The Ukraine-Russia war has caused a deep crisis on the global feed market, especially on the European feed market, because the Black Sea region meets a significant portion of the world’s grain and oilseed needs. However, the war has caused a very serious disruption in the supply chain. The heads of states and governments of the European countries, who came together a week after the start of the war, announced the Versailles Declaration. In the 27-item declaration, the title of food was also included. Reducing dependency on imported agricultural products was the main theme of this title and the declaration explained the target in this direction with the following sentences: “We will improve our food security by reducing our dependencies on key imported agricultural products and inputs, in particular by increasing the EU production of plant-based proteins.” This declaration was the first expression of the crisis that could arise due to the war. The European Feed Manufacturers’ Federation (FEFAC), which made a statement after the declaration, also pointed to the problems to be experienced in the supply of raw materials. Asbjørn Børsting, President of FEFAC, said in the statement: “The European Union needs to establish a comprehensive EU food and feed security contingency plan, prioritising food and feed use of grains and oilseeds, both covering the short-term impacts linked to the loss of Black Sea grain deliveries from Ukraine, but also for the mid-term to buffer the Ukraine crisis impacts, which will be felt for a long time. The EU needs to support innovative plant breeding technologies and good agricultural practices to boost its own grain, oilseeds and vegetable protein production”. However, it was not possible to increase the production of grain, oilseed and plant-based protein in a very short time and make it available to the feed industry. It could only be part of a long-term goal. Although the market is tried to be relieved with short-term measures, the problem in the supply of feed raw materials over the Black Sea continues to put a serious pressure on feed prices for months. However, the grain shipment agreement among Turkey, Ukraine, Russia and the United Nations (UN) was finally concluded and the “Grain Corridor” has been actively opened. The maize-laden Razoni, which is the first ship to leave Ukrainian ports, continues its journey towards Lebanon's Tripoli Port. Panama-flagged Navistar carrying 33.000 tons of corn to go to Ireland, Maltese-flagged Rojen loaded with 13.000 tons of corn to England, and Turkish-flagged Polarnet carrying 12.000 tons of corn to Turkey departed from different ports in Ukraine. These shipments are expected to have a relief effect in a short time. However, we will see in the process whether this will meet the expectations or not. The solution that can offer more than this agreement will be the end of the war as soon as possible... I hope we will have the chance to see this very soon. Enjoy reading… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors James Watson Bahadır Büyükkılıç [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Branch: Ste B69, East Rutherford, New Jersey 07073, USA Publication Type: Periodic (Monthly) EDITOR The grain corridor: A solution to the feed crisis? Derya YILDIZ All copyrights belong to Three Plus Media.© May not be used without permission. Responsibility of the ads belongs to the advertisers. feedandadd i t i ve
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48 MIAVIT – MORE THAN JUST GERMANY’S MARKET LEADER IN PREMIX PRODUCTION MIAVIT GmbH C O N T E N T S 18 ISSUE FOCUS 26 MANAGING THE MYCOTOXIN RISK IN LOWER QUALITY INGREDIENTS Martin Minchin, Marketing Manager, Alltech 37 A CONSTANT ANTAGONIST: CONSEQUENCES OF ENDOTOXINS IN ANIMALS Josep Garcia-Sirera, Toxin Binders Product Manager, Agrimprove 20 SHOULD WE WORRY ABOUT MYCOTOXINS IN DAIRY COWS? Dr. Swamy Haladi, DVM., PhD, Global Programme Manager Mycotoxin Risk Management, Selko 32 GUIDANCE ON HOW TO REGISTER A MYCOTOXIN BINDER Dawn Botha, Technical Marketing Manager, Pen & Tec Consulting 50 A SMART NEWWAY TO DEAL WITH HEAT STRESS Ellen Bettonviel-Damen, MSc, R&D Manager, FRAmelco 56 INSIGHTS FROM SCANDINAVIA ON PERFORMANCE AND ROI OF BLENDED FEED ADDITIVES Yvonne van der Horst, Global Product Manager Gut Health, Selko® Feed Additives SPECIAL STORY MYCOTOXIN MANAGEMENT IN ANIMAL FEED Premixes in Animal Nutrition
59 OPTIMIZING STRATEGIES TO MANAGE COCCIDIOSIS IN POULTRY Shelby Ramirez, Global Poultry Technical Manager, DSM 62 THE USE OF HIGHER LEVELS OF PHYTASE TO REDUCE DIETARY INCLUSION OF INORGANIC PHOSPHATES Diego Parra, Technical Manager EMEA, AB Vista 66 MITIGATE THE CLIMATE STRESS IN BROILER CHICKENS WITH PHYTOGENICS Mojca Osredkar Mergole, DVM MSc, Global Technical Manager – Poultry, Delacon Biotechnik GmbH C O N T E N T S ARTICLES FeedTechnoVision 2022 to spotlight feed production strategies 15 New FAO report: Animal health important for helping cut GHG emissions 12 Cargill, Continental Grain complete acquisition of Sanderson Farms 77 Marco Baumann appointed VP Business Unit Capital at ANDRITZ Feed & Biofuel 78 Novus to release new book for breeder management and nutrition 83 Tyson Foods, Tanmiah of Saudi Arabia sign strategic partnership 85 NEWS INTERVIEW “WITH OUR MINERALS, WE ARE PROMOTING HEALTHY LIVING CONDITIONS FOR FARM ANIMALS” 42 Eleni Ipsilanti, Imerys Marketing Manager for Animal Feed EMEA REPORTS GLOBAL AQUACULTURE MARKET 70
NEWS 6 FEED & ADDITIVE MAGAZINE August 2022 Biochem announced the completion of its 4,500 square meter, GMP+ certified production and logistic facility located in Lohne, Germany. The location houses a modern 1,000 cubic-meter tank storage unit and an energy-efficient, fully automated filling system and provides 60 additional office workstations for Biochem’s growing workforce. “We are very pleased to announce the completion of this facility,” says Eckhard Thölke, CEO and owner of Biochem. “This lets us further expand our manufacturing capabilities to meet the growing needs of the animal feed market”. At the heart of the facility is the modern liquid production line. Driven by factors including rising awareness about animal health and feed quality, the Biochem opens new production plant in Germany Biochem has completed its 4,500 square meter, GMP+ certified production and logistic facility located in Lohne, Germany. The new facility, which has an energy-efficient, fully automated filling system, will significantly boost liquid feed supplement capabilities. AB Agri announced it has opened its ninth feed production site with a capacity of 240,000 tons in China to meet growing customer demand. AB Agri announced that it has opened a new 240,000 tonne capacity feed mill in Tongchuan City, Shaanxi Province, China, to further expand production capacity in the region as it grows its global footprint. The new 34,000 square metre site becomes AB Agri China’s second largest facility and comprises separate production lines for swine and ruminant feeds. The Tongchuan mill is the latest in a significant investment programme in China for AB Agri. The business is now producing in excess of 1.7 million tonnes of compound feed equivalent. “We are passionate about producing affordable, high quality and responsible food across the globe,” said José Nobre, AB Agri’s Chief Executive Officer. “The new mill increases our capacity and reliability across the supply chain and helps develop a sustainable future for the feed and food industry in China.” The mill is AB Agri’s ninth production site in China. The completion of construction was delayed by two months because of Covid-19 restrictions and bad weather. “We are delighted and proud of the effort and passion the team demonstrated to complete this project with just a two-month delay, despite all the obstacles faced,” said Nie Kuo, AB Agri China, Managing Director. “As part of our responsible approach, production at the new site is free of antibiotic growth promoters (AGPs), which is important given the widespread restrictions on their use and potential impact on human health antibiotic resistance.” AB Agri opens ninth feed production site in China
NEWS FEED & ADDITIVE MAGAZINE August 2022 7 global liquid feed additive market is projected to grow at a compound annual growth rate of 5% and is expected to increase its share of the feed additive space throughout 2025. “This new location gives us great flexibility in our liquid feed additive filling sizes – we can now fill from 500 millilitres to 25,000 litres,” says Eckhard Thölke. “We can better align our services with our customers’ demands without sacrificing our core mission of safe animal nutrition”. The facility will also serve as a climate-controlled warehouse to ensure product availability and quicker production times. Sixty new workspaces are also provided to meet the needs of the company’s increasing staff. German chemicals giant BASF is expanding its world-scale formulation capacities at its Verbund site in Ludwigshafen. The state-of-the art facility will support and further expand the production of high-quality vitamin A powder products for the animal nutrition industry. BASF is strengthening its market position in vitamin A by expanding its world-scale formulation capacities at its Verbund site in Ludwigshafen. The state-of-the art facility, which is fully integrated into vitamin production at the site, will support and further expand the production of high-quality vitamin A powder products for the animal nutrition industry. Start-up is planned for mid-2023 and will stepwise increase BASF’s vitamin A powder formulation capacities in line with the increased vitamin A acetate production capacity. The expansion of the vitamin A acetate plant in Ludwigshafen was successfully completed in 2021, increasing BASF’s total annual nameplate capacity for vitamin A acetate to 3,800 metric tons. With the expansion of the formulation plant, BASF is further enhancing its vitamin A production footprint. Close integration of the powder plant facility into the BASF Verbund will additionally ensure a best-in-class CO2 footprint and an efficient use of resources. BASF is a leading global producer of vitamin A for animal nutrition. With the expansion of the worldscale formulation plant, BASF supports its customers’ growth plans and emphasizes the role of vitamin A as a strategic pillar for the animal nutrition business. “This investment is part of our new operating model, leveraging and further strengthening core product platforms of our nutrition ingredients business. It underlines our ambition to meet market demands for vitamin A in the long term and ensures reliable, high-quality supply to our customers.” said Julia Raquet, Senior Vice President of the new global business unit Nutrition Ingredients. BASF expands world-scale vitamin A formulation plant in Ludwigshafen
NEWS 8 FEED & ADDITIVE MAGAZINE August 2022 Mitsubishi Corporation (MC) and Maruha Nichiro Corporation (Maruha Nichiro) announced that they would establish a new joint venture company, ATLAND Corporation (ATLAND), which will specialize in the land-based production of salmon. ATLAND will be established in Nyuzen town of Toyama prefecture in around October 2022. “The investment ratio of ATLAND will be MC 51% and Maruha Nichiro 49%. Following the establishment of the company, a land-based aquaculture facility with a capacity of 2,500 tons (live weight equivalent) will be constructed in Nyuzen town, with the aims of starting operations in 2025 and completing the first delivery in 2027,” the companies said in a statement. MC and Maruha Nichiro have been discussing the joint promotion of this project since March 2021. The project is expected to help develop a sustainable and stable land-based production system, efficient digital-tech-based operations, local production for local consumption, and progress in decarbonization. Both companies are dedicated to leveraging their strengths and businesses to simultaneously generate economic, environmental and societal value. The aim of the joint project is to create a local-production-for-local-consumption business model in Japan’s salmon industry. This business model is expected to produce fewer greenhouse gas emissions compared to the practice of importing fresh salmon to Japan by air from salmon-farming countries. In addition, land-based aquaculture that uses Recirculating Aquaculture Systems (RAS) is highly compatible with digital technologies. These systems use advanced water-treatment technologies to control and manage the farming environment. By employing these methods, the companies aim to take advantage of AI and IoT to stabilize production, and otherwise optimize own salmon farming operations. Mitsubishi, Maruha Nichiro to establish new joint venture for land-based salmon Spain-based Tebrio, one of the leading companies in the production and processing of Tenebrio molitor insects, together with other major players in the swine industry, announced that it launched an innovative project to improve sector efficiency and sustainability. Porcisost research program aims to offer farmers a natural alternative to zinc oxide in order to control piglet mortality in the first weeks of life. To this end, it proposes diets including protein from Tenebrio molitor insects Porcisost: a sustainable alternative to control piglet mortality without zinc oxide Spanish biotechnology company Tebrio has launched an innovative project, together with Grupo Jorge, Nutega and Vallehermoso. Porcisost research program aims to offer farmers a natural alternative to zinc oxide in order to control piglet mortality in the first weeks of life.
NEWS FEED & ADDITIVE MAGAZINE August 2022 9 The most important additive is intelligence In your quest for profitable, sustainable production draw on our global resources and leading-edge science. They provide you with relevant insights to help you make complex decisions with confidence. We’re just a phone call or an email away www.abvista.com. Global intelligence, localised. Result, POWER PROCESSING SERIOUS
NEWS 10 FEED & ADDITIVE MAGAZINE August 2022 and other synthetic compounds and amino acids. In addition, alabaster will be used to recover slurry nutrients and minimize the polluting effect of the waste on the environment. The recent ban on zinc oxide to treat the common gastric disorders suffered by piglets after weaning represents a new problem for productivity in the swine industry. The five-year moratorium offered by Brussels in 2017 expired last June 26, meaning that this chemical compound can no longer be used in medicated feed. The reason is scientific studies developed to date show zinc oxide poured via slurry has a devastating effect on the environment. All this is forcing the industry to look for alternatives to replace it, since E.Coli bacteria, which could be controlled with this additive, represent one of the main causes of mortality during the first two weeks of life of piglets' life. In order to fight gastric infections without having to abuse antibiotics, the Spanish biotech company Tebrio, together with Grupo Jorge, Nutega and Vallehermoso, has embarked on an innovative research project called Porcisost. This program aims to improve the efficiency and sustainability of Iberian and Large White pig production through nutrition. Specifically, it foresees introducing insects into the diet of animals that have just been weaned to take advantage of the great potential of this new sustainable protein source. Bühler Group has announced a new multi-million dollar investment in a state-ofthe art Grain Innovation Center (GIC) at its headquarters in Uzwil, Switzerland. Bühler to build state-of-the art Grain Innovation Center in Uzwil Swiss technology group Bühler is investing a double-digit million Swiss Franc amount in a new Grain Innovation Center (GIC) at its site in Uzwil, Switzerland. The GIC will replace the old technology center, which was built in the 1950s and no longer fulfils the requirements of a stateof-the art innovation hub. At the new GIC, Bühler and its customers and partners will develop, test, and scale sustainable and efficient solutions for grain and feed processing to improve food and feed solutions. The focus will be on yield, quality, energy efficiency, and the flexibility of the plants together with nutritious and great tasting recipes based on a broad variety of grains and pulses. Embedded in Bühler’s Application & Training Center ecosystem at Uzwil, which includes bakery, pasta, proteins, and chocolate, the GIC will enable the development of innovative solutions along complete value chains, from raw materials to finished products. The GIC is scheduled to start operations by the end of 2024.
NEWS FEED & ADDITIVE MAGAZINE August 2022 11 2, avenue Ker Lann | CS 17228 35172 BRUZ Cedex - FRANCE mi science INNOVATE FOR LIFE www.mixscience.eu Checkmate! BIOTOXINS: Multiprotect the winning strategy against biotoxins 2, avenue Ker Lann | CS 17228 35172 BRUZ Cedex - FRANCE i ience INNOVATE FOR LIFE www.mixscience.eu l i i i i i i
NEWS 12 FEED & ADDITIVE MAGAZINE August 2022 Evonik, Interoceanic Corp. sign ammonium sulfate supply deal Evonik Corporation has signed an agreement to supply blueSulfate®, a liquid ammonium sulfate solution from its site in Alabama, US, to Interoceanic Corporation (IOC). Evonik has entered into an agreement to supply blueSulfate®, a liquid ammonium sulfate (8-0-0-9) solution from its site in Mobile, Alabama, to Interoceanic Corporation (IOC). This agreement supports Evonik’s strategy to focus on its core business in Animal Nutrition by marketing high-value co-products of its methionine production network for fertilizing crops via IOC. Interoceanic is a marketer of fertilizer and industrial chemicals with a terminal network and multi-modal transportation fleet in North America, linking producers and end users. This joint effort allows Evonik to bring valuable nitrogen fertilizer to the market that meets the needs of US farmers, contributing to the circularity of macronutrients in agriculture. Evonik manufactures liquid ammonium sulfate (8-0-0-9) solution and a potassium-based fertilizer, AgraLi®, as co-products of its methionine production. “This agreement was the result of a lot of hard work and forward- thinking by both Evonik and IOC to provide additional products to both American Agriculture and a growing population,” says Doug Mills, Plant Nutrition Business Manager at the Nutrition & Care division of Evonik. “We look forward to a successful relationship with IOC.” A new study by the Food and Agriculture Organization of the United Nations (FAO) and partners shows that improving animal health is important for helping cut greenhouse gas (GHG) emissions. Improving animal health can help cut greenhouse gas (GHG) emissions, but more granular approaches to measuring progress are vital if countries are to be able to include it in their national climate commitments, a new report shows. Diseases affecting animals, how long they live and how productive they are all have a significant impact on GHG emissions, says the report by the Food and Agriculture Organization of the United Nations (FAO), Global Dairy Platform and the Global Research Alliance (GRA) on Agricultural Greenhouse Gases, entitled “The role of animal health in national climate commitments.” This means greater investments are needed to establish systems for measurement, reporting and verification (MRV). There is currently no standardized method to include improved animal health in most countries’ GHG national inventories or nationally determined contributions (NDCs). As a result, the importance of animal health is often not clearly reflected in countries’ commitments to fight climate change. The report shows how countries can develop an MRV system at national level to be able to include animal health improvements in national climate commitments. But to do that, the report says, it’s essential for countries to use the detailed methodNew FAO report: Animal health important for helping cut GHG emissions
NEWS FEED & ADDITIVE MAGAZINE August 2022 13 Grand opening for FoodTechIndonesia demonstration broiler farm A demonstration broiler farm was opened following an upgrade as part of FoodTechIndonesia, a public-private partnership initiated and coordinated by Larive International and supported by several leading Dutch companies. In attendance of officials from the Embassy of the Netherlands and representatives of the FoodTechIndonesia consortium, the grand opening of the demonstration broiler farm at the premises of PT. Januputra Sejahtera farm in Sleman, Central Java, took place on July 4, 2022. As part of the FoodTechIndonesia initiative, an existing open broiler farmhouse (16,000 birds, 2 floors) of Januputra was upgraded in 2020-2021 to a closed farmhouse by implementing Dutch solutions, fitting to local conditions. Furthermore, technical assistance was provided via implementing training programs to the Januputra staff and independent broiler farmers from the Central Java region. The approach of investments in farm equipment (heating, ventilation, closed drinking systems, lighting and disinfection) in combination with theoretical and practical training, allowed Januputra to increase its technical performance substantially. Furthermore, labour, energy and medicine costs per bird significantly decreased. In total, FoodTechIndonesia invested EUR 0.43/bird in terms of equipment. For Januputra, the improvements and costs reductions resulted in a profitability increase of >200% and return of investment is <2.5 years. Partners in FoodTechIndonesia include Aeres, De Heus, DSM, Hato, Kanters, Marel Poultry, Mavitec, Moba, Pas Reform, Trouw Nutrition and Van Aarsen. ologies known as Tier 2 or 3, developed by the Intergovernmental Panel on Climate Change (IPCC). While the commonly used Tier 1 approach only allows for estimating GHG emissions per animal with regional averages, Tier 2 looks at specific local production systems. This includes herd parameters to estimate impacts on animal numbers such as mortality, fertility, age at first parturition and replacement rate, as well as production data including milk yields and animal weights at different life stages. Data on feed for different categories of animals and manure management systems are also critical as these have a strong influence on emission factors. Measuring parameters such as the methane (CH4) conversion factor may even require using Tier 3 approaches with more complex modelling and associated data, the report says.
NEWS 14 FEED & ADDITIVE MAGAZINE August 2022 Blumar and Veramaris with the collaboration of Skretting are working on an innovative feed protocol to achieve better health, welfare and quality outcomes for Atlantic salmon. Nutreco has received a US$4.8 million grant from the Bill & Melinda Gates Foundation. The funds will be used to roll-out sustainable feed mills in Africa. It’s a global first for Blumar: an innovative program that will improve the quality and nutrition of their Atlantic salmon. Blumar and Veramaris with the collaboration of Skretting are working on an innovative feed protocol rich in both EPA & DHA Omega-3 using Veramaris ASC-MSC certified sustainable algal oil. The program consists of two components: introducing Veramaris algal oil into the salmon’s feed supplied by Skretting; and following Veramaris’ Optimum Omega Nutrition (OON) guidelines to meet the nutritional requirements of Atlantic salmon for better health, welfare and quality outcomes. Thanks to innovations of this kind, Blumar seeks to achieve its environmental goals, and continue to improve sustainability across the entire value chain, decreasing dependency on wild-capture forage fish for Omega 3. This partnership will show that innovations like Veramaris algal oil can be implemented along the value chain at speed, to improve Atlantic salmon nutrition and provide the consumers with a product that is suited to human health, helps fish welfare and is raised within planetary boundaries. Veramaris’ algal oil contains the highest amount Blumar and Veramaris innovate to achieve better outcomes for Atlantic salmon Nutreco receives $4.8M grant to roll out feed mills Nutreco, part of the SHV group of companies, and a global animal nutrition leader based in the Netherlands, has received a US$4.8 million grant from the Bill & Melinda Gates Foundation. The grant is to accelerate the implementation of localized, sustainable complete feed production in sub-Saharan Africa, driving forward Nutreco’s purpose of Feeding the Future. The US$4.8 million grant will directly fund 21 Hendrix4U complete feed production projects initially in Ghana, Ivory Coast, Nigeria and Uganda. Hendrix4U provides a ‘factory-in-a-box’ for rural areas ensuring access to quality compound feed production for small-scale producers, in a financially sustainable way. This is one of the first investments from the foundation in the animal feed space - a powerful endorsement of the extensive work done to date by Nutreco. Since 2018, the business has tried and tested the implementation of 16 Hendrix4U projects, demonstrating its critical impact for producers. The 37 Hendrix4U projects in total, which all include a full-service package for small-scale feed production, will not only improve local feed value chains, but also critically improve the profitability of over 15.000 poultry and dairy producers. Nutreco partners and supports organisations around the planet to ensure it can play its role in Feeding the Future. Across the African continent, Nutreco is active in over 40 countries with teams present in 15 countries, with over 500 people dedicated to both aquaculture and animal nutrition.
NEWS FEED & ADDITIVE MAGAZINE August 2022 15 of both EPA & DHA Omega-3s currently available on the market. Implementing the OON guidelines can support farm production by meeting the nutritional requirements of the fish during the grow-out phase. Optimum Omega Nutrition is a guideline for meeting both EPA & DHA Omega-3 and ARA Omega-6 requirements, whilst maintaining the appropriate Omega-3 to Omega-6 ratio in salmon diets, leading to improved salmon health and welfare throughout production. By using Veramaris algal oil in conjunction with the OON guidelines, fish farmers not only stand to improve productivity, product quality and yield but also lower their dependency on marine ingredients. Laguna Blanca branded salmon is further strengthened through this collaboration, enhancing its premium quality in response to consumer demand for high quality, nutritious and sustainable seafood. These characteristics include the fact that it is never treated with antibiotics, originating from the pristine waters of Patagonia’s Magallanes region 12, is ASC certified, rich in both EPA & DHA Omega 3 and fed on natural marine algae. Production takes place in Blumar´s Magallanes farms in Chile. FeedTechnoVision 2022 to spotlight feed production strategies As historic fluctuations in grain prices, supply chain disruptions, escalating energy costs and extreme weather events threaten feed producers’ margins, a panel of five global experts on feed processing and quality will reflect on sustainable production strategies for managing feed safety, quality and energy consumption during FeedTechnoVision 2022. The programme will be livestreamed Thursday, 8 September from 9 am to 12 noon CEST. The agenda includes a look at how feed producers can secure their position on raw material quality and availability as key drivers of input costs, how adaptions to process technology can help producers manage local raw material quality, and strategies to reduce feed processing energy costs. Finally, as extreme weather events become more common in many regions, the programme will address how to manage the special challenges that high temperature climate zones pose for feed production. Expert panellists will take an indepth look at the economics and operational efficiencies of feed production in today’s unpredictable production environment. The panel is comprised of five experts in the global feed sector: Robert van den Breemer, Procurement Director Macro Ingredients at Nutreco; Ernst Nef, feed industry consultant and former Director at the Swiss Institute of Feed Technology; Jan Jonkers, former R&D manager at the Aquaculture Research Centre of Skretting; Paul Koolen, Livestock Programme Manager for Middle East and Africa, Trouw Nutrition; and Geke Naaktgeboren-Stoffels, Global Quality Director at Trouw Nutrition.
NEWS 16 FEED & ADDITIVE MAGAZINE August 2022 Kemin Industries, a global ingredient manufacturer that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services, has launched ENTEROSURE™ to control the growth of pathogenic bacteria in poultry and livestock. Kemin unveiled its latest intestinal health product at a global launch event in Dubai. The company’s newest probiotic solution promotes a healthy microbiome, drives intestinal resilience, manages gut health challenges and improves animal productivity. Enteric disease challenges are an ever-present pressure on livestock and poultry producers, who are already facing significant performance and Kemin launches new probiotic solution Hendrix Genetics, CSIRO partner for egg laying innovation Hendrix Genetics is partnering with Australia’s national science agency, CSIRO, to test the viability of an innovative point of lay sex sorting technology for the egg laying industry. The poultry industry is committed to finding a sustainable solution for the practice of euthanizing male layer chicks. The chickens that lay eggs (layers) and the chickens that produce meat (broilers) are different breeds of chickens with each type being best suited to their purpose. Broiler chickens are very effective at producing meat in a sustainable way; laying chickens are excellent at laying eggs and produce an egg a day. Both male and female broiler chickens produce meat with a low carbon footprint. Layer breed males can't produce eggs, and due to being a layer-breed they are very poor at producing meat in sustainable way. Solving this ethical dilemma would improve both animal welfare and food system sustainability. Australia’s national science agency, CSIRO, has developed sex sorting technology which can identify eggs containing male embryos at point of lay before they are incubated and hatched. To support this initiative, Hendrix Genetics has partnered with CSIRO to conduct exploratory research to assess the viability of this solution. A major objective of the project is to explore how this technology can best be integrated with current industry practice. The project will study technology developed by CSIRO that uses a biomarker protein that is only found in male embryos and not in female embryos. This allows researchers to identify male embryos during the very early stages of development that occur prior to egg incubation. Therefore, the hens hatched and the eggs they lay remain the same as they are today. This exploratory research is an important first step that could lead to a solution for a major animal ethics and welfare challenge as well as improving the carbon footprint and sustainability of the egg industry. Kemin Industries announced it has launched ENTEROSURE™, new probiotic solution. The global company’s next-generation probiotic helps reduce the risk of diseases affecting the intestinal health of poultry and livestock.
NEWS FEED & ADDITIVE MAGAZINE August 2022 17 economic impact from the global trend toward reduced antimicrobial use and the rising cost of raw materials. These challenges require an effective and comprehensive solution that helps drive intestinal resilience to prevent disease before it develops—all while safeguarding animal health, welfare, growth and performance. “Leveraging the pioneering research that launched CLOSTAT™, our novel solution addresses the changing needs of animal producers,” said G.S. Ramesh, Worldwide Group President – Animal Nutrition and Health, Kemin Industries. “ENTEROSURE, through its proprietary blend of probiotic Bacillus strains, expands on the scientifically proven efficacy of CLOSTAT’s Bacillus subtilis PB6 against Clostridium perfringens by also managing the growth of Escherichia coli and other Enterobacteriaceae, such as Salmonella.” Intestinal resilience is a crucial factor in producers’ hierarchy of needs for their animals; up to 80 percent of antimicrobial use is intended to achieve resilience in the gastrointestinal system, a vital component in animal production. Kemin continues to drive innovation through its probiotic research program to support intestinal health management. The company undertook a multiyear, global project to discover advanced solutions to enhance intestinal resilience while maintaining a robust program to improve feed conversion and weight gain and combat pathogens that contribute to dysbiosis, diarrhea, wet litter issues, foot-pad lesions and mortality. ForFarmers United Kingdom (ForFarmers UK) and 2Agriculture have come to an agreement to merge their businesses into a joint venture to serve a wider customer base. The joint venture will have a balanced feed portfolio across species, with an expected combined sales volume of more than 3 million tonnes of compound feed per year. The mutual agreement to enter into a joint venture meets the strategic objectives of both partners. ForFarmers UK strengthens its position in its home country in the promising poultry sector and at the same time creates possibilities to make the organisation more efficient. 2Agriculture benefits from shared investment opportunities across a larger volume, an increased geographic spread of manufacturing sites and exposure to other species markets. The joint venture will bring together 2Agriculture’s expertise in the promising poultry feed sector with ForFarmers’ capabilities in research and development as well as in formulation, particularly in ruminant and pig feeds. The merger agreement is a noncash transaction. The share split will be 50.1% for ForFarmers UK and 49.9% for 2Agriculture. The deal will be subject to approval from the UK competition authority. The share split also reflects the fact that 2Agriculture is fully focused on the promising poultry sector and has existing supply arrangements in the integrated market. ForFarmers will consolidate 2Agriculture fully into its financial results. ForFarmers and 2Agriculture join forces in UK Commissioning and start-up activities have commenced at the world’s first industrial-scale FeedKind® facility, to produce a new sustainable functional protein that does not use animal or plant ingredients in its production.
ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE August 2022 MYCOTOXIN MANAGEMENT IN ANIMAL FEED
ISSUE FOCUS FEED & ADDITIVE MAGAZINE August 2022 19 Guidance on how to register a mycotoxin binder Dawn Botha Pen & Tec Consulting A constant antagonist: Consequences of endotoxins in animals Josep Garcia-Sirera Agrimprove Should we worry about mycotoxins in dairy cows? Dr. Swamy Haladi, DVM., PhD Selko Feed Additives Managing the mycotoxin risk in lower quality ingredients Martin Minchin Alltech
ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE August 2022 Unlike what is perceived in the animal industry, the risk of mycotoxin exposure is the highest for dairy cows. Their TMR contains not only grains and protein sources, but many unconventional by-products, silages, hay, haylage, and green grass/pasture. The consumption of such TMR induces multiple mycotoxin toxicity and therefore, the intervention strategy must be holistic, practical, and multi-pronged. The global animal industry considers mycotoxins as a major threat to the health and performance of pigs and poultry. Does everyone in the animal industry believe the same for dairy cows? Probably not, as there is a myth in the animal industry that dairy cows can handle mycotoxins effectively due to their rumen microbial activity. Why can dairy cows succumb to mycotoxins? Although rumen microbes can reduce the toxicity of some mycotoxins, they cannot eliminate the problem completely. Not all mycotoxins are equally degraded in the rumen. Modern high-yielding dairy cows are fed with high-starch diets which compromises the detoxification capacity of rumen microbes. For some mycotoxins, like zearalenone (ZEN), rumen degradation may increase the toxicity. Among mycotoxins not completely inactivated in the rumen, only aflatoxin (AF) B1 is transferred into dairy milk as AFM1 in levels that create a public health concern. Research has demonstrated that cows genetically selected for high milk production may also excrete higher levels of AFM1 into milk. The global dairy industry must also be aware that among all production animals, dairy cows are exposed to a greater number of mycotoxins. How is that possible? Looking at the diets of poultry and pigs, it is mainly comprised of grains such as wheat and corn, and protein sources such as soybean meal, and sunflower meal. What about dairy cows? In addition to the feed ingredients mentioned above, TMR of dairy cows contains silages, hay, haylage, green grass/ pasture and many other unconventional ingredients. Such complex TMR composition results in multiple mycotoxin challenges in dairy cows. Although it varies across the globe, in general high-quality raw materials are prioritized for humans, pets, pigs, poultry and dairy cows, in that order. What else can make dairy cows more susceptible to mycotoxins? It is very well known that dairy cows are exposed to low levels of multiple mycotoxins for an extended period. Acute toxicity due to mycotoxins such as ergot toxins and T-2 toxin is lower now but chronic toxicity due to relatively lesser toxic mycotoxins such as DON, fumonisins and silage SHOULD WE WORRY ABOUT MYCOTOXINS IN DAIRY COWS? A holistic look at multiple mycotoxin management in TMR Dr. Swamy Haladi, DVM., PhD Global Programme Manager Mycotoxin Risk Management Selko Feed Additives
ISSUE FOCUS FEED & ADDITIVE MAGAZINE August 2022 21 mycotoxins is on the rise. The chronic multiple mycotoxin toxicity is comparable to cancer as it is very difficult to diagnose the problem at the early stages. What are so called “Silage” mycotoxins? Many new names for mycotoxin classification have been used lately. “Big 6” mycotoxins refer to the major six mycotoxins that are analysed regularly at feed mills and labs using rapid tests. These are aflatoxins (AF), ochratoxin A (OTA), T-2 toxin, DON, zearalenone (ZEN) and fumonisins (FB) and are measured as “marker mycotoxins” and their presence indicates the potential presence of another 30 to 40 mycotoxins. These mycotoxins along with ergot toxins in the total mixed ration (TMR) can cause health concerns when present in the ration at high concentrations. All these mycotoxins are mainly produced at the pre-harvest stage. What are “Silage” mycotoxins then? “Silage” mycotoxins are those that are predominantly produced during the process of silage fermentation. A well-managed silage will have less production of such mycotoxins as the anaerobic condition will not allow moulds to overgrow and produce mycotoxins. More than 80 micro-aerobic fungal species can grow in silages producing diverse mycotoxins. Penicillium roqueforti, Aspergillus fumigatus and Bysspchlamus are the major moulds in silages and the mycotoxins produced by them have antibacterial and anti-protozoic activity. Since most of the mycotoxins produced during silage fermentation are from the genus “Penicillium”, “Silage” mycotoxins are often referred as “Penicillium” mycotoxins. Some of the examples are roquefortine C, mycophenolic acid, and penicillic acid. What are “Emerging” and “Masked”mycotoxins? In recent times there is a lot of reference to “Emerging” and “Masked” mycotoxins and these mycotoxins add further toxicity to the regular mycotoxins in TMR. “Emerging” mycotoxins such as enniatins and fusaric acid can also have antimicrobial effects in the rumen and this can be one of the reasons for a reduced rumen function and a reduced mycotoxin degradation capacity of the rumen. Some mycotoxins like conjugates of DON, ZEN and T-2 toxin are difficult to detect in feed when routine extraction methods are applied. These so-called “Masked” mycotoxins remain active and are often released by enzymatic and/or microbial activity in the digestive tract. How does mycotoxicosis manifest in dairy cows? Alone and in combination, mycotoxins can threaten dairy cows’ health, rumen function, feed intake, milk yield, milk quality, lameness, and reproductive abilities. Many “mouldy silage syndrome” cases in the field have shown incidences of increased somatic cell counts, undigested faecal feed particles, laminitis, mastitis and ruminitis cases. The reproductive challenges range from increased number of inseminations per conception to retention of placenta or even abortions. Many cases of vaccination failures have been reported with multiple mycotoxins in TMR. How can mycotoxin issues be diagnosed? The major challenge of mycotoxin risk management lies in the diagnosis of the problem and the ability to establish the cause-and-effect relationship. Mycotoxin symptoms in dairy cows can be confounded with that of pathogen challenge, nutritional deficiency, and management related challenges. Although feed mycotoxin analysis has its own sampling error issues, it is the most used diagnostic tool at feed mills and bigger dairy farms. As part of its mycotoxin risk management programme, Selko uses the Mycomaster+ system to check raw materials, feeds, and milk for the “Big 6” mycotoxins and AFM1. Selected feed samples can also be analysed for multiple mycotoxins using LCMS/MS. Based on the mycotoxin concentrations, NutriOpt Mycotoxin Adviser provides customer-specific interpretations on what those concentrations mean and how the toxicity can be managed with the use of right dose of mycotoxin mitigation product (TOXO Range). Is mycotoxin binding strategy good enough? Mycotoxin mitigation strategies in dairy cows
ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE August 2022 demonstrate the importance of an integrated approach. It starts from optimal crop management, includes harvesting and storage of raw materials and finally the management of TMR (Figure 1). Innovations in organic acid application (Selko Fylax range) are allowing for better storage of raw materials in silos, leading to optimal silage production and face management, and preventing heating of TMR (Selko-TMR). Mycotoxin mitigation products (Selko TOXO range) can be added to TMR directly or via concentrate to effectively reduce mycotoxin risk for animal health and human health, by keeping AFM1 levels within statutory limits. As mycotoxins differ in their structure, scientific research has shown that all mycotoxins cannot be bound by a mycotoxin binder. Addressing this limitation, Selko developed the TOXO portfolio, using four modes of action to reduce the absorption of mycotoxins and to protect the animal against toxin damage. Based on the main objective of the feed mills or dairy farms, a selection of the right TOXO product can help in meeting those objectives. How to manage Aflatoxin M1 in dairy cows? Milk AFM1 management should be based on HACCP approach. This means all the critical control points of AFB1 entry into the dairy feed must be given proper attention and efforts should be made to prevent such entry. Regular feed mill audits and hygiene management will help in controlling unwarranted levels of AFM1 in milk. Since moulds are ubiquitous, irrespective of the efforts made there still be a chance of AFM1 appearing in the milk. The U.S. Food & Drug Administration (FDA) has set an upper limit of 0.5ppb AFM1 in milk while for the European Union has set this limit to 0.05ppb, ten times more stringent than FDA. Depending on the country the feed mills or dairy farms are in, these regulations should be followed both for milk used for domestic consumption as Figure 1. Tackling mycotoxin risk requires a fully integrated approach.
ISSUE FOCUS FEED & ADDITIVE MAGAZINE August 2022 23 well as export. AFM1 requirements in the importing countries should be studied thoroughly before planning the export of milk and milk products. There are many instances of milk being rejected at the port of entry due to higher than stipulated AFM1 concentrations in milk. At the animal level, fortunately there are effective strategies to bind AFB1 in the intestine thereby preventing its entry into blood circulation. Selko has incorporated a high quality smectite binder in their product TOXO-MX and this product has shown to significantly lower AFM1 levels by 65%. Such effect was achieved at very low concentrations of AFB1 in TMR indicating product’s high affinity towards AFB1 (Figure 2). Can the TOXO range bind multiple mycotoxins? A series of in vitro trials conducted at independent labs have shown that TOXO range can bind multiple mycotoxins. In addition to more than 90% binding to AFB1, TOXO range can bind T-2 toxin, ZEN, and OTA to the tune of 35 to 45%. Other two “Big 6” mycotoxins are hard to bind, and hence different modes of action need to apply. On the other hand, TOXO range has shown to bind ergot toxins up to 93.6% at pH 3 and 7. Given the increased emphasis on emerging mycotoxins, a study done in 2021 in Germany looked at the TOXO range ability to bind emerging mycotoxins at a pH of 3 or 6.5. All three of the emerging mycotoxins (roquefortine C, sterigmatocystin and enniatin) showed to be bound at more than 74% (Figure 3). How tomanage the effects of multiplemycotoxins on milk production? TOXO-XXL is Selko’s most broad-spectrum mycotoxin mitigation product encompassing four mode of actions – reduction in mycotoxin bioavailability, strengthening gut barrier function, modulation of immune response, and enhanced antioxidant status. Controlled research was carried out at University of Cattolica in Italy to understand the efficacy of TOXO-XXL in reducing the negative impact of multiple Fusarium mycotoxins on the dry matter intake (DMI), milk production, and rumination time. A total of 31 Holstein lactating cows were enrolled in the study, where 16 cows were used for a trial in the spring period and the trial was repeated in the following summer period with another 15 cows. Each period consisted of a 7-day of adaptation and a 54-day intoxication, where cows were blocked based on days in milk (DIM) and parity, and randomly assigned to specific treatments. Treatments are listed in Table 1. The daily milk production and milk composition was measured by AfiLab system. Cows were milked twice a day and weighted after each milking. During a 54-day exposure to moderate levels of Fusarium mycotoxins, DMI (expressed as a percentage relative to body weight) reduced from 4.02 to Figure 2. TOXO-MX lowering AFM1 levels in milk (CTR-0: Control feed, CTR-AFLA: Feed with AFB1, TRT: Feed with AFB1 and Toxo-MX) Figure 3: Adsorption capacity of TOXO range against some emerging mycotoxins
ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE August 2022 About Dr. Swamy Haladi, PhD Dr. Haladi is Selko’s Global Programme Manager for the Mycotoxin Risk Management programme. He obtained his Bachelor and Master degrees in veterinary science in India, and then moved to Canada to obtain his PhD in animal and poultry science. During studies and career, he continued to gain more interest and knowledge in the area of mycotoxins, especially the global challenges around this topic. He published various articles in both peer-reviewed journals as well as industry magazines and he truly understands the global challenge of mycotoxins. Furthermore, he developed practical guidance values for mycotoxins in various species. 3.99%. Rumination time saw a reduction as well from 513 to 505 minutes. Additionally, milk yield decreased from 38.29 to 37.55 kg/cow/day (Figure 4). Supplementation of TOXO-XXL at 100 g/cow/ day, however, was able to increase DMI, rumination time and milk yield to 4.09%, 525 minutes and 39.28 kg/cow/day, respectively. CONCLUSIONS • Unlike the perception, dairy cows can succumb to the negative effects of low levels of multiple mycotoxins originating from wide variety of raw materials in TMR. Negative effects can be manifested on their health, milk production, reproductive capacity and milk quality. • Many organs and organ systems are compromised by mycotoxins in dairy cows. Moreover, mycotoxin binding approach alone is not sufficient for the effective management of mycotoxins. It takes combination of mycotoxin binder with ingredients capable of supporting gut, immune system and anti-oxidant system to protect the high-yielding dairy cows. Mycotoxin mitigation methods should be based on the specific objective of feed mills or dairy farms in question. Table 1: Description of treatments for TOXO-XXL trial Description Negative control Positive control Positive control + TOXO-XXL Diet Day 8-62 (intoxication) TMR with minor levels of DON, ZEN and FB, at 284.5, 43.2 and 129.6 ppb, respectively TMR with moderate levels of DON, ZEN and FB, at 1021.0, 196.8 and 238.4 ppb, respectively TMR with moderate levels of DON, ZEN and FB, at 1009.6, 248.5 and 241.7 ppb, respectively and supplemented with 100 g/cow/day TOXO-XXL Treatment 1 (CTR) 2 (MTX) 3 (TOXO-XXL) Day 1-7 (adaptation) TMR with minor levels of DON, ZEN and FB, at 284.5, 43.2 and 129.6 ppb, respectively Figure 4. The efficacy of TOXO-XXL on milk yield; *FCM: fat corrected milk; **ECM: energy corrected milk
ISSUE FOCUS FEED & ADDITIVE MAGAZINE August 2022 25 www.selko.com/FeedTechnoVision2022 As several global developments cause crisis in raw material availability and cost, and pressure on reducing energy consumption is increasing, there is a clear need to look at your feed production processes. How to cope with increasing cost and volatility? How to maintain feed quality? How to reduce energy while maintaining performance? FeedTechnoVision 2022 brings together world renowned experts on feed processing and efficiency for a round table discussion on how the industry will respond and is expected to adapt to the current crisis, highlighting potential short-term solutions to cope with high input cost for feed manufacturers, while providing safe and high quality feed, on our mission of Feeding the Future. We look forward to your live interaction and participation during FeedTechnoVision. YOU ARE INVITED TO FEEDTECHNOVISION 2022 Sustainable feed production in a changing world DATE 8 September 2022 TIME 9AM – 12PM CEST FORMAT Livestream
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