Feed & Additive Magazine Issue 30 July 2023

July 2023 Year: 3 Issue: 30 Feed Additive INTERNATIONAL MAGAZINE FOR ANIMAL FEED & ADDITIVES INDUSTRY Marisabel Caballero, EW Nutrition Heat stress in poultry Dr. Liz Homer, Trouw Nutrition 10 questions about the environmental footprint of milk Ian Carr, Veramaris Alternative aquafeed sources can meet omega-3 demand www.feedandadditive.com Ways to Reduce Impact of Global Warming on Animal Health and Performance Algae and Seaweed Use in Animal Nutrition

Water is the starting point of life and indispensable for the continuity of life. It is the source of life not only for humans, but also for every living creature on our planet, from the smallest to the largest. However, this extremely valuable source of life has been under serious threat in recent years. Human activities, global warming and climate change cause rapid depletion of water resources. Some facts and figures shared about water scarcity are unfortunately very worrisome. Here are some of them; • 2.3 billion people live in water-stressed countries, of which 733 million live in high and critically water-stressed countries. (UN-Water, 2021) • 3.2 billion people live in agricultural areas with high to very high water shortages or scarcity, of whom 1.2 billion people - roughly one-sixth of the world's population - live in severely water- constrained agricultural areas. (FAO, 2020) • Today, 1.42 billion people - including 450 million children - live in areas of high or extremely high water vulnerability. (UNICEF, 2021) • About 4 billion people, representing nearly two-thirds of the global population, experience severe water scarcity during at least one month of the year. (Mekonnen and Hoekstra, 2016) • 72% of all water withdrawals are used by agriculture, 16% by municipalities for households and services, and 12% by industries. (UN-Water, 2021) • When a territory withdraws 25% or more of its renewable freshwater resources it is said to be ‘water-stressed’. Five out of 11 regions have water stress values above 25%, including two regions with high water stress and one with extreme water stress. (UN-Water, 2021) It is up to people that this threatening picture does not deepen. In order to emphasize this responsibility, the United Nations (UN) declared tackling the water crisis as one of its Sustainable Development Goals (SDG) in 2015. The announced SDG made a commitment to “ensure availability and sustainable management of water and sanitation for all”. However, it is stated that the water crisis is spreading much faster than expected. In other words, although it is up to us not to deepen the table, but it is also certain that we do not act very actively in this regard. However, climatologists continue to emphasize at every opportunity that hotter summers due to global warming have caused a great decrease in the level of surface and groundwater since 2018. In other words, if we do not use the existing resources more efficiently and in a planned way, it is not a remote possibility that our water and animal and vegetable food sources will run out. We shouldn’t forget that water is our most important stress reduction source. In this issue, we cover the impact of global warming on animal health and performance. Enjoy your reading…! See you in the next issue ! Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR How will we cope with water scarcity? Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadditive

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CON T E N T S 18 ISSUE FOCUS 24 DETECT AND PROTECT Dr. Liberty Sibanda, Randox Food Diagnostics Ltd. 38 SIMPLE MEASURES CAN HAVE A BIG EFFECT ON COW COMFORT AND PRODUCTION Dr. Glenn Holub, Phibro Animal Health Corporation 20 BRAVING THE HEAT: WHAT POULTRY NEED TO COPE WITH HEAT STRESS Anne Möddel & Dr Bernhard Eckel, Dr. Eckel Animal Nutrition 34 HOW BEEF CATTLE COPE WITH HEAT STRESS Bruno Martin, Lallemand Animal Nutrition 28 HEAT STRESS IN POULTRY Marisabel Caballero, EW Nutrition 40 HELP DAIRY CATTLE BEAT THE HEAT FOR MAXIMUM PRODUCTIVITY Dr Ruby Wu, Arm & Hammer Animal and Food Production 42 HOW DOES HEAT STRESS IMPACT RUMINANT PERFORMANCE? Nicolas Cirier, ADM Animal Nutrition SUCCESS STORY 49 INSIGHTS FROM NOBLE FOODS' SUSTAINABLE POULTRY STRATEGY Elizabeth Trollinger, Alltech INTERVIEW 46 10 QUESTIONS ABOUT TECH, TRANSPARENCY, AND THE ENVIRONMENTAL FOOTPRINT OF MILK Dr. Liz Homer, Trouw Nutrition WAYS TO REDUCE IMPACT OF GLOBAL WARMING ON ANIMAL HEALTH AND PERFORMANCE

CON T E N T S SPECIAL STORY dsm-firmenich completes acquisition of Adare Biome 6 Adisseo presents mycotoxin guidebook Mycopedia 8 Neogen launches enhanced genomic test for cats 83 Alltech introduces its new swine product Triad 10 Lely presents vision Farm of the Future 2035 85 F3 - Future of Fish Feed launches krill replacement challenge 16 Loch Duart switches to BioMar's new Blue Impact diet 80 NEWS REPORTS MIDDLE EAST AND AFRICA ANIMAL FEED MARKET 74 57 ALTERNATIVE AQUAFEED SOURCES CAN MEET OMEGA-3 DEMAND Ian Carr, Veramaris 52 SEAWEED SUPPORTS GUT HEALTH AND PERFORMANCE IN ANIMAL NUTRITION Dr Ian Hutchinson, Ocean Harvest Technology Algae and Seaweed Use in Animal Nutrition ARTICLES 68 ROLE OF NUTRACEUTICALS IN LIVESTOCK FEED Suyesha Kadam & B.C. Mondal, GBPUAT 64 ARE INSECTS THE PROTEIN OF THE FUTURE? José C. Soares, The Tomorrow Company 60 YEAST SUPPLEMENTATION SUPPORTS ZERO ZnO MISSION Wouter de Bruin, Phileo by Lesaffre

NEWS 6 FEED & ADDITIVE MAGAZINE July 2023 Neogen® Corp. launched Igenity® BeefXDairy, a new and novel leading genomic test for beef-on-dairy calves. According to the company's statement, genetic testing is critical to the efficient management and marketing of beef-on-dairy cattle, and the new Igenity BeefXDairy test provides producers with insight into key traits such as carcass quality, average daily gain, and the Igenity Terminal Index, which can then be used to market the calf's growth potential to buyers. The test will also allow buyers to receive breed composition data (e.g., percentage beef vs. percentage dairy) to help them best manage those cattle for optimal health and maximum growth. "Neogen is excited to be the first to offer up a commercial genomic tool for this growth cattle market," said Shelby Smith, Bovine Genomics Product Manager at Neogen. "This product offering is a massive step forward in helping to characterize beef-ondairy animals and allowing dairy producers, cattle buyers, and, ultimately, consumers of beef products to benefit. With increased DNA testing, we can enable improved quality, efficiency, and sustainability within beef production systems." Read more>> Neogen® launches DNA test for beef-on-dairy cattle dsm-firmenich, innovators in nutrition, health, and beauty, confirmed the completion of its acquisition of Adare Biome, a pioneer in the development and manufacturing of postbiotics, for an enterprise value of €275 million. This transaction represents an estimated 2023 EV/ EBITDA multiple of 18x. Philip Eykerman, dsm-firmenich’s President Health, Nutrition & Care, said: “Adare Biome, as a global leader in the research and manufacturing of postbiotics with over a century of pioneering science in its heritage, is a perfect fit for dsm-firmenich that will complement three of our four Business Units. The Adare Biome teams will greatly help in driving our ‘Health from the Gut’ strategy and enable us to accelerate the creation of next-generation biotics to support the health of people and animals. We are excited about the new opportunities this move will unlock, as dsm-firmenich’s strong global presence and reach in local markets will enable us to deliver Adare Biome products to customers in a faster, more efficient way to bring the proven benefits of postbiotics to a wider range of people around the world.” Tom Sellig, CEO of Adare Pharma Solutions, commented: “dsm-firmenich is the ideal company to take Adare Biome to the next level and realize the growth potential of postbiotics. They have the infrastructure, together with strong commercialization and science capabilities, to scale the significant scientific research that we’ve achieved over the years. Moreover, dsm-firmenich’s purpose of bringing progress to life resonates strongly with the team. We look forward to contributing to the realization of this purpose as part of the dsm-firmenich family.” Read more>> dsm-firmenich completes acquisition of Adare Biome

NEWS FEED & ADDITIVE MAGAZINE July 2023 7 Lallemand Animal Nutrition introduced its refreshed brand image, encapsulated in the new slogan: “Partnering in microbial solutions for a changing world.” The new image and company brand charter are showcased on the revitalized company website, www.lallemandanimalnutrition.com. With an enhanced design, the website provides an elevated user experience, complemented by a comprehensive media library featuring technical articles, expert webinars, and podcasts. According to the company, this valuable resource serves as an educational hub for the animal nutrition and animal health community. Michel Vericat, Lallemand Animal Nutrition Corporate Marketing Director explains: “In 2015, Lallemand Animal Nutrition started to reinforce and establish a strong corporate image branding on top of the specific products and services we can provide to the animal nutrition industry. We are extremely proud today to continue investing in our corporate communications strategy. This new messaging and image better reflects who we are today, as a global leader in the science of fermentation and a primary producer of yeast and bacteria. We are creating value in new markets beyond animal nutrition, including microbial solutions to improve animal environments, biosecurity, biofilms, animal immune health, and welfare, and strengthening our presence in the companion animal market.” Read more>> Lallemand Animal Nutrition introduces new brand image and website GMP+ International is working together with Wageningen Food Safety Research, SGS, Cargill, Alltech and the Committee of Grain Traders to develop an early warning system for early detection of the presence of mycotoxins (natural toxins) in cereal grains. The project is entitled ‘Early warning of mycotoxins in European grain supply chain using machine learning and big data’ and focuses on cereals of European origin. The aim is the early prediction of – and control of – mycotoxin formation in cereal crops. Big data, machine learning and existing prediction models are being used to develop the early warning tool, and new prediction models for mycotoxins are also being developed. The system is intended for various stakeholders in the supply chain, such as traders, food and feed producers, government agencies, and farmers. Mycotoxins are produced by fungi that grow naturally in cereals. The cereal crops grown in many regions of Europe are susceptible to contamination by those fungi, and also to infection with mycotoxins. Consuming these cereals can cause health problems in both humans and animals. Read more>> GMP+ International works on early warning system for mycotoxins

NEWS 8 FEED & ADDITIVE MAGAZINE July 2023 Mycotoxins have long been recognized as a significant challenge in livestock production, jeopardizing animal health, performance, and overall profitability. However, some in the industry continue to downplay the impact these compounds can have on their operations and/ or rely on misconceptions or outdated information when developing their mitigation strategies. With Mycopedia, Adisseo aims to empower industry professionals, who may not be experts in these toxins but require comprehensive knowledge, to effectively mitigate their adverse effects, with the latest in insights and opinions from academic and industry experts in the field. The official launch of this ultimate Guidebook was held at ESPN in Rimini on June 20th, Italy. Adisseo’s easy-to-navigate guidebook offers industry representatives the opportunity to discover the world of mycotoxins. Unique in its kind, it is also easy for any reader interested in a specific topic to delve into it further with its section on data sources. According to the company, as a tool, it is both handy and timesaving for anyone interested in learning more about mycotoxins in animal nutrition. Read more>> Adisseo presents mycotoxin guidebook Mycopedia Nutrition Technologies welcomed Bunge Ventures, the for-profit principal investing arm of Bunge, a leading global agribusiness, food, feed and ingredients company, as an investor. “We are very excited to have Bunge Ventures as a new investor,” said Tom Berry, Co-CEO and Co-founder of Nutrition Technologies. “Their global network and experience in the agribusiness sector are unrivalled and this investment will allow us to scale our tropical bioconversion system and make insect-based products a mainstay ingredient of the future.” Nutrition Technologies has a proprietary controlled industrial microbial decomposition process that uses Black Soldier Fly Larvae (BSFL) to bio-convert food waste and industrial organic by-products diverted from landfills. The company’s patent-pending fermentation technology also provides a scalable platform for a range of insect-based products for crop health and animal feed. Nutrition Technologies manufacture and supply insect meal, oil and bio-fertilisers to help feed the growing agriculture and feed industries around the world. After extensive R&D, they have focused on developing a unique biotechnology approach within the insect sector. This process uses beneficial microbes and BSFL to provide a zero-waste, low energy and low-cost production model. “This has not only resulted in our ability to out-compete competitors on pricing, but also on carbon emissions and sustainability credentials,” said Nick Piggott, Co-CEO and Co-Founder of Nutrition Technologies. Read more>> Bunge Ventures invests in agtech company Nutrition Technologies

NEWS FEED & ADDITIVE MAGAZINE July 2023 9 Supplant D Optimizing broiler performance • Improves feed intake • Supports feed conversion • Reduces mortality • Increases ROI agrimprove.com M-prove As demand for plant-based pet food gathers pace, BENEO, one of the leading manufacturers of functional ingredients, presented its new toolbox of high-quality and non-GMO vegetal proteins. Featuring rice protein, vital wheat gluten, and faba bean protein concentrate, with each offering specific nutritional and technical benefits, BENEO’s range of plant-based proteins provides everything manufacturers need to tap into this trend. With a range of versatile solutions that can also be combined, BENEO’s vegetal proteins provide high-quality concentrated and non-GMO sources, with excellent amino acid profiles which enable the development of plantbased or hybrid pet foods. According to the company's statement, BENEO’s vital wheat gluten also offers a high protein density of approximately 80%. It delivers an interesting amino acid profile, as it is rich in glutamine, which is the preferred fuel for intestinal cells that can help repair damaged cells, as well as tyrosine, which plays an important role in maintaining fur color. On the other hand, BENEO’s faba bean protein concentrate, listed in the EU Catalogue of Feed Materials, is a good alternative to animal and soy proteins and is suitable for “no grain” claims in pet food. Its amino acid profile is relatively rich in lysine and can nicely complement cereals’ protein, meaning it can notably be blended with rice protein or vital wheat gluten. Read more>> BENEO launches its new vegetable proteins for pet food

NEWS 10 FEED & ADDITIVE MAGAZINE July 2023 Alltech introduced Triad™, an innovative solution that promotes successful farrowing and pig livability through a palatable, proprietary blend of Alltech ingredients. Peer-reviewed research has suggested that supplementation of these compounds in combination can support the parturition process, reduce the incidence of stillborn pigs, and boost the number of wean pigs per sow. “It is exciting to bring a solution to market with such a strong return opportunity,” said Andy Rash, general manager of Alltech’s U.S. swine business. “Minimizing stillborns and low-viability pigs at the rate in which we can with Triad is a direct improvement in profit, as more pigs equal more profit.” Sow throughput can be compromised by a higher incidence of stillborn pigs and pre-wean death losses, decreasing overall performance for swine producers. Effective during short feeding intervals, Triad supports sows during parturition and lessened pre-wean mortality, driving more pigs and more pounds long-term. Read more>> Alltech introduces its new swine product Triad AgriVision 2023 illuminates pathways to future-proof protein More than 300 delegates representing every segment of the feed-to-food value chain convened at AgriVision, 2628 June, in Noordwijk aan Zee, the Netherlands, to reimagine, debate and discuss pathways for future-proofing proteins. Leaders at the forefront of industry, research and development, agri-tech, policy, and consumer behaviour shared emerging insights, moderated panel conversations, and challenged attendees to take action in order to meet a projected 70% increase in protein demand by 2050. Nutreco COO David Blakemore opened AgriVision, noting that the present moment offers an opportunity for collaboration and innovation to accelerate across the feed-to-food value chain. “The good news is that the people in this room today have incredible capabilities and potential to make a difference,” Blakemore stated. “As players in the feed-to-food value chain, today’s threats will drive us to be better and what we do over the coming years will have a significant impact on the future of the planet. AgriVision continues to be a platform to bring us together and drive transformation forward.” Paul Polman, former CEO of Unilever, and an active climate analyst, author and contributor to the UN Sustainable Development Goals, delivered keynote remarks and inspired delegates to apply a net-positive perspective to rethinking the future of protein away from a linear production model toward a collaborative approach. “We are literally playing with the future of humanity, Polman noted. “The world has been incredibly flexible and increased its capacity to absorb our CO2 emissions, but it’s run out and we are very close to a negative tipping point.” He urged AgriVision delegates to rethink the future of protein and create the more sustainable, collaborative, and transformative partnerships now needed to address the most burning challenges. Read more>>

NEWS FEED & ADDITIVE MAGAZINE July 2023 11 FEFAC, DAKOFO, and FS, representing respectively the European, Danish and Swedish feed industries, organised the 30th FEFAC Congress on 14-16 June 2023 in Ystad (Sweden). The congress dedicated to the “Resilience of Sustainable EU food production systems – Role of circular feed”. The public conference on 15 June welcomed a large range of national, European and international speakers and was attended by over 200 participants. Two high-level sessions analysed key policy and market drivers for circular feed solutions, followed by three expert workshops focusing on key sustainability pressure points for different animal species. In the keynote opening, Pierre Bascou (DG AGRI Acting Deputy Director General) expressed his appreciation to FEFAC and supply chain partners for ensuring functional food supply chains in times of crises, causing disrupting effects. He shared a relatively positive short-term market outlook for the livestock and feed industry, with more cost-efficient feed cereal grains becoming available, despite ongoing severe droughts in parts of Southern Europe. He pointed to a range of EU policy drivers & measures that aim to accelerate the pace of transition towards the improved environmental and climatic performance of the livestock sector via CAP National Strategic Plans. He also confirmed the release of the updated EU Protein Plan at the beginning of 2024, which this time will be broader in scope, covering the different protein sources for feed and food use, while it would also address the circularity role of livestock production in food production systems. Newly elected FEFAC President Pedro Cordero closed the 30th FEFAC Congress stating “The Congress allowed to put the spotlight on current sustainability challenges and opportunities that the feed and livestock sectors are facing. We know that we still have a lot to learn and do, but we will continue to deliver practical and viable tools jointly with our chain partners which will allow the EU livestock and aquaculture sector to stay on track to achieve most of the relevant EU Green Deal Goals”. Read more>> FEFAC 30th Congress focuses on sustainability and circular feed Mars, Incorporated announced the successful completion of Mars’ acquisition of Heska. On April 3, 2023, the companies announced they had entered into a definitive agreement under which Mars agreed to acquire Heska for $120.00 per share. Heska is now part of Mars Petcare’s Science & Diagnostics division, enabling broader coverage across diagnostics and technology, while accelerating R&D and expanding access globally to pet healthcare solutions. Nefertiti Greene, President, Mars Science & Diagnostics, said: “It’s an honor to welcome Heska to the Science & Diagnostics division of Mars Petcare. Like us, Heska has grown into a purpose-driven business, supporting veterinary professionals globally.” Read more>> Mars completes acquisition of Heska

NEWS 12 FEED & ADDITIVE MAGAZINE July 2023 Ÿnsect, one of the world leaders in insect production, announced the creation of a genotyping chip named Axiom® YNS_Mol1, a world-first for insect breeding and a major step in the evolution of selection of larvae lines to produce insect-based proteins. This novel chip dedicated to the Tenebrio molitor mealworm will allow for selection based on the genomic diversity of the species. Made available to the wider scientific community, it represents a key element of Ÿnsect’s strategy, as well as a groundbreaking tool for fundamental research in the sector. “Ÿnsect’s ambition is to contribute to the development of a new economic, social and sustainable model, which proposes new ways of consuming and producing, in order to meet the major environmental and climatic challenges of our era. For 12 years we have been innovating, with the goal of advancing the food industry and democratising the insect. Our genotyping chip for the Tenebrio molitor beetle is a world-first for our industry and will contribute to the sustainable structuring of the entomoculture sector,” said Antoine Hubert, CEO of Ÿnsect. This genotyping chip, developed with Thermo Fisher, represents a very powerful lever for the sustainable development of insect farms. Until now, producers have mainly focused on selecting the bigger larvae, but this kind of overly restrictive practice of mass selection could lead to inbreeding and its detrimental consequences. For insect breeding in particular, it is essential for large-scale farms like Ÿnsect to select the best lines while ensuring real genetic diversity. The genomic selection delivered by the Axiom® YNS_Mol1 chip makes it possible to achieve these objectives. “The chip is made up of 679,205 markers (SNPs or Single Nucleotide Polymorphisms), distributed throughout the genome and covering more than 99% of the gene regions. These SNPs, representing modifications of a DNA base at a precise position between individuals of the same species, were selected to represent the entire genetic diversity of the insect population at our farms,” commented Thomas Lefebvre, Biotech R&D Innovations Director at Ÿnsect. Read more>> Ÿnsect reveals high-density genotyping chip for insect breeding Skretting, a global leader in providing innovative and sustainable nutritional solutions for the aquaculture industry, introduced a new shrimp feed Elevia engineered to offer superior nutrition and water quality in shrimp hatcheries and nurseries. According to the company statement, Elevia, formulated to mimic the natural feeding approach of shrimp larvae, is a next-generation solution that surpasses conventional feeding methods and traditional aquafeed ingredients, setting a new standard for hatchery performance. Incorporating new sustainable raw materials such as essential long-chain omega-3 fatty acids, algae-derived DHA, and hydrolyzed marine proteins, it enables shrimp to develop into strong and healthy post larvae with increased capacity to thrive in nursery environments. “Elevia reduces the production cycles in hatcheries and provides shrimp with the necessary energetic reserve to improve resilience for the transport Skretting introduces Elevia, its latest shrimp feed

NEWS FEED & ADDITIVE MAGAZINE July 2023 13 to the farm and acclimation,” said Marita Montserrate, Technical Director at Skretting Ecuador. “In addition, Elevia ensures better performance in the nursery, reduces the cost of the post larvae, and promotes increased survival and growth throughout the entire production cycle.” Elevia improves the ability of shrimp to handle challenges by providing them with nutrients that improve their immune system and overall resilience. This enables the shrimp to cope more effectively with stressful environmental changes. As a result, shrimp production becomes more reliable and successful, reducing the risks associated with variations in water conditions and other factors. Through Elevia’s advanced formulation, physical properties, and color, the need for multiple diets and flakes are significantly reduced, resulting in simplified operations and feed management. Another key feature that contributes to streamlining operations is the diet’s ability to maintain water stability. Thanks to its unique composition and encapsulation of omega-3 fatty acids, the leaching of lipids into the production system is prevented, ensuring cleaner and uncompromised water quality. Consequently, intact feed particles remain stable for extended periods, minimizing the necessity for frequent replacements. This not only promotes optimal water conditions but also facilitates essential system maintenance, all while alleviating the strain on bio-filters and mechanical filters. Read more>> Protecting feed ingredients from farm to feed www.anitox.com/feed-ingredients

NEWS 14 FEED & ADDITIVE MAGAZINE July 2023 Finland's only fish feed factory, formerly known as Raisioaqua, is now operating under a new name Alltech Fennoaqua Oy, reflecting its new ownership. The company, which was previously owned by the Raisio Group, was recently acquired by Finnforel Oy and Alltech, an animal nutrition company headquartered in Nicholasville, Kentucky, USA. The new name, Alltech Fennoaqua Oy, is a reference to the company’s home country of Finland and the region around the Baltic Sea. Alltech Fennoaqua ensures Finnish domestic aquaculture production as a result of its domestic feed production in Raisio, Finland. Before the acquisition by Alltech and Finnforel, fish feed production in Finland was under threat. If the factory had shut down, Finland’s rainbow trout would have been entirely dependent on foreign feed. "Fish feed production could have stopped in Finland without this change of ownership,” said Tomi Kantola, CEO of Alltech Fennoaqua. “After that, one could have questioned whether fish raised in Finland could be called Finnish in the end. Now, Alltech Fennoaqua will continue to provide Finnish feed for fish raised by Finns." Fish feed is a core business of the new owners of Alltech Fennoaqua, who are pioneers in nutrition for fish in recirculating aquaculture systems (RAS). The volume of production at the Alltech Fennoaqua factory will increase to accommodate additional production of RAS feeds. Read more>> Finnish fish feed factory continues its production as Alltech Fennoaqua BioMar expands its marine hatchery trial facilities BioMar Group announced the expansion of the marine hatchery trial facilities at its Aquaculture Technology Centre (ATC) Hirtshals in Denmark. The investment will allow for an expansion into a new, larger facility with the capability of performing trials in semi-industrial conditions. The investment in this state-of-the-art facility follows the continued success of the LARVIVA hatchery feeds across the main hatchery markets, together with the two capacity expansions at the production facility in France to cover the market demand. The decision further reinforces BioMar’s commitment to driving innovation and meeting the evolving needs of hatcheries across the globe. “We believe that this investment will unlock potential for growth in new markets and new species. This will bring innovations, further solidifying our position as a leading provider of premium-quality hatchery feeds. The expansion of the ATC Hirtshals facility aligns with BioMar’s strategic plan for the hatchery segment, which is a key pillar for the development of marine fish and shrimp feeds,” said Henrik Aarestrup, VP LATAM, Shrimp & Hatchery at BioMar. Read more>>

NEWS FEED & ADDITIVE MAGAZINE July 2023 15 Ocean Harvest Technology Group plc, a leading global producer of animal feed supplements from multispecies seaweed blends, announced the results from four recently completed feed trials. The first three trials were carried out by universities in conjunction with potential customers whilst the swine trial was undertaken directly by a potential customer. According to the company statement, the highlights of the trials are as follows: • A laying hen trial confirmed improvements in both egg production and feed efficiency when birds were fed an OceanFeed™ Poultry supplemented diet. These performance improvements materially increased income per hen. • A catfish trial demonstrated that fish fed with OceanFeed™ Aqua in their diets had higher feed intake and weight gain, leading to a substantial increase in final weight. • A trial with juvenile shrimp where OceanFeed™ Aqua improved both weight gain and feed efficiency, thus reducing production costs. OceanFeed™ Aqua also helped reduce mortality in a disease challenge trial run in parallel. • A commercial swine trial reported material improvements in feed efficiency in piglets with OceanFeed™ Swine included in their diet. OceanFeed™ Swine successfully replaced a combination of seven conventional gut health additives. These results add to the company’s substantive dataset demonstrating the efficacy of OceanFeed™ in improving animal performance across a range of species, and highlights the important benefits of using OceanFeed™ ingredients in a number of applications. The substantial and growing breadth of data across multiple species is helpful in driving new customer adoption which remains an important aspect of OHT’s revenue growth. Read more>> New trials: OceanFeed improves animal performance VAFO Group, a leading European producer of super premium pet foods, officially opened its first factory in Finland. The new facility is the largest of its kind in Finland and the eighth overall for the group. With a production capacity of 20,000 tonnes of pet food each year, VAFO (under the direction of its subsidiary Prima Pet Premium) has thus further strengthened its dominant standing in the local market. The total investment in the new factory exceeded 16 million euros, and at full capacity it will employ up to 20 people. In addition to a positive economic impulse for the region, the project marks the return of production of the HauHau Champion brand to the local market, which means VAFO is also increasing its overall production capacity in the private label segment, an area that has seen remarkable growth in recent times. Test operation at the new factory in Nokia, Finland, got underway at the beginning of March. The factory is situated in the Kolmenkulma Eco3 park, which features a system of organic and circular economy based on the most advanced production technologies. According to Timo Pärssinen, CEO of Prima Pet Premium, a Finnish subsidiary of VAFO Group, this makes the new factory the most sustainable pet food production facility in the whole of Finland. Read more>> VAFO opens its first pet food factory in Finland

NEWS 16 FEED & ADDITIVE MAGAZINE July 2023 The second stop of the Alltech ONE World Tour (ONE) wrapped up in Dublin, Ireland, following a robust agenda of presentations focused on collaborative solutions to the challenges facing the agri-food industry as it confronts the “4 Cs” — the major forces of climate, conflict, consumer trends and rising costs. ONE Dublin welcomed more than 500 international delegates in person at Croke Park. This worldclass event brought industry leaders to the stage to share valuable insights in live presentations and focus-track sessions while uncovering the challenges and opportunities related to agriculture. Tara McCarthy, global vice president for ESG at Alltech, discussed demonstrating the ROI of sustainability. “Our industry is navigating unprecedented disruption yet remains confident and committed to evolving towards a more sustainable food system,” said McCarthy. “The key to success will be the development of innovative solutions, but even more critical the capacity of the industry to work together across the value chain.” Delegates at ONE Dublin also heard presentations from Russell Smyth, head of sustainable futures at KPMG Ireland, about “The metrics that justify the investment”; Nina Prichard, head of sustainable and ethical sourcing for McDonald’s U.K. and Ireland, on “Our journey to net zero: The role of supply chain”; and Constance Cullman, president and CEO of the American Feed Industry Association (AFIA), on “The forgotten role of the feed industry”. These speakers were then joined by Hans Jöhr, former corporate head of agriculture at Nestle and current sustainability and ESG specialist and coach, for a panel discussion exploring “How do we feed the ecosystem, not just ourselves?” “The conversations that we are having here at ONE, the ideas that are being fostered and the science and the data being developed can help to create a story where agriculture is the hero,” said Dr. Mark Lyons, president and CEO of Alltech. “Together, we have the collective courage and impact to work together for a Planet of Plenty™.” Read more>> ONE Dublin welcomes more than 500 international delegates The F3 - Future of Fish Feed launched its newest aquaculture feed contest — the F3 Krill Replacement Challenge — to spark innovation for a substitute for krill in aquaculture feeds. Up to 10 companies are invited to register for the contest that will award a $100,000 grand prize for the krill replacement product that results in the best growth, feed consumption, and survival during a 12-week feeding trial on Atlantic salmon (Salmo salar). Registration is open until August 31, 2023. “We are upping the stakes in our fourth challenge to the aquaculture industry to replace another critical marine animal ingredient in fish feed,” said Kevin Fitzsimmons, professor at the University of Arizona and chair of the Future of Fish Feed. “We F3 - Future of Fish Feed launches krill replacement challenge

NEWS FEED & ADDITIVE MAGAZINE July 2023 17 invite innovators from the feed supplement, feed ingredient, and synthetic biology sectors to join us in advancing more sustainable aquaculture practices that will improve food security globally.” The F3 Krill Replacement Challenge—the fourth contest hosted by the Future of Fish Feed—was motivated by scientific research that has shown sharp declines in krill populations by as much as 80 percent, the result of climate-induced changes in ocean temperature, currents, acidification, and regional overfishing. Krill is a popular aquaculture feed ingredient for its nutritional benefits and is thought to increase feed palatability and fish growth. As a result, the commercial krill fishery located in the Arctic and Antarctic has steadily increased production over the last decade from a high of 200,000 tons in 2010 to 450,000 tons in 2020. The rapidly expanding industrial fishery coupled with climate-induced stressors presents considerable risks to the global krill supply. A wide variety of marine life depends upon these tiny shrimp-like crustaceans at the base of the marine food chain including whales, penguins, and commercially important wild fisheries like salmon, rockfish, squid, and sardines. Krill is also important for its role in removing carbon dioxide from the atmosphere. Read more>> Kemin Industries, a global ingredient manufacturer that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services, presented latest findings on gut health and nutrient digestibility at 23rd European Symposium on Poultry Nutrition held at Palacongressi di Rimini, Italy on June 21 – 24. The company’s experts shared insights into the value of chromium and its innovation in poultry. Kemin Animal Nutrition and Health – EMENA (Europe, Middle East, North Africa) presented multiple abstracts, showcasing the leading role its innovative solutions Lysoforte® Extend and Clostat® can offer to poultry, premix and feed producers. These abstracts included some of the latest scientific findings regarding proof of concept and the impact of a nutrient-absorption enhancer on turkey, broiler and layer performance. Other abstracts highlighted the benefits of a novel probiotic on the gut microbiome in pheasants, broilers and laying hens. "ESPN provided a unique opportunity for us to present Kemin’s scientific and technical achievements in poultry nutrition, while also gaining new scientific insights from various lectures and discussions with industry peers and leading poultry scientists in multiple areas of poultry nutrition,” said Frederika Somers, Business Manager – Monogastrics, Kemin Animal Nutrition and Health – EMENA. Read more>> Kemin presents latest findings on poultry gut health and nutrient digestibility

ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE July 2023 WAYS TO REDUCE IMPACT OF GLOBAL WARMING ON ANIMAL HEALTH AND PERFORMANCE

ISSUE FOCUS FEED & ADDITIVE MAGAZINE July 2023 19 Simple measures can have a big effect on cow comfort and production Dr. Glenn Holub, Phibro Animal Health Corporation Braving the heat: What poultry need to cope with heat stress Anne Möddel & Dr Bernhard Eckel, Dr. Eckel Animal Nutrition Help dairy cattle beat the heat for maximum Productivity Dr Ruby Wu, Arm & Hammer Animal and Food Production Detect and protect Dr. Liberty Sibanda, Randox Food Diagnostics Ltd. How does heat stress impact ruminant performance? Nicolas Cirier, ADM Animal Nutrition Heat stress in poultry Marisabel Caballero, EW Nutrition How beef cattle cope with heat stress Bruno Martin, Lallemand Animal Nutrition

ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE July 2023 BRAVING THE HEAT: WHAT POULTRY NEED TO COPE WITH HEAT STRESS Heat stress is a common problem for layers and broilers, because they are unable to regulate their body temperature effectively in hot environments. One way to support poultry during heat stress is to provide them with access to cool, fresh water. This is also the best means to administer supplements that will give extra support to the animals. Dr Bernhard Eckel Vice President Dr. Eckel Animal Nutrition Anne Möddel Senior Technical Sales Manager Dr. Eckel Animal Nutrition When temperatures inside and outside the barn are rising, often enough tempers are going up, too. Heat is a general stressor for poultry and other birds, especially when high temperatures and high humidity come together. Reduced feed intake, dehydration and heat stroke are only a few of the health issues related to heat stress, often resulting in lower production, poorer quality and a higher number of deaths. Feed additives can do a lot to support the animals and ease the stress. But one very common result of heat stress is loss of appetite – the birds refuse to feed. The easiest way, therefore, is to get animals’ stress level down fast and reliably by supplying stress relief via the drinking water. WHY IS HEAT STRESS SO DAMAGING? Heat stress occurs when the animals’ body cannot regulate its temperature anymore to prevent overheating. It is a problem that very often occurs in high-performing livestock and has gained severity with the ongoing climate change. When an animal’s body overheats, it tries to cool down, for instance by way of sweating. Birds like poultry do not possess the same ability to sweat as mammals do, they mainly regulate their body temperature through panting. But if the outside air is already hot, this is barely effective, and they still lose significant amounts of water through rapid respiration. This can easily lead to dehydration and an imbalance in vital electrolytes such as sodium and potassium.

ISSUE FOCUS FEED & ADDITIVE MAGAZINE July 2023 21 Normal physical functions don't work properly anymore, the immune system is weakened and birds become vulnerable to pathogens that they would normally be able to resist. In addition to adjustments in management and housing conditions, additives are invaluable in improving the comfort, health and welfare of animals in high temperatures and ensuring their performance. Here it is particularly important that they are applied accurately and can act quickly. That is why MagPhyt WS was developed. TRIPLE EFFECTIVE AGAINST HEAT STRESS MagPhyt WS helps the birds to cope with the effects of heat stress. The secret behind MagPhyt WS’ fast and reliable relief lies in the unique triple complex of vitamin C, magnesium and selected plant extracts. First of all, vitamin C is a powerful antioxidant that can help to reduce oxidative stress in the body. When birds are exposed to high temperatures, they do not only suffer from heat. Their body also produces more free radicals. Those are real troublemakers which can do a lot of harm to an organism by damaging cells and tissues. This is nothing to trifle with! In chicken, for instance, this can lead to a wide range of symptoms, from severe appetite and weight loss to abnormal or even aggressive behaviour to digestive issues, poor growth and higher susceptibility to illnesses. Vitamin C is among the best agents to help neutralize these free radicals, thereby reducing the risk of cellular damage.

ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE July 2023 Second, magnesium plays an important role in regulating body temperature, and it is also involved in the production of energy. During periods of high heat, birds require more energy to maintain their body temperature and stay hydrated. Magnesium supplementation can support this increased energy demand. MagPhyt WS has a magnesium source that is highly bioavailable, which means it can be easily absorbed from the digestive system and used by the cells and tissues in the body. And third, phytogenics, also known as plant-based additives. They have a number of beneficial effects on poultry performance and health. One of the ways that phytogenics can support poultry during heat stress is by helping to reduce stress and promote relaxation. MagPhyt WS has this extra phytogenic component that makes it more than just any old magnesium-based stress relief: additional stress component lavender. Lavender contains a number of compounds with calming effects on the nervous system. For hundreds of years, humans have been using it as a strong and effective stress relief. Its soothing scent and its distinctive taste add up to a unique combination of fast and natural support. SEE IT, SMELL IT, TASTE IT MagPhyt WS is a novelty. A high-speed antistress agent whose effect you can not only see, but also taste and smell. And so can your animals. The product's white powder has been carefully manufactured to dissolve immediately and distribute evenly in the water. Once dissolved, the calming scent of lavender fills the air while the anti-stress ingredients do their work. The animals appreciate the fresh taste and will soon visibly calm down. There is no need for feed replacements or changes. In addition, the product does not promote the formation of a biofilm in the water. It can therefore be safely used, as long as the usual and, especially at high temperatures, necessary hygiene procedures are followed in the drinking system. This is how new MagPhyt WS can help birds maintaining their health and productivity even in challenging environments and hot temperatures. About Anne Möddel Anne Möddel is Senior Technical Sales Manager at Dr. Eckel Animal Nutrition. With a background in pig farming and a master's degree in agricultural sciences, Möddel brings extensive expertise to her role. She regularly conducts technical trainings and workshops and engages in international conferences. About Dr Bernhard Eckel Bernhard Eckel has been with the company from the very beginning. The key figure behind Dr. Eckel’s pioneering feeding solutions, he is responsible for technical sales, product development and animal welfare, and thus plays a major role in the success of the company.

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ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE July 2023 “Mycotoxins pose a significant threat to food safety, animal health, and the overall well-being of both humans and animals. The global impact of climate change on mycotoxin prevalence is becoming increasingly evident, leaving a profound imprint on agricultural practices, and necessitating urgent attention.” Climate change is casting a dark shadow over agricultural landscapes. As temperatures rise, precipitation patterns shift and extreme weather events become more frequent, the prevalence of mycotoxins - toxic substances produced by fungi - is escalating. Three of the main mycotoxigenic fungi affected by climate change are from the genus Aspergillus, Fusarium and Penicillium. The ability of mycotoxigenic fungi to respond to climate change has induced a shift in their geographical distribution and the pattern of mycotoxin occurrence. Mycotoxins pose a significant threat to food safety, animal health, and the overall well-being of both humans and animals. The global impact of climate change on mycotoxin prevalence is becoming increasingly evident, leaving a profound imprint on agricultural practices, and necessitating urgent attention. Research data has revealed that increased global temperatures, drought stress, and CO2 levels have a measurable impact on Aspergillus flavus resulting in higher Aflatoxin B1 production. Mycotoxin co-contamination occurs when different fungal species produce various mycotoxins, or when a single fungus produces multiple mycotoxins simultaneously. In a global study, 74,821 feed samples were collected from 100 countries from January 2008 to December 2017. Results of this survey indicate that co-occurrence of mycotoxins is the rule rather than the exception. Consequently, the toxicological effect of frequently detected mycotoxin mixtures [most importantly combinations of Deoxynivalenol (DON), Zearalenone (ZEA), and Fumonisins B1,2,3 (FBs)] should be investigated more closely. This is paramount for dietary exposure to concentrations commonly detected in feed. These combinations of mycotoxins can have detrimental consequences on animal health. Animal species vary in their susceptibility to different mycotoxins. Poultry is more susceptible to Aflatoxin B1,2, G1,2 (AFBs), T-2/HT-2 Toxins, Ochratoxin A (OTA) and FBs, while swine are most affected by AFBs, ZEA and T-2/HT-2 Toxins. Therefore, tailored feeds for different animal species are vital as they account for specific nutritional requirements, digestive physiology, and susceptibility to mycotoxins. To protect animal health, regulations have been DETECT AND PROTECT The urgent need for testing in the face of climate change's influence on mycotoxin occurrence Dr. Liberty Sibanda Applications Manager Randox Food Diagnostics Ltd.

ISSUE FOCUS FEED & ADDITIVE MAGAZINE July 2023 25 set stipulating maximum levels of mycotoxins in feed and feed products. By formulating and testing feeds to lower mycotoxin risks and meet the unique needs of different animals, it becomes possible to minimise the adverse effects of mycotoxin co-contamination and ensure optimal health and performance. The list of regulated mycotoxins includes AFB1,2, G1,2, OTA, DON, ZEA, FBs, and T-2/ HT-2 Toxins. Diacetoxyscirpenol (DAS) has been shown to have similar effects as T-2/HT-2 Toxins in animals. Paxilline (PAX), on the other hand, has tremorgenic activity and is a selective and reversible blocker of the smooth muscle high conductance calcium-activated channels. The need to comply with international mycotoxin regulations for feed, and to protect livestock from mycotoxin exposure has necessitated a multi-mycotoxin approach to feed testing. Randox Food Diagnostics Ltd. has developed immunoassay-based Biochip Array Technology (BAT) for the accurate and specific detection of all regulated mycotoxins in a single run. BAT is designed as a mycotoxin detection array and is presented in three formats i.e., Myco 6, Myco 7 and Myco 9 detecting six (6), seven (7) and nine (9) mycotoxins, respectively. The Myco 9 Array is a method which simultaneously and quantitatively detects AFB1,2, G1,2, OTA, DON, ZEA, FBs, T-2/HT-2 Toxins, DAS and PAX in feed and feed products. The Biochip is a ceramic tile on which antibodies, for each of the mycotoxins, are inter-spaced and spotted on predetermined positions [Discrete Test Regions (DTRs)] on the surface. DTRs enable the accurate identification of the different mycotoxins based on the spatial location of each antibody spot. Randox mycotoxin arrays are capable of accurately detecting all regulated mycotoxins i.e., AFBs, OTA, DON, ZEA, FBs, T-2/HT-2 Toxins, PAX and DAS. In the area of multi-mycotoxin determination in feed, LC-MS/MS is the only other platform capable of simultaneous and quantitaTest Menu Ochratoxin A Diacetoxyscirpenol T2/HT2 Toxins Zearalenone Deoxynivalenol Fumonisins Aflatoxin B1 Aflatoxin GI Paxilline Our mycotoxin arrays allow simultaneous detection of up to 9 main groups of mycotoxins from a single sample. [email protected] randoxfood.com Mycotoxin Arrays Validated in accordance with Commission Decision 2002/657/EC and Commission Regulation (EU) No 519/2014. Export / Import Testing for Feed & Grain

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