ISSUE FOCUS 32 FEED & ADDITIVE MAGAZINE June 2023 The tight junction dysfunction that is observed under heat stress is in part driven by a reduction in feed intake. Recent literature in ruminants demonstrated deleterious effects of feed restriction on gut barrier integrity. A study in Holstein cows under feed restriction fed zinc from IntelliBond or a sulphate source was therefore designed to evaluate the effect on gut permeability, metabolism and inflammation. Feed restriction tended to decrease ruminants’ intestinal surface area, with IntelliBond ameliorating that decrease. Overall, replacing zinc sulphate with IntelliBond zinc improved barrier morphology and modulated acute-phase protein response and neutrophil function. As global temperatures rise year upon year, threatening economic losses and placing increased environmental pressure on livestock farming, it is essential that diets are formulated to support animals in achieving proper performance, especially under challenged conditions. Data from commercial trials and studies at research centres around the globe show that IntelliBond minerals improve the resilience of animals. Feeding the right trace mineral can helps sustain proper performance and reduce the impact of heat stress on producers’ bottom lines. References 1. United Nations. (2022, January 19). 2021 joins top 7 warmest years on record: WMO. United Nations News. https://news.un.org/en/story/2022/01/1110022 2. Zhuge, Q., and C. F. Klopfenstein. “Factors affecting storage stability of vitamin A, riboflavin, and niacin in a broiler diet premix.” Poultry Science 65.5 (1986): 987-994. 3. Luo, X. G., et al. “Effects of dietary supplementation with copper sulfate or tribasic copper chloride on broiler performance, relative copper bioavailability, and oxidation stability of vitamin E in feed.” Poultry Science 84.6 (2005): 888-893. 4. Harshman, Jared A., et al. “115 Effects of a Chronic Lipopolysaccharide Challenge on Growth Performance and Immune Response of Nursery Pigs Fed Differing Sources of Dietary Zinc.” Journal of Animal Science 100.Supplement_2 (2022): 52-53. 5. Key, Nigel, Stacy Sneeringer, and David Marquardt. “Climate change, heat stress, and US dairy production.” USDA-ERS Economic Research Report 175 (2014). 6. Huynh, Thi Thanh Thuy. Heat stress in growing pigs. Wageningen University and Research, 2005. 7. Horst, E. A., et al. “Evaluating effects of zinc hydroxychloride on biomarkers of inflammation and intestinal integrity during feed restriction.” Journal of dairy science 103.12 (2020): 11911-11929. About Gavin Boerboom Gavin Boerboom received his Bachelor’s in Biomedical Sciences and Master’s degree in Human Food sciences from Maastricht University in 2016. He joined Trouw Nutrition’s R&D department right after focussing on feed additives. In 2018 he combined this role in R&D with a PhD position at Wageningen University focussing on trace mineral nutrition in monogastric animals. He completed his PhD in 2021 and joined the Selko USA team afterwards focussing on providing technical support on trace minerals for the North American market. As of August 2022, he is part of the Global Selko Feed Additives team responsible for supporting trace mineral solutions in all animal species across the globe.
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