ISSUE FOCUS FEED & ADDITIVE MAGAZINE April 2023 51 About Josep Garcia-Sirera Josep Garcia-Sirera is a Technical Support Manager in the animal nutrition industry with over 20 years of experience. He holds a Ph.D. in Animal Science and a Master's degree in Animal Science from Michigan State University, USA, and a D.V.M. from Universitat Autónoma Barcelona, Spain. Josep is a licensed veterinarian in the Col·legi Oficial de Veterinaris de Barcelona, Spain, and a member of the American Society of Animal Science (ASAS). He has held various managerial positions and is currently the Global Technical Lead of Toxin Solutions at Agrimprove. There, Josep combines the responsibilities of supporting awareness of mycotoxins’ impact on animal health as well as expanding the current understanding of endotoxins in agriculture. tokine production that results from endotoxin activation of the inflammatory response. As mentioned before, the cytokines studied in this trial were very similar to those that have been associated with SINS. SINS is known to result from a range of factors, including stress, production practices, genetics, and endogenous causes. Inflammatory cytokines play a role in the pathogenicity of SINS, as they mediate the action of both SINS and LPS (endotoxins). This relationship supports the theory that LPS is one of the causes of SINS. By using toxin binders to regulate LPS action, we can mitigate the severity of SINS. Piglet A 1) Control loops with no LPS induced 2) 200,000 EU LPS 3) 200,000 EU LPS + HSCAS (0.3% w/v) 4) HSCAS (0.3% w/v) Piglet B 1) Control loops with no LPS induced 2) 200,000 EU LPS 3) 200,000 EU LPS + HSCAS (0.3% w/v) Figures 3-4. When the toxin binder (HSCAS) was included, the production of inflammatory cytokines was decreased The inflammatory cytokines measured via qPCR analysis were IL-1β, IL-6, and MCP-1.
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