ISSUE FOCUS FEED & ADDITIVE MAGAZINE April 2023 39 can support animal global health from mycotoxins negative effects. It can be antioxidant, immunostimulatory agents or specific amino acids or other molecules that can allow liver, gastro intestinal tract, kidneys, and other organs to function without interference from toxin. It can also involved compounds that strengthen the intestinal barrier and tight junctions, thus limiting the transfer of endotoxins or (emerging) mycotoxins into the organism. For example, in pigs, deoxynivalenol is known to affect immune response and impaired gut health, by reducing the proliferation of enterocytes and the intestinal surface, resulting in impaired weight gain. Due to this chemical structure, DON is also well known to be poorly managed by adsorption strategy. A trial performed on 32 piglets per group, with 21 days post-weaning piglets supplemented by Bacillus strains for 21 days and receiving 0.9 mg DON/Kg of complete feed, has shown that Bacillus significantly limit the passage of DON in serum (Figure 3). Since these bacteria didn’t show evidences neither for adsorption, nor for biotransformation/biodegradation effects in vitro, the prevalent hypothesis was their bioprotection effects, as largely well-documented in literature data through their ability to reinforce tight junctions of the gut barrier to limit the mycotoxins, specially DON, transfer into the organism. This bioprotection effect was associated with improvement of animal performance, with an increase of weight gain between days 14-21 of + 64 g (+8%) (p value = 0.09). Mean weight gain (g/D) were 720 and 784, for contaminated DON control group and supplemented group, respectively. The best strategy to counteract the adverse effects of biotoxins on animals: to combine complementary actions - In vivo results in poultry Considering the ubiquitous presence of multiple mycotoxins, their different levels and also the diversity of other environmental and stresses that animal have to cope in their production cycle, especially with the presence of other biotoxins such as bacterial toxins, the best strategy to counteract the adverse effects of toxins on animal is to combine complementary actions. Based on this principle, the MiXscience premium product Multiprotect Up, is an association of carefully selected ingredients, including Bacillus strains, that allow to combine multiple mode of action, such as adsorption, biotransformation and bioprotection properties. In different production context, it has demonstrated its ability to support animals coping with naturally, low and multiple mycotoxins challenge through different animal species contributing also to their better health and performance. In broilers, a study was performed in Ivory Coast, with locally raw materials naturally challenged with mycotoxins, mainly aflatoxins, fumonisins (FB1 and FB2) and deoxynivalenol with levels up to 0.8, 1.7 and 0.05 mg/Kg of finished feed, respectively. Compared to the control group, in supplemented group, body weight was significantly increased (+ 60g; +3%), the final mortality of the animals was reduced, and blood analysis showed a significant decrease in Figure 3. DON (µg/L) in piglets' serum at 21 days (Tarrallardona et al., 2022)
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