ARTICLE FEED & ADDITIVE MAGAZINE December 2022 67 (1,3)-beta-glycosidic backbone with β-(1,6)-linked side chains of various lengths that are recognized by innate immune cells as microbial-associated patterns through the Dectin-1 receptor (Walachowski et al., 2017). β-glucans have also shown to increase phagocytic activity and the production of antibody titers (Jacobs et al., 2017). The effect of β-glucans on the production of antibody titers was seen in a Salmonella challenge experiment, where administration of Safglucan® containing more than 50% of β-glucans has led to a higher production of secretory IgA against Salmonella LPS and flagellin. Thanks to the potential of β-glucans to increase antibody titers, yeast β-glucans Safglucan® is also very efficacious vaccine potentiator. This is demonstrated in several vaccination trials, were the administration of Safglucan® led to the increase in titers against Newcastle Disease (ND). Safglucan® increased anti-ND specific antibodies in serum when supplemented through the diet (Figure 8). CONCLUSION The withdrawal of antibiotics from the poultry industry has made it clear that gut health is an important factor determining animals’ performance but also animal health and wellbeing. Yeast based advanced solutions have shown to be able to modulate gut health by interfering on several aspects e.g. stress and pathogen reduction, epithelial barrier strengthening and microbiota and immune modulation. As such yeast based nutritional products assurance to maintain animals’ performance and to meet global increasing food demands for high quality animal proteins while also improving animal health and welfare. Phileo by Lesaffre’s source references for this article are available upon request. Figure 8. Antibody titers against Newcastle Disease was increased in birds in Safglucan group, compared to control group
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