ISSUE FOCUS 30 FEED & ADDITIVE MAGAZINE October 2023 In our opinion, a better insight in the evaluation and in the progression of several GIT conditions, associated with nutritional interventions to optimize gastrointestinal functionality, needs to be made a priority by the scientific community, to translate such knowledge into practical applications, for animal scientists and feed formulators, for ultimately further conferring health and welfare to the animals. References 1. Allen, H.K., Levine, U.Y., Looft, T., Bandrick, M., Casey, T.A., 2013. Treatment, promotion, commotion: antibiotic alternatives in food-producing animals. Trends Microbiol. 21, 114-119. 2. Celi, P. Cowieson, A.J., Fru-Nji, F., Steinert, R.E., Kluenter, A-M., Verlhac, V. 2017. Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production. Animal Feed Science and Technology 234: 88-100. 3. Cheng, G., Hao, H., Xie, S., Wang, X., Dai, M., Huang, L., Yuan, Z., 2014. Antibiotic alternatives: the substitution of antibiotics in animal husbandry? Front. Microbiol. 5, 217. 4. Conway, P.L., 1994. Function and regulation of the gastrointestinal microbiota of the pig, In: Souffrant, W.B., Hagemeister, H. ((Ed.), Proceedings of the VIth International Symposium on Digestive Physiology in Pigs, EAAP Publication, Dummerstof, pp. 231–240. 5. Davin, R., Manzanilla, E.G., Klasing, K.C., Perez, J.F., 2012. Evolution of zinc, iron, and copper concentrations along the gastrointestinal tract of piglets weaned with or without in-feed high doses of zinc oxide compared to unweaned littermates. J. Anim. Sc.i 90 Suppl 4, 248-250. 6. Davin, R., Manzanilla, E.G., Klasing, K.C., Perez, J.F., 2013. Effect of weaning and in-feed high doses of zinc oxide on zinc levels in different body compartments of piglets. J. Anim. Physiol. Anim. Nutr. 97 Suppl 1, 6-12. 7. Eberl, G., 2010. A new vision of immunity: homeostasis of the superorganism. Mucosal immunol. 3, 450-460. 8. Hoste, H., Torres-Acosta, J.F., Sandoval-Castro, C.A., Mueller-Harvey, I., Sotiraki, S., Louvandini, H., Thamsborg, S.M., Terrill, T.H., 2015. Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock. Vet. Parasitol. 212, 5-17. 9. Khadem, A., Lourenço, M., Delezie, E., Maertens, L., Goderis, A., Mombaerts, R., Höfte, M., Eeckhaut, V., Van Immerseel, F., Janssens, G.P.J., 2016. Does release of encapsulated nutrients have an important role in the efficacy of xylanase in broilers? Poult. Sci. 95, 1066-1076. 10. Klasing, K.C. 2007. Nutrition and the immune system. Br. Poult. Sci., 48 , 525-537 11. Kogut, M.H., Arsenault, R.J., 2016. Editorial: Gut Health: The New Paradigm in Food Animal Production. Front. Vet. Sci. 3. 12. Koutsos, E.A., Calvert, C.C., Klasing, K.C., 2003. The effect of an acute phase response on tissue carotenoid levels of growing chickens (Gallus gallus domesticus). Comp. Biochem. Physiol. A Mol. Integr. Physiol. 135, 635-646. 13. Koutsos, E.A., Garcia Lopez, J.C., Klasing, K.C., 2006. Carotenoids from in ovo or dietary sources blunt systemic indices of the inflammatory response in growing chicks (Gallus gallus domesticus). J. Nutr. 136, 1027-1031. 14. Lee, W.-J., Hase, K., 2014. Gut microbiota-generated metabolites in animal health and disease. Nat. Chem. Biol. 10, 416-424. 15. Marchesi, J.R., Adams, D.H., Fava, F., Hermes, G.D.A., Hirschfield, G.M., Hold, G., Quraishi, M.N., Kinross, J., Smidt, H., Tuohy, K.M., Thomas, L.V., Zoetendal, E.G., Hart, A., 2016. The gut microbiota and host health: a new clinical frontier. Gut. 65, 330-339. 16. Pluske, J.R., 2013. Feed- and feed additives-related aspects of gut health and development in weanling pigs. J. Anim. Sci. Biotechnol. 4, 1. 17. Round, J.L., Mazmanian, S.K., 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nat. Rev. Immunol. 9. 18. Salzman, N.H., Underwood, M.A., Bevins, C.L., 2007. Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa. Semin. Immunol. 19, 70-83. 19. Starkey, J.D., 2014. Triennial Growth Symposium--A role for vitamin D in skeletal muscle development and growth. J. Anim. Sci. 92, 887-892. 20. Van Loo, J., 2007. How chicory fructans contribute to zootechnical performance and well-being in livestock and companion animals. J. Nutr. 137, 2594s-2597s.
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