January 2023 Year: 3 - Issue: 24 Matthijs de Jong, Orffa Additives The natural way to support a pet’s gut health Tien Le, Alltech The future of antibiotics in poultry feed Nataliya Roth, DSM Global success to reduce antimicrobial consumption in farm www.feedandadditive.com Antibiotic Reduction Strategies and Alternative Feed Additives
Frankly, about 10 years ago, I thought we were living in one of the most ordinary period in the history of the world. Yes, a lot had happened until that day, but at that time we were living a routine life in a routine world… But it was never ordinary… As people in the world, we continued to experience many things. While preparing a leading article for this first issue of 2023, I wanted to go back and look at what we went through. Actually, my aim was just to use the past to create a preview for the future, but I lost control and got lost myself in the events of the past. As a result, I found myself compiling to share some different events with you which marked the world's agenda in the last 10 years… For example; • The economic crisis and protests in Greece • Syrian civil war and refugee crisis • Macron era in France • The Panama Papers leakage • Donald Trump's election as US President • Terrorist attacks in Europe and escalation of racism • Mosque attack in New Zealand • Amazon fires in Brazil • The young Swedish environmentalist Greta Thunberg bocoming the symbol of the climate movement • Coup attempt against Maduro in Venezuela • Historical summit between North and South Korea • Yellow vest protests in France • The death of the world-famous physicist Stephen Hawking • Assassination of Saudi journalist Jamal Khashoggi • Assassination of Maltese journalist Daphne Caruana Galizia • Brexit negotiation process and the UK's withdrawal from the EU • Paris Climate Agreement • #Metoo, the women’s movement • Annexation of Crimea by the Russian Federation • Catalonia's independence movement from Spain • Iran Nuclear Deal • Russian invasion of Ukraine • The Queen II. Elizabeth's death • Mahsa Emini protests in Iran • Acquisition of Twitter by Elon Musk • World population exceeding 8 billion • Biden's victory in the US presidential elections and the Capitol attack by a crowd of Trump supporters • Coup in Myanmar • Egyptian military coup • Covid-19 pandemic • Blockage of the Suez Canal • Flying a helicopter on Mars • El Salvador becoming the first country to use Bitcoin as legal tender • Taliban takeover in Afghanistan • Promising to stop using coal and forest loss at COP26 • End of Merkel era in Germany • Assassination of Qassem Soleimani and shot down passenger plane in Iran • Extinguished Bushfires in Australia after 240 days • Explosion in Lebanon's capital Beirut • Nagorno-Karabakh conflict between Azerbaijan and Armenia • …. and of course much, so much more… While reading all this, have you thought that bad events are more on the agenda than good ones? Do you remember that some of them have a serious impact on our industry as well? No event should be trivialized because it takes place in another part of the world or in another area…The butterfly effect also includes spreading to the world or to different areas. I wish 2023 and beyond will be remembered with good events and successes and only their positive effects will spread to our world and our industry. See you in the next issue. Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors Bahadır Büyükkılıç Burak Varol [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Publication Type: Periodic (Monthly) EDITOR THE 10 YEARS WE LEFT BEHIND… Derya YILDIZ © Three Plus Media | All rights reserved. Reproduction, in whole or in part, is prohibited without the written permission of the publisher. *DISCLAIMER: All views and ideas expressed in articles published in the magazine reflect the point of views of the author(s), not that of the Editor-in-Chief, Editors, Editorial Board or Publisher of Feed & Additive Magazine. The Editor-in-Chief, Editors, Editorial Board and Publisher assume no responsibility or liability in such cases. The publisher does not give any warranty and representation to the accuracy or completeness of the contents and data published in the magazine. All responsibility of the contents, articles and information published in the magazine belongs to the authors. The publisher and the authors cannot be held responsible for any damages resulting from the use of the whole or part of the content of the magazine. feedandadd i t i ve
We know you want to help reduce antimicrobial resistance, but it’s hard to know where to begin. Our integrated feed-farm-health approach can help you use antibiotics more responsibly – one step at a time! Antibiotic Reduction Program Prepare your business for the future! Learn more about these and other potential switches on www.trouwnutrition.com/switch
C O N T E N T S 18 ISSUE FOCUS 26 FEED ADDITIVES TO DECREASE ANTIBIOTIC USE IN FISH AND SHRIMP PRODUCTION Matthijs de Jong, Orffa Additives BV. 38 MULTIPLE MODES-OF-ACTION MAY HELP WHEN AGPs ARE REMOVED By Amlan International 46 GLOBAL SUCCESS TO REDUCE ANTIMICROBIAL CONSUMPTION IN FARM ANIMALS Nataliya Roth, DSM Animal Nutrition and Health 20 HOW AN ADDITIVE STRATEGY CAN DECREASE ANTIBIOTICS IN LIVESTOCK? Giseli Heim & Yvonne van der Horst & Barbara Brutsaert, Trouw Nutrition & Selko® 32 SEAWEED HAS A POSITIVE INFLUENCE ON THE GUT MICROBIOME OF SWINE Ian Hutchinson, Ocean Harvest Technology 42 THE FUTURE OF ANTIBIOTICS IN POULTRY FEED Tien Le, Alltech SPECIAL NEWS ARGENTA ACQUIRES PEN & TEC 16 ANTIBIOTIC REDUCTION STRATEGIES AND ALTERNATIVE FEED ADDITIVES
C O N T E N T S ARTICLES AB Agri begins to grow algae in Pond Algae Lab 8 Alltech European Harvest Analysis points high levels of mycotoxins 12 BioMar appoints Andrew Campbell as CEO for AQ1 78 QRILL Pet partners with Chinese pet food brand Fullpet 86 Animal protein industry to face high costs along in 2023 14 Salmon producers are among top 10 in new sustainability index 81 Si-Ware collaborates with Eurofins Agro 88 ADM reveals 5 trends influencing pet nutrition, health & wellness 74 Japfa Vietnam opens state-of-the-art poultry hatchery 76 Amlan International celebrates 15th anniversary with new website 83 NEWS REPORTS WORLD COMPOUND FEED MARKET 68 56 ALPHA KETOGLUTARATE – A PROMISING SUPPLEMENT IN AQUAFEED Gokulnath S R & Phibi Philip Naduvathu, Tamil Nadu Dr J Jayalalithaa Fisheries University 62 FISH PROTEIN HYDROLYSATES IN AQUAFEED G. Sathishkumar & Mir Ishfaq Nazir, Tamil Nadu Dr. J. Jayalaithaa Fisheries University 50 BAN OF PHARMA ZNO IN PIGLETS: TIPS ON ITS MODE OF ACTIONS TO SELECT PROPER ALTERNATIVES Agathe Romeo & Jennifer Maurin, Animine 53 FEEDING BEHAVIOUR: UNDERSTANDING THE SCIENCE BEHIND FEED PALATABILITY Dr Stéphanie Ladirat, NUQO
NEWS 6 FEED & ADDITIVE MAGAZINE January 2023 Nutreco has been named ‘Most Innovative Company in the Animal Nutrition Industry - 2022’ by World Finance, the influential international business quarterly. The accolade is part of the publication’s annual Innovation Awards, which honour excellence in various industries. "Receiving the award is a positive endorsement of our achievements to date. The work we have done in harnessing cutting-edge science and technology in animal nutrition and sharing expertise on new farming techniques with our customers is already shifting the dial and enabling farmers to improve productivity," said Nutreco representatives. "The ‘Most Innovative Company in the Animal Nutrition Industry’ award is also a powerful reminder that only by continuing to push boundaries will we be able to deliver the outcomes we seek over the longer term." "Better nutrition for fish, shrimp and land animals will be an essential part of the fundamental changes Nutreco named ‘Most Innovative Animal Nutrition Company’ Nutreco has been honored by World Finance with the "Most Innovative Animal Nutrition Company" award, part of the annual Innovation Awards honoring excellence in various industries. Danish food ingredients and enzymes makers Novozymes and Chr. Hansen announced that they have agreed to merge. As part of the merger, which is expected to be completed in the fourth quarter of 2023, Chr. Hansen will be dissolved. Novozymes and Chr. Hansen have entered into an agreement to create a leading global biosolutions partner through a statutory merger of the two companies. The combination is expected to unleash the full potential of biological solutions and generate significant value for all stakeholders and society at large. The proposed combination of Novozymes and Chr. Hansen Holding will create a strong biosolutions group with a broad biological toolbox and a diversified portfolio across markets. Uniting two strategically complementary biosolutions companies will accelerate their already best-in-class performance. Novozymes and Chr. Hansen together will meet customers’ growing demands for efficient, scalable, and sustainable biosolutions. The combined group will have a global talent pool of diverse and passionate employees who will benefit from its strong purpose-driven culture, expanded global presence and shared ambition to provide answers to the biggest challenges facing society. Together, the combined group will be equipped to stand stronger in addressing global challenges including enabling healthier lives, transforming food systems, and accelerating towards a climate neutral society. Novo Holdings A/S, the largest shareholder in both Novozymes and Chr. Hansen, has affirmed its confidence in the two companies being a perfect match, and that a transaction would create a global leader in biosolutions that would capitalize on attractive growth opportunities while serving societal needs. Read more>> Danish leaders Novozymes and Chr. Hansen join forces
NEWS FEED & ADDITIVE MAGAZINE January 2023 7 The Adisseo Group announced that it has signed an agreement to acquire NorFeed and its subsidiaries, a French group that designs, manufactures, and markets plant-based specialty ingredients and plant extracts for animal nutrition. This acquisition is part of the Adisseo Group’s global leadership strategy for specialty feed ingredients. This investment is a key step for Adisseo in its strategy of developing specialty ingredients, and its ambition to make Nor-Feed a French leader in functional plant extracts for animal nutrition. By offering natural and sustainable solutions to its customers, Adisseo is positioning itself on a market with an annual growth of almost 10%. Adisseo and Nor-Feed have already identified some synergies, in particular, to strengthen and develop the penetration and adoption of these products in very high growth markets where Adisseo is already well-established and has real legitimacy. Nor-Feed will continue to autonomously manage its R&D, production and sales network. Olivier Clech and Pierre Chicoteau will continue to lead the company. ADISSEO will give Nor-Feed the benefit of all its expertise and network to help it achieve its objectives and implement the synergies identified. “We are pleased to have signed an agreement to acquire the NorFeed Group, which is consistent with the Adisseo mission to offer its customers sustainable, affordable, qualitative, and safe solutions. This operation is part of our strategy to accelerate the growth of our Specialty products on unique and differentiating technologies,” said Jean-Marc Dublanc, CEO of Adisseo. Read more>> Adisseo acquires French plant-based ingredient producer Nor-Feed we need to make to achieve our mission,” the representatives said. "Our Innovation teams work to help farmers optimise their practices with data-driven decision making through precision farming and nutrition; customised to an animal’s specific requirements. This helps farmers produce more, strengthen animals’ health and resilience and reduces the need to use external additions such as antibiotics in a sustainable way. So, while we remain fully committed to supporting animal and fish farmers, we know that to feed a growing population, our industry must maximise all sources of food protein." For Nutreco this means adhering to its core principle of “and/and” rather than “either/or” and continuing to investigate different ways to optimise all protein sources, including plant-based proteins, cultured proteins and fungal fermentation. Through its NuFrontiers team, for example, the company has developed innovative partnerships with the likes of Mosa Meat, BlueNalu, Enough and Roslin Technologies. The company's newest team NutEx (short for Nutreco Exploration) was set up to explore new science that unlocks novel nutritional solutions for animals. The company's representatives said that they have especially focused on exploring the potential of phytotechnology and biotechnology, to capitalise on the tech-accelerated “big bang” in biological sciences over the last 15 years. Read more>>
NEWS 8 FEED & ADDITIVE MAGAZINE January 2023 Layn Natural Ingredients, one of the world’s largest vertically integrated innovators and direct manufacturers of natural botanical extract ingredients and solutions, announced its new European office within the Savona Sustainability Campus of the University of Genova in Italy. This move reflects the company’s commitment to research, innovation and sustainability. The University has a stringent qualification and approval process requiring tenant companies to meet strict social and environmental responsibility criteria and demonstrate a true commitment to sustainability. Layn fully met 100% of these requirements. The new strategic location is also home to a number of other large corporations, governmental energy providers, and startups dedicated to renewable energy and other environmental solutions. The campus provides opportunities and collaboration for research, connection and exchange of ideas through shared lab spaces, internship programs and R&D opportunities. “It is a great honor for Layn to be a part of this collaborative campus community whose values align so well with ours regarding sustainability, ecology, renewable energy, biomass upcycling and social responsibility issues,” said Luca Pennestri, General Manager, EMEA at Layn Natural Ingredients. “This environment drives and inspires discovery and innovation through open collaboration among companies, government agencies, students and PhDs.” Read more>> Layn Natural Ingredients opens its new European office AB Agri begins to grow algae in Pond Algae Lab Pond Technologies Holdings announced that AB Agri has begun to grow algae following the delivery of a Pond Algae Lab. The initial algae grown in this lab will be used in the bioreactor scale up process. Pond Technologies Holdings Inc., an ESG company addressing global sustainability challenges of wellness and climate change, has provided an update on its agreement with Livalta, an AB Agri company which is a subsidiary of Associated British Foods. Pond explained that the installation of an algae lab, along with a number of Pond designed algae bioreactors, has been successfully installed on site at AB Agri’s British Sugar plant in Wissington, UK. Pond built a system of smaller 60 L bioreactors and controls at its Canadian headquarters in Markham, Ontario, and has delivered, installed, and commissioned the system at the AB Agri Wissington location. Pond worked with AB Agri to specify the equipment needed to set up the lab which is an important step to support the 1,500 L and 10,000 L pilot bioreactors in Wissington in 2023. The initial algae grown in this lab will be used in the bioreactor scale up process. “This is our first step towards piloting Pond’s technology to grow algae using CO2 emissions as feedstock – or, as we would put it, take a problem (CO2 emissions) out of the air and convert it into high value protein. There is still some way to go, but we have made a start with a great team effort between Livalta, AB Agri, British Sugar and Pond Technologies,” said Valerie Schuster, Managing Director of Livalta (a division of AB Agri). Read more>>
NEWS FEED & ADDITIVE MAGAZINE January 2023 9 Louis Dreyfus Company B.V. (LDC) announced the creation of a new Food & Feed Solutions Platform (or business line) within its Value Chain Segment from January 2023, to address favorable market trends and customer preferences toward healthy, nature-based products. The new platform will focus on developing and growing LDC’s presence in the lecithin, glycerin and specialty feed protein space, leveraging the Group’s strong raw material origination and processing capabilities. “Demand growth for ingredients of natural origin is accelerating, fueled by increasing use in functional foods, nutraceutical products, personal care products and other non-food and industry applications,” said Michael Gelchie, LDC’s Chief Executive Officer. “As part of LDC’s strategic plans for revenue diversification through more value-added products, we see an opportunity to participate in this rapidly growing nature-based ingredients market.” With its global asset network and market presence, the Group is well-placed to scale up its participation in the nature-based ingredients market, both through organic growth of production capacity and through targeted acquisitions and investments to diversify and expand the geographic scope of its portfolio. Read more>> Louis Dreyfus Company creates new platform for natural ingredients Supplant D The third generation of fiber • Lowers E. coli colonization • Improves feed conversion ratio • Optimizes for health & profitability • Increases piglet performance agrimprove.com Vitafibra
NEWS 10 FEED & ADDITIVE MAGAZINE January 2023 Ÿnsect establishes insect farms in Mexico and US Rumin8 expands global footprint to the US Ÿnsect, one of the world leaders in insect production, announced that it will establish new insect farms in Mexico and the USA. Ÿnsect signed an agreement with Corporativo Kosmos to establish a new insect vertical farm in Mexico and also to work with Ardent Mills for the project to expand its insect farm in the US. Mexico is the leading country in terms of consumption of insects and insect-based proteins. Ÿnsect's new insect farm would offer proximity to the United States, by far the largest future market for insect protein. In November 2022, Antoine Hubert, CEO of Ÿnsect, and Jack Landsmanas, CEO of Corporativo Kosmos signed an exclusive Joint Development Agreement (JDA) to begin developing this insect farm in Mexico. This agreement marks the continuation of a two-yearlong collaboration between two key players within the global food industry: Ÿnsect, the world leader in insect production, and Corporativo Kosmos, leader in providing comprehensive food and food facilities services in Mexico. The company also announced its intent to expand its insect production sites within the United States. The move builds off Ÿnsect’s first mealworm farm opening in March 2022 in Nebraska. Ÿnsect anticipates initial construction on the additional production site to begin by end of 2023. As part of this expansion, Ÿnsect will explore potential synergies with Ardent Mills, the premier flour milling and ingredient company. “Ynsect aims to help contribute to reinventing the global food system, while also focusing on sustainability. We are excited to examine potential opportunities with the North America leader in flour milling. This exploration marks the start of potential collaborations between two key players within the global food industry,” said Hubert. Read more>> Rumin8 announced that it will open an office in Northern California, US. Rumin8’s expansion to the United States provides the company with exposure to a significant source of capital for climate technology start ups from climate impact funds, as well as proximity to a large market of sophisticated beef and dairy industry participants seeking to reduce their impact on global warming. Rumin8 Chief Commercial Officer Kosta Stavreas said the company’s expansion to the United States coincide with significant investment from the US Department of Agriculture in market opportunities for American agriculture participants to be leaders in climate-smart agricultural production. “The appetite for methane reducing solutions is astounding in the US market and participants in both dairy and beef have pushed open a door for us to enter the market,” he said. Stavreas will head up Rumin8 USA as well as leading Rumin8’s commercial expansion. “It’s an exciting time to be in the US with growing interest from the private sector to develop these technologies, as well as producers being open to trying new solutions that will help reduce livestock greenhouse gas emissions,” said Stavreas. “The new office will be a base for the Americas and help us to work regionally with key markets where there are more than 400 million head of cattle concentrated across a small number of countries.” Read more>>
NEWS FEED & ADDITIVE MAGAZINE January 2023 11 Rabobank explains challenges of poultry industry to face in 2023 Rabobank has announced its foresights of global poultry industry for 2023 in its report titled “Poultry Quarterly Q1 2023: Outlook 2023 – Bullish Markets Amid Rising Cost, Supply, and Avian Flu Worries”. For most markets, the outlook for 2023 is positive according to the report. Demand remains strong and supply limited, but the context is changing. An economic downturn will affect market conditions, and ongoing high inflation will pressure consumer spending power. This typically translates to strengthening demand for chicken, eggs, and cheaper cuts, and, in markets where more expensive, slower-growing, and organic options are available, strengthening demand for conventional chicken products. Although a rising number of countries are risking oversupply, global markets are expected to stay strong in 2023, with global poultry demand expected to benefit from trading-down. However, in many countries, demand growth will be restricted by tight supply, leading to ongoing high prices. Although chicken is the best positioned protein in terms of affordability, it raises the question of what price consumers are prepared to pay. This could lead to demand destruction, especially among low-income consumers. This is happening globally but especially in emerging markets in Asia, Africa, and Latin America. Read more>> Cherkizovo Group has won the auction for the sale of Russian Grain Ufa's poultry, crop, and fodder production businesses. The acquisition will strengthen the company's position in the poultry market in the Urals and neighboring regions. In the auction held at the Auction House of the Russian Federation for the sale of the assets of Russian Grain Ufa, the seller was the non-core asset bank Trust. The single lot included 100 % shares in JSC Bashkir Poultry Farm, JSC Turbaslinsky Broilers, JSC Ufa Grain Products Plant, Bashkir Grain+ LLC, Bashkir Grain LLC and Turbaslinsky Broiler Trading House LLC, as well as rights to claim under loan agreements between Trust and JSC Bashkir Poultry Plant and JSC Turbaslinsky Broilers. The winning bidder was AIC Mikhailovsky (part of Cherkizovo Group), which had previously obtained approval from the Federal Antimonopoly Service to acquire these assets. The purchase price is RUB 6.37 billion (about US$92.2 million). For Cherkizovo Group, the acquired companies are the first production assets in Bashkortostan. They include five poultry farms with an annual live-weight capacity of 65,000 tonnes of broiler meat, annual processing capacity of 25,000 tonnes, annual marketable egg production of 750 million eggs, a feed mill with an annual capacity of 240,000 tonnes and a land bank of 18,000 ha. Read more>> Cherkizovo acquires Bashkortostan’s largest agricultural holding
NEWS 12 FEED & ADDITIVE MAGAZINE January 2023 Alltech, one of the leading companies in the animal nutrition industry, announced the results of the 2022 European Harvest Analysis. The analysis reveals that grains in Europe contain high levels of mycotoxins due to drought. According to the company statement, similar to 2021, widespread drought throughout Europe during the 2022 growing season has directly impacted the presence of moulds and mycotoxins in new crop grains and forages. The Alltech 2022 European Harvest Analysis uncovers the true threat mycotoxins pose to animals and producers. To determine the most accurate representation of mycotoxin risk across Europe, Alltech has again collaborated with SGS, a global leader in mycotoxin testing and certification. Data for this programme has been collected for key feed ingredients on a regional level, and analysis indicates moderate to high levels of mycotoxin risk. The results of the 2022 analysis are based on over 1,000 samples of the most common grains and forages produced and used in the European livestock industry. Samples have been collected from farms or animal feed production sites in 20 different countries, offering a representative picture of the contamination risk in all regions, with an overall moderate to high risk. ''Generally, the current results look very similar to the analysis we performed in 2021, with the aflatoxin issue in Central and Southeastern Europe dominating the headlines and creating the greatest challenge for feed and livestock producers to manage,” said Dr. Radka Borutova, European technical support manager with the Alltech Mycotoxin Management team. Read more>> Fonterra and Nestlé agreed the sale of their Dairy Partners Americas (DPA) Brazil joint venture to French dairy company Lactalis for BRL 700m (approximately NZD $210m subject to closing transaction adjustments). The deal is expected to be completed by mid-2023, subject to regulatory authority approvals. Fonterra Chief Executive Miles Hurrell says the sale of DPA Brazil is aligned with the Co-op’s strategy of prioritising its New Zealand milk pool. “DPA Brazil has reached maturity as an investment for us, and the sale allows us to prioritise our resources to the businesses that are core to our strategy.” Hurrell said that Fonterra was pleased to have secured the sale, which had been delayed due to market conditions related to COVID-19. DPA Brazil has been held for sale in Fonterra’s financial statements since January 2020. Fonterra and Nestlé created DPA in 2003 to manufacture and commercialise dairy products throughout Latin America. In 2014, the joint venture refocused its activities on Brazil and chilled dairy. Fonterra holds a 51% stake and Nestlé 49%. DPA operates two plants and employs 1,300 people. Nestlé, Chamyto, Ninho, Chandelle, Chambinho, Neston and Molico are among the well-known brands marketed by DPA in Brazil. Read more>> Fonterra and Nestlé agree sale of DPA Brazil joint venture Alltech European Harvest Analysis points high levels of mycotoxins
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NEWS 14 FEED & ADDITIVE MAGAZINE January 2023 Rabobank announced its report titled Global Animal Protein Outlook that includes forecasts for 2023. According to the report, even though global animal protein production is expected to grow modestly in 2023, it will be another year of change for the sector. The industry will face high costs along the full supply chain, swings in consumption, and other areas of uncertainty for producers, such as elevated disease pressure and regulatory and market-driven changes. As a result, margins will be squeezed as buyers push back on higher production costs. But opportunities still exist, although they will be more restricted. "We see growth favoring value-for-money products, efficient producers and processors, agile companies, exporters advantaged by FX movements, and biosecure producers," says the Rabobank's experts. “Some animal protein companies will see 2023 as a year to recalibrate their growth expectations and plans,” says Justin Sherrard, Global Strategist – Animal Protein. “Some companies will maintain a near-term focus and strengthen agility so they can roll with the cyclical changes. Other animal protein companies will focus on longer-term growth and start investing and positioning for success given the structural changes ahead.” The overall trend for 2023 is for production growth to slow further, with small gains in some regions but contraction in others for the main terrestrial species. Slow growth is expected in China across all species groups, and ongoing growth is expected in Brazil and Southeast Asia. Oceania will experience slow growth, while North American and European production will contract. Aquaculture leads global growth across the species groups, once again, and its continuing expansion is supported by its relative independence from agri commodity prices. Poultry is set to maintain its consistent growth pattern, wild catch is set to expand slightly, beef production will decline slightly, and pork will see a decline. Read more>> Rabobank report: Animal protein industry to face high costs along in 2023 The 15th CRU Phosphates Conference returns as a live, in-person gathering between 27 February to 1 March 2023 in Istanbul, Turkey. CRU Phosphates is an important annual gathering where the global phosphate community meet to network, do business and learn about the key trends and technical innovations affecting the entire phosphate value chain. Istanbul, located at the crossroads of Europe and Asia represents an ideal location to connect a global audience from across the international supply chain involved in the phosphate fertilizer, feed and industrial industries. Participants will have the opportunity to learn how the latest technologies are driving sustainability and efficiency improvements in the phosphate industry. As the leading annual forum regularly attracting 400+ senior commercial and technical decision-makers from across the supply chain, and over 50 exhibitors, the event in Istanbul in February offers the ideal opportunity to reconnect in-person for important discussion, debate, and business development. Read more>> CRU Phosphates Conference to be held in 2023 in Turkey Rabobank has released Global Animal Protein Outlook 2023 report. According to the report, margins will be squeezed as buyers push back on higher production costs, but opportunities still exist in the animal protein industry.
NEWS FEED & ADDITIVE MAGAZINE January 2023 15 HEALTHY ANIMALS. LET'S MAKE IT HAPPEN, TOGETHER. www.pentec-consulting.eu www.argentaglobal.com pharmaceutical sciences innovation clinical services regulatory services manufacturing Bunge to invest $550m in soy protein concentrate facility Bunge, a global leader in agribusiness, food and ingredients, plans to invest approximately $550 million to build a fully integrated soy protein concentrate (SPC) and textured soy protein concentrate (TSPC) facility. The new facility is expected to meet rising customer demand for key ingredients in the production of plant-based foods, processed meat, pet food, and feed products. Construction of the facility, which will be adjacent to and integrated with Bunge’s soybean processing plant in Morristown, Indiana, is expected to start in the first quarter of 2023 and to be commissioned in mid-2025, creating around 70 full time jobs. It is expected to ultimately process close to an additional 4.5 million bushels of soybeans. “As the world’s largest oilseed processor, plant proteins are a natural extension of our industry leading oils, fats, and specialty ingredient portfolio. This new facility is an important step in our long-term strategy to strengthen our capabilities in downstream higher value food ingredients,” said Greg Heckman, Bunge CEO. The new facility is expected to add significant scale, efficiencies, and non-GMO capability to the company’s existing US-based conventional SPC and TSPC operation in Bellevue, Ohio. The company plans to contract with farmers to establish a traceable soybean sourcing program starting with the 2025 harvest. Read more>>
NEWS 16 FEED & ADDITIVE MAGAZINE January 2023 On 6 July 2022, Argenta acquired 100% of the shares of Pen & Tec Consulting S.L.U. This is exciting news as both these companies have a shared mission of working in close partnership with customers by providing high-quality services to assist in taking their products to market. The rationale behind the acquisition is that Argenta has a growth strategy to continue to improve services provided to global animal health and nutrition industry partners. With Pen & Tec on board, this will mean more longterm continuity for customers. Argenta is the only combined global contract research organization (CRO) and contract development & manufacturing organization (CDMO) dedicated to animal health. The company was founded in New Zealand in 2006 and has continued to grow throughout the world with operations in New Zealand, the United States, Germany and the United Kingdom. Pen & Tec will remain in the current location in Barcelona, Spain, which allows Argenta to further establish its presence within Europe. The combined business will offer clients a wide range of global capabilities and product development services, with the Argenta and Pen & Tec teams working in partnership with customers to stimulate innovation in the feed and food business. Pen & Tec will particularly complement Argenta's regulatory services teams based in Germany (Klifovet) and the United States, offering an unmatched level of expertise. Will Downie, CEO of Argenta, said: “Pen & Tec’s expertise in feed and food is well-recognized in the industry. We are very excited about the combined expertise of Argenta and Pen & Tec in the animal health market. This powerful combination will provide tremendous value for customers around the globe." Regulatory requirements for Europe have become increasingly stringent and difficult to navigate over the last few years. With Pen & Tec´s established footprint in the EU they will be able to continue assisting customers in obtaining regulatory approval for animal feed related products. Pen & Tec´s wealth of knowledge and experience will further establish Argenta as an authority in regulatory affairs to benefit current and future customers. Laura Payo Lewis, Regulatory Affairs Director – Animal Nutrition, said: “I am excited for what the future holds for Pen & Tec Consulting within Argenta, and am confident that we will be able to achieve more together through our combined knowledge, experience, and expanded service offerings. We will continue to advise companies on meeting regulatory requirements related to the food chain, and assisting in every step of the process of the product development journey until market access, including building top quality registration dossiers or running regulatory trials. Through an expanded geographical footprint, Argenta’s different business units can also offer commercial manufacturing and a variety of technology transfer solutions.” Customers will benefit from the expanded global capabilities in regulatory affairs, product research and development with the two companies coming together. A global footprint, increased service breadth as well as long-term continuity are but a few of the benefits to customers. Argenta´s vision of “Healthier Animals, Sustainably” positions the company to be involved in the European Union Green Deal projects. Argenta acquires Pen & Tec Combined knowledge, experience, and expanded service offerings for customers around the globe. SPECIAL By Dawn Botha, Technical Marketing Manager at Pen & Tec Consulting
NEWS FEED & ADDITIVE MAGAZINE January 2023 17 Elinor McCartney, founder of Pen & Tec, said: “Becoming part of Argenta provides our clients with access to a full range of services and solutions to get their products to market, and guarantees long-term business continuity for our customers as well as attractive career development opportunities for our global employee base and future talent. I am eager to continue our legacy as part of Argenta and am confident in a bright future together.” Going forward, we will be able to provide a complex, full range of services to assist our customers with their Molecule to Market ideas. Pen & Tec, as a part of the Argenta Group, will be able to cover the needs of our customers in the following areas as well: • The evaluation of market potential and strategic opportunities • Testing of the molecular entity to evaluate pilot efficacy and safety • Testing of the final formulation to evaluate pivotal clinical studies • Fully support the safeguarding the quality of the product from R&D to commercialisation • Commercial manufacturing in one of the three GMP-certified sites in New Zealand, the UK and the US Ing. Justyna Pałasińska, Regulatory Affairs Director – Human Nutrition, said: “Argenta is focused on animal health and nutrition. Nevertheless, I believe that they will be able to provide added value to Pen & Tec food clients as well. Their experience in manufacturing & product development can surely be extrapolated onto the food side, especially in regard to novel foods. I also look forward to introducing Argenta to the world of human nutrition & how we can grow in this area together.” Argenta together with their newly acquired business partners will be in London from 6-8 March, 2023 at the Animal Health, Nutrition and Technology Innovation Europe Summit hosted by Kisaco. As an Associate Sponsor of this prestigious summit, Argenta will be hosting a workshop on “A strategic approach to early-stage product development”. During this workshop, potential customers can: • get a perspective of early-stage development strategy in the area of their choice: veterinary medicinal products, animal nutrition, or medical devices. • gain clarity around the pre-clinical, clinical and regulatory requirements in the EU and the US market and the process for achieving approval • acquire insights on when and how to select the right partner(s) or strategic alliances to accelerate the development of your product We are excited to announce that the speakers for the event will be Dr Elinor McCartney, Founder of Pen & Tec Consulting; Dr Klaus Hellmann, founder of Klifovet as well as Dr Patxi Sarasola, Managing Director of Ondax Scientific. The speakers will also highlight the challenges of the economic downturn on clinical studies and discuss potential solutions. If you are considering attending this event, we invite you to join us at the workshop and meet out experts in person. We encourage customers to get in contact as this will be the first step in discovering new opportunities for their business. Our team is standing by to offer tailored solutions and exceptional service. Customers can keep in touch with us through multiple channels. Make sure to subscribe to our newsletter and stay up to date on the latest from Pen & Tec as well as news from the industry. We are active on social media and customers can follow us on Linkedin, Twitter as well as Youtube. Apart from regulatory services, we also host training sessions for the industry in the form of seminars and training video courses. We are excited for what the future holds and believe that this new acquisition will be an invaluable partner for animal health and nutrition customers globally. SPECIAL
ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE January 2023 ANTIBIOTIC REDUCTION STRATEGIES AND ALTERNATIVE FEED ADDITIVES
ISSUE FOCUS FEED & ADDITIVE MAGAZINE January 2023 19 How an additive strategy can decrease antibiotics in livestock? Giseli Heim & Yvonne van der Horst & Barbara Brutsaert, Selko® Feed additives to decrease antibiotic use in fish and shrimp production Matthijs de Jong, Orffa Additives BV. Seaweed has a positive influence on the gut microbiome of swine Ian Hutchinson, Ocean Harvest Technology Multiple modes-of-action may help when AGPs are removed By Amlan International The future of antibiotics in poultry feed Tien Le, Alltech Global success to reduce antimicrobial consumption in farm animals Nataliya Roth, DSM Animal Nutrition and Health
ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE January 2023 The start of a New Year is a good time to measure how much progress has been made toward achieving long-term goals. Reducing antibiotic use in livestock production is a critical goal shared by producers around the globe. Rising rates of antimicrobial resistance remain a global public health concern and some reports have projected that antimicrobial resistance could cause 10M human deaths annually by 20501. Encouraging progress is being made and the use of antimicrobials in agriculture is declining in many nations. A European Surveillance of Veterinary Medicine report published in November 2022 reports that sales of antimicrobials for use in food-producing animals in 25 countries fell 47% between 2011 and 2021.2 Similarly, the U.S. Food & Drug Administration’s summary report on Antimicrobials Sold or Distributed for Use in Food-Producing Animals published in December 2022 notes that domestic sales and distribution of medically important antimicrobials approved for use in food-producing animals decreased by 33% from 2012 through 2021.3 Despite these reductions, progress against antimicrobial resistance has lapsed since the pandemic.4 As 2023 gets underway, much opportunity remains to reduce antimicrobials and protect human and animal health. The good news is that it is possible to significantly reduce or even eliminate antibiotics in livestock production while achieving similar or even improved performance compared to antibiotic growth promoters. HOWAN ADDITIVE STRATEGY CAN DECREASE ANTIBIOTICS IN LIVESTOCK? “Antimicrobial reduction efforts around the globe have shown that an integrated approach to reducing antibiotics on the farm must consider feed, farm, and health management. Introduced in 2022, Trouw Nutrition’s ‘Small Switches. Big Change’ antibiotic reduction program is tailored to the objectives of each producer.” Yvonne van der Horst Selko® Global Product Manager Presan® Barbara Brutsaert Trouw Nutrition Sustainability Manager Antibiotic Reduction Program Giseli Heim Selko® Global Product Manager Gut Health
ISSUE FOCUS FEED & ADDITIVE MAGAZINE January 2023 21 ON THE FARM SUCCESS DEMONSTRATES THE BENEFITS OF AN INTEGRATED APPROACH Antimicrobial reduction efforts around the globe have shown that an integrated approach to reducing antibiotics on the farm must consider feed, farm, and health management. Introduced in 2022, Trouw Nutrition’s “Small Switches. Big Change” antibiotic reduction program is tailored to the objectives of each producer. For some farms, the goal may be to reduce the use of antibiotics for non-therapeutic purposes or to achieve certain reduction targets. Other farms may aim to eliminate antibiotics from their production. The program consists of five steps: 1. profile and understand the producer’s objective 2. assess the entire production environment 3. design a value-added program tailored to the farm 4. assist with implementation 5. evaluate the results and determine how much further to take the program Farms’ results show that small changes can indeed drive big improvements. A broiler integrator in Spain reduced its use of antibiotics by 95% over a six-year period, while lowering mortality by 36%. Similarly, a swine feed mill in Spain saw a decrease in year-over-year antibiotic use and, by 2021, it had reduced antibiotics by 86% compared to 2016. The feed mill continues to reduce antibiotics without sacrificing animal performance. ALTERNATIVE APPROACHES TO STEER GUT HEALTH When reducing the need for antibiotics, maintaining gut health is essential. Many times, chronic health issues in pigs and poultry are related to gut health challenges. About 70-80% of antibiotics used in poultry are intended to manage gut health problems. Given that most immune cells are in the gut, it stands to reason that improving gut health can also support immunity. This realization introduces possibilities to deploy feed additives such as combinations of organic acid blends; or change the source of existing dietary elements, like trace minerals, to better support gut health. Recognizing the importance gut health plays in animal health and performance, the Selko® portfolio of feed and water additives is designed around five-pillars (Figure 1). Selko invests annually to evaluate feed additives’ mode of action. R&D trials and field studies are conducted in global research centers, through partnerships with universities and on real-world commercial farms. Such research validates science-based feed additives that support the five pillars of gut health. Organic acids delivered in feed and in water provide an interesting opportunity to support multiple gut health objectives. For example, specific blends of organic acids dosed at the proper level have been demonstrated to lower the pH in the crop, provenFigure 1. Five gut health pillars of Selko Feed Additives.
ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE January 2023 triculus and stomach of broilers and pigs so that harmful bacteria find it hard to survive. At the same time, these carefully blended acids support efficient digestion. The gut barrier function can be strengthened, and the microbiota can be balanced using specially developed feed additives. Research on dietary components has revealed that the practice of super dosing copper in fast growing animals, such as broilers, is a long-used alternative to AGP’s for improving gut health. Supplementing copper above the nutritional level could help optimize intestinal structure and function and balance the animal’s microbiome, resulting in improvements to growth performance without antibiotics. However, it is important to consider the source of copper supplementation. For example, copper sulphate has weak ionic bonds resulting in high water solubility. This means the bonds break easily in the presence of moisture, releasing positively charged copper ions. Reactive copper ions can reduce feed intake, damage vulnerable tissue in the digestive tract, and bind with other nutrients in the feed, reducing their availability to the animal. With the advent of Selko® IntelliBond® C, producers now have an option to gain all the benefits of completely replacing copper sulphate with a less reactive copper source. And from a cost management perspective, IntelliBond® C offers an economically viable strategy for supplementing copper to support the animal. Reducing the use of antimicrobials in agriculture is a responsibility shared by stakeholders across the supply chain. Nutreco’s Sustainability Roadmap has established a set of metrics to guide its antibiotic reduction efforts. Beyond lowering overall antibiotic use and ensuring that medications are applied under direct supervision by qualified veterinarians when needed, the roadmap eliminates the use of any AGP or any antibiotic listed on the World Health Organization's “Critically Important for Human Health” list. Just one example of progress toward this goal is an initiative that reduced the use of amoxicillin in swine by 50% in 1 year at one important swine organization. A Roadmap for Sustainability Includes Reducing Antibiotics
ISSUE FOCUS FEED & ADDITIVE MAGAZINE January 2023 23 When fed at higher levels (125 to 155 mg/kg), copper has a bactericidal and bacteriostatic effect on the bad bacteria present in the animal gut microbiome. As bacterial levels are reduced, the gut can increase nutrient absorption, which positively impacts feed efficiency and growth rate. Feed and water offer dual opportunities to support animal health while antibiotics are removed from the diet. As a water acidifier, Selko®-pH contains a blend of buffered organic acids. In feed, the Selko® Presan®-FY gut health additive, containing patented slow-release C12, butyrates, and a phenolic compound, works to stabilize microbiota in the gut and improve the integrity of the gut barrier. Additionally, Selko’s hydroxy trace minerals (Selko® IntelliBond® C) delivers a strong antimicrobial effect and improves growth promotion in regions where feeding copper is highly regulated. RESEARCH VALIDATES EFFICACY OF ANTIBIOTIC ALTERNATIVES EQUAL TO AGPs IN BROILERS Collaborating with research facilities and universities, Selko conducted seven studies in different production environments with varying production schemes and regulatory requirements. The studies were conducted between 2017 and 2020. Researchers evaluated how a combination approach of using Selko-pH in water and Presan-FY (combined or not with IntelliBond C) in feed could influence broiler growth performance and efficacy compared to the use of antibiotic growth promoters (AGPs). Each study compared an AGP group (BMD or zinc bacitracin) with a combination of Selko products (Presan-FY, IntelliBond C, Selko-pH). Results revealed that the performance for birds receiving the Selko additives was equal to the performance of birds receiving AGPs (Figure 2). WHAT IS THE REAL GAIN WHEN REPLACING AGPs IN THE FIELD? A comprehensive, customized approach conducted in collaboration with the customer and combining feed, farm, and health management strategies across the entire value chain can drive even better performance. The combination of feed additives is a crucial part of Trouw Nutrition’s health management strategy Figure 2. Broilers’ performance relative to AGPs in seven independent studies of Selko Presan-FY and Selko IntelliBond C in feed, and Selko-pH in water Horizontal line indicates AGP performance results. BW (body weight), FCR (feed conversion ratio), AGP (antibiotic growth promoter), BMD (bacitracin methylene disalicytate). IntelliBond C included at high levels (125-155 ppm), AGPs (BMD, zinc bacitracin) included at 50-55 ppm. *Including IntelliBond Z and IntelliBond M, ** Including high copper sulphate Trial 1 2 3 4 5 6 7 Selko Feed Additives Presan-FY, IntelliBond C, Selko-pH Presan-FY, IntelliBond C, Selko-pH Presan-FY, IntelliBond C Presan-FY, IntelliBond C* Presan-FY, IntelliBond C Presan-FY, IntelliBond C Presan-FY, Selko-pH AGP Zinc bacitracin BMD BMD BMD BMD, Flavomycin Zinc bacitracin** Zinc bacitracin
ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE January 2023 About Barbara Brutsaert Barbara Brutsaert is Sustainability Manager Antibiotic Reduction at Trouw Nutrition, the livestock division of Nutreco. Trouw Nutrition is a global leader in innovative feed specialties, premixes, and nutritional services for the animal nutrition industry. Barbara holds a degree in Veterinary Medicine cum laude from the University of Ghent in Belgium. She started to work at universities and as an independent vet in South-Africa, Germany, and Belgium. After that, Barbara worked for four years for a multinational pharmaceutical company Johnson & Johnson, before joining Trouw Nutrition in 2003. The first eleven years working at Trouw Nutrition, she was a sales manager of feed additives, premix, and young animal feed in Belgium and partly in France. In 2014, she moved to the global organization, first as product manager for Selko health feed additives and then as a global program manager for gut health programs in monogastric, focusing on antibiotic reduction. Her expertise lies in implementing antibiotic reduction programs across the entire value chain at customers worldwide. She has authored several articles on gut health and antibiotic reduction for industry publications. Barbara’s passion and commitment is to support livestock producers to raise animals with healthy nutrition, in healthy conditions and with regular health monitoring to ensure a responsible use of antibiotics. About Giseli Heim Giseli Heim is veterinarian and holds a master’s degree in Veterinary Science (Swine Reproduction - Brazil) and a PhD in Animal Science (Swine Nutrition - Ireland). She works for Trouw Nutrition for almost six years, starting from Global Marketing Swine, joining Nutreco Africa as Swine Specialist and finally finding her passion in the Feed Additives, Gut Health Team, as Global Product Manager Gut Health. She has worked at Cargill (Spain), Orffa (Netherlands) and IDEXX (Netherlands). Giseli is originally from Brazil and has been living in Ireland, Spain and finally The Netherlands. About Yvonne van der Horst Yvonne van der Horst holds a Master’s degree in Animal Sciences from Wageningen University in The Netherlands. After working in a commercial position in the Animal behaviour sector, Yvonne acquired the position of technical manager Feed in the organic acids industry. In 2013 she moved to Selko Feed Additives in the position of technical manager Preservation and Health being responsible for technical support of the organic acid based portfolio. In 2016 she became responsible for the Presan portfolio as the Global product manager. and works alongside farm management improvements and optimizing the microbiological, nutritional, and physical properties of the feed. The integrated strategy effectively reduces the use of AGPs while supporting animal productivity and protecting producers’ economics. Next to the immediately tangible benefit of improved performance, customers are prepared for future trends and legislation. Additionally, reducing or removing antibiotics can help customers meet the requirements of market segments that command higher prices for their end products. For example, producers can meet the demands of retailers with specific requirements such as AGP-free or “no antibiotics ever” labels. By improving the resilience of the animal, results are more consistent. And from an animal welfare perspective, reducing the risk of antimicrobial resistance (AMR) helps assure antibiotics are available for responsible use when necessary to treat animals. Data proves that a combination approach utilizing a synergistic combination of Selko feed additives can support animal health and performance in AGP-free production. Rooted in science, the multifactorial approach supports animals by supporting gastrointestinal development and immunity functions, improving digestion, and optimizing absorption of essential nutrients. References: 1Tackling drug-resistant infections globally: final report and recommendations | The review on antimicrobial resistance 2European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) | European Medicines Agency (europa.eu) 3FDA Releases Annual Summary Report on Antimicrobials Sold or Distributed in 2021 for Use in Food-Producing Animals | FDA 4COVID-19 Reverses Progress in Fight Against Antimicrobial Resistance in U.S. | CDC Online Newsroom | CDC
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