ISSUE FOCUS 26 FEED & ADDITIVE MAGAZINE November 2022 Cu had higher concentration of conjugated BA in the intestine (showing a lower deamination activity of BSH) than Cu sulfate group. Monovalent Cu group also presented significatively lower concentrations of secondary BA in liver and numerically (-18%) in colon content. One of possible explanations for the difference between Cu sources would be related to their ionic form. In vitro studies have shown the potency of monovalent copper (Cu+) over divalent Cu (Cu+2) in inhibiting gram-positive and gram-negative bacteria. This would suggest that monovalent Cu would have an indirect effect on BSH activity by reducing BSH-producer bacteria more than divalent Cu. 4. TAKE HOME MESSAGE For years, the use of monovalent copper (CoRouge®) in monogastric consistently resulted in higher body weight. Recent scientific investigations revealed that higher amount of conjugated bile acids produced by a healthy liver are only part of the explanation. Indeed, the unique ability of monovalent copper to modulate microflora also reduce bacterial deconjugation of bile acids and provides a higher fat emulsification capacity. This results in a better fat digestion and utilisation, providing more energy to improve performance. About Alessandra Monteiro Dr. Alessandra Monteiro is an animal scientist graduated in Brazil. In 2014 she started her PhD degree in Animal Production in partnership between the State University of Maringá (Brazil) and INRAe (France). In 2017, she worked as a Postdoctoral Research Associate at INRAe. Alessandra joined Animine in 2018 and have been working with the research and development group since then. About Axel Minetto He is an agronomic engineer and worked for the past 8 years in Valorex (France) where he gained solid monogastric and international skills to push nutritional solutions. His particulars skills are trace minerals, essential fatty acids, omega 3 enrichment, feed formulations, protein sources evaluations, nutritional matrix development and applications.
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