May 2022 Year: 2 - Issue: 16 Behnaz Shakersain, AstaReal The promising future of animal nutrition in hands of microalgae! Janus Fouche, Devenish Production with optimal moisture or more expensive raw materials? Aleksandar Selakov, AFOS Feed formulation software and benefits www.feedandadditive.com Feed Formulation Software and Benefits Effects of Zinc Oxide Restrictions and Its Alternatives New Trend in Animal Nutrition: Algae
Dear readers, We are happy to bring you another issue with its rich content. This month’s issue, unlike our previous issues, focuses on 4 different topics: Algae, software, zinc oxide and feed phosphates… Today, I would like to talk a little bit about algae. As you know, we humans and our animals share a very large part of food resources. In other words, we are fed with almost same raw material sources. However, world population is increasing rapidly and the need for food gets its share from this rise. Unfortunately, we have limited resources. This concerning situation for the future has become an important matter of sustainability. Therefore, it is now an inevitable necessity to turn to more sustainable food ingredients for both humans and animals. In addition, environmental problems and the tendency towards natural resources are among other factors that trigger this necessity. Algae is one of these new nutritional ingredients that emerged in the process of searching for different sources and has started to gain popularity with the benefits it offers. It is known that algae, used as biofuels, human food and animal feed, has positive effects on animal growth and immunity. Likewise, it is stated that it has yield-enhancing properties in animal products such as meat, milk and eggs in the field of livestock and that their environmental impact is lower. Its multifunctional, natural and healthy structure makes algae an ingredient worth keeping on the agenda and researching. In this month’s issue, we made an effort to prepare a detailed file that includes all these issues related to algae, with contributions from the industry’s leading suppliers of seaweed, macro and micro algae. I hope it will be a useful file that you will enjoy reading. Another topic you can find in this month’s issue is about the use of zinc oxide. This dossier will contribute to the development of a new approach, especially for pig breeders, before the restrictions of the use of zinc oxide at pharmacological level will be in effect in European Union countries as of June 2022. I would also like to remind you that you can review our May 2021 issue for more resources on this subject. You can find details and other valuable content about feed/additive formulation software and feed phosphates market in the following pages. Enjoy reading… Publisher Muhammed Akatay [email protected] Responsible Manager Özlem Buyruk Akatay [email protected] Editor-in-Chief Derya Yıldız [email protected] Editors James Watson Bahadır Büyükkılıç [email protected] Design Alper Kandemir [email protected] Web Design Caner Cem Pulat [email protected] Proofreading Lisa Atakul [email protected] Circulation and Data Responsible Amine Şengün [email protected] Ataturk St. Metropol Istanbul Ste. Block C1, No:376 Atasehir, Istanbul/TURKEY Phone: +90 850 220 5064 E-Mail: [email protected] Web: www.feedandadditive.com Branch: Ste B69, East Rutherford, New Jersey 07073, USA Publication Type: Periodic (Monthly) EDITOR Sustainable alternative sources Derya YILDIZ All copyrights belong to Three Plus Media.© May not be used without permission. Responsibility of the ads belongs to the advertisers. feedandadd i t i ve
C O N T E N T S 18 ISSUE FOCUS 26 SEAWEED POLYSACCHARIDES AS A SOURCE OF HIGHLY EFFECTIVE PREBIOTIC FIBRE Dr Jason Sands, Head of Nutrition, Ocean Harvest Technology 20 THE PROMISING FUTURE OF ANIMAL NUTRITION IN HANDS OF MICROALGAE! Behnaz Shakersain, PhD, Marketing & Scientific Liaison, AstaReal Sweden 31 EXPLORING THE POTENTIAL OF MICRO-ENCAPSULATED PHYCOGENICS Dr. Stephanie Ladirat, R&D Director, NUQO Feed Additives 34 SEAWEED SOLUTIONS FOR PERFORMANCE, HEALTH & WELLBEING Ingrid Jonker, MSc, Business Development Lead Blue Farming, The Seaweed Company 38 MICROALGAE AS A SUSTAINABLE AND VALUABLE FEED INGREDIENT Görkem Koyun, Founder, Marin Biotechnology NEW TREND IN ANIMAL NUTRITION: A L GA E TRENDING FILE 46 WEANING PIGLETS WITHOUT THERAPEUTIC ZINC OXIDE: IT’S POSSIBLE AND EFFICIENT! Anne-Sophie Valable, Monogastric Product Manager, CCPA Group 50 ZnO MODE OF ACTION IN PIGLETS: FOCUS ON ZN BLOOD LEVELS, ITS HOMEOSTASIS AND ADG Jennifer Maurin, Marketing & Sales Director & Agathe Roméo, R&D manager, Animine 54 ZERO ZINC BAN IS NOTHING NEW FOR THE FRENCH FEED INDUSTRY David Guillou, Senior Researcher, miXscience
61 3 WAYS TO INCREASE MILK PRODUCTION WHILE REDUCING YOUR CARBON FOOTPRINT Dr. Saheed Salami, Research Fellow, Solutions Deployment Team, Alltech 64 BILE ACID – NOT JUST ANOTHER EMULSIFIER Kayla Wong, Technical Specialist, Manuka Biotech 68 THE PLAY OF PROPOLIS: A NOVEL COMPONENT IN FISH FEED Kamalii Ahilan & Mahalakshmi Shankar, Research Scholar, Department of Aquaculture, TNJFU-Dr. M.G.R. FCRI 71 ADVANTAGES OF USING MEDIUM CHAIN FATTY ACIDS IN ANIMAL FEED Paroma Bhattacharya, Reports and Data 74 THE NEXT GENERATION FOR THE PHOSPHATES MARKET Andrés Donadeu, Technical Manager, GlobalFeed C O N T E N T S ARTICLES INTERVIEW CCPA Group develops THERMO® range to tackle heat stress 16 Perstorp launches Gastrivix™ Avi for poultry 10 Arla Foods, DSM start on-farm pilot to reduce GHGs from dairy cows 90 Hendrix Genetics, Coraqua sign strategic partnership for Troutlodge egg production 92 AquaBounty begins construction of state-of-the-art salmon farm 94 SPECIAL STORY 56 AN ONLINE FORMULATION SOLUTION FOR ADDITIVE PRODUCERS Bruno Duranthon, President / CEO, A-SYSTEMS SAS 58 FEED FORMULATION SOFTWARE AND BENEFITS Aleksandar Selakov, CEO, AFOS REPORTS GLOBAL FEED PHOSPHATE MARKET 78 NEWS PRODUCTION WITH OPTIMAL MOISTURE OR MORE EXPENSIVE RAWMATERIALS? 42 Janus Fouche, Product Manager for SmartMoisture at Devenish
NEWS 6 FEED & ADDITIVE MAGAZINE May 2022 Marel has announced an agreement to acquire Wenger Manufacturing LLC, a global leader in processing solutions focused on pet food, plant-based proteins, and aqua feed. The acquisition of Wenger is a platform investment into new, complementary and attractive growth markets for Marel and will form the fourth business segment alongside poultry, meat and fish. The acquisition is subject to customary closing conditions such as anti-trust and approval of Wenger’s shareholders. A new business segment, based on the Wenger platform, will constitute Marel’s fourth pillar alongside poultry, meat and fish, and will be focused on the sizeable and attractive growth markets of pet food, plant-based proteins and aqua feed. On a pro-forma basis, this new business segment will acMarel to acquire Wenger for $540 million Iceland based Marel announced that it would acquire Wenger Manufacturing LLC, a leading US based company for processing solutions for pet food, plantbased proteins, and aqua feed. As part of a new strategic partnership, Elanco Animal Health has gained exclusive licensing rights to develop, manufacture, and commercialize Bovaer®, a revolutionary, methane-reducing feed additive by DSM for cattle, in the U.S. Elanco Animal Health Incorporated and Royal DSM have announced a strategic alliance connecting two leading, sustainability-focused companies to address one of society's most significant opportunities of the decade, mitigating climate change by reducing greenhouse gas emissions from farming. Elanco has secured the exclusive U.S. licensing rights to develop, manufacture and commercialize Bovaer® for beef and dairy cattle. Bovaer® is a first-in-class and best-in-class methane-reducing innovative feed additive for beef and dairy cattle, already available in Europe, Brazil, Chile and Australia. More than 50 peer-reviewed studies and 48 on-farm trials in 14 countries show Bovaer® consistently reduces enteric methane emissions by approximately 30% for dairy cows and even higher percentages for beef cattle. The strategic alliance is expected to enable both parties to maximize the opportunity for the product in the U.S. market, once approved, while also nearly doubling previously announced Bovaer® production capacity globally. Elanco will be responsible for the U.S. approval process, commercialization strategy and product supply, supporting DSM supply in markets outside the U.S. Elanco will assess and evaluate the regulatory submission and manufacturing options with the intent to bring Bovaer® to the U.S. market as quickly as possible. The methane reduction from feeding a million cows Bovaer® is equivalent to planting 45 million trees or removing 300,000 cars from the road. With 9 million dairy cows and 14 million beef cattle on feed in the U.S. alone, the product would contribute to a significant and immediate reduction of the environmental footprint of meat and dairy products, supporting the Global Methane Pledge to cut emissions 30% by 2030. With an estimated global market opportunity for livestock methane reduction of $1 billion to $2 billion, Elanco expects Bovaer® to have blockbuster annual revenue potential in excess of US$200 million in the U.S. market with initial contribution by mid-decade. Elanco, DSM create strategic alliance for Bovaer®
NEWS FEED & ADDITIVE MAGAZINE May 2022 7 count for around 10% of Marel’s total revenues and 12% of combined EBITDA. This new growth platform is an important addition to Marel’s product portfolio to meet customers’ rising demand for high-quality food and feed that is processed in a sustainable and affordable way. The two companies have a great strategic and cultural fit with highly complementary product portfolios and geographic presence, creating a strong platform to enhance further growth. Wenger shares Marel’s passion for innovation and commitment to best-in-class products, backed by an experienced team and long-standing partnerships with customers. Wenger enjoys a diversified and loyal customer base ranging from blue-chip pet food processors to startup companies in plant-based proteins. This has resulted in healthy profitability, strong cash flow and solid return on invested capital. Capitalizing on Marel’s global reach and digital platform, the two companies are well positioned to explore future growth opportunities together. Marel agreed to acquire Wenger Manufacturing LLC., including all relevant business activities of the group. The total investment for the acquisition is USD 540 million. The purchase price will be paid with cash at hand and existing credit facilities. Phileo unveils tilapia program with functional yeasts Phileo by Lesaffre has introduced Program Aquasaf Tilapia, a new nutrition program designed to maximize productivity, profitability and sustainability of tilapia farming by using Phileo’s functional yeast probiotics and postbiotics. Gathering more than 10 years of work in the tilapia industry, Phileo by Lesaffre has launched a dedicated program aiming to improve gut health and support disease prevention strategies. The Program Aquasaf Tilapia was conceived to maximize productivity, profitability and sustainability of tilapia farming using Phileo’s functional yeast probiotics and postbiotics. To build the program, Phileo draws on knowledge from more than 10 R&D projects carried out in China, Thailand, Vietnam, Brazil, Mexico and the Philippines using different products and their combination, both in lab and field conditions. The program provides science-based recommendations to address some of the most impacting challenges faced by producers such as mortalities caused by bacterial infections from Aeromonas hydrophila and Streptococcus agalactiae, reduced growth associated with oxidative stress, economic losses due to poor gut health and feed conversion, while avoiding the use of antimicrobial and chemical substances. Otavio Serino Castro, Phileo’s Aquaculture Global Species Manager explains: “We designed Program AquaSaf Tilapia to provide a clear view on the mechanisms of action of our solutions and their benefits on immunity, microbiota and performance in different production conditions. It is a tool to support and empower professionals when developing preventive care strategies for a more sustainable tilapia production”.
NEWS 8 FEED & ADDITIVE MAGAZINE May 2022 Finland-based Valio, a major player in the international dairy ingredients market, announced that it would sell its Russian operations to Velkom Group. Valio to sell its Russian operations to Velkom Group Valio has completed negotiations on the divestment of its Russian operations. Valio will sell the operations to Velkom Group. The transaction will take place immediately. The transaction includes Valio’s Russian operations and the processed cheese factory in Ershovo. The Viola® brand processed cheese sold and produced in Russia is also part of the transaction. With the transaction, Valio’s personnel in Russia will transfer to Velkom Group. The parties have decided not to disclose the value of the transaction. With the completed transaction, Valio’s operations in Russia have now ended. In 2020, Valio’s net sales in Russia were 87 million euros and accounted for approximately 5 percent of Valio’s global net sales of about 1.8 billion euros. Valio decided on 7 March 2022 to withdraw from operations in Russia. With this transaction, Valio is immediately withdrawing from all operations in Russia. Valio exports products to some 60 countries around the world. The total value of Valio’s international operations and exports is about 750 million euros annually, i.e. about 40% of Valio’s total net sales. Of the interested buyers, the Russian food producer Velkom Group was selected as the most suitable. Perstorp to double carboxylic acid production capacity Leading specialty chemicals company Perstorp plans to have extra capacity of around 70,000 tonnes/year for production of carboxylic acids onstream by 2024. The investment will enable Perstorp to increase output significantly and strengthen its position as the sustainable solutions provider. Increased capacity will meet growing demand in various high-value applications, including carboxylic acids for use in animal feed gut health and preservation products. Most of the output will be used in downstream production operated by Perstorp itself. Perstorp will build a new plant on the site of its existing carboxylic acid production operation in Stenungsund, Sweden. Like the original unit, it will be capable of producing acids from C3 to C9 chemistry, significantly strengthening the company’s portfolio. Both plants will be fully integrated into Perstorp’s Oxo production platform. Perstorp also uses carboxylic acids for its in-house production of various grades of food preservative (Profina™ CP) and animal feed preservative (ProSid™ MI 208). It is the only company in the world making these products with upstream integration. Sweden-based Perstorp will build a new plant to have extra capacity of around 70,000 tonnes/year for production of carboxylic acids onstream by early 2024.
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NEWS 10 FEED & ADDITIVE MAGAZINE May 2022 Perstorp launches Gastrivix™ Avi for poultry Perstorp is expanding on its innovative range of broiler feed solutions after the launch of Gastrivix™ Avi in late March 2022. The company is the first to pioneer the commercial use of valeric acid in animal nutrition, following successful trials of Gastrivix™ Avi. Like butyric acid, valeric acid is naturally created by the gut microbiota of broilers, although in too small quantities for optimal gut health during production cycles. Perstorp has used complex organic chemistry to create esters of valeric acid, which were tested over many years in a multitude of combinations with butyric acid esters to develop the right synergy, and the best match with nature. Gastrivix™ Avi has been created to meet the bird’s biological needs, support gut integrity and promote reliable growth and performance. Perstorp believes that the solution will solve multiple challenges for the industry, by reducing feed volumes for the broiler’s lifecycle, providing consistent growth results, and boosting ROI. “We can now prove that the synergy of these two esterified acids works better than one. After multiple trials, we have seen a reliable and consistent improvement on FCR for broilers thanks to the effects of butyric and valeric acid. With valeric acid, we have essentially found the missing ingredient,” commented Dr. Antonia Tacconi, Global Product Manager of Gut Health at Perstorp. Perstorp has introduced Gastrivix™ Avi - a unique poultry feed additive for gut health that combines the benefits of valeric and butyric acid. Vitapro announced that the company will make an investment of over $80 million in a new Nicovita plant in Ecuador. The new shrimp feed plant will expand the production capacity by around 45%. Nicovita accompanies the growth of the shrimp sector with the firm decision to make an investment unprecedented in its history, which strengthens its history of commitment and leadership in the industry, and marks the beginning of a new era to now drive the sector to "evolve with confidence”, that confidence that has always characterized the brand. “We are proud to announce the investment of more than 80 million dollars destined to expand approximately 45% of our production capacity, thus consolidating the Guayaquil plant as one of the largest production centers in the world in relation to balanced feed specialized in shrimp,” Fabricio Vargas, General Manager of Vitapro Ecuador. “This new investment, which is planned to begin in 2022, is a tangible reflection of Nicovita's commitment to accompany the exponential growth of the shrimp sector for the coming years, because it will allow it to expand by approximately 45% the land destined for the production and storage of balanced feed, consolidating a new plant with the most advanced digital technology, as well as more efficient production systems and processes with high quality standards aligned with the brand's seal of Vitapro invests $80m in Nicovita plant in Ecuador
NEWS FEED & ADDITIVE MAGAZINE May 2022 11 Zeewaar, the first Dutch and organically certified seaweed farm, has been acquired by The Seaweed Company. Zeewaar, the first Dutch and organically certified seaweed farm and located in a unique location in the Oosterschelde National Park, has a new owner. After years of inspiring leadership by the seaweed pioneers Rebecca Wiering and Jennifer Breaton, the duo and the partners involved (e.g. impact investors DOEN Participaties and Goeie Grutten Impact Fonds) have decided to sell the company to The Seaweed Company. With the acquisition of Zeewaar, The Seaweed Company strengthens its position in the 'Blue Food' market to put seaweed applications and ingredients on the menu in a fast growing market of consumers and companies in Europe looking for high-quality and reliable seaweed. The Zeewaar company, founded in 2013 by Rebecca and Jennifer, produces seaweed organically in its own seaweed farm and processing facility in and at the Jacobahaven, Kamperland. Over the past decade, Zeewaar has further developed the market for seaweed products in the Netherlands by collaborating with brands such as Hema, ProLaTerre (part of SoFine Foods) and The Dutch Weedburger (part of Livekindly Collective). Partnerships have been set up with several sustainable European seaweed companies to meet the increasing demand for seaweed. “The seaweed industry in the EU is growing but is still in its infancy. After 10 years of pioneering as an impact entrepreneur, the time has come to transfer our seaweed farm and wholesaler to a passionate team with a different composition. Joining The Seaweed Company will ensure that Zeewaar continues to develop and we are confident that the impact achieved will be further increased.” says Rebecca Wiering. First Dutch seaweed farm Zeewaar joins The Seaweed Company trust,” the company said in a statement. The contribution to the economic and productive development of the country is also tangible in the generation of employment that this new investment will bring. “Once the plant starts operating, we calculate an increase of between 40 and 50% of workers,” explained Fabricio Vargas. In 2021, Nicovita expanded its production and storage capacity for 35 million dollars, which is about to be consolidated during the first half of 2022. With this new investment, Nicovita and Vitapro further strengthen the aquaculture infrastructure of the country, guaranteeing the food for the shrimp that its clients will produce and export in the coming year. Thus it contributes to Ecuador maintaining the leadership it achieved in 2020 by registering record figures in exports and positioning itself in 2021 as the world’s largest producer of shrimp, above strong Asian competitors such as China, Vietnam, India and Indonesia.
NEWS 12 FEED & ADDITIVE MAGAZINE May 2022 Elanco and Ginkgo Bioworks launched BiomEdit, a new animal health company leveraging microbiome technology. Elanco Animal Health Inc. and Ginkgo Bioworks announced the launch of BiomEdit, a microbiome innovation company that is expected to discover, develop and introduce novel probiotics, bioactive molecules, engineered microbial medicines and microbial monitoring services for animal health. BiomEdit intends to discover, develop and introduce differentiated products that address some of the greatest needs for innovation in animal health, including medicated feed ingredients, nutritional health and therapeutics for livestock and pet species, as well as biosecurity technology for animal disease monitoring. Elanco will contribute intellectual property and a pipeline of ongoing programs to BiomEdit, which will be staffed with members of the former Elanco microbiome R&D team. By leveraging foundational programs from Elanco, intellectual property from both Elanco and Ginkgo, and an experienced team, BiomEdit should be well positioned as a stand-alone company to develop and launch innovative products to address unmet needs in animal health. BiomEdit plans to leverage Ginkgo's state-of-the-art cell programming platform to improve the design and development of probiotics, bioactives, engineered microbial medicines, and microbial monitoring services. Elanco and Ginkgo Bioworks launch BiomEdit Amlan launches two new natural alternatives to antibiotics Amlan International, the animal health business of Oil-Dri® Corporation of America, has launched two new natural feed additives products - Phylox® Feed and NeutraPath® - that help optimize intestinal health and production economics in the absence of antibiotics for poultry and livestock. Phylox Feed is a natural alternative to anticoccidial drugs and vaccines that can help producers increase profitability. Phylox can be effective for full-time use or in rotation, and/or in a bio-shuttle program when resistance is a concern. Phylox is an ideal solution for all poultry species, including broilers, egg layers and broiler breeders, all of which can be sensitive to fungal and bacterial toxins during grow-out and egg production when exposed to fecal oocysts that are being shed as coccidia cycle. NeutraPath is a natural pathogen control product for antibiotic-free production that uses multiple modes of action to increase livability and improve feed conversion. Using a proprietary and co-active blend of essential oils, fatty acids and Amlan’s proprietary mineral technology, NeutraPath reduces pathogenic bacterial load and colonization, and improves intestinal health and structural integrity. Both of the new products can be used individually or in a program with Amlan’s mineral-based products, like Calibrin®-Z and patented Varium® and NeoPrime®, to help support gut health and improve productivity and efficiency. Amlan has expanded their broad portfolio of animal health feed additives to include a natural alternative to anticoccidial drugs and vaccines and a natural pathogen control product for antibiotic-free production.
NEWS FEED & ADDITIVE MAGAZINE May 2022 13 EuroTier 2022, the world's leading trade fair for animal farming and livestock management, is set to take place in Hanover, Germany on 15-18 November, 2022. Strong exhibitor interest is being registered for the EuroTier trade fair, to be held in Hanover, Germany, 15 -18 November 2022. Seven months before the start of the trade fair, 80 percent of the exhibition space has already been booked. Many of the world's leading companies offering technical solutions for modern animal husbandry will be present at the world's leading trade fair for animal farming and livestock management. The trade fair is a platform to meet practitioners and experts live, accompanied by an international technical program with conferences and partners on key topics in international pig, cattle and poultry production. EnergyDecentral, which takes place in parallel to EuroTier, focuses on the opportunities offered by decentralized energy generation as part of the current energy debate. EuroTier, the world's leading trade fair for animal farming and livestock management, plays a central role in the national and international livestock industry with its overarching concept for the entire value chain for the production of food of animal origin. "With the guiding theme 'Transforming Animal Farming', we have our finger on the pulse. The high level of exhibitor interest shows that, even in challenging times, EuroTier is the leading platform not only for showcasing leading technology and innovation, but also for discussing the influencing factors for successful livestock farming," says Ines Rathke, EuroTier project manager. EuroTier 2022 to be held on 15-18 November IntelliOpt Precision mineral nutrition The next generation of trace mineral solutions, combining science, technology and convenience to support wellbeing, performance and profitability through precision mineral nutrition. Learn more, visit www.selko.com
NEWS 14 FEED & ADDITIVE MAGAZINE May 2022 Phibro Animal Health and Vetos Europe partnered to introduce RelyOn™, a new natural feed additive to help support rumen health for beef and dairy cattle. NeoSpectra by Si-Ware partnered with AB Vista’s Aunir to offer customers affordable NIR calibration choices for in-field analysis. The partnership will offer NeoSpectra Scanner users Aunir’s INGOT NIR calibration models for accurate infield analysis across animal and aqua feed, feed ingredients, pet food, forage and other products. NeoSpectra by Si-Ware partners with AB Vista’s Aunir Phibro, Vetos introduce RelyOn for beef and dairy cattle NeoSpectra by Si-Ware, the creator of NeoSpectra material analysis solutions built on single-chip FT-NIR spectrometers, announced a partnership with AB Vista’s Aunir, a global leader in the development and supply of near infrared reflectance (NIR) spectroscopy calibrations. For the first time, the partnership will give customers subscription-based access to all Aunir INGOT NIR calibration models on the NeoSpectra LabStore to empower in-field analysis and decision making across animal feed, feed ingredients, flour, and milling, pet food, aquafeed, forages, animal by-products, plant breeders and other specialty products. NeoSpectra by Si-Ware will implement the full Aunir INGOT NIR calibration database on the Phibro Animal Health announced that it has joined with Vetos Europe to introduce RelyOn™, a feed additive used to help support rumen health which can lead to better control of metabolic disorders and help support animal health and production. RelyOn is a blend of natural compounds to support improved animal efficiency and performance. Its synergistic combination of essential oils, tannins and flavonoids support optimal rumen and tissue function. RelyOn will be available to international markets soon. Phibro has been a leader in animal health and nutrition for decades. Phibro’s broad portfolio of products, backed by innovative research and exceptional service, are the core to collaborations with farmers, ranchers, nutritionists and veterinarians. Now with a growing line of natural, sustainably produced products, Phibro offers responsible solutions to help support the health of all animal species, including cattle, poultry, swine and aquaculture. Vetos Europe is an innovative Swiss agri-tech company fully dedicated to the research and development of new feed additives for ruminants. Founded in 2013, Vetos has been successfully distributing feed additives for several years through international cattle networks, helping care for thousands of cattle around the world. Vetos products play an important role in customers’ ESG strategies, as they are making it possible for nutritionists and farmers to help improve animal performance and help reduce methane emissions.
NEWS FEED & ADDITIVE MAGAZINE May 2022 15 NeoSpectra LabStore. The NeoSpectra platform has the first and largest LabStore in the market, offering thousands of calibration models to users from trusted partners around the globe such as labs, researchers and universities. Today, the INGOT calibration library is the world’s most extensive with more than 500,000 analyzed samples and over four million data points. The partnership will provide portable NeoSpectra Scanner users with additional top-tier choices in NIR calibrations across a multitude of industry applications. NIR analysis is a quick, accurate and reliable method to measure the nutritional, chemical, and physical properties of ingredients and products. Together, Aunir and NeoSpectra by Si-Ware will give users the autonomy to choose the right calibration model to make important business decisions in real time. Users will be able to measure the integrity of raw materials and ensure their finished product meets specifications. In addition, NeoSpectra Scanner users will have access to the very latest calibrations across various markets and finished products through Aunir’s automatic calibration updates when subscribing via the NeoSpectra LabStore. The Aunir INGOT calibration database and models will be available for NeoSpectra Scanner users to browse and subscribe to in the NeoSpectra LabStore at the end of April.
NEWS 16 FEED & ADDITIVE MAGAZINE May 2022 Phileo by Lesaffre has launched Actisaf® Sc50 PET in the USA, the first probiotic ever to remain viable throughout the entire shelf life of dry food. This new generation probiotic has proven its health benefits backed up by extensive non-invasive trials in dogs, to fully respect animal welfare & strict ethics in cooperation with international experts & universities. Stability and viability are prerequisites to keep the micro-organisms alive until reaching the intestine of the dogs and deliver maximum benefits to the host and this, without hindering the palatability of the food. Actisaf® Sc50 PET has a record-breaking viability of 18 months onto dry food solving the challenge of stability of dry food. A versus test conducted on 40 dogs confirmed that the supplementation of Actisaf® Sc50 PET does not modify the palatability of the kibbles. Dr. Rodolphe Rabot, Phileo’s Pet Global Species Manager explains: “We designed Actisaf® Sc50 PET Phileo launches new probiotic for premium dry dog food CCPA Group develops THERMO® range to tackle heat stress High heat is not without consequences for livestock. In order to ensure their thermal comfort, to support the breeding performance and to ensure the income of the breeder, it is essential to set up a complete feeding and breeding management strategy. That's why CCPA Group has developed the THERMO® range, specific nutritional solutions for each species, to be used in prevention or intervention, and digital solutions to anticipate and better manage the impact of high temperatures. “This year again, new products and services have been added to our offer,” the French company said in a statement. Because guaranteeing the thermal comfort of animals also means maintaining their performances and the income of the breeders, CCPA Group has developed Thermo®, a complete range of solutions to meet the specific needs of each species. The Thermo® products strengthen the natural systems involved in evacuating heat, by helping improve gut integrity, offset electrolyte, and stimulate ingestion. Every type of production is affected by heat stress. That is why this year, an organic version of its ruminant solution: Thermo®Plus UOA is launched. It is very difficult for a farmer to estimate the economic impact of heat on his farm. Consequently, preventive actions are rarely implemented. However, the consequences are serious and will intensify with global warming. To address this challenge, CCPA Group has developed Farm-e-Val, a digital service, which relies on temperature and humidity sensors installed in the barn. This service then assesses the exact heat stress the animals were subjected to and can link it to variation in performances. As nutrition plays an important role in helping animals fight heat stress, a new thermal comfort indicator was added, this year, in CCPA group ruminant feedstuff rationing tool: Chorus. CCPA Group has developed the THERMO® range, specific nutritional solutions for each species, to be used in prevention or intervention, and digital solutions to anticipate and better manage the impact of high temperatures.
NEWS FEED & ADDITIVE MAGAZINE May 2022 17 after 4 years of research and development with universities, research centres and key industry partners. Based on our expertise in strain selection and petfood technology application, we have selected Actisaf® Sc50 PET (CNCM 5660) a Saccharomyces cerevisiae yeast probiotic specifically formulated to address technological challenges in relation to pet foods. With unique characteristics to secure convenience and shelf life, Actisaf® Sc50 PET has been specifically processed to blend easily and safely with powder palatants and allow post extrusion coating of dry food”. “To be able to implement this application strategy, continues Cécile Sampsonis, R&D Manager - Products formulation at Phileo by Lesaffre, we developed a specific process to produce Actisaf® Sc50 PET with a micropearl form. Each micropearl, with an average of 500 microns, contains more than 4 000.000 active live probiotic cells each as there are 1E10 CFU of yeast per gramme of product. This micropearl form also helps to limit environmental exchanges with water and oxygen to enhance resistance. This unique patent pending form was developed thanks to a dedicated fermentation & drying process on a specific line of manufacturing used by Lesaffre and the company’s mastery of yeast production. Actisaf® Sc50 PET has confirmed an exceptional flowability and being dust free compared to standard powder forms.” BENEO, one of the leading manufacturers of functional ingredients, has announced a €50 million investment in a new pulse processing site in Offstein, Germany. The site will produce protein rich pulse ingredients for food and animal feed. It will focus initially on protein concentrate, starch rich flour and hulls from Faba bean, with the option to process other pulses in the future. The new production site further strengthens the company’s plant-based protein portfolio and enables BENEO to meet growing demand for plant-based food and feed ingredients. Work has already begun on constructing the plant and is expected to be completed within the second half of 2024, creating up to 25 jobs at the Offstein site. However, to ensure that food and feed customers can benefit as soon as possible from Faba bean ingredients, BENEO will process the raw ingredients in intermediate production facilities, until the new plant is fully operational. This means that first quantities of BENEO’s Faba bean ingredients will be available from the start of June 2022 onwards. Pulses help to reduce green house gas emissions at farm level. For example, Faba beans provide nitrogen for themselves and subsequent plants and therefore nitrogen fertilisation is not necessary. The Faba beans will be locally sourced from farmers that are certified by the Sustainable Agriculture Initiative (SAI) and thus follow sustainability standards. As BENEO is manufacturing Faba bean protein, starch rich flour and hulls, the crop will be fully used and completely valorised for functional ingredients. BENEO invests €50 million in pulse-processing plant German ingredients manufacturer BENEO has unveiled a €50 million investment in a new pulse processing site in Offstein, Germany. The site will produce protein rich pulse ingredients for food and animal feed.
ISSUE FOCUS 18 FEED & ADDITIVE MAGAZINE May 2022 NEW TREND IN ANIMAL NUTRITION: A L GA E
ISSUE FOCUS FEED & ADDITIVE MAGAZINE May 2022 19 Exploring the potential of micro-encapsulated phycogenics Dr. Stephanie Ladirat NUQO Feed Additives The promising future of animal nutrition in hands of microalgae! Behnaz Shakersain AstaReal Sweden Microalgae as a sustainable and valuable feed ingredient Görkem Koyun Marin Biotechnology Seaweed solutions for performance, health & wellbeing Ingrid Jonker The Seaweed Company Seaweed polysaccharides as a source of highly effective prebiotic fibre Dr Jason Sands Ocean Harvest Technology
ISSUE FOCUS 20 FEED & ADDITIVE MAGAZINE May 2022 "As nature’s “green gold”, microalgae address sustainability & environmental protection challenges.1 The use of microalgae in animal nutrition sector is attracting a fast-growing interest because of their unique properties and capabilities for health promotion and environmental protection." WHAT ARE MICROALGAE? Alga is defined as a simple, non-flowering, and typically aquatic plant that contains chlorophyll but has no true stems, roots, and leaves. More than 70,000 different algae species have been identified worldwide (European Algae Biomass Association, 2021), ranging from giant kelp (large seaweeds belong to multicellular macroalgae family) to unicellular microalgae. Microalgae are microscopic organisms found in both seawater and freshwater. They can be classified as eukaryotic microorganisms or prokaryotic cyanobacteria (blue-green algae), with more than 25,000 species already isolated and identified.2 MICROALGAE IN NATURE Microalgae play a vital role in aquatic ecosystems being the foundation of the food chain for all aquatic organisms. They perform photosynthesis, which is an important natural mechanism to reduce the atmospheric carbon dioxide concentration through converting sunlight, water and CO2 to algal biomass and oxygen. It is estimated that these single-celled microorganisms produce most of the oxygen we breathe. They are also able to lower the concentrations of nitrogen and phosphorus in wastewater and help tackling the environmental pollution and climate change. AN UNTAPPED NATURAL RESOURCE FOR ANIMAL NUTRITION Microalgae cultivation benefits from a short generation time as the microorganisms can multiply exponentially under favorable environmental conditions. However, of the several thousand microalgae species, only a few dozen are currently commercialized. Microalgae are considered as indispensable resources for food, bioactives, nutraceuticals, pigments, bioenergy molecules, biofertilizers, and agents for bioremediation.3 The main applications of microalgae are summarized in Figure 1.2 Future success of animal nutrition industry in sustainably safeguarding the animals’ food security depends on utilization of innovative feed resources which do not compete with human food. Carole Anne Llewellyn, Professor in Applied Aquatic Bioscience at Swansea University believes THE PROMISING FUTURE OF ANIMAL NUTRITION IN HANDS OF MICROALGAE! Behnaz Shakersain, PhD Marketing & Scientific Liaison AstaReal Sweden
ISSUE FOCUS FEED & ADDITIVE MAGAZINE May 2022 21 that in order to meet our global climate change targets and achieve a sustainable equilibrium, we need to work towards a circular economy that eliminates waste and pollution, keeps materials in circulation and regenerates nature. This must replace our existing linear “use and discard” model which has led to unbalanced nutrient cycles.1 Food and feed industries are playing a significant role in this matter. Given the negative impact of conventional animal feed sources, such as soy, on climate and forested lands, alternative solutions are highly sought-after. So, the use of microalgae in animal nutrition sector is attracting a fast-growing interest because of their unique properties and capabilities for health promotion and environmental protection. The key factors driving today’s interest in microalgae and its derivatives include microalgae’s high yield of healthful macro- and micro-nutrients such as carotenoids, its rapid accumulation of biomass, and its non-competing nature with crops for arable land.3 Adding to those is the growing market demand for natural, sustainable, plant-based, environmental- and planet-friendly food and feed solutions. MICROALGAE AS RICH SOURCE OF HEALTHFUL PHYTONUTRIENTS Carotenoids are a class of bioactive natural molecules synthesized by plants and certain photosynthetic microorganisms, like microalgae. They are an essential component due to their eminent photoprotective and antioxidant properties. Astaxanthin is a reddish pigment from the xanthophyll carotenoids family responsible for the red-orange color of a number of marine animals and microorganisms like salmon, crabs, krill, lobsters, and even flamingos. It has a potent antioxidant and anti-inflammatory activity, higher than most other commonly known antioxidants. For instance, it has been shown that natural astaxanthin is 110 times stronger than vitamin E and 6000 times stronger Figure 1. Main commercialized applications for microalgae.2
ISSUE FOCUS 22 FEED & ADDITIVE MAGAZINE May 2022 than vitamin C in quenching free radicals and so protecting the cells from oxidative stress.4 It is also shown that natural astaxanthin has a 20-fold higher antioxidant potency than synthetic astaxanthin.5 In marine environments, algae rich in astaxanthin is a food for zooplankton which in turn is ingested by fish (e.g. salmonids) and exoskeleton-bearing creatures (e.g. crabs, crayfish, lobsters, krill and shrimp).6 Natural astaxanthin´s color has physical and biological functions in the animal kingdom. It protects animals in the peak of their struggle against harsh environmental conditions. In salmon, for instance, astaxanthin is thought to play an important role during their exhaustive upstream migration. The unicellular green microalgae Haematococcus pluvialis are known as the richest source of natural astaxanthin. They can be found in freshwater bodies that dry out periodically, like the rock pools in Stockholm (Sweden) archipelago. H. pluvialis accumulates high astaxanthin content under stress conditions such as high salinity, nitrogen deficiency, high temperature and light.7 In this situation, the green algae turn red. Astaxanthin protects the algae’s DNA, lipids and cell structure from UV radiation and other sources of free radicals during the whole dormant period. In this form the algae can survive for months or even years until the environment conditions improve again – this highlights the power of natural astaxanthin for increasing the chance of survival. However, the health benefits of astaxanthin are not limited to better survival rates. Its benefits have been scientifically proven for various bodily organs and systems, including muscles, eyes, brain, skin, immune and reproductive systems, etc. With the increasing awareness about the potential health benefits and safety of natural astaxanthin, its commercial use in various industries, such as aquaculture, food and feed, cosmetics, nutraceuticals, and pharmaceuticals are expanding rapidly. The most common use of commercially produced astaxanthin is in fish farming (aquaculture) where it imparts the natural, pink-red color to farmed salmonids and crustaceans. However, a wide range of animals, including pets and animals in competitive sports (e.g. race horses), and agriculture (livestock) can benefit from this potent natural ingredient.
ISSUE FOCUS FEED & ADDITIVE MAGAZINE May 2022 23 HEALTH BENEFITS OF NATURAL ASTAXANTHIN AstaReal as the global pioneer and expert in microalgae cultivation, natural astaxanthin production, R&D and clinical science is an authority in both animal and human food supplements. It is the only brand of natural astaxanthin backed by over 70 clinical studies. AstaReal AB (Sweden) offers its well-studied natural astaxanthin products for animal nutrition in different formats. AstaReal’s H. pluvialis algal flour (biomass that is the crushed and spray-dried aplanospores of microalga) is not only rich in astaxanthin, but also contains valuable proteins, carbohydrates, and essential fatty acids, as well as other carotenoids including lutein, beta-carotene, and canthaxanthin that provide additional health values. Health benefits of its natural astaxanthin has been studies in different animal categories. In a study by Zanghi et al. on dogs, astaxanthin has shown a significant effect on muscle recovery through facilitating carbohydrate sparing and promoting lipid utilization in muscles during exercise.8 In another study on dogs suffering from an inflammatory eye condition, the dogs were fed an antioxidant/anti-inflammatory nutraceutical diet containing natural astaxanthin for 60 days. The diet appeared to significantly increase the eye’s tear production and to clinically ameliorate the inflammation status as well as the corneal keratinization, corneal pigment density and mucus discharge in these dogs that were initially poorly responsive or unresponsive to immune-suppressive therapy.9 In addition, Sato et al. studied the effects of dietary supplementation with astaxanthin (75 mg/day) and L-carnitine (3,000 mg/day) for eight weeks on serum markers and clinical incidence rate of exercise-induced muscle damage Discover the POWER of AstaReal® Astaxanthin! Sustainable and environmentally sound source We truly believe that: ”What benefits my body can benefit my companion animal!” Novasta® is pure algal flour, derived from microalgae Haematococcus pluvialis. It contains astaxanthin, one of the most powerful antioxidants known to science. Our Novasta®, either in form of biomass or encapsulated EB15, could support: • Mobility and muscle recovery • Eye health and visual function • Attentiveness and cognitive response • Immune defence • Liver function and lipid metabolism • Myocardial function • Improved fertility • Growth performance Let our astaxanthin expertise work for you and get in touch with us. www.astareal.se | [email protected] The Trusted Leader in Natural Astaxanthin Production, R&D and Clinical Science.
ISSUE FOCUS 24 FEED & ADDITIVE MAGAZINE May 2022 in training Thoroughbred horses.10 Markers of exercise-induces muscle damage (serum creatine kinase[CK] activity) and muscle fatigue (lactate dehydrogenase-5, LDH-5) were significantly lower in the supplemented group of horses. Exertional rhabdomyolysis (tying-up syndrome) is one of the most common muscle disorders occurring in horses either during or immediately after exercising. The clinical signs of this disease are variable, ranging from slight stiffness to immobility, signs of pain, and reluctance to move. These can limit and inhibit the performance of the horse.10 So, it is crucial to prevent or at least ameliorate the burden through safe dietary and non-invasive interventions such as natural astaxanthin supplementation. Natural astaxanthin supplementation in dogs11 and cats12 could also enhance immune defense and improve immune response. Moreover, astaxanthin supplementation has been associated with improved fertility13,14, and better growth performance15 in livestock, as well as optimum reproduction, growth, survival and immunocompetence in aquaculture.16,17,18 CURRENT MICROALGAE PRODUCTION AND FUTURE POTENTIAL Microalgae production volume globally, and in Europe are estimated to be around 30 206, and 182 tons of dry weight per year, respectively. Food supplements and nutraceuticals (24%), cosmetics (24%), and feed (19%) are the main applications of microalgae biomass, contributing together to 67% of the total use.19,20 The scale of microalgal cultivation is currently not big enough to fully substitute the conventional livestock, and animal feed. Therefore, the focus is on the use of microalgae products as food supplements, to improve and maintain the health of variety of animals. The market for algae-based animal feed and ingredients is set to grow rapidly as the techno economic analyses have shown good potential for scaleup and cost reduction of microalgae cultivation. Microalgae are cultivated by different production methods, such as open pond raceway systems and photobioreactors (PBR). The latter is the most commonly used method in Europe. The disadvantages of open cultivation systems are the increased
ISSUE FOCUS FEED & ADDITIVE MAGAZINE May 2022 25 risk of contamination, lower control of the environmental conditions and greater land and water requirements.20 AstaReal AB uses the indoor PBR technology, which allows for stricter control of the environmental factors and biomass quality with no environmental impurities. Natural astaxanthin has a wide array of applications and the various ingredient formats that are available in the market, offers a huge possibility for formulating innovative animal food and feed. References: 1Carole Anne Llewellyn. Microalgae is nature’s ‘green gold’: our pioneering project to feed the world more sustainably. 2022. Accessed on April 28th, 2022 at: https://theconversation.com/microalgae-is-natures-green-gold-our-pioneeringproject-to-feed-the-world-more-sustainably-170158 2Vale M A, Ferreira A, Pires J C,Gonçalves A L(2020) CO2 capture using microalgae. In: Mohammad Reza Rahimpour, Mohammad Farsi, Mohammad Amin Makarem (Eds) In Advances in Carbon Capture. Woodhead Publishing, Duxford, pp 381 - 405. ISBN 9780128196571. 3Global Perspectives on Astaxanthin From Industrial Production to Food, Health, and Pharmaceutical Applications. Gokare A. Ravishankar, Ambati Ranga Rao. 2021, Elsevier Inc. ISBN: 978-0-12-823304-7. DOI: https://doi. org/10.1016/C2019-0-01800-6. 4Nishida et al. Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants against Singlet Oxygen Using Chemiluminescence Detection System. Carotenoid Science (2007) Vol.11:16-20. 5Oslan, S.N.H. et al. Bioprocess Strategy of Haematococcus lacustris for Biomass and Astaxanthin Production Keys to Commercialization: Perspective and Future Direction. Fermentation 2022, 8, 179. https://doi.org/10.3390/ fermentation8040179. 6Lim KC et al. (2018), Astaxanthin as feed supplement in aquatic animals. Rev Aquacult, 10: 738-773. https://doi. org/10.1111/raq.12200 7Ambati RR et al. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Mar. Drugs 2014, 12, 128-152; doi:10.3390/md12010128. 8Zanghi BM et al.: Effects of postexercise feeding of a supplemental carbohydrate and protein bar with or without astaxanthin from Haematococcus pluvialis to exercise-conditioned dogs. Am J Vet Res. 2015 Apr;76(4):338-50. 9Destefanis S et al.: Clinical evaluation of a nutraceutical diet as an adjuvant to pharmacological treatment in dogs affected by Keratoconjunctivitis sicca. BMC Vet Res. 2016 Sep 22;12(1):214. 10Sato F et al.: Effects of Daily Astaxanthin and L-Carnitine Supplementation for Exercise-Induced Muscle Damage in Training Thoroughbred Horses. Journal of Equine Veterinary Science. 35. 2015. 11Chew BP et al.: Dietary astaxanthin enhances immune response in dogs. Veterinary Immunology and Immunopathology. 2011;140(3-4):199-206. 12Park et al. Astaxanthin stimulates cell-mediated and humoral immune responses in cats. Veterinary Immunology and Immunopathology. 2011;144:455–461. 13Kamada H et al.: Astaxanthin increases progesterone production in cultured bovine luteal cells. J Vet Med Sci. 2017 Jun 29;79(6):1103-1109. Epub 2017 Apr 23. 14Wan FC et al.: Protective effects of astaxanthin on lipopolysaccharide-induced inflammation in bovine endometrial epithelial cells†. Biol Reprod. 2020 Feb 14;102(2):339-347. 15Hosseindoust et al. Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature. Antioxidants 2020, 9, 1032. 16Daly B et al.: Dietary astaxanthin supplementation for hatchery-cultured red king crab, Paralithodes camtschaticus , juveniles. Aquacult Nutr. 2013 Jun;19(3):312–20. 17Li M et al.: Comparison effect of dietary astaxanthin and Haematococcus pluvialis on growth performance, antioxidant status and immune response of large yellow croaker Pseudosciaena crocea. Aquaculture. 2014 Oct;434:227–32. 18Cai M et al.: Dietary Haematococcus pluvialis promotes growth of red swamp crayfish Procambarus clarkii (Girard, 1852) via positive regulation of the gut microbial co-occurrence network. Aquaculture. 2022 Mar;551:737900. 19Janssen et al. Microalgae based production of single-cell protein. Current Opinion in Biotechnology 2022, 75:102705. 20Araújo et al. (2021) Current Status of the Algae Production Industry in Europe: An Emerging Sector of the Blue Bioeconomy. Front. Mar. Sci. 7:626389. doi: 10.3389/ fmars.2020.626389.
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