Feed & Additive Magazine Issue 21 October 2022

October 2022 Year: 2 - Issue: 21 Nick Piggott, Nutrition Technologies Unlocking the real value of insect meal Suzanne van den Eshof, Protix Insect protein - A sustainable alternative Christophe Blondet, ADM Exploring the future of animal resilience www.feedandadditive.com Impact of Increased Animal Welfare Trends on the Animal Nutrition Industry Alternative Protein Sources in Animal Nutrition

Dear readers, Although the global population growth rate will continue to decrease in the coming years, the world population is predicted to reach 8.5 billion by 2030 and 9.7 billion by 2050, according to the figures of the United Nations (UN) and UN Population Fund (UNFPA). This simply means that the world will need more food in the upcoming decades. As a matter of fact, feeding the animals raised to meet nutritional needs in a responsible and sustainable way on this planet with limited natural resources is now among the most important issues. As it is known; cattle, poultry and aquaculture have been fed mainly by grain, soybean and fishmeal for more than 50 years. Thus, the agricultural industry continues to take the pressure off our planet's limited natural resources while developing innovations for sustainable feed solutions that optimize productivity and animal health. However, according to the data of the UN Food and Agriculture Organization (FAO), feed production and processing account for 45 percent of the overall carbon footprint of livestock industry. According to the data of the US Department of Agriculture (USDA), 75% of the soybean produced in the world is used in animal nutrition. The World Wide Fund for Nature (WWF), on the other hand, is concerned about the damage to the ecosystem due to the rainforests used for the cultivation of soybean, which is consumed for both human and animal nutrition. Furthermore, experts predict that if climate change negatively affects this production, we may face a crisis in meeting protein needs. Based on this information, we see that the importance of alternative protein sources, which will minimize the environmental impacts of the feed industry and the use of arable land and which have high nutritional value for animals, is on the rise. And these resources need to feed livestock more sustainably and efficiently, and with less costs. So, is it possible to achieve this by protecting our planet for future generations? In this issue, we are focusing on alternative protein sources that will minimize the environmental impact without placing an additional burden on the existing nutritional ecosystem. See you in our next issue… Enjoy reading… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors James Watson Bahadır Büyükkılıç [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Branch: Ste B69, East Rutherford, New Jersey 07073, USA Publication Type: Periodic (Monthly) EDITOR How much possible to minimize the environmental impact for the feed industry? Derya YILDIZ All copyrights belong to Three Plus Media.© May not be used without permission. Responsibility of the ads belongs to the advertisers. feedandadd i t i ve

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C O N T E N T S 18 ISSUE FOCUS 26 INSECTS, A SUSTAINABLE PROTEIN FOR A GROWING MARKET Sabas de Diego, Co-founder and CTO, Tebrio 34 UNLOCKING THE REAL VALUE OF INSECT MEAL Nick Piggott, Co-founder and Co-CEO, Nutrition Technologies 46 PROGRESSIVE YET TRADITIONAL, SUSTAINABLE, AND ECONOMICAL PROTEIN... Masa Ivkovic, AgTech Expert, AFOS 42 EU POLICY AND INSECT ALTERNATIVE PROTEIN, PANACEA OR CHIMAERA? Jacopo Moccia, Political Advisor, Eurogroup for Animals (EfA) 52 INSECT PROTEIN - A SUSTAINABLE ALTERNATIVE Suzanne van den Eshof, Director Marketing & Business Development, Protix 60 FOOD FOR FEED Evelien van Donselaar, Business Manager Food2Feed, Selko Feed Additives 20 EUROPEAN INSECT SECTOR IS COMMITTED TO PROVIDING INNOVATIVE.... Christophe Derrien, Secretary General & Alice Grassi, Communication Manager, IPIFF 30 NON-CONVENTIONAL ALTERNATIVE PROTEINS IN FEED REGULATIONS IN THE EU Dawn Botha, Technical Marketing Manager, Pen & Tec Consulting 38 NEW SINGLE-CELL ALTERNATIVE PROTEIN: PROTONTM John Hays, VP of Commercial & Sales, Deep Branch 49 MEALWORMS FOR PREMIUM QUALITY, NUTRIENT RICH AND SUSTAINABLE PET FOOD Bénédicte Lorrette, PhD, Animal Nutrition & Health R&D Director, Ÿnsect 56 CREATING CIRCULAR ECONOMY FOR ANIMAL FEED WITH INSECTS Volant Wills, Head of Facilities at Canberra, Goterra ALTERNATIVE PROTEIN SOURCES IN ANIMAL NUTRITION

C O N T E N T S 68 EXPLORING THE FUTURE OF ANIMAL RESILIENCE Christophe Blondet, Vice President of Product Development & Applications, ADM Animal Nutrition 71 MINERAL AND ITS IMPORTANCE IN FISH NUTRITION Amit Ranjan, Assistant Professor, TNJFU-Institute of Fisheries Post Graduate Studies, India ARTICLES Alltech appoints Tara McCarthy as global vice president of ESG 83 Adisseo launches 180,000-ton-per-year liquid methionine project 8 Danisco Animal Nutrition & Health leverages FeedCalculator app 85 Cooperation between eniferBio and Skretting expanding 92 Lallemand Animal Nutrition opens offices in Poland 86 Bond Pet Foods closes $17.5m in Series A funding to scale meat proteins 97 ADM opens new extrusion facility in Serbia 89 AB Vista partners with Volac for Mycocheck, new mycotoxin service 90 NEWS REPORTS GLOBAL FEED PROBIOTICS MARKET 74 SPECIAL STORY IMPACT OF INCREASED ANIMAL WELFARE TRENDS ON THE ANIMAL NUTRITION INDUSTRY 64 Pierre-Joseph Paoli President of Feed Additives & Ingredients ADM Animal Nutrition

NEWS 6 FEED & ADDITIVE MAGAZINE October 2022 Innovafeed, a leader in the production of insects (Hermetia Illucens) for animal and plant nutrition, announced it has raised US$250 million in Series D funding. This round, led by Qatar Investment Authority (QIA), also includes existing investors Creadev and Temasek, and new strategic and financial investors: global agribusiness leaders ADM and Cargill – both of which have strategic partnerships with Innovafeed – as well as Future French Champions, ABC Impact, IDIA Capital Investissement and Grow Forward. This new round of financing brings Innovafeed's total cumulative financing to US$450 million. Innovafeed has already secured commercial partnerships for volumes representing more than €1 billion over the next 10 years. Innovafeed will use the capital to: • Continue to increase production capacity in France through the further expansion of its Nesle site in the north of France, the world's largest vertical insect farm; • Accelerate its international expansion, notably in the United States with the construction of a new production plant in Decatur, IL, in collaboration with ADM; and prepare global roll-out of Innovafeed's technology, including development in Asia; and Innovafeed raises US$250m in Series D financing round to accelerate growth Global science-based companies BASF and Evonik have joined forces in order to help customers to produce more sustainable feed and animal protein. BASF and Evonik entered into an agreement, granting Evonik certain non-exclusive licensing rights to Opteinics™ - BASF’s digital solution to increase understanding and reduce the environmental footprint of the feed and animal protein industries. Evonik integrates the digital ready-to-use sustainability platform Opteinics™ into its global feed consultancy services. Combining BASF's digital sustainability solution Opteinics™ with Evonik’s innovative farm management tools and sustainability services will help customers to produce more sustainable feed and animal protein. Opteinics™ is a software solution launched by BASF in 2021 to measure, analyze and minimize the environmental impact of animal protein, with an emphasis on animal feed production. Currently the software offers modules for pig and poultry production and can be integrated with feed formulation software. Opteinics™ for pork has recently been fully verified to conform with the ISO 14040 and 14044 LCA standards as well as with the UN Food & Agriculture Organization Livestock Environmental Assessment & Performance (LEAP) Partnership guidelines. Applications for the dairy value chain and for the optimization of compound feed mixtures will follow soon. With the use of Opteinics™, Evonik can even better support the livestock industry to make significant progress in fighting climate change, safeguarding ecosystems, and ensuring health and well-being as it works to achieve sustainable food production. BASF and Evonik are already targeting further developments in digital sustainability offerings as they both aim to help the animal production sector become more sustainable. BASF and Evonik partner to reduce environmental footprint

NEWS FEED & ADDITIVE MAGAZINE October 2022 7 RelyOn™ feed additive, a new solution by Phibro Animal Health to help support rumen health, animal efficiency and performance, has received validation from the Carbon Trust. This spring, Phibro Animal Health introduced RelyOn™ feed additive, a new solution to help support rumen health, animal efficiency and performance. Now, the alternative natural product has received validation from the Carbon Trust, a global climate consultancy, for its ability to reduce methane emissions. The validation is based on results from laboratory and onfarm testing against a valid baseline. Based on these test results, the Carbon Trust validated and formed the opinion that, when fed as directed, RelyOn can reduce methane emissions in ruminant livestock. RelyOn is a natural and innovative formulation that allows producers to maintain the performance of their high-producing animals while reducing methane emissions. Phibro, in conjunction with Vetos Europe, introduced the product to meet producer demand for a natural compound to help them achieve the performance trifecta of maintaining feed intake, increasing nutrient absorption and improving production. Phibro’s own preliminary research demonstrated the effectiveness of RelyOn in reducing methane emissions, a feat that led the company to seek this stringent, third-party validation. The Carbon Trust validation is the latest evidence of Phibro’s commitment to help producers meet the increasing demand for safe and affordable protein more sustainably. The company published its inaugural Environmental, Social and Governance (ESG) Report earlier this year to outline and establish baselines for its global ESG efforts. More than 120 countries, including the United States and the European Union, took the Global Methane Pledge at the United Nations global climate summit, or COP26. The participating countries committed to collectively reduce methane emissions by at least 30% below 2020 levels by 2030 in an effort to reduce global warming by 0.2 degrees Celsius by 2050. Carbon Trust validates GHG effects of Phibro feed additive • Continue to invest in breakthrough technology and R&D for the formulation of high-precision and high-performance ingredients for animals, plants and, in the future, for human food. "The confidence demonstrated in us by our partners through a new round of fundraising confirms the insect industry is a key solution for our planet's food production needs. Their support will allow us to accelerate our deployment in service of an ever healthier, natural and sustainable food system," said Clément Ray, Co-founder & CEO of Innovafeed.

NEWS 8 FEED & ADDITIVE MAGAZINE October 2022 Adisseo brings together the most recent information in recommendations and nutritional values to offer a unique platform: NESTOR, which gives nutritional recommendations for poultry & swine. In the current context of raw material prices increase and knowing the need to strengthen the sustainability of the animal protein production, it is critical to find ways of optimizing feed use by the animal. Lots of energic systems are already used to formulate diet for monogastric animals. Net Energy system is the most appropriate to be closer to the animal needs. Indeed, compared to metabolizable energy, formulating in Net Energy enables to focus on providing the nutrients used for the animal maintenance and for its growth (fat and protein deposit). Net Energy system is already used in 50% of swine production and has shown satisfactory results. There is a demand to use this system also in poultry. A lot of science exists on the topic, but it has never been brought to the market yet. With its long-standing expertise in feed formulation, and previous software for precise nutrition released on the market (PNE, Adict), Adisseo brings together the most recent information in recommendations and nutritional values to offer a unique platform: NESTOR. To formulate, there are two necessary elements: To know the animal's needs in the most accurate possible way and to precisely know the value of the feedstuffs given to the animals. NESTOR gives nutritional recommendations for poultry & swine in net energy, digestible amino acids and minerals to adapt them with specific conditions (rearing period, sex, age, breed). It also gives nutritional values for raw materials in proximate, energy, total & digestible amino acids and minerals. With these two sets of data, formulation in Net Energy gets easy! NESTOR provides: • Ready-to-use science: Find all the updated information on the nutritional recommendations and values to formulate. All shared data are supported by a supportive scientific board composed of eminent experts on energy topics. • A step further in formulation accuracy: use the recommendations which match the real needs of animals and are adaptable depending on the context and breeding conditions. • Support to better associate nutritional values and performance: optimizing the use of feed for animal performance. • Net energy formulation for more sustainable animal production by reducing waste and allowing the best use of alternative feedstuffs. NESTOR: A new software by Adisseo to formulate in Net Energy Adisseo, one of the world's leading experts in feed additives, held the start-up ceremony of the 180,000-ton/year liquid methionine project (BANC2) on September 16th. Being one of the core subsidiaries and the only company focusing on animal nutrition in Sinochem's life science segment, Adisseo is among the few manufacturers who can produce liquid and solid methionine simultaneously and owns the world-leading fully vertical-integrated production process for liquid methionine. The operation start-up of the 180,000-ton liquid Adisseo launches 180,000-ton-per-year liquid methionine project

NEWS FEED & ADDITIVE MAGAZINE October 2022 9 BE THE MASTER OF ENERGY! www.adisseo.com ADISSEO presents NESTOR A brand new innovating software to analyse Net Energy values. 4 Ready to use science 4 A step further in formulation accuracy 4 To convert performance effect in nutritional needs 4 Net energy formulation for sustainable animal production Feedstuffs Monogastrics Additives Requirements

NEWS 10 FEED & ADDITIVE MAGAZINE October 2022 methionine project signifies that Adisseo's Nanjing plant has scaled to new heights to become the single plant with the most significant liquid methionine capacity in the world. The official launch of the BANC2 means that the Adisseo Nanjing plant will double its methionine capacity to 350,000 tons annually. Adisseo will be vested with more space and flexibility to optimize its capacity allocation, thereby cushioning the impact of fluctuations in raw material and energy prices. Thanks to this new capacity together with its global market coverage and expertise in customizing digital spray systems, Adisseo is well equipped and confident to continue the penetration of liquid methionine in China and globally. As an expert with 80+ year industry experience in feed additives on a global scale, Adisseo strives to design, produce, and promote sustainable nutritional solutions in the field of animal feed, as stated by Adisseo CEO Jean-Marc Dublanc. Key players in the aqua sector launch a new feed for shrimp production Leading aqua sector experts Förde Garnelen, Aquafeed Germany, Protix, neomar and Crusta Nova announced that they have launched SHR EX, a new feed, giving a sustainable boost to shrimp production. Leading industry experts Förde Garnelen, Aquafeed Germany, Protix, neomar and Crusta Nova have joined forces to launch a new shrimp feed: SHR EX. The feed has been exclusively designed for the needs of European land-based shrimp farms as they increasingly move towards greater sustainability. SHR EX replaces marine proteins with locally produced insect protein from a circular process. The product, which will be sold by Aquafeed Germany, is not only more sustainable, initial research also shows a significant improvement in shrimp growth and survival rates. Shrimp consumption is growing across the globe. Traditional sea farming faces challenges such as the depletion of natural resources for feed, environmental destruction, disease and the use of antibiotics, coupled with issues arising from complex transport chains. Landbased farming, away from coastal areas, is a sustainable alternative, built around the concept of local production. It improves the growth and survival rate of shrimp and maintains shrimp welfare. However, it requires feed tailored for the demands of the shrimp and its farmers. Land-based shrimp producers increasingly want to create feed produced with locally sourced ingredients in response to growing consumer demand for sustainability. Moreover, the feed needs to be healthy and taste good. The partners worked closely together to develop SHR EX, using the black soldier fly produced by Protix in the Netherlands as the insect protein source. Crusta Nova and Förde Garnelen are implementing insect meal in their specially developed land-based shrimp feeds for the first time in Europe.

NEWS FEED & ADDITIVE MAGAZINE October 2022 11 OCP Group to acquire 50% stake in GlobalFeed Morocco-based OCP Group, a global phosphate based products plant and animal nutrition leader, has signed a deal to acquire 50% of GlobalFeed from Fertinagro Biotech, a major Spanish fertilizers producer. OCP Group, a global phosphate based products plant and animal nutrition leader, has signed a definitive agreement under which OCP would initially acquire 50% of GlobalFeed S.L. from Fertinagro Biotech S.L., a major Spanish fertilizers producer. GlobalFeed operates in the animal nutrition segment, manufactures and distributes a wide range of products, including phosphate based commodities and high value solutions dedicated to several species. The Company owns flexible production units with a capacity of 200,000 tons of phosphate based products and 30,000 tons of iron sulphate located in Huelva, Spain and benefits from a large global sales footprint. The animal feed market has been strong these last years thanks to livestock production growing around the world, in order to feed the population’s increasing needs for adequate meat and protein products, especially in the emerging countries of the global South. In this context, this transaction will contribute to OCP’s strategy to grow in the animal nutrition segment by expanding its presence geographically and offering a diversified, customized and innovative product portfolio. The transaction is subject to customary closing conditions, including regulatory approvals. France-based Animine, one of the leading suppliers of precision minerals, has partnered with Grupo ISA for exclusive distribution of its products and solutions in Mexico. Animine, the French independent supplier of precision minerals, has recently joined its efforts with the Mexican company Grupo ISA to ensure the distribution of its solutions in the country. The terms of the agreement are attributing the exclusivity of the supply to Grupo ISA. Established in 1980, Grupo ISA is headquartered in Obregon with several warehouses over the country to better serve customers. Its main business divisions are genetics, biosecurity, animal health and nutrition. The leading products of Animine, the potentiated zinc HiZox® and the monovalent copper CoRouge®, have been registered by the SADER and are now available in the country. “I am very excited to be the first to offer these unique minerals to the national market. Our solutions will help producers to have more sustainable use of highly bioavailable microminerals, securing gut health and reducing their environmental footprint,” stated José Ramon Perez, LATAM Sales Manager for Animine. Animine will benefit from the large and skilled team of Grupo ISA to develop the market. “This start in Mexico is key for our company development. Animine is already represented in Chile but we can now continue our geographical expansion targeting Guatemala, Columbia and Ecuador as next steps,” concluded Jennifer Maurin, Sales Director at Animine. Animine partners with Grupo ISA for exclusive distribution in Mexico

NEWS 12 FEED & ADDITIVE MAGAZINE October 2022 Earlyfeed incorporates a novel flavor strategy for piglet feed intake Novus International to shift from direct sales in China Inspired by newborn piglets, Earlyfeed - the young animal nutrition brand of Royal Agrifirm Group - incorporated an innovative flavoring in its piglet feed portfolio in September 2022. This pioneering flavor looks not only to the masking effect of sweet tastes, traditionally used in the industry, but also to the attractive and calming impact of maternal recognition. The flavoring, Piglet's Flavorit, will be included in the Babi® creep feed line and the Vitastart starter concentrates. The initial launch took place at their Factory of the Future awarded Drongen, Belgium facility and then will be integrated at their other plants for the European market. The traditional diet of a piglet 10-years ago looks much different than the diets fed today, this is related to legislation—antibiotic-free, ban on medicated zinc-oxide—and added inclusion of functional feed ingredients. These changes led to Earlyfeed seeking a new and innovative flavor solution for its piglet feed product line. Instead of pursuing the traditional concept of using only sweeteners to attract piglets and mask undesirable flavors, they considered what a piglet finds appealing. This started with observing the piglet and what naturally draws it to feed. The groundbreaking feed intake solution, called Piglet's Flavorit, is based on how olfactory cues can create feelings of familiarity and recognition. When applied correctly, a smell can trigger the piglet's innate reflex to search for its mother and food. Through this maternal recognition, piglets can achieve smoother feed transitions to result in improved continuous feed intake, reduced stress levels, and increased overall welfare and performance. When developing the new flavor blend, Earlyfeed looked to the base flavor profile of the products and added the necessary tastes and smells to mimic the maternal fluids a piglet is accustomed to. By including both sweet and umami, Piglet's Flavorit creates both an appealing odor and taste for the piglet. International feed additives, animal nutrition and health solutions manufacturer company Novus International plans to change to an indirect business model in China as part of better serving drive in its core markets. Company leaders said they are working to establish channel partners to continue serving customers in that country. This change is part of the international feed additive company’s drive to better serve those in its core markets through its strategic business plan, Project Destiny. While this decision will allow the company to invest in other parts of Asia, Novus leaders recognize the importance of their customers in China and the country’s own vital position in the animal protein industry. The decision to change business models in China is aligned with Novus’s business strategy to simplify operations and invest in markets that are aligned with its core strengths for driving sustainable growth.

NEWS FEED & ADDITIVE MAGAZINE October 2022 13 SeaMark seeks to turn tide for bio-based industries Hosted by Ocean Rainforest, over 50 major players in the European seaweed industry convened in Tórshavn to officially launch the SeaMark Horizon Europe project. The SeaMark public-private partnership comprising 25 multi-disciplinary partners will deliver 12 seaweed-based products for commercial exploitation over four years. SeaMark is the first Horizon project to be hosted by a Faroese company. SeaMark’s cross-disciplinary team will scale up macroalgae cultivation and processing techniques to develop 12 innovative products in the first seaweed biorefinery plant for cultivated seaweed. The innovations will show that macroalgae – a zero-carbon crop – can be used in multiple industries, with multiple concurrent socioeconomic and environmental benefits compared to other industrial feedstocks such as terrestrial crops or petrochemicals. Alongside market applications, SeaMark will quantify ecosystem services provided by seaweed farms, contributing to a body of evidence justifying large-scale seaweed cultivation as a bioremediation tool and key element of a new circular bioeconomy. Learn more, visit www.selko.com Sustainable alternatives that make a little go a long way Sustainability goals and rawmaterial scarcity mean by-products from the food and beverage industry is now seen as a viable, nutritious source of energy for animals. Selko offers solutions to help the industry use resources more efficiently and move towards a circular, more sustainable economy. THE BENEFITS FOOD2FEED QUALITY Reduce landfill Upcycle by-products Maintain nutritional value

NEWS 14 FEED & ADDITIVE MAGAZINE October 2022 Nutrition Technologies, Asia’s first industrial insect company, has completed an equity venture round of US$ 20 million. The round was led by PTT Ventures and supported by Sumitomo Corporation, ING Sustainable Investments, Mandala Capital, as well as continued participation from existing investors: Openspace Ventures, SEEDs Capital and Hera Capital. The round was advised by ING Corporate Finance. The new funding will be used to launch new products, expand into new markets, accelerate R&D and create new strategic partnerships. “It is great to welcome our new investors, who collectively bring vast expertise and experience to help us realise our vision. We are also humbled by the continued support provided from our existing shareholders,” said Tom Berry, Co-CEO and Co-founder, Nutrition Technologies. “We are increasing production to meet market demand and providing essential ingredients to the domestic agricultural sector as well as boosting exports through shipping our products to Korea, Japan, Indonesia, Thailand, Vietnam, Philippines and Chile. We will also commence shipments to the UK and EU very soon,” said Nick Piggott, Co-CEO and Co-founder, Nutrition Technologies. Nutrition Technologies will use these funds to further expand production capacity both at its current operating plant in Malaysia as well as through a new joint-venture project in a soon-tobe-announced second country in Southeast Asia. The Company also intends to expand its R&D capabilities in Singapore; commence commercial activities in the UK and EU; and add several new patents to its existing IP portfolio. French animal feed producer Avril Group and its subsidiary for animal nutrition, Sanders, have announced a €6 million aid plan for livestock producers. Intended for the livestock farmer and not for the farm, the aid can range from €2,000 to €100,000. First announced last spring by Avril Group and Sanders, its leading business unit specialized in animal nutrition, the €6 million aid plan for livestock farmers has just been launched for eligible breeders who request it, regardless of their production, or whether they are clients or future clients. "Given the increasing prices of raw material over the last two years and the consequent increase in the price of feed aggravated by the war in Ukraine, the increase in energy costs, and finally the avian flu, livestock farmers are facing a very complex economic situation. The aid plan we implemented is consistent with our mission to provide them with support throughout their transition to profitable and sustainable farming", explains Philippe Manry, General Manager of Sanders. The aid plan addresses three main objectives: to promote the transfer, installation, and development of farms thus contributing to the sustainability of French livestock, to support the modernization of facilities towards more sustainable livestock farming, and finally, within an unpredictable inflationary context, to provide solutions to facilitate access to quality protein nutrition. Avril Group, Sanders to give €6 million in aid to livestock farmers Nutrition Technologies closes US$20 million equity round

NEWS FEED & ADDITIVE MAGAZINE October 2022 15 Ocean Harvest Technology has unveiled the results of a successful trial demonstrating OceanFeed™ Swine, produced from seaweeds, can be effective in low Zinc (Zn) in piglet diets. Ocean Harvest Technology, the largest global producer of animal feed additives from multispecies seaweed blends, announced the results of a successful trial that demonstrate OceanFeed™ Swine can be effective in low Zinc (Zn) in piglet diets. The EU, followed by some other countries such as the UK, have recently significantly reduced the levels of Zn that can be included in piglet diets. Zn has traditionally been used in piglet diets to suppress bacteria growth in the gut, with levels around 2,500-3,500 ppm often employed relative to the 150 ppm current limit. The results of this trial show that in piglet diets free from therapeutic Zn, OceanFeed™ supplemented diets showed similar, and in some cases better, piglet performance than the diets with high Zinc inclusion. Faster growth, lower inflammation markers, higher levels of good bacteria and great microbiome diversity were observed in piglets fed diets supplemented with OceanFeed™ Swine. This trial provides another example of the benefits of seaweed blends, showing why OceanFeed™ use is growing in swine, and particularly the antibiotic-free, low-Zn piglet segment, and other animal feed sectors. Ocean Harvest unveils successful OceanFeed™ swine trials AB Vista continues to expand across the Asia Pacific region with the launch of Signis, a feed additive that improves the gut health of poultry and swine. AB Vista is to continue its expansion across the Asia Pacific region with the launch of Signis in three more countries: Vietnam, the Philippines and Thailand. Signis – the world’s first ‘stimbiotic’ product – is a feed additive that improves the gut health of poultry and swine and improves animals’ resilience to challenges. It works by stimulating and accelerating the microbiome’s ability to ferment fibre efficiently, thereby improving nutrient digestibility and optimising gut function. This makes the animals more efficient, perform better and improves liveability. What’s more, using Signis helps to significantly reduce production costs – a particularly welcome benefit at a time when animal producers are having to grapple with increasing prices. Signis, which is already available in Indonesia and Malaysia, was launched in Vietnam – in Ho Chi Minh City on 21 September and Hanoi on 23 September – followed by the Philippines and Thailand in November. AB Vista to extend reach across Asia Pacific with Signis

NEWS 16 FEED & ADDITIVE MAGAZINE October 2022 US-based global agricultural commodities trader Bunge agreed to sell its oilseed processing business in Russia to Karen Vanetsyan, the controlling shareholder of Exoil Group. Bunge agrees to sell oilseed processing business in Russia Bunge Ltd announced that it has agreed to sell its oilseed processing business in Russia to Karen Vanetsyan, the controlling shareholder of Exoil Group. The sale includes the sunflower processing plant in Voronezh. “We are grateful to the team for continuing to deliver essential food and feed in this challenging environment. With Karen Vanetsyan's more than 25 years of experience in agricultural processing, we are confident the team will continue to successfully serve customers,” said Greg Heckman, Bunge’s CEO. The completion of the sale is subject to customary closing conditions, including regulatory approval. Leading clinical scientist calls for greater transparency around red meat studies Professor Alice Stanton, Professor of Cardiovascular Pharmacology at the Royal College of Surgeons in Ireland and Director of Human Health at Devenish, said policy makers should be extremely wary of any studies which aren’t “rigorously and transparently evidence based and ignore the protections against nutritional deficiencies afforded by animal-sourced food”. She was speaking at the 12th Global Agenda for Sustainable Livestock multi-stakeholder meeting held this week in Dublin where over 150 professionals from 42 countries convened for a weeklong event entitled ‘Livestock Sector Actions Towards More Sustainable Food Systems’. In her address, Professor Stanton highlighted the protective effects of animal-source foods, including red meat, and emphasized the need for clear and consistent evidence-based health messages. Professor Stanton said: “Animal-source foods are an important source of many key health promoting nutrients and, as part of a balanced diet, they protect against nutritional deficiencies, helping to reduce the likelihood of childhood stunting, iron deficiency anaemia, and elderly frailty. In recent months, Professor Stanton has led a campaign calling for the authors of the very influential Global Burden of Disease (GBD) Risk Factors study to provide evidence for the dramatically increased number of deaths attributed to unprocessed red meat consumption, contained in The Lancet published GBD 2019 report. She also queries why the editors of The Lancet have not required immediate correction of the serious author confirmed errors in this report.

NEWS FEED & ADDITIVE MAGAZINE October 2022 17 Evonik using epigenetics to trace animal welfare Evonik has developed a test for chicken products that shows how the animals were kept and fed. This reliable new method, which was developed with the aid of epigenetics, enhances transparency and therefore raises consumer confidence. Epigenetics is a branch of biology that determines how the environment an animal has been exposed to influences patterns on its genetic material. Evonik sees potential users along the entire chicken production chain, especially agricultural enterprises and retailers. Evonik's new epigenetic test will extend its range of system solutions for sustainable meat production. At present, experts are working to tailor the test method to the requirements of different customers. For this purpose, Evonik is building up an epigenetics and bioinformatics platform in Singapore. This will have around 10 employees in the future. Development work is well advanced, so the specific tests can be made available to customers in the short- to mid-term. Walter Pfefferle, a biologist who works as a manager at Creavis, Evonik's strategic research entity and business incubator says: “Our technology opens up a completely new insight into poultry production. Chickens can now tell their own story.” In cooperation with Illumina, a leading provider of systems for large-scale analysis of genetic variation and function, Evonik has now developed an epigenetic chip that allows rapid analysis of, for example, samples of meat, despite the enormous amount of data. A pretreated sample is applied to a test area on the chip, which measures changes in the genome of the sample. The data can be read with a special appliance and are then evaluated using AI-based algorithms. In its laboratories in Singapore, Evonik is now validating the method, feeding data to the algorithms, and exploring new areas of application. ADM celebrates 120th anniversary ADM, formally known as Archer-Daniels-Midland Company and one of the world’s largest human and animal nutrition companies with 41,000 employees in around 200 countries, celebrated its 120th anniversary. September 30 marked the 120th birthday for ADM, formally known as Archer-Daniels-Midland Company. ADM was incorporated on Sept. 30, 1902, in Minneapolis, Minnesota, as a regional linseed oil business. Today, ADM – with 41,000 employees serving customers in nearly 200 countries – is an indispensable global agricultural supply chain manager and processor, a premier human and animal nutrition company, a trailblazer in groundbreaking solutions to support healthier living, a cutting-edge innovator in replacing petroleum-based products, and a leader in sustainability. “Over the past 120 years, our company has evolved from a regional startup into an irreplaceable leader providing needed nutrition to billions around the globe. We’ve transformed at many moments along the way, but unlocking the power of nature to enrich lives has always been at the heart of everything we do,” said Juan Luciano, Chairman and CEO. To celebrate the milestone, ADM conducted a Fight Hunger Challenge to bring employees together around the world to raise money for hunger relief. As a result, ADM Cares has donated 1.2 million meals in partnership with the World Food Program, Feeding America and Food Banks Canada.

ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE October 2022 ALTERNATIVE PROTEIN SOURCES IN ANIMAL NUTRITION

ISSUE FOCUS FEED & ADDITIVE MAGAZINE October 2022 19 Non-conventional alternative proteins in feed regulations in the EU Dawn Botha, Pen & Tec Consulting Unlocking the real value of insect meal Nick Piggott, Nutrition Technologies New single-cell alternative protein: ProtonTM John Hays, Deep Branch EU policy and insect alternative protein, panacea or chimaera? Jacopo Moccia, Eurogroup for Animals (EfA) Progressive yet traditional, sustainable, and economical protein source – Edible insects Masa Ivkovic, AFOS Mealworms for premium quality, nutrient rich and sustainable pet food Bénédicte Lorrette, PhD, Ÿnsect Insect protein - A sustainable alternative Suzanne van den Eshof, Protix Creating circular economy for animal feed with insects Volant Wills, Goterra Food for Feed Evelien van Donselaar, Selko Feed Additives European insect sector is committed to providing innovative and sustainable solutions Christophe Derrien & Alice Grassi, IPIFF Insects, a sustainable protein for a growing market Sabas de Diego, Tebrio

ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE October 2022 The popularity of the insect industry has been increasing in recent years. Europe, in particular, occupies a special position in this area. In fact, it is one of the points where the fastest industrialization in this field is experienced... It can be said that the European Union's efforts to reduce animal-based emissions and environmental footprint, ensure sustainability in production, meet the food needs of the increasing population and self-sufficiency, which has recently gained importance, are influential in this. Insects, which are an important link in the food chain in natural life, are considered as an extremely productive food and feed ingredient due to their low environmental, water and land footprint. The amino acid- and vitamin-rich content of insect proteins, as well as the potential to recycle wastes that cannot be used in human nutrition, are some of the factors that make it attractive. However, this industry is just at the beginning and for now continues its growth within the framework of the cautious approach of the European Commission. We talked to Christophe Derrien, Secretary General of the International Platform of Insects for Food and Feed (IPIFF) about 1.5 years ago, about the importance of the insect industry and its development in the EU. There have been many important developments in the meantime, and we have once again evaluated these developments with IPIFF representatives. This time, Christophe Derrien answered our questions on the subject together with Alice Grassi, IPIFF Communication Manager. "EUROPEAN INSECT SECTOR IS COMMITTED TO PROVIDING INNOVATIVE AND SUSTAINABLE SOLUTIONS" “In synergy with other EU agri-food sectors and stakeholders, the European insect sector is committed to providing innovative and sustainable solutions which should contribute to reducing our dependence on imported proteins as well as mineral fertilisers and strengthen EU self-sufficiency of our food supply chains.” Alice Grassi Communication Manager International Platform of Insects for Food and Feed (IPIFF) Christophe Derrien Secretary General International Platform of Insects for Food and Feed (IPIFF)

ISSUE FOCUS FEED & ADDITIVE MAGAZINE October 2022 21 Insects are one of the most important alternative protein sources that come to mind first today. First of all, can you tell us about the features that make insects a good alternative protein source for both feed and food? Insect farming activities and their derived products respond to the demand for sustainable and high-quality protein to feed a growing population, by generating locally produced food, as well as feed ingredients which could be used in fish or livestock farming. The sustainability of insect farming is given by its reduced environmental footprint and high efficiency in terms of water and land footprint. Thanks to vertical farming techniques, insect farming requires less arable land as insect farmers use ‘crates’ aligned vertically to rear their insects. Most commonly farmed species are able to absorb the water they need from their substrates. Moreover, insects can also contribute to reducing the burden of food waste, being fed with underused agri-food by-/ co-products (e.g., vegetable/fruits/starch origin) or food no longer destined for human consumption (e.g., unsold products from supermarkets, food products arising from the food manufacturing and being discarded for technical reasons). Insect proteins contain relevant amino acids and vitamins for both animal nutrition and human consumption. Insects are quite versatile ingredients and can be added to foods and feed in different ways. Both directly as whole insects (e.g., boiled, fried or in dried form), processed into powder or paste to increase nutritional value or functionality, as well as various ingredients (e.g., protein powder, insect oil, etc). We had our last interview with IPIFF in April 2021. Since then, there have been many developments in the insect industry. Especially at the European Commission, new regulations were passed regarding the use of insects and insect products. Can you tell us a little about these regulations and their impact on the insect industry? Since April 2021, the European insect sector has welcomed several regulatory developments which helped and will help the industry to upscale. Following the positive vote from the EU Member States in April 2021, Commission Regulation (EU) 2021/1372, which formally authorised the use of Processed Animal Proteins derived from farmed insects (insect PAPs) in pig and poultry feed, entered into force on 7 September 2021. This authorisation opened two of the most relevant EU animal feed markets, which represent circa 65% of the EU compound feed production. Following the entry into force of this implementing regulation, the demand for insects as feed is expected to grow, leading to an increase in the production capacity of the sector. The authorisation of insect PAPs in poultry and pig feed will offer new opportunities - starting with the incorporation of such ingredients into the diet of such animals, the subsequent use of insects in organically farmed chicken and pigs, implicitly strengthening partnerships between insect and animal farms. With regards to edible insects, since 2021 with the first Novel Food authorisation, several other positive EFSA (European Food Safety Authority) opinions and consequent authorisations have followed. Currently (Autumn 2022), four Novel Food authorisations concerning products derived from edible insects have entered into force: dried yellow mealworm (22 June 2021), dried and frozen migraEssento (Insect burger - Switzerland)

ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE October 2022 tory locust (3 December 2021), dried, ground and frozen house cricket (2nd March 2022), the second on frozen, dried and powder yellow mealworm (28th February 2022). Two EFSA opinions are still waiting for authorisation (partially defatted house cricket (EFSA’ opinion 13 May 2022) and frozen and freeze-dried formulations of the lesser mealworm (EFSA’ opinion published on 4 July 2022)) 1. Last but not least, the European insect sector also welcomed Regulation (EU) 2021/1925 which defined EU baseline standards for the production and placing on the market of insect frass as organic fertiliser. The legal text aligned the heat treatment process standards for the placing on the market of frass with those applying to processed animal manure, creating harmonisation in the processing standards in the Member States, and paving the way for the commercialisation of these products on the whole EU market. The animal feed industry has been experiencing serious problems such as the supply of feed ingredients/grains due to global warming, drought, pandemic and the war between Russia and Ukraine. And, an energy crisis has now been added to this, as well. Could insects or other alternative proteins contribute to the solutions of such problems in the future? How do you evaluate the potential of the EU insect industry in this regard? In synergy with other EU agri-food sectors and stakeholders, the European insect sector is committed to providing innovative and sustainable solutions which should contribute to reducing our dependence on imported proteins as well as mineral fertilisers and strengthen EU self-sufficiency of our food supply chains. By expanding the list of feeding substrates for farmed insects, the sector could notably help generate locally produced feed and food products while contributing to safely upcycle losses originating from European agri-food industries. Indeed, up to a third of the food waste generated presently in the EU may be used as insect substrate - before it is classified as ‘waste’. Currently, by-/co-products from grains, starch, fruit and vegetable supply chain products are authorised as substrates for insects. In the future, the possible authorisation of former foodstuffs containing and meat and fish and catering waste would play a key role in upcycling the production capacity of the sector and help facing the supply challenges of our times. Hermetia Baruth (Germany)

ISSUE FOCUS FEED & ADDITIVE MAGAZINE October 2022 23 We see that the use of insects as feed and food is now more encouraged by senior leadership due to many topics such as sustainable production, climate and environmental problems, and food safety. What does this mean for the insect industry? As mentioned in question 1, sustainability and environmental performance of insect farming are topics of great importance for our sector. In spite of the young age of the insect sector, there is growing evidence around the environmental performance indicators of such farming activities. IPIFF is working internally with its Members in order to continue the research and respond to the sustainability performance with scientific data, as other alternative protein sectors. On the food safety aspect, insect farmers conduct farming practices which follow the EU regulation and, in this regard, continues to update its ‘Guide on Good Hygiene Practices’ which is soon to be approved as EU guide for insect producers. Is the insect industry in the world able to fulfill all the responsibilities attributed to it? For example, how much of the current capacity can meet the world's protein needs for feed and food? Regarding this need, do you have a future goal that you have set as representatives of the insect industry? With several thousand tonnes of insect PAPs produced, the production of insects for food and feed is expected to increase rapidly in the coming years. Building on the total investment raised by the mid2020s, the sector may reach a total turnover of circa 2 billion euros/year by the end of the decade2. While IPIFF is convinced that insects may soon constitute a reliable complement or partial substitution to fishmeal and soy in feed formulae for aquaculture, poultry and swine animals, we do not however, forecast that insects will fully replace ingredients such as soy meal. “Insect proteins and oils will be new raw material categories, which, in combination with ‘more traditional’ or other novel ingredients, will create better performing feeds with lower environmental footprints”, according to Rabobank report ‘Non longer crawling: Insect protein to come of age in the 2020s’ - 2021. Yet, if insect production would be reaching around 1 million tonnes of insects proteins, that would contribute to improve EU’s self-sufficiency in terms of High-Pro (30-50%) (today the EU self-sufficiency high pro materials for animal feed is only of 26 %) and Super-Pro (>50%) (today the EU self-sufficiency super- pro materials for animal feed is of 85 %) considering the high protein content of these materials See EU Feed Protein Balance Sheet (forecast) June 2021 through the following link. IPIFF has a kind of alternative protein coalition with EABA and COFALEC. What is the purpose and goal of this coalition that you name as InnovProtein EU? Following the joint presentation addressed during the IPIFF Annual Conference on the 1st December 2021; IPIFF, EABA (algae) and COFALEC (yeast) have decided to delineate a joint roadmap on common interests and objectives. ‘InnovProtein EU’ shares the ‘common aim’ of supporting the overall objectives of ‘EU Farm to Fork Strategy’ and the transition towards more sustainable EU food supply chains. The coalition will work together on unlocking the EU policy opportunities s which could support the development of alternative proteins, exploring nutritional and environmental potential and/or benefits of the sectors, through the streamlining of EU Regulatory frameworks, appropriate R&D efforts as well as developing joint communication activities. Within the scope of InnovProtein EU, what have you done so far and what are your future plans? Together with the algae and yeast sectors, IPIFF outreached to EU decision makers in order to support regulatory advancements or the unlocking of EU funded research opportunities to the benefit of our respective sectors. We also consolidated our ties with EU industry sectors from the food and feed chain and participated in different events in the context of promoting the sectors as innovative solutions inspired by nature, encompassing products of both vegetal and animal origin.

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