ISSUE FOCUS FEED & ADDITIVE MAGAZINE August 2023 33 There are several products on the market that aim to control Salmonella at the feed level. However, recent data from the European Food Safety Authority revealed that less than 0.5% of poultry feed samples tested in the EU were positive for Salmonella from 2020 to 2021. This indicates that only looking at the feed level is insufficient in controlling the risk of Salmonella entering the poultry house. A more effective control strategy may be to make the birds less susceptible to Salmonella colonization, as in the bird all potential entry points can be tackled in one movement. A huge asset of certain MCFAs, over most short-chain fatty acids (SCFAs), is that they reduce Salmonella virulence by reducing its potential to invade gut epithelial cells (Figure 1.5) at concentrations below those that directly kill or inhibit the growth of this bacterium. Figure 2 clearly shows how crucial it is to select the right acids to reach the Less colonization & translocation Bacterial death Cell leakage MCFA approaching bacteria Destabilisation and degradation of bacterial cell membrane Enters bacteria Dissociation and cell acidification Dissociation and DNA intercalation Reduced virulence and invasiveness of bacteria Less viable/virulent bacteria reach hindgut Figure 1. The antibacterial mode of action for medium-chain fatty acids in a schematic form Supplant D Health and performance go hand in hand • Improves health status • Stablizes the rumen environment • Aids in a smooth transition • Reduces somatic cell count agrimprove.com Aromabiotic® Cattle
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