors impacting input costs. “With beef calves, for example, the price of animals going into the feedlot has more than doubled compared to recent years.” Read more>> CBS Bio Platforms warns farmers and feed mills about mycotoxin dsm-firmenich develops carbon net zero Single Cell Proteins dsm-firmenich has announced that it has developed new, industry-leading, Single-Cell Proteins (SCPs) that have the capacity for the production of net-zero carbon protein to help meet demand and feed the global population within planetary boundaries. The company stated that SCP will ensure the sustainability of food systems by partially decoupling animal production from conventional inputs and associated challenges, e.g., fertilizer use, deforestation, and water while helping to fill the projected protein gap. The use of SCPs as an animal feed ingredient is a game-changer that can reduce the land and water footprint required for animal farming and contribute to 1.5 degrees of global warming goals, according to dsm-firmenich. SCPs are in essence a protein production powerhouse produced by fermentation technology. These proteins have an incredible potential for scalability. With very high growth rates these organisms can produce a considerable amount of protein compared to their initial weight and are the frontrunner when it comes to emerging proteins. These naturally occurring microorganisms can convert platform molecules into proteins, perfectly suited to replace fishmeal, wheat gluten, guar meal, soy or pea protein concentrates, and other plant proteins. SCP provides a readily available, protein-rich microbial biomass, in the form of yeast, bacteria, or fungi. This can be achieved by combining biotechnology with new bioscience to train and evolve microorganisms to become super protein producers and maximise the nutritional value of the non-protein part of the cell structures. Read more>>

NEWS FEED & ADDITIVE MAGAZINE November 2023 7 Kemin Industries, a global ingredient manufacturer that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services, will launch the MEFLUVAC™ H5 PLUS 8 vaccine in partnership with ilender in Latin America to assist in building immunity against the highly pathogenic Avian Influenza. Kemin Biologics, the global veterinary vaccine division of Kemin, debuted the new vaccine in Peru at an event and roadshow held in the Peruvian cities of Lima, Trujillo, and Chincha in October. At this event, policy and distribution stakeholders, along with customers from the poultry meat and layer industries, came together to discuss vaccinology and risk management programs. The industry leaders focused on the importance of addressing major pathogens that compromise animal performance and food security for the growing population. "We are excited to introduce our technology and best practices to empower the poultry industry in Peru and Latin America to mitigate the growing threat of highly pathogenic Avian Influenza," said Dr. Ricardo Neto, Technical Service Manager, Kemin Biologics. "The high degree of homology with local strains makes MEFLUVAC™ H5 PLUS 8 the vaccine of choice." "The launch of MEFLUVAC™ H5 PLUS 8 is a major milestone for Kemin Biologics' expansion into the Latin America market," said Dr. Matias Jansen, Regional Business Director, Kemin Biologics. "Together with our partner, ilender, we will be able to reach producers all across Peru and support them with vaccination strategies that are based on our expertise and experiences from all over the world." Read more>> Kemin and Ilender launch Avian Influenza vaccine in Peru Lallemand Animal Nutrition announced the launch of Lalprobiome, its new platform of innovative microbial solutions tailored for pets. The new brand offers a broad range of yeast and bacteria-based solutions including prebiotics, probiotics, postbiotics, and antioxidants. From digestive care to immune support, and antioxidant optimization to cognitive function, Lalprobiome offers a broad range of specific solutions allowing for petfood, treat, and supplement customization and differentiation. Dr. Francesca Susca, Global Pet Product Manager, explained: “Our company is a global leader in the selection and application of microbial strains to address the nutrition and well-being of humans and animals. We’ve capitalized on this legacy to bring Lalprobiome to the pet food market. Lalprobiome leverages the natural power of yeast and bacteria with cutting-edge science to support pet health and well-being.” She added: “We understand that every business is unique, which is why we’re thrilled to launch Lalprobiome. This gives our customers the ability to elevate and differentiate their brands with novel ingredients that support unique and specific benefits. Lalprobiome products have been exhaustively tested for safety and efficacy, providing customers with proven, healthy products.” Read more>> Lallemand launches new platform of innovative microbial solutions for pets

NEWS 8 FEED & ADDITIVE MAGAZINE November 2023 Alltech brings ideas and inspiration of its annual ONE Conference to Dubai The Alltech ONE World Tour will bring international agriculture leaders to Dubai on November 27-28. Alltech ONE Dubai will explore collaborative solutions to some of the greatest challenges facing the agri-food industry in the Middle East, Africa, and beyond. Alltech ONE Dubai will feature global and local experts discussing trends in sustainable agriculture, animal nutrition, and business, including keynote presentations from Dr. Mark Lyons, president and CEO of Alltech, and Tara McCarthy, Alltech’s global vice president for ESG, and Dr. Marc Larousse, vice president of the Middle East of Alltech. The conference will explore species-specific nutrition and production topics in greater detail through two dedicated breakout sessions, one focused on dairy and the other on poultry, as well as an interactive panel discussion featuring industry experts. A variety of social activities, including networking breakfasts, a gala dinner, and tours of local industry sites will also take place during Alltech ONE Dubai. Read more>> Tyson Foods and Protix join forces for sustainable protein production Tyson Foods, Inc., one of the world’s largest food companies, has reached an agreement for a two-fold investment with Protix, the leading global insect ingredients company. The strategic investment will support the growth of the emerging insect ingredient industry and expand the use of insect ingredient solutions to create more efficient sustainable proteins and lipids for use in the global food system. The agreement combines Tyson Foods’ global scale, experience and network with Protix’s technology and market leadership to meet current market demand and scale production of insect ingredients. Through a direct equity investment, Tyson Foods will acquire a minority stake in Protix to help fund its global expansion. In addition, Tyson Foods and Protix have entered a joint venture for the operation and construction of an insect ingredient facility in the continental United States. Upon completion, it will be the first at-scale facility of its kind to upcycle food manufacturing byproducts into high-quality insect proteins and lipids which will primarily be used in the pet food, aquaculture, and livestock industries. “Our partnership with Protix represents the latest strategic investment by Tyson Foods in groundbreaking solutions that drive added value to Tyson Foods’ business,” said John R. Tyson, chief financial officer of Tyson Foods. “The insect lifecycle provides the opportunity for full circularity within our value chain, strengthening our commitment to building a more sustainable food system for the future.” Kees Aarts, CEO of Protix, said: “We are very excited to announce the next step in our international growth strategy. Tyson Foods’ and Protix’s strategic partnership advances our joint work towards creating high-quality, more sustainable protein using innovative technology and solutions. Moreover, we can immediately use their existing byproducts as feedstock for our insects. This agreement is a major milestone for Protix and significantly accelerates our ambition to grow through international partnerships.” Read more>>

NEWS FEED & ADDITIVE MAGAZINE November 2023 9 Andritz opens test center for the food and feed industry International technology group Andritz has opened a leading-edge test and research center for the food and feed industry in Waddinxveen, the Netherlands. The Food Innovation Xperience center will be the development and technology hub where customers and Andritz’s experts team up to turn visions into reality. The test center is equipped with the latest milling, extraction, dewatering, and drying technologies from Andritz, enabling customers to conduct feasibility studies, and pilot plant tests for scale-up or R&D activities under food-grade or even ATEX conditions. Covering a total area of 850 m2, the center is available to customers in the food and feed industry as well as to research and development organizations. Developing new, sustainable food ingredients and food manufacturing processes has become particularly important today as food and feed manufacturers must respond to the fast-changing market and consumer demands, governmental regulations, and environmental requirements. “In this context, it is essential to act quickly and scale-up new ideas, make existing production processes more efficient, and reduce operations’ environmental impact, like freshwater consumption or CO2 footprint,” explains Marco Buis, Managing Director at Andritz Gouda B.V. “Our Food Innovation Xperience center offers customers the opportunity to determine the best possible manufacturing process for their need, building on latest technologies and line solutions as well as expert support from Andritz.” Read more>> Supplant D Replacing zinc oxide • Strengthens the gut barrier function • Reduces diarrhea occurrence • Blocks inflammation induced by toxins agrimprove.com Vitazero

NEWS 10 FEED & ADDITIVE MAGAZINE November 2023 Hill's Pet Nutrition increases production capacity with its new smart facility Hill's Pet Nutrition, a division of Colgate-Palmolive and one of the global leaders in science-led nutrition, announced the grand opening of its newest manufacturing plant in Tonganoxie, Kansas. Located on more than 80 acres, the 365,000 square foot, fully designed smart facility will increase the company's production capacity for canned pet food and provide a runway for continued expansion of Hill's Science Diet and Prescription Diet brands. "It's only appropriate that as we celebrate Hill's 75th anniversary, we are able to unveil the next chapter of smart manufacturing innovation in the pet food industry," said John Hazlin, President and CEO of Hill's Pet Nutrition. "The Hill's Tonganoxie plant helps set the stage for the continued growth of our science-led nutrition, increasing our capacity and our ability to better serve the evolving needs of pets and pet owners in the United States and around the world." The new Hill's Tonganoxie plant marks a step change in strategic automation and technological advancements in the pet food industry. The new technology and processes will help to improve speed to market by shortening the production cycle, while also offering long-term flexibility to innovate new formats and products that help deliver on the company's mission to support the health and wellbeing of pets. Among the more than 170 varieties of wet pet food the plant will make, it will produce Hill's Prescription Diet k/d, the world-renowned original science-based formula designed for the nutritional management of renal (kidney) conditions, pioneered by Hill's Founder Dr. Mark Morris Sr. in 1948, which marked the launch of the first Zinpro Corporation, the world’s leading innovator and manufacturer of high-performance trace minerals and animal nutrition solutions, announced the opening of its new stateof-the-art blending facility in Marialva, in the state of Paraná, Brazil. “This new facility marks an exciting growth milestone for Zinpro,” said Rob Sheffer, President, and CEO. “But even more important is our ongoing commitment to serving customers in Brazil. We look forward to delivering greater efficiency and flexibility for producers and agribusinesses in this critically important region of the world – especially as the demand for animal proteins continues to increase with the growing global population.” According to Sheffer, the new plant will give Zinpro increased flexibility to innovate and develop breakthrough solutions for animals and producers. “By delivering products locally, we can increase speed and efficiency while enhancing sustainability.” “Through our close partnerships with customers across Brazil, we have discovered a need for innovative nutrition solutions in this market,” said José Francisco Mendes, Zinpro vice president of sales – Latin America. “This new, modern blending facility allows us to offer our proven Zinpro products, solutions, and tools more efficiently than ever before. We look forward to working with our customers to enhance animal health and wellbeing and drive better animal performance.” Read more>> Zinpro opens its new state-of-the-art blending facility in Brazil

NEWS FEED & ADDITIVE MAGAZINE November 2023 11 veterinarian-developed pet food line intended to help manage specific conditions through nutrition. Hill's Prescription Diet k/d was recently upgraded this year with a new proprietary microbiome technology that helps reduce harmful waste products. "Hill's will utilize technology to work alongside Hill's staff and a new state-of-the-art Mission Control Center to provide unprecedented visibility and monitoring through every aspect of pet food making from ingredient intake to final packaging," said Chad Sharp, Director of Manufacturing for the Tonganoxie Plant. "The production process is an entirely "enclosed system" from ingredient mixing to cooking and container filling – designed to prevent food exposure to environmental contaminants." Read more>> JBS and Silvateam, one of the global leaders in producing plant extracts for animal feed, unveiled the results of a study demonstrating the effectiveness of tannin in curbing greenhouse gas (GHG) emissions within the beef industry. This research, conducted by the São Paulo Institute of Zootechny (IZ), concluded that utilizing a feed additive called SilvaFeed BX®, containing a blend of tannins and saponins, can reduce enteric methane emissions by as much as 17% for feedlot beef cattle. Moreover, the study's measurement methodology will enable JBS and other industry players to track emission reductions on their GHG accounting in the future. "JBS has been a key supporter in developing various studies on food additives, including the use of tannins in feed for cattle in feedlots. This technology isn't just of interest to our company; it's a matter of significance for the entire livestock sector. By making these solutions accessible throughout the production chain, we are actively contributing to the promotion of low-carbon livestock farming in Brazil," said Fabio Dias, Director of Livestock at Friboi and leader of Regenerative Agriculture at JBS Brazil. "Cattle have often been associated with a significant share of greenhouse gas emissions. However, through our studies, evidence, and practical application of tannins in animal nutrition, we have demonstrated that a substantial reduction in methane emissions is possible. This shows that livestock farming actively contributes to achieving climate neutrality," stated Marcelo Manella, director of Silvateam. The research was conducted by experts from IZ's recently established Science Center for Advancing Climate Neutrality in Beef Cattle Raising. They closely monitored the cattle at JBS's feedlot in Guaiçara (SP) for approximately six months. When applying the study's results retroactively between 2019 and 2022, it's evident that the use of the tannin and saponin mixture in their diet prevented the emission of more than 30,200 tons of carbon dioxide (CO₂) equivalent in JBS feedlot cattle. To put this in perspective, it's like taking around 24,000 gasoline-powered cars off the road or planting over 2,000 trees during that timeframe. Read more>> New study: Tannin cuts greenhouse gas emissions by 17% in livestock farming

NEWS 12 FEED & ADDITIVE MAGAZINE November 2023 ADM, one of the global leaders in human and animal nutrition, invested $33 million to build and open a new pet food production line in Guadalajara, Jalisco. ADM has been present in Mexico for over 65 years. Adding this new production line will increase the manufacturing workforce by 65 percent and optimize dry pet food production flow for the Ganador® and Minino® pet food brands, as well as support the development of new ranges in ADM’s portfolio. In recent years, Jalisco has shown an increase in economic activity and is placed among the three main states in Mexico as a growing and attractive location for qualified talent and investments. ADM’s new production line offers a wide range of capabilities throughout Mexico and will expand its capacity to reach foreign markets, specifically in Central America and Colombia. “Without a doubt, Guadalajara is a strategic, economic location for ADM in Mexico. The integration of this new production line adds range and flexibility to our capabilities in Mexico and enables ADM to triple its capacity and give us wider international visibility within the pet food market,” said Jorge Martínez, President of ADM’s pet nutrition business. Martínez was joined at the inaugural ceremony to open the facility by Pablo Lemus, Mayor of Guadalajara, and Amy Scanlon, U.S. Consul General in Guadalajara. The plant will be equipped with new technology, such as automated systems, as well as implement work practices aligned with the NOM-036, a Mexican regulation on Ergonomic Risks Factors at Work which aims to reduce risks for workers loading heavy packages. Read more>> ADM invests $33 million for new pet food production line in Guadalajara Hendrix Genetics, one of the global leaders in multi-species breeding, genetics, and technology, has announced the grand opening of its new shrimp Breeding Multiplication Center (BMC) in Ranasthalam - Mandal, Srikakulam District in the Andhra Pradesh region of India. In early 2022, Hendrix Genetics formed a strategic Joint Venture partnership with Sapthagiri Hatcheries, one of the largest - and most successful - hatchery businesses in India. The company stated, this significant expansion marks a milestone in Hendrix Genetics' mission to enhance shrimp breeding and meet the growing demand for high-quality shrimp genetics in the Indian market. The Indian BMC is managed by Kona Bay, a subsidiary of Hendrix Genetics, and is under the local leadership of Deepak Patnaik. The opening of the BMC is also in line with the idea of Kona Bay’s will to decentralize its production to avoid high risk export business, ensuring clients of Hendrix Genetics always have access to products. With a broodstock capacity exceeding 150 000, Indian BMC is set to greatly improve shrimp breeding Hendrix Genetics opens its new shrimp Breeding Multiplication Center

NEWS FEED & ADDITIVE MAGAZINE November 2023 13 in the region. According to the statement by Hendrix Genetics, Indian BMC will produce the same high-quality shrimp products as those currently imported from Hawaii facility of Hendrix Genetics, ensuring that their customers continue to receive the superior genetics they have come to trust. Moreover, the BMC maintains the same genetics as the current imported broodstock from Hawaii, which is renowned for its far from pathogens biosecurity environment, thus maintaining a Specific Pathogen Free (SPF) status. In addition, local sentinel and commercial challenges allow for a direct line of data to the breeding nucleus in Hawaii. Shrimp reared under Indian conditions will result in a more adapted and resilient shrimp suited for the Indian market. "The PPL will be stocked in Q4 2023 from our Hawaii facility, and the first broodstock sales will take place in Q2 2024. We also have started to build our local team of experts, aiming for up to 40 employees. Thank you to the entire team for making this possible. Together we are stronger," added David Danson, Director of Operations and Shrimp at Hendrix Genetics. Read more>>

NEWS 14 FEED & ADDITIVE MAGAZINE November 2023 Evonik China Co., Ltd and Shandong Vland Biotech Co., Ltd agreed to build a joint venture to expand their presence in gut health solutions products for farm animals globally. Evonik will be the majority shareholder in this joint venture with 55 percent of the shares. The joint venture, called Evonik Vland Biotech (Shandong) Co., Ltd. will have its headquarters in Binzhou, China, and is planned to enter the market in Q1/2024. The joint venture will combine the specific strengths of both partners, including Vland's market access, regulatory capabilities in China as well and its fast innovation cycles. In addition, the joint venture will benefit from Evonik’s global sales force and market access, R&D, and global regulatory capabilities. Sales of the new joint venture are expected to be in the low double-digit million-euro range. Evonik announced earlier this year that it is developing its specialty nutrition business with system solutions and specialties for Evonik and Shandong Vland Biotech join forces to gut health solutions FOLIUM Science, a UK-based biotechnology business, will be taking to the stage at the AgriTechE REAP Conference on November 8th to launch the latest of their innovative product range to improve animal health and productivity. The new product, called SWIFTR, is a lateral flow test for the detection of bacterial infection. The first product in the range will be launched at REAP and is for the rapid detection of Salmonella in poultry production. The time it takes to get the test result and identify an infection is reduced to one hour compared to currently available tests which can take up to five days. According to the company's statement, the test is also simple to use and requires no special training or laboratory equipment so that it can be carried out on the farm or where action can quickly be taken to protect the health of the flock and to prevent the spread of infection. Because SWIFTR is a molecular test that uses advanced molecular biology, it can identify small pieces of genetic material from the pathogenic bacteria that the user is looking for in the sample, even down to individual Salmonella serovars where necessary. This means that the test is extremely accurate. The company stated that the extent of the infection can also be quantified so that the appropriate measures can be put in place. “We know that rapid testing for bacterial infection is the Holy Grail for the food industry,” said Ed Fuchs, CEO of FOLIUM Science. “Our first SWIFTR test is for the detection of Salmonella but we are also developing tests for other bacteria such as Enterococcus, Clostridium, and E.coli. While poultry production is the first step on the ladder, there are numerous applications in animal farming and across the food industry for a test that is quick, simple, and accurate. We are working with our partners in the poultry industry to roll out the use of SWIFTR in poultry production in early 2024.” SWIFTR uses the same Guided Biotics® technology that has been developed for FOLIUM Science’s feed additive BiomElix. Next year sees the launch of the first product in Brazil, BiomElix One, a feed additive for poultry that targets all Salmonella serotypes. Read more>> FOLIUM Science to launch lateral flow test for Salmonella

NEWS FEED & ADDITIVE MAGAZINE November 2023 15 poultry, swine, and ruminants. The partnership with Vland on gut health solutions is an essential element of Evonik’s strategy to offer system solutions for its customers in the animal feed industry. Customized system solutions consisting of products, services, and know-how delivering sustainability benefits are part of the strategic core of Evonik's life science division Nutrition & Care, which includes the Animal Nutrition business line. Biosolutions such as probiotics for animal gut health will strengthen the division’s biotechnology platform. “This joint venture combines the strengths of two successful players in the feed additives business and provides a solid platform for future growth,” says Gaetano Blanda, head of the Animal Nutrition business line of Evonik. “Together, both partners gain broader market access for their products and combine their innovative strength.” "I am happy to join forces with Evonik. The joint venture builds on the successful cooperation between our two companies, which we are now taking to a new level," says Arron Chen, Chairman and President of the Vland Group. Read more>> New study confirms positive benefits of Alltech’s Bioplex® in layer production Dedicated to providing solutions and products that contribute to the success of the global animal health industry, Alltech announced a new study on Bioplex®. According to the new study, “The Effect of Organic Trace Mineral Supplementation in the Form of Proteinates on Performance and Sustainability Parameters in Laying Hens: A Meta-Analysis”, recently published in the journal Animals, the inclusion of Bioplex® organic trace minerals in layer diets significantly benefits production performance and egg quality traits and contributes to a lower carbon footprint. The findings also suggest that the most bioavailable form of essential minerals is crucial for optimizing health and performance in laying hens. The meta-analysis, led by Dr. Laurann Byrne, research project manager at the Alltech European Bioscience Centre, considered the importance of mineral form on production performance, egg quality traits, and carbon footprint. It combined data from 32 global studies involving 107 dietary assessments of 30,992 laying hens. Dr. Byrne looked at the impact of supplementing laying hen diets with organic trace minerals in the form of mineral proteinates, specifically Bioplex copper, iron, manganese, and zinc. The study demonstrated that using Bioplex led to improvements in hen-day production, feed conversion ratio, egg mass, egg weight, and egg loss. Eggshell parameters such as thickness, strength, weight, and eggshell percentage also were improved. “With correct formulation, more cost-effective feeds can be produced, resulting in a greater return on investment and a lower carbon footprint,” Dr. Byrne said. “As the results show, there is a proven track record of improvement in performance and sustainability with organic trace minerals.” Read more>>

NEWS 16 FEED & ADDITIVE MAGAZINE November 2023 AB Vista organised a Feed Intelligence Conference in Dubai, October 3-4, 2023. The event, hosted by the company’s ASPAC team, brought together diverse leading academic and industry experts to share the latest developments from their key fields, exploring how the findings of this research can be practically applied to commercial situations to deliver improved profitability. “We are proud to have hosted this successful Feed Intelligence Conference, another example of our commitment to bringing new nutritional perspectives to the industry," said Marylan Rivera, AB Vista’s Regional Commercial Director (SEA). “Not only are we helping professionals meet demands and achieve production goals in a competitive industry, events like this help the industry to further advance in the sharing of research findings – and, of course, encouraging further research.” The conference included four sessions: Dietary Fibre and Gut Health; Fibre Utilisation; Phosphorus and Calcium Nutrition, and Hot Topics, where participants were invited, and encouraged, to participate in Q&A forums with the speakers. Read more>> Experts focus on dietary fibre at AB Vista's conference in Dubai The Bel Group, APBO (Bel’s Milk Producers Association in the West of France) and dsm-firmenich, in partnership with Institut de l’Elevage (Idele), the French institute for livestock breeding), announced the promising results of a pilot project aimed at reducing methane emissions from dairy cows. Conducted on five dairy farms, the pilot demonstrated the ease of implementation of Bovaer®, the feed additive for dairy cows, in real-life farming conditions. This study paves the way for a more sustainable dairy industry, according to the companies. Five farms were selected for the pilot project, as they were representative of the diversity of APBO farms, in terms of feed distribution equipment, type of ration at the trough and distribution arrangements throughout the day. Bovaer® was added at a rate of around a quarter teaspoon a day to the diet of dairy cows, it suppresses the enzyme, so less methane gets generated. As it acts, Bovaer® is safely broken down into compounds already naturally present in the rumen. According to the companies' statement, all the data and analyses of ration samples collected by Bel technicians during the test and interpreted by experts from Idele, demonstrate the success of Bovaer® implementation, whatever the type of ration and distribution method used on the farms. Under optimal conditions of use (dosage and regularity of consumption throughout the day), the reduction in enteric methane was estimated at between 29% and 42%, depending on the farm, over the two months of the study. These results confirm the 30% methane reduction expected on average from previously published studies on Bovaer®. Yoann Lézé, Vice-Chairman of APBO, said: “As responsible milk producers, we keep a close eye on ways to reduce the carbon footprint of our farms, and are fully aware of the innovations coming onto the market, such as Bovaer®.” Read more>> Promising pilot test to reduce enteric methane emissions from dairy cows


NEWS 18 FEED & ADDITIVE MAGAZINE November 2023 Benson Hill, Inc., a food tech company unlocking the natural genetic diversity of plants, announced plans to improve its financial position and accelerate its transition to an asset-light business model with a focused expansion into broadacre animal feed markets, complementing its accomplishments in human food ingredients. According to the company, the near-term opportunity in animal nutrition is consistent with Benson Hill’s strategy to expand and diversify its proprietary product portfolio, improve nutrition security, and foster collaboration with industry partners within the food value chain. In connection with this announcement, the Board of Directors has appointed Deanie Elsner, who had served as Interim CEO since June, to the position of Chief Executive Officer, effective immediately. Elsner, CEO of Benson Hill, commented: “Benson Hill has the agility to persevere. Based on our ongoing strategic review, we believe that strengthening of our financial foundation, moving to an asset-light business model, and introducing our innovations into attractive broader end markets, is the most feasible path forward for Benson Hill. Through the actions we have taken and are continuing to implement, we are poised to deliver significant value as a leader in AI-driven proprietary seed innovation.” Elsner continued, “We are already making progress on our strategic path. With the expected divesBenson Hill focuses on animal feed markets A new opportunity for poultry and swine farmers to dramatically improve production and sustainability at reduced cost was featured at the Mexican Association of Animal Nutrition Specialists (AMENA) conference in Puerto Vallarta. Research presented at the conference showed that supplementing diets with multi-component protease (MCP) offers strong advantages to produce more from less feed – transforming performance, health, and profitability. The findings showcase a major opportunity not only for Latin American production but for poultry and swine farmers globally, says Dr. Jorge Perez Palencia, Research Associate at South Dakota State University. “Our findings reinforce that it makes sense to supplement monogastric diets with protease. But even more importantly, for the best results, it is critical to use a multi-component protease.” The potential for animal agriculture is significant, he says. “MCP provides a solution to address the rising cost of feed, which today is one of the biggest challenges for livestock farmers, the feed industry, and animal nutrition worldwide.” The feed can account for up to 70 percent of total production expenses, he notes. In recent years the cost of feed has peaked further due to a range of factors including supply challenges, market volatility, and – particularly for developing markets such as Latin America – more limited economical choices in protein sourcing. In Latin America, many farms have not yet started supplementing with any protease, let alone MCP, Dr. Jorge Perez Palencia notes. “If we can increase adoption of not only protease supplementation but specifically MCP supplementation, this will allow Latin America farmers to quickly improve the economics of production.” The research results presented by Palencia at AMENA make a strong case not only for protease supplementation but for the specific type of MCP available today that can be most effective. The SDSU research was conducted in collaboration with CBS Bio Platforms, a leading science-based and innovation-focused company in the animal feed industry. Read more>> Science sheds light on power of multi-component protease

NEWS FEED & ADDITIVE MAGAZINE November 2023 19 As one of the first stages of the new plan, Benson Hill transferred ownership of its Seymour, Ind., soybean crush facility to White River Soy Processing, LLC for approximately $36 million of total gross proceeds, subject to working capital and other adjustments. The agreement represents the completion of an expected milestone as Benson Hill implements cost and operational improvements as part of its Liquidity Improvement Plan. The Company intends to use the proceeds to improve its liquidity position, pay down debt, and reduce operating and working capital costs while maintaining relationships with farmer partners in Indiana. Read more>> Seymour soybean crush facility was transferred to White River Soy Processing titure of our processing facilities, we plan to retire high-cost debt and extend our liquidity by more than 12 months. In addition, we are engaged in discussions with potential partners to scale our current proprietary portfolio and product pipeline for large-acre U.S. animal feed and pet food markets. I am excited about the opportunities to leverage the core strengths of the business for long-term value creation.” Read more>> Yield10 Bioscience and BioMar Group signed an agreement to form a long-term partnership to commercialise a Camelina crop containing enriched levels of EPA and DHA equal to fish oil. After a decade of research, this Omega-3 Camelina technology is now advancing toward market availability and has the potential to become another important, high-quality supplement to the scarce supply of marine long-chain fatty acids. According to the Biomar's statement, this new Omega-3 Camelina product contains EPA and DHA levels comparable to many of the marine oil sources utilised today. It is ideally designed for the needs of the aquaculture industry and is a complementary fit into the BioMar Omega Technology concept together with other sources of essential omega-3s. BioMar has been actively involved with the Rothamsted Omega-3 Camelina development effort since its inception in 2013 and has conducted many of the salmon trials published by the Rothamsted research team. Producing omega-3 oil in Camelina represents a land-based way to make this key aquafeed ingredient. Over the next year, Yield10 expects to scale-up planted acres of Camelina to supply BioMar with oil for formulation and testing while also working towards securing regulatory approval for commercial production of Omega-3 Camelina oil and meal in the targeted production geographies. Yield10 and BioMar believe that the Omega-3 Camelina technology will play an important role in the future omega-3 market, enabling access to key nutrients from sustainable sources and paving the way for future growth within the aquaculture industry. Read more>> Yield10 Bioscience and Biomar aim to grow fish oil on land


ISSUE FOCUS FEED & ADDITIVE MAGAZINE November 2023 21 Ensuring an optimal weaning transition Marine Gauthier, Lallemand Animal Nutrition Phytogenics: A tool to improve efficiency in lamb feedlots Gonçalo Martins, Delacon™, Cargill A new dimension in protein source evaluation Jessika van Leeuwen, Hamlet Protein Butirex C4: Increasing feed intake in 0-14 day old chicken Dr. Javier Sánchez & Dr. Beatriz Saldaña, Novation 2002 Cryptosporidia in calves – chickens can help Lea Poppe, EW Nutrition Post-weaning diarrhea in piglets Estefania Perez Calvo, dsm-firmenich A major discovery in the science of fatty acids By Trouw Nutrition High milk production is a biomarker for wellness Ken Sanderson, Balchem Animal Nutrition & Health

ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE November 2023 “The weaning transition is a major challenge in calf management. With a proper plan for nutrition (milk and solid feed), producers can help support calves at this critical period to safeguard future performance, health and longevity.” Calf management is crucial and will influence the performance of the the adult cow. Replacement costs can be critical to determining profit or loss on dairy farms. One way to reduce this cost is lowering the age at first calving. Actions that contribute to the reproductive performance of heifers can improve the financial position of the farm overall. In addition, supporting greater milk production during the first lactation helps investments in heifers reach economic equilibrium earlier. Research (Abuelo et al. 2021) shows heifers affected by diarrhea as calves showed lower average daily gain at weaning and a lower first lactation performance with -325 kg of milk when looking at the 305 day mature equivalent (ME) milk production standardized value. In addition, heifers diagnosed with diarrhea and bovine respiratory disease (BRD) rend to have increased difficulty at insemination and during calving. The weaning transition is a major challenge in calf management. With a proper plan for nutrition (milk and solid feed), producers can help support calves at this critical period to safeguard future performance, health and longevity. EARLY RUMEN DEVELOPMENT IS THE KEY TO LONG-TERM PERFORMANCE This is the period when the digestive tract of calves undergoes significant and extensive changes as it evolves from its initial monogastric function towards a ruminant function. During the first days of life, milk is the single dietary compound of the baby calf diet. The baby calf reticulo-rumen is bypassed. The rumen starts from a volume of 0.5L to 4L at 4 months of age and will grow drastically to 100-150L in the adult cow. In addition, the rumen papillae will develop with the rumen. Knowing that the papillae surface represents the rumen nutrient absorption surface, it is important to take care of its development for an optimal nutrient absorption in the adult cow. Rumen papillae development is strongly linked to the diet and rumen microbiota of calves during the first month of life (Chaucheyras-Durand et. al, 2001). Feeding solid grain will nurture the microbiota that will produce propionic acid and butyric acid. These two volatile fatty acids (VFAs) will stimulate papillae development. ENSURING AN OPTIMAL WEANING TRANSITION: Activate gut immunity and positively influence rumen microbiota to benefit calf performance Marine Gauthier Ruminant Technical Development Manager Lallemand Animal Nutrition

ISSUE FOCUS FEED & ADDITIVE MAGAZINE November 2023 23 In a nutshell, there are two parameters to ensure proper rumen function development: a beneficial microbiota and a beneficial diet to allow these microbiota to thrive. Practical tips: How to assess proper rumen development on the farm - Calf starter intake is an important indicator. The target for early weaned calves (~6 weeks) is 0.9-1.4 kg of starter grain per head per day for 3 consecutive days before weaning. This goes up to 1.8-2.3 kg/head/ day for calves weaned at 8 weeks (DCHA, 2016). WEANING: A STRESSFUL EVENT FOR THE CALF AND ITS DIGESTIVE TRACT During early life, while immunity is still weak, calves experience a lot of external stressors (transportation, transition from liquid to solid feed, dehorning, etc.). All these stressors increase the risk of morbidity and mortality by making the immune system more vulnerable. This can lead to visible signs of poor immune defenses such as digestive and respiratory diseases. The major causes of mortality and morbidity are digestive challenges (32% and 51%, respectively) (Urie et al., 2018). In addition, weaning is a challenge for the animal, the rumen and its microbiota. Ruminal diversity decreases due to increased starter intake and decreased rumen pH. The microbial composition changes dramatically at weaning (Figure 1). HOW TO SUPPORT CALVES AT THE WEANING TRANSITION THROUGH NUTRITIONAL STRATEGIES First, the objective will be to strengthen gut immunity to secure the fragile digestive system and limit diarrhea and respiratory diseases. The gut plays an important role in the immune defense system as innate and acquired immunity are concentrated within the gastrointestinal lymphoid tissue (GALT). GALT gathers up to 70% of the body’s white blood cells. Using nutritional additives to support a balanced immune response can be a winning strategy to improve calf health and performance around weaning. In U.S. dairy calf operations, economic consequences of long-term diarrhea outbreaks are estimated to be around 71.15$ per calf (USDA, 2014). “Research has shown a positive correlation between the number of bacterial strains in the rumen and the length of rumen papillae, as well as the thickness of the rumen wall and weight of the rumen, all linked to optimal rumen function and efficiency.” Figure 1. Pre- and post-weaning major rumen bacterial populations (Adapted from Meale et al., 2016).