Today's consumers are paying more attention to the connection between food and factors such as health, environment and well-being when choosing foods. This natural nutrition trend, which includes concepts such as sustainability, plant-based nutrition, proactive health and functional foods, means consumers are making better choices for themselves and the planet. The intensification of this trend among consumers with increasing awareness has started to affect all sides of the food production sectors. The livestock sector cannot be independent from this trend. These effects can be both positive and negative. On the positive side, we can say that this trend encourages the raising of animals in a healthy, high quality and environmentally friendly way. Feed produced with more natural and plant-based ingredients improves digestion, immunity, stress tolerance and productivity. But this trend is also driving up costs. This is because the production, processing and distribution of these feeds require more labor, time and resources. This drives up feed prices and reduces the profit margin of animal breeders. Therefore, parties in the animal nutrition industry are focusing on solutions to enhance the positive effects of natural ingredients and animal feed on health and performance, thus offsetting the additional costs with increased productivity. Along with this trend, there are other factors that are also emerging such as the growing demand for plant-based foods and the resulting reduction in animal food consumption. But this is not our topic today. Suffice it to say that we will focus on this topic in the following issues. Our main topic in this issue is the effects of natural feed additives on the health and performance of animals. These additives can be derived from a variety of sources such as plant-based substances, plant extracts, essential oils, spices, herbs and microorganisms. And they have positive effects on animal health, performance and product quality. They can reduce the need for human health risks such as antibiotics. So they are sustainable and therefore extremely important. Today, due to all these positive aspects, many representatives of the animal nutrition sector are working intensively on this subject. You can see some of them in this issue. We hope it will be useful and wish you a pleasant reading… Hope to see you in the next issue… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR Natural nutrition trend reshapes animal nutrition Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadditive Dear Readers,
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CON T E N T S 18 ISSUE FOCUS 24 THE FUTURE OF COCCIDIOSIS CONTROL Madalina Diaconu & Twan van Gerwe, Ph.D. EW Nutrition 41 INNOVATIVE BIO-INGREDIENTS FOR FEED AND PET FOOD: IT’S ALL ABOUT THE OLIVE Kathrin Schilling, BioPowder 50 THE RISE OF HIMALAYAN FLORA IN PROMOTING ANIMAL HEALTH AND WELLNESS Naveed A. Chikan, Daskdan Innovations 20 USING PLANT-BASED PRODUCTS TO IMPROVE RUMINANTS’ PERFORMANCE Isabelle Coudray, miXscience 36 OVERCOMING REGULATORY HURDLES FOR PLANT-BASED FEED ADDITIVES By Pen & Tec Consulting, part of the Argenta Group 30 POLYPHENOLS AS A NATURAL STRATEGY TO EFFECTIVELY CONTROL OXIDATIVE STRESS IN LAYERS Steven Beckers, Impextraco - Belgium 44 PLANT-BASED INGREDIENTS OFFER A ROUTE TO ENHANCED LIVESTOCK HEALTH Irene Trigueros, Golden Agri-Resources 46 HARNESSING HEAT SHOCK PROTEIN RESPONSES: IT’S ABOUT MORE THAN HEAT STRESS David Harrington, teamTWO Solutions, Denmark & Reginaldo Teixeira Filho, Natturo Agronegócios, Brazil & Charles Saliba, Nutri Biotech Services, Malta EFFECTS OF PLANT-BASED AND NATURAL (PHYTOGENIC) FEED ADDITIVES ON ANIMAL HEALTH & PERFORMANCE INTERVIEW 52 AXITAN FOCUSES ON ANTIBIOTIC-FREE PRODUCTION AND IMPROVING PRODUCTIVITY Dr Kane Miller, Axitan
55 UNDERSTANDING THE ROLE OF DIETARY LEUCINE ON VALINE REQUIREMENT IN POULTRY DIETS Jason Lee, PH.D. Poultry Science at Texas A&M University (USA) CON T E N T S SPECIAL STORY AB Agri partners with agri-tech firm Aceae Nutra 8 Kemin opens first facility to produce Proteus® for meat and poultry industry 12 EW Nutrition welcomes Jan Vanbrabant as new CEO 94 Bühler and Entocycle join forces for industrial insect production 14 Novus adds Michaela Braun to its methionine team 101 PwC names Skretting, Lerøy, Mowi, and SalMar as Climate Leaders 90 Devenish expands international aquaculture team 93 NEWS REPORTS NORTH AMERICA ANIMAL FEED MARKET 86 63 BIOACTIVE MOLECULES IN EGG POWDER CONTRIBUTE TO PIGLET’S HEALTH Jordi Ysamat, MVetMed VEOS Group 72 NEW SWINE VITAMIN RECOMMENDATIONS FOR MORE PRODUCTIVE AND SUSTAINABLE FARMING Gilberto Litta & José-María Hernández, dsm-firmenich 60 Zinc supplementation to cover nutritional requirements: FOCUS ON BONE ZINC Alessandra Monteiro & Axel Minetto, Animine France 66 METHIONINE ANALOGS IN RUMINANTS: DATA-DRIVEN INSIGHTS Eyüp Eren Gültepe & Diego Martinez del Olmo, Kemin Europa NV Nutritional Additives: Vitamins & Pro-vitamins & Amino Acids & Trace Elements ARTICLES 79 CHOLINE: A REQUIRED NUTRIENT FOR TRANSITION DAIRY COWS Usman Arshad, University of Wisconsin-Madison & Dr José E.P. Santos, University of Florida
NEWS 6 FEED & ADDITIVE MAGAZINE September 2023 Adisseo, one of the world's leading companies in feed additives, announced that it will build a new powder methionine plant with an annual production capacity of 150K tons in Fujian Province in China. The total investment amount is expected to be around RMB 4.9 billion. The plant is expected to operate in 2027. “By demonstrating unparalleled cost and size leadership in the liquid methionine, Adisseo is willing to also complement its leadership in the powder methionine to become one of the global frontrunners in 2030. This project will strengthen our leading position in the methionine industry as well as optimize our methionine product portfolios and global production capacity layout, thereby creating value for our customers," said Dr. Zhigang Hao, Chairman and CEO of Adisseo. "Sustainability and digitalization are key success factors of the project. Adisseo is fully committed to implementing FORUS (SinoChem HSE strategy: For Runner Strategy), to fully leverage digital capabilities to design a smart plant, apply green technologies and source low-carbon raw materials, etc., aiming to build a greener, smarter, and more competitive plant.” Adisseo can produce liquid and solid methionine simultaneously. The Adisseo Nanjing plant is one of the world's largest, most technologically advanced, and most competitive liquid methionine production platforms in the world. In China and other emerging markets, the demand for powder methionine is still strong. The global demand for various types of methionine is expected to continue especially in China and other Asia Pacific countries (APAC). With this investment, Adisseo is willing to become one of the global frontrunners in the powder methionine market in the future. The 150Ktons/year powder methionine project will be located at Quanhui Petrochemical Industrial Zone, Quanzhou City, Fujian Province, China, with an estimated investment amount of around RMB 4.9 billion. Thanks to the adjacent SinoChem sister company, the project is expected to benefit from strong synergies in the supply chain, receiving operational support and further gaining cost advantages by optimizing capital investments and operating costs as well as enhanced whole value-chain sustainability. Read more>> Adisseo builds new methionine plant in China Cargill Aqua Nutrition released its 2022 Sustainability Report. This is Cargill’s 14th year in reporting its continued progress in making a positive impact from the center of the aqua value chain and building on its transparency on key sustainability topics, providing reports on its supply chain, its operations, and its product performance. Key highlights from the Cargill Aqua Nutrition Sustainability Report 2022 include: • With our signature SeaFurther™ Sustainability program, we work with salmon farmers as well as ingredient suppliers to reduce greenhouse gas (GHG) sources embedded in the value chain. we aim to help reduce carbon emissions from salmon farming by 30% by 2030. • Aquaculture’s carbon footprint mainly stems from the mix of raw materials in the feed. In 2022, we teamed up with eight U.K. farms to pilot climate-friendly regenerative agriculture practices to achieve a 1,000-tonne carbon reduction. In 2023, our goal is to sign up more farmers and avoid over 10,000 tonnes of emissions. • Our work to improve the sustainability of marine ingredients continues by buying certified fishmeal and Cargill Aqua Nutrition releases its Sustainability Report 2022
NEWS FEED & ADDITIVE MAGAZINE September 2023 7 Alltech, a leading global animal health and nutrition company, celebrated 30 years of operations at its production facility in the Mexican city of Serdán, in a ceremony on Tuesday that included Dr. Mark Lyons, president and CEO of the company, local officials, and Alltech team members. Thirty years ago, Alltech’s research into the benefits of Yucca schidigera extract for animal health, performance, and welfare paved the way for the company to establish a Yucca schidigera processor in the city of Serdán. The place was chosen for its semi-desert climate, where the yucca plant grows naturally. Serdán is located 190 kilometers southeast of Mexico City and has access to one of the most important ports in the country: Veracruz; from which two of its most important technologies are exported: De-Odorase® and Allzyme® SFF. Alltech’s investment in Serdán increased Alltech’s operational footprint and offered new nutritional solutions that improve animal health and production efficiency. However, the resulting partnership between Alltech and the community of Serdán has been even more significant. “The way the community and our company work together is incredible,” said Dr. Mark Lyons. “From the very beginning, we have been linked, as the success of one builds the success of the other.” Alltech and the residents of Serdán have worked together on numerous community engagement projects that support underserved families and vulnerable populations. The collaboration began with supporting a local orphanage, Casa Hogar, and has now grown to 23 active projects. “Serdán has served as a template for Alltech’s community involvement activities all around the world,” Lyons said. “We ask our colleagues in 350 communities around the world to ‘make a difference’ as our founder Dr. Pearse Lyons encouraged us, and Alltech Serdán is the best example of this spirit. This is a place where the culture of Alltech is truly alive.” Read more>> Alltech celebrates three decades of making a difference in the community oil as before, but with an increased engagement in fishery improvement programs to develop more sustainable management and fishing practices, and an increase in the use of fishery by-products as feed ingredients. • We continue to increase our use of alternative ingredients like insect meal and algae oil, for instance, to help expand our raw material basket so we can produce more feeds sustainably, as well as develop better feed packaging solutions that keep many tonnes of plastic out of the environment. • In 2022, sales of functional feeds, which help keep fish healthy, reducing the need for medication like antibiotics, reached their highest level since 2017. We saw a 71% reduction in coldwater antibiotic feed sales since 2017. Read more>>
NEWS 8 FEED & ADDITIVE MAGAZINE September 2023 AB Agri partnered with agri-tech company Aceae Nutra on the development of an innovative new product made from tomatoes that could offer a new natural way to reduce traditional treatments in animals. AB Agri and Aceae Nutra are now working together to assess its application in livestock animals. AB Agri is currently growing the tomatoes for use in trials which will determine the product’s effectiveness in animals as a feed material. Aceae Nutra is an IP-focused SME founded in 2018 specializing in research, innovation, and product development of plantbased solutions. The company’s approach incorporates plant sciences and agronomic expertise to generate viable solutions for conditions affecting human and animal health. “We’re committed to nurturing new technologies that have the potential to make a real impact in the production of responsible, affordable food – and turning those ideas into industry-relevant solutions," said Natasha Whenham, Head of Innovation at AB Agri. “The industry is looking for ways to responsibly reduce the use of traditional treatments that bring either environmental or resistance concerns and this product is an exciting new prospect that offers real potential to achieve this goal.” Read more>> AB Agri partners with agri-tech firm Aceae Nutra Novozymes and Arla Foods Ingredients agreed on a partnership to develop advanced protein ingredients using precision fermentation. Biotechnology company Novozymes is a world leader in precision fermentation, a technique that fine-tunes the molecular output of microorganisms, offering greater control over the fermentation process and enabling tailor-made protein compositions. Specializing in the production of enzymes through precision fermentation, it has focused on the exploration of new protein solutions for health and nutrition since 2019. In the co-funded partnership with nutrition leader Arla Foods Ingredients, it will contribute its expertise in the creation of microbial strains for the industrial-scale production of proteins by precision fermentation. This will be combined with Arla Foods Ingredients’ food technology knowhow – in particular about separation and drying processes – and its knowledge of the regulatory landscape. The initial focus of the collaboration will be a solution for disease-specific medical nutrition – a category in which protein is an essential component – with expansion into other segments anticipated in the future. Henrik Andersen, Group Vice President of Arla Foods Ingredients, said: “This partnership brings together two market leaders in our respective areas. Collaborating with Novozymes fits perfectly with our ambition to explore alternative nutrition platforms and complement our portfolio of dairy and whey solutions.” Read more>> Novozymes and Arla Foods join forces to develop protein ingredients
NEWS FEED & ADDITIVE MAGAZINE September 2023 9 REGISTER NOW! 3rd & 4 th OCTOBER 2023 Thanks to last year success, Phileo accelerates its focus on microbiota and invests in a virtual industry event taking place October 3 and 4, 2023. High level keynote speeches will be given by scientists from academia, institutes, and industry from Europa, USA and Asia. Followed by well-known scientists & key opinion leaders, and our own Phileo experts, who will elaborate further on microbiota specie specific topics. More than 28 presentations centered around 4 topics : • Impact of pathogens on microbiota • Interaction between microbiota and the host response • The force of nutrition to positively influence microbiota • Technological tools and strategies for culturing a healthy microbiota. The aim of the Microbiota days is to promote the unifying concept that a balanced microbiota drives animal health and performance. Participants at the Phileo Microbiota days will have two days of live presentations focused on the role of gut and rumen microbiome in animal production and the dynamic and essential role gut health plays. The full programme will be available soonest. Microbiota days are coming back this year on October 3 and 4, 2023. Phileo’s global virtual event giving easy access to top talks from your own desk. Our event speakers phileo-microbiota-days.com 3 & 4 OCTOBER 2023 Prof. S. BLANQUET Université de Clermont-Ferrand. Fr. J.B. DARODES DE TAILLY Phileo by Lesaffre Prof. L.F. CARON Immunova - Brazil Prof. L. BAUMGARD Iowa State University USA Prof. P. TREVISI University of Bologna. Italy Dr. A. ADIB-LESAUX Phileo by Lesaffre Dr. H. DERAKHSHANI University of Manitoba. Canada Dr. R. GUABARIBA INRAe Fr. Dr. M. KOGUT USDA USA Dr. S. KANTI KAR Wageningen Livestock Research - NL Prof. T. OPRIESSNIG University of Edinburgh. UK Dr. A. RIGGI Phileo by Lesaffre Dr. I. RYCHLIK Veterinary Research Inst. of Brno - CZ Rep. Dr. L. RHAYAT Phileo by Lesaffre Prof. G.ROSSI University of Camerino. Italy Dr. E. SANTIN Advisor for R&D and Sustainability - Brazil Prof. G. ANTONISSEN University of Ghent. Belgium Dr. A.T. GONÇALVES SPAROS Portugal Dr. M. TERRA-LONG Phileo by Lesaffre
NEWS 10 FEED & ADDITIVE MAGAZINE September 2023 Innovasea, a global leader in technologically advanced aquatic solutions for aquaculture and fish tracking, announced that its AI-driven biomass estimation solution, BiomassPro, is now available for use with Atlantic salmon. Recent field trials in British Columbia, Canada, have shown the solution’s algorithm for Atlantic salmon is highly effective at estimating the size and weight of that species in real-time. “The technology behind BiomassPro continues to perform well in the field, which is really exciting,” said Rafael Cordero, vice president of engineering at Innovasea. “Customers have been asking for some time when it would be available for Atlantic salmon, but we wanted to take time to fine-tune the algorithm and ensure we were bringing a quality product to the marketplace.” BiomassPro is an AI-powered solution that estimates the size and weight of fish stocks in real-time to help farms optimize production and reduce feeding costs. It also provides accurate growth projections to improve resource planning and sales forecasting and ultimately boost revenues. Read more>> Innovasea adds Atlantic salmon algorithm to BiomassPro Anchor launches its new technical services division Anchor Ingredients, a trusted name in the pet food industry, introduced its new Technical Services division which is dedicated to providing unbiased and comprehensive support to pet food manufacturers and brands, catering to their unique production and formulation needs. With a diverse range of services aimed at optimizing processes, troubleshooting quality issues, and fostering innovation, Anchor Ingredients’ new Technical Services division is set to revolutionize the industry's approach to challenges and advancements. The new division will offer an array of services, including production process optimization, product quality troubleshooting, ingredient technology support, product development, and formulation expertise, facility and process flow design services, as well as educational seminars and training opportunities. Anchor Ingredients is committed to sharing its expertise and insights to empower manufacturers and brands with the tools they need to excel in an evolving landscape. Heading this division is Brian Streit, an industry veteran with a 27-year track record of operations, quality control, equipment technology, formulation, and innovation within pet food manufacturing and related sectors. Brian's leadership will infuse the division with a wealth of practical knowledge, enabling it to serve as a resource for manufacturers and brands seeking excellence in every aspect of their business. "We are very excited to bring this service to the pet food industry and our customers," commented Brian Streit, Director of Technical Services at Anchor Ingredients. Read more>>
NEWS FEED & ADDITIVE MAGAZINE September 2023 11 CULT Food Science announces world's first cat treat with cell-cultivated fish CULT Food Science Corp., a pioneer in the investment, development, and commercialization of cellular agriculture technologies and products, introduced Marina Cat™, a hybrid cell-cultivated pet food brand for cats developed in partnership with Umami Bioworks. "My vision for the future is that we no longer have to slaughter other animals to feed our cats," said Joshua Errett, VP of Product at CULT. "This brand brings me one very great step closer to making that a reality." "We are pleased to be embarking on this partnership with Marina Cat to power a new category of cultivated pet food products that are healthier for cats and better for our oceans. As a platform technology provider, we are committed to delivering the technology stack that powers the commercialization of cultivated products across a range of applications. This first collaboration with Marina Cat and CULT Food Science is the first step to delivering on that promise," said Mihir Pershad, CEO of Umami Bioworks. Marina Cat™ is a blend of ocean snapper, cultivated by Singapore-based biotech startup Umami Bioworks, and enriched with Bmmune® to provide a high protein, low-calorie snack with super savory umami flavors that cats enjoy. With its unique nutritional properties, this first-of-its-kind treat provides benefits to a cat's cognitive function, based on its high levels of omega 3, 6, and 9 fatty acid chains. Studies have shown that DHA and EPA provided in the treat can boost brain, vision, and nervous system development in cats and kittens. Read more>> Barentz, one of the leading global distributors of life science and specialty ingredients, announced that Origination rebranded as Barentz, effective immediately. The name change follows the acquisition of Origination by Barentz International (Barentz) in August 2021. For nearly eight decades, Origination has been a leading distributor of high-quality animal feed ingredients. Its focus on production automation as well as a strong supply chain has provided a long history of stability through economic and commodity cycles. In order to better serve its customers, the company enjoys the advantage of strategic access to river, rail, and road transport, which allows for extensive domestic and international distribution. With this rebranding, the company will be focusing on expanding its feed additive portfolio through strategic partnerships and M&A, as well as making its DCAD products more accessible to customers globally. "This is a significant milestone for our company as we accelerate our growth under Barentz," commented John DeVos, President, of Animal Nutrition of Barentz North America. "I am pleased by our organization’s commitment to market leadership and continuous improvement to deliver better solutions for our customers and principal partners." Read more>> Feed ingredients distributor Origination rebranded as Barentz
NEWS 12 FEED & ADDITIVE MAGAZINE September 2023 Neogen Corporation announced that it launched Igenity® Enhanced Dairy, a new and progressive genomic data management tool. Igenity Enhanced Dairy is a new digital service that empowers dairy producers to make better selection and mating decisions. By integrating in-herd phenotypic data, pedigree information, and existing predicted transmitting abilities (PTAs) from the Council on Dairy Cattle Breeding (CDCB), the platform delivers a genomic evaluation of dairy cattle. Producers are able to utilize the data provided by Igenity Enhanced Dairy to make an in-herd assessment of the genetic potential by pairing each animal’s performance data with the results received from an Igenity Select profile. The ability to apply on-farm phenotype data to a standard genetic assessment leverages the management and geography of the individual animals to ultimately enable better decision-making. “Neogen is thrilled to introduce a useful tool that contributes to the improvement of genetic selection in the dairy cattle market,” said Dr. Victor Pedrosa, Neogen’s Director of Genetic Prediction. “Data plays a crucial role in decision-making, and the Igenity Enhanced Dairy platform allows producers to take an additional step forward. Read more>> Neogen launches Igenity Enhanced Dairy Kemin opens first facility to produce Proteus® for meat and poultry industry Kemin Industries, a global ingredient manufacturer that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services, opened a new manufacturing facility in Verona, Missouri, to produce its Proteus® line of clean-label functional proteins that are used to increase yield and enhance the quality of meat and poultry products within the food industry. Kemin broke ground on the new building in November 2021, and on August 23, the company hosted a ribbon-cutting ceremony to officially open the 38,000-square-foot facility. The operation is a $70 million investment that employs nearly 30 full-time workers in the Verona community. The facility, which will run under FSSC 22000 Certification and completed its first run under United States Department of Agriculture (USDA) inspection on July 25, 2023, will manufacture Kemin Food Technologies – North America's patented Proteus line of clean-label, functional protein ingredients for a variety of meat and poultry applications. The Proteus portfolio of muscle-based protein ingredients can help food processors naturally retain moisture typically lost in processing, which translates to processing efficiencies with improved quality. The state-of-the-art Proteus production plant will have an initial capacity to produce enough functional protein to treat more than a billion pounds of meat, poultry, and protein-based applications. "Since acquiring Proteus in April 2021, we've been eager to open this site and serve customers, who continue to demand sustainably sourced, technologically advanced solutions," said Marc Scantlin, President, of Kemin Food Technologies – North America. "Opening our first-ever Proteus dry production plant provides the opportunity to partner with more meat and poultry manufacturers, positively impacting the quality of our global food supply." Read more>>
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NEWS 14 FEED & ADDITIVE MAGAZINE September 2023 Bühler, one of the world’s leading processing technology groups, and Entocycle, an insect technology company, joined forces to drive the adoption of large-scale black soldier fly (BSF) farms. The companies will provide solutions and expertise to serve customers in this segment, covering the multiple steps of the journey, from concept and basic engineering to execution of BSF facilities worldwide. The non-exclusive partnership creates a highly complementary offering with Entocycle delivering proprietary breeding technology and Bühler bringing proven industrial-scale technologies in feedstock processing, larvae rearing, and product processing. One of the challenges of the highly promising, emerging insect industry has been how to ensure a steady supply of young larvae at an industrial scale. “While the pioneers in this industry had to develop their own technology out of necessity to ensure a robust BSF breeding, companies now venturing into this industry will be able to rely on a proven and scalable solution,” says Andreas Baumann, Head of Market Segment Insect Technology at Bühler. Although there are specialized breeding service companies in certain regions, in large parts of the world, there is no alternative to having an in-house breeding operation. With this partnership, Bühler and Entocycle address this challenge by offering scalable end-to-end solutions that significantly reduce the time to market for companies building an insect facility. “We are incredibly proud to partner with Bühler, a company with 163 years of illustrious history. Our team is really excited to work with Andreas Baumann and his team to deliver large-scale BSF facilities around the world and make the impact that we know BSF farming can make in creating a more sustainable and efficient global food system,” says Keiran Whitaker, Founder, and CEO of Entocycle. Read more>> Bühler and Entocycle join forces for industrial insect production BioZyme® Inc. entered into a distribution partnership with the Hirshberg Brothers Group in Herzliya, Israel. Hirshberg Brothers started as a single company in 1925, founded by brothers Avraham and Yakov Hirshberg, and has since grown to be one of the leading companies in Israel. “We are very happy with the addition of Hirshberg Brothers as our distribution partner. The company has an important relationship with the Israeli feed manufacturers,” said Volker Altenbokum, Director of International Business Development. “As most of the rations in the highly technical Israeli dairy industry are concentrate based, the incentive of using AO-Biotics® Amaferm® to support digestive health and performance is very high.” “AO-Biotics® EQE, the firstand-only AO postbiotic developed specifically for layers, is also a great addition to the portfolio of Hirshberg. The market is asking for more natural solutions and we are able to provide them with such,” added Peter Windhausen, Ph.D., Business Development and Innovation Manager at BioZyme. “We are excited to move forward with Hirshberg to provide AO-Biotics products to customers in Israel.” Read more>> BioZyme partners with Hirshberg Brothers in Israel
NEWS FEED & ADDITIVE MAGAZINE September 2023 15 Global Food and Ingredients Ltd. announced that it created a new subsidiary named Big Sky Milling Inc. as part of the previously announced planned minority investment in its pet food ingredients division (the Pet Food Transaction) with 35 Oak Holdings Ltd. GFI will be transferring all of its pet food ingredients assets and business into Big Sky, which will be fully dedicated to serving the North American pet food industry with existing products as well as new growth planned through product expansion and new investments. As GFI completes the formation of the new dedicated pet food operations under the Big Sky brand, 35 Oak has advanced a $3.0 million deposit for the pending investment. GFI may immediately use such advance in funding its day-to-day operations. GFI is working to complete the Pet Food Transaction reorganization in September 2023, subject to the completion of definitive agreements, satisfaction of customary closing conditions, and receipt of regulatory approvals, including the approval of the TSXV. Read more>> GFI announces creation of pet food ingredients subsidiary Supplant D Supporting sustainable egg production • Improves general hen health • Promotes better albumen and shell quality • Supports egg production persistency • Enhances day old chick vitality • Ameliorates skeleton strength agrimprove.com Shellbiotic
NEWS 16 FEED & ADDITIVE MAGAZINE September 2023 Hill's Pet Nutrition, one of the global leaders in science-led nutrition, and Harvard T.H. Chan School of Public Health researcher Dr. Curtis Huttenhower are joining forces to create the One Health Microbiome Resource (OHMR). Not only will the OHMR be the first of its kind, it will also be the largest and most comprehensive reference database of human and companion animal microbiomes, which provides unique opportunities to understand the health of both pets and pet owners. "Because pets are members of the family, many consider their nutrition to be just as crucial as that of our human family members," said Dr. Huttenhower, Professor of Computational Biology and Bioinformatics at Harvard Chan School and Co-director of the Harvard Chan Microbiome in Public Health Center. "The same can be said for their microbial communities. The OHMR provides a new way to improve both human and animal health through nutrition, better environmental exposures, and inter-individual resource sharing on a day-to-day basis. We believe improving a pet's microbiome positively impacts a pet parent's well-being and vice versa." The OHMR includes microbial genomes, companion animal microbial community profiles, Hill's Pet Nutrition and Harvard researcher collaborate to create One Health Microbiome Resource IFF announced the completion of its new North American Creation and Design Center in New Century. The IFF Creative Center brings together the company’s flavor and ingredient expertise with its food design capabilities to better support the growth of the region’s food industry. The infrastructure upgrade includes the addition of two new flavor creation labs, the expansion of existing food application design labs for dairy, bars, culinary, and bakery, and a new lab solely for pet food development. The New Century facility is now the company’s second-largest creative center in North America and houses ten labs, and six stateof-the-art pilot plants, which serve two purposes: – providing better customer support and enhancing innovative product development. “Our capability expansion in New Century provides a significant advantage to our customers,” said Carmen Cain, regional president for IFF’s Nourish division. “By integrating flavors, ingredients, and food design in one space, we can increase our speedto-market while offering a breadth of knowledge and resources across multiple food categories. This investment strengthens our end-to-end IFF PRODUCT DESIGN™ approach in which we reimagine future-proof concepts and experiences by combining our expertise in ingredients and flavors with a deep understanding of consumer behavior.” The two new flavor creation labs – for sweet and savory flavors, respectively – mark the first time flavorists will be based at the New Century facility. The expert flavorists will develop alongside the dairy, bakery, bars, culinary, and pet food product application and design teams. Read more>> IFF expands innovation footprint in North America Creative Center
NEWS FEED & ADDITIVE MAGAZINE September 2023 17 and tools to utilize them together. This is a key development for researchers, as microbiome research has become an increasingly important area of focus in maintaining health, as well as understanding diseases. This is in turn increasingly applicable to pet health specifically. "We're excited to build on the foundation of human microbiome research to bring better nutrition and immune health to companion animals as well," said Dr. Huttenhower. "In the past decade, we've learned quite a bit about the human microbiome that can be applied to pets, and with the OHMR, we hope to expand this and make the reverse true as well. Living with pets is already known to improve immune development in infants, and the OHMR will help us to understand how and why this occurs. Plus, it's especially important to build healthy, microbiome-aware diets for pets." Read more>>
ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE September 2023 EFFECTS OF PLANT-BASED AND NATURAL FEED ADDITIVES ON ANIMAL HEALTH & PERFORMANCE
ISSUE FOCUS FEED & ADDITIVE MAGAZINE September 2023 19 Innovative bio-ingredients for feed and pet food: It’s all about the olive Kathrin Schilling, BioPowder Using plant-based products to improve ruminants’ performance Isabelle Coudray, miXscience Plant-based ingredients offer a route to enhanced livestock health Irene Trigueros, Golden Agri-Resources The future of coccidiosis control Madalina Diaconu & Twan van Gerwe, Ph.D., EW Nutrition Harnessing heat shock protein responses: It’s about more than heat stress David Harrington, teamTWO Solutions & Reginaldo Teixeira Filho, Natturo Agronegócios & Charles Saliba, Nutri Biotech Services Beyond chemicals: The rise of himalayan flora in promoting animal health and wellness Naveed A. Chikan, Daskdan Innovations Polyphenols as a natural strategy to effectively control oxidative stress in layers Steven Beckers, Impextraco - Belgium Overcoming regulatory hurdles for plant-based feed additives By Pen & Tec Consulting, part of the Argenta Group
ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE September 2023 “There is a significant economic advantage to monitor feed efficiency. It allows farmers to regularly adjust the nutrition of the herd in order to maximize income from milk production regarding feed price of the moment. The use of single or blend of phytogenics can be part of the global approach to increase feed efficiency.” In dairy farming, performance can be expressed by Energy Corrected Milk (ECM), which takes into account milk yield, but also protein and fat contents. ECM is an accurate herd indicator reflecting diet valorization and herd’s productivity. Economic performance is key to control farm rentability taking into account that milk prices are still volatile in different markets and tend to decrease, whereas raw materials prices globally increase. RUMEN FLORA MODULATION IS ONE OF THE LEVERS TO IMPROVE PERFORMANCE Dietary proteins are more or less degraded by ruminal flora to produce microbial proteins and ammonia. Microbial proteins and certain dietary proteins not degraded in the rumen are then digested in the intestine to produce milk. Protein supply in the feed and protein degradation level in the rumen need to be adjusted in order to provide sufficient essential amino acids supply for absorption in the gut to maximize performance and limit ammonia production. Research has demonstrated that usually less than 30% of protein intake can be retrieved in milk protein content form. Up to 80% of energy supply to ruminants comes from volatile fatty acids. Rumen fermentations produce mainly acetic, butyric, lactic and propionic acids. Levels and ratio of each volatile fatty acids for optimum rumen efficiency have been determined after years of research and constitute nutrition standards. Due to high level of concentrates in modern dairy farming, rumen functioning can be disturbed and this can lead to misbalanced ratios of volatile fatty acids. Increase of concentrates intake has been shown to increase acetic and lactic acids production and to decrease ruminal pH. At short term this strategy can in fact lead to more volatile fatty acids production from important and rapid starch degradation of concentrates. But constant drops in ruminal pH cause non-ideal condition for cellulolytic flora development. This leads to the decrease of fiber digestibility, whereas it accounts for a consequent amount of ruminants’ diets. USING PLANT-BASED PRODUCTS TO IMPROVE RUMINANTS’ PERFORMANCE Isabelle Coudray Product Manager miXscience
ISSUE FOCUS FEED & ADDITIVE MAGAZINE September 2023 21 Both protein and energy valorization are important and furthermore, correlated. Indeed, microbial synthesis of protein is energy dependent, and research has shown that “synchronizing” the timing of energy supply with protein degradation may maximize protein synthesis and minimize nitrogen waste into ammonia. HOW PHYTOGENICS CAN IMPROVE ENERGY AND PROTEIN USE IN THE RUMEN? Phytogenics are added to the overall diet and can affect protein and energy from all the different feed components (forages, cereals, meals, etc.). There are numerous types of phytogenics and some of the most effective ones for feed efficiency are: • Tannins: Complex polyphenol compounds of plants. They can vary a lot in types and concentration from extraction. Their nature allows binding with protein, notably, but the quantity and the quality of the extract is very important to ensure adequate binding in the rumen and liberation in the gut. • Essential oils: There are various families with different mode of actions. In the literature, these compounds have shown antimicrobial activities used to modify ruminal fermentations of protein and energy, to secure digestion and improve, and to improve nutrient digestibility and increase productivity. • Spices: Spices have shown to increase dairy cows’ intake in different trials, and have been linked to increase of natural buffer from salivation positively affecting ruminal pH. MiXscience has developed a specific range of products including different combination of these components. These products have been developed and tested in the Mixscience Research Center (MRC, Saint-Symphorien, France) in order to increase protein and energy efficiency of ruminants. In studies, high doses of essential oils have been associated with detrimental effect on rumen microorganisms but doses and effects were varying. One of these products, Valopro NRJ, has been recently tested at MRC with higher dosage to assess cows’ response: • 30 lactating Holstein dairy cows (60% primiparous cows; 184 ± 64 days in milk (DIM); 35.6 ± 6.8 kg of milk/day; 723 ± 67 kg body weight) • Herd diet: 16.2% protein, 34.8% NDF, 1.65 MCal/kg • Cows blocked by lactation number, DIM, milk yield, protein and fat contents • Two groups: Herd diet (42 days) with 0 g/cow/d (control group) or 30 g/cow/d of Valopro NRJ group. • Individual milk yield and composition (protein, fat, urea, SCC) monitored daily and weekly respectively • Individual intake and body weight assessed every day Per cow per day Partial Mixed Ration AMS* Feeder Production concentrate from 0 to 5 kg linked to Milk Yield (average 3 kg) Trial feed 3.0 kg Control feed 3.0 kg AMS* = Automatic Milking System AMS Feeder Corn silage 10kg DM Grass silage 3.3kg DM Liquid feed 1.0 kg Basemix 0.23 kg Rumen protected Fat 0.1 kg Protein concentrate 1.7 kg Energy concentrate 2.0 kg Control Valopro NRJ
ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE September 2023 Milk production was more stable for cows fed with Valopro NRJ during the trial so persistancy is improved with Valopro NRJ. At the end of the trial, milk composition was similar between the two groups (+1.7 g protein/kg and +1.8 g protein/kg for Valopro NRJ and Control groups respectively and +1.1 g fat/kg for both Valopro NRJ and Control groups) so that energy corrected milk was improved. There was no difference between groups for milk urea, intake and body weight. CONCLUSION Results indicates that 30 g/cow/d of Valopro NRJ can significantly improve milk yield and ECM and is a suitable solution to increase profitability in dairy cows system. There is a significant economic advantage to monitor feed efficiency. It allows farmers to regularly adjust the nutrition of the herd in order to maximize income from milk production regarding feed price of the moment. The use of single or blend of phytogenics can be part of the global approach to increase feed efficiency. The implementation of this kind of products can be performed in two different ways: in top feeding or in diet optimization, to increase performance or decrease the feed cost of diets without degrading animal performance. A lower diet cost thanks to optimization is very interesting especially in contexts of low milk prices and high raw materials cost. Diet optimization with Valopro solutions also makes it possible to limit the environmental impact of the feed or diet by selecting more local raw materials or by-products with a lower environmental impact. miXscience has developed the MatriCiel tool to calculate the environmental impact of feed according to various criteria, including a Climate Change Impact Criterion in CO2 equivalent. These calculations depend on the context (area and period). References are available upon request. Product not available in all countries, local regulations should be consulted. Intended only for the export outside the European Union. Figure 1. Energy Corrected Milk evolution during the trial (kg/cow/d *p-value = 0.015
ISSUE FOCUS FEED & ADDITIVE MAGAZINE September 2023 23 2, avenue Ker Lann | CS 17228 35172 BRUZ Cedex - FRANCE www.mixscience.eu Valopro Range Valopro the boss to optimize feed efficiency Your solutions to combine performance and better environmental impact Multiple solutions and services to fit with diet diversity Decrease carbon footprint per kg of milk or meat Improve performance thanks to ruminal degradation modulation
ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE September 2023 Due to still rising antimicrobial resistance, consumers push for meat production without antimicrobial usage. However, antibiotic reduction must also target ionophores for producers and regulators alike. As a natural solution, phytomolecules might be the optimal completion to current coccidiosis control programs and create opportunities to make poultry production more sustainable by reducing dependency on harmful drugs. THE FUTURE OF COCCIDIOSIS CONTROL Twan van Gerwe, Ph.D. Technical Director EW Nutrition Madalina Diaconu Product Manager Pretect D EW Nutrition With costs of over 14 billion USD per year (Blake, 2020), coccidiosis is one of the most devastating enteric challenges in the poultry industry. With regard to costs, subclinical forms of coccidiosis account for the majority of production losses, as damage to intestinal cells results in lower body weight, higher feed conversion rates, lack of flock uniformity, and failures in skin pigmentation. This challenge can only be tackled, if we understand the basics of coccidiosis control in poultry and what options producers have to manage coccidiosis risks. CURRENT STRATEGIES SHOW WEAK POINTS Good farm management, litter management, and coccidiosis control programs such as shuttle and rotation programs form the basis for preventing clinical coccidiosis. More successful strategies include disease monitoring, strategic use of coccidiostats, and increasingly coccidiosis vaccines. However, the intrinsic properties of coccidia make these parasites often frustrating to control. Acquired resistance to available coccidiostats is the most difficult and challenging factor to overcome. Optimally, coccidiosis control programs are developed based on the farm history and the severity of infection. The coccidiostats traditionally used were chemicals and ionophores, with ionophores being polyether antibiotics. To prevent the development of resistance, the coccidiostats were used in shuttle or rotation programs, at which in the rotation program, the anticoccidial changes from flock to flock, and in the shuttle program within one production cycle (Chapman, 1997).
ISSUE FOCUS FEED & ADDITIVE MAGAZINE September 2023 25 The control strategies, however, are not 100% effective. The reason for that is a lack of diversity in available drug molecules and the overuse of some molecules within programs. An additional lack of sufficient coccidiosis monitoring and rigorous financial optimization often leads to cost-saving but only marginally effective solutions. At first glance, they seem effective, but in reality, they promote resistance, the development of subclinical coccidiosis, expressed in a worsened feed conversion rate, and possibly also clinical coccidiosis. MARKET REQUESTS AND REGULATIONS DRIVE COCCIDIOSIS CONTROL STRATEGIES Changing coccidiosis control strategies has two main drivers: the global interest in mitigating antimicrobial resistance and the consumer's demand for antibiotic-free meat production. AUTHORITIES HAVE LEFT IONOPHORES UNTOUCHED Already in the late 1990s, due to the fear of growing antimicrobial resistance, the EU withdrew the authorization for Avoparcin, Bacitracin zinc, Spiramycin, Virginiamycin, and Tylosin phosphate, typical growth promoters, to "help decrease resistance to antibiotics used in medical therapy". However, ionophores, being also antibiotics, were left untouched: The regulation (EC) No 1831/2003 [13] of the European Parliament and the Council of 22 September 2003 clearly distinguished between coccidiostats and antibiotic growth promoters. Unlike the antibiotic growth promoters, whose primary action site is the gut microflora, coccidiostats only have a secondary and residual activity against the gut microflora. Furthermore, the Commission declared in 2022 that the use of coccidiostats would not presently be ruled out "even if of antibiotic origin" (MEMO/02/66, 2022) as "hygienic precautions and adaptive husbandry measures are not sufficient to keep poultry free of coccidiosis" and that "modern poultry husbandry is currently only practicable if coccidiosis can be prevented by inhibiting or killing parasites during their development". In other words, the Commission acknowledged that ionophores were only still authorized because it believed there were no other means of controlling coccidiosis in profitable poultry production. CONSUMER TRENDS DROVE RESEARCH ON NATURAL SOLUTIONS Due to consumers' demand for antibiotic-reduced or, even better, antibiotic-free meat production, intensified industrial research to fight coccidiosis with
ISSUE FOCUS 26 FEED & ADDITIVE MAGAZINE September 2023 natural solutions has shown success. Knowledge, research, and technological developments are now at the stage of offering solutions that can be an effective part of the coccidia control program and open up opportunities to make poultry production even more sustainable by reducing drug dependency. Producers from other countries have already reacted. Different from the handling of ionophores regime in the EU, where they are allowed as feed additives, in the United States, coccidiostats belonging to the polyether-ionophore class are not permitted in NAE (No Antibiotics Ever) and RWE (Raised Without Antibiotics) programs. Instead of using ionophores, coccidiosis is controlled with a veterinary-led combination of live vaccines, synthetic compounds, phytomolecules, and farm management. This approach can be successful, as demonstrated by the fact that over 50% of broiler meat production in the US is NAE. Another example is Australia, where the two leading retail store chains also exclude chemical coccidiostats from broiler production. In certain European countries, e.g., Norway, the focus is increasingly on banning ionophores. THE TRANSITION TO NATURAL SOLUTIONS NEEDS KNOWLEDGE AND FINESSE In the beginning, the transition from conventional to NAE production can be difficult. There is the possibility to leave out the ionophores and manage the control program only with chemicals of different modes of action. More effective, however, is a combination of vaccination and chemicals (bio-shuttle program) or the combination of phytomolecules with vaccination and/or chemicals (Gaydos, 2022). COCCIDIOSIS VACCINATION ESSENTIALS When it is decided that natural solutions shall be used to control coccidiosis, some things about vaccination must be known: 1. There are different strains of vaccines, natural ones selected from the field and attenuated strains. The formers show medium pathogenicity and enable a controlled infection of the flock. The latter, being early mature lower pathogenicity strains, usually cause only low or no post-vaccinal reactions. 2. A coccidiosis program that includes vaccination should cover the period from the hatchery till the end of the production cycle. Perfect application of the vaccines and effective recirculation of vaccine strains amongst the broilers are only two examples of preconditions that must be fulfilled for striking success and, therefore, early and homogenous immunity of the flock. 3. Perfect handling of the vaccines is of vital importance. For that purpose, the personnel conducting the vaccinations in the hatchery or on the farms must be trained. In some situations, consistent high-quality application at the farm has shown to be challenging. As a result, interest in vaccine application at the hatchery is growing.
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