ISSUE FOCUS FEED & ADDITIVE MAGAZINE June 2023 31 Control - No LPS ZnSO4 IBZ ZnO 726 626 526 426 326 226 126 26 1,46 1,42 1,38 1,34 1,30 1,35 1,42 1,38 1,44 FCR 85 598 359 509 Hr 3 - d35 TNFα, pg/mL B A A A AB BC AB C B 57 58.6 Inorganics A B A 1.529 1.496 Egg mass, g FCR/doz egg 59 58.5 58 57.5 57 56.5 56 IntelliBond Inorganics IntelliBond 1.54 1.53 1.52 1.51 1.5 1.49 1.48 1.47 INTELLIBOND BENEFITS IN THE ANIMAL Because IntelliBond minerals suffer less from reactivity, their improved availability for animals means a higher likelihood of meeting the animal’s requirements. The ability to meet an animal’s nutrient requirements under different circumstances enables it to respond properly to stressors. This ability can help make animals more resilient in heat stress conditions. A trial done in Australia with the University of New England indicated that feeding IntelliBond rather than sulphate trace minerals improved laying hen performance in cyclical heat stress conditions, as shown by a better egg mass and improved FCR/ dozen egg (Figure 3). During heat stress, tight junction dysfunction can lead to the influx of lipopolysaccharide (LPS) from Gram-negative bacteria into the portal and systemic blood. This can lead to stimulation of macrophages to release pro-inflammatory cytokines like TNF-α. A LPS infection trial with pigs comparing IntelliBond to inorganic minerals showed that the use of IntelliBond alleviates the immune response and appears to mitigate the drop in performance induced by LPS (Figure 4). IntelliBond M MnSO4 Trial 1 Trial 2 Trial 3 Trial 4 Average 40 35 30 25 20 15 10 5 0 CV% complete feed IBM vs MnSO4 Figure 2. Coefficient of variation of Manganese within complete feeds. 10 feed samples were analysed per trial. Figure 3. Response of IntelliBond vs inorganics when fed to laying hens challenged with cyclical heat stress. Figure 4. Response of pigs fed differentt sources of zinc during an LPS infection trial.
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